Gene Symbol: Rps6ka1
Description: ribosomal protein S6 kinase polypeptide 1
Alias: Mapkapk-1a, Rsk, Rsk-1, Rsk1, S6K-alpha-1, p90-Rsk1, p90Rsk1, p90S6K, p90rsk, ribosomal protein S6 kinase alpha-1, 90 kDa ribosomal protein S6 kinase 1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1
Species: mouse
Products:     Rps6ka1

Top Publications

  1. Zeniou M, Ding T, Trivier E, Hanauer A. Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning. Hum Mol Genet. 2002;11:2929-40 pubmed
    ..In humans, RSK2 belongs to a family of four highly homologous proteins (RSK1-RSK4), encoded by distinct genes. RSK2 mutations in CLS patients are extremely heterogeneous...
  2. Chaturvedi D, Cohen M, Taunton J, Patel T. The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function. J Biol Chem. 2009;284:23670-81 pubmed publisher
    Previously, we showed that interactions between p90(RSK1) (RSK1) and the subunits of type I protein kinase A (PKA) regulate the activity of PKA and cellular distribution of active RSK1 (Chaturvedi, D., Poppleton, H. M., Stringfield, T...
  3. Chaturvedi D, Poppleton H, Stringfield T, Barbier A, Patel T. Subcellular localization and biological actions of activated RSK1 are determined by its interactions with subunits of cyclic AMP-dependent protein kinase. Mol Cell Biol. 2006;26:4586-600 pubmed
    Cyclic AMP (cAMP)-dependent protein kinase (PKA) and ribosomal S6 kinase 1 (RSK1) share several cellular proteins as substrates...
  4. Takata T, Tsuchiya Y, Watanabe Y. 90-kDa ribosomal S6 kinase 1 is inhibited by S-glutathionylation of its active-site cysteine residue during oxidative stress. FEBS Lett. 2013;587:1681-6 pubmed publisher
    Previously, we reported that p90-RSK1 phosphorylates neuronal nitric oxide synthase (nNOS) at Ser847 in cells treated with mitogens, leading to the inhibition of NOS activity...
  5. Yang Q, Inoki K, Ikenoue T, Guan K. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 2006;20:2820-32 pubmed
    ..These data demonstrate that Sin1 together with Rictor are key components of mTORC2 and play an essential role in Akt phosphorylation and signaling. ..
  6. Cavet M, Lehoux S, Berk B. 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity. J Biol Chem. 2003;278:18376-83 pubmed
    p90 ribosomal S6 kinase 1 (RSK1) is a serine/threonine kinase that is activated by extracellular signal-related kinases 1/2 and phosphoinositide-dependent protein kinase 1 upon mitogen stimulation...
  7. Laugel Haushalter V, Paschaki M, Marangoni P, Pilgram C, Langer A, Kuntz T, et al. RSK2 is a modulator of craniofacial development. PLoS ONE. 2014;9:e84343 pubmed publisher
    ..and dental anomalies present in Rsk2 knockout mice, a model of Coffin-Lowry syndrome, as well as in triple Rsk1,2,3 knockout mutants. We report Rsk mutation produces surpernumerary teeth midline/mesial to the first molar...
  8. Pennini M, Perkins D, Salazar A, Lipsky M, Vogel S. Complete dependence on IRAK4 kinase activity in TLR2, but not TLR4, signaling pathways underlies decreased cytokine production and increased susceptibility to Streptococcus pneumoniae infection in IRAK4 kinase-inactive mice. J Immunol. 2013;190:307-16 pubmed publisher
  9. Zaru R, Edgar A, Hanauer A, Watts C. Structural and functional basis for p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells. Mol Cell Biol. 2015;35:132-40 pubmed publisher
    b>Rsk kinases play important roles in several cellular processes such as proliferation, metabolism, and migration...

More Information


  1. Lin J, Spolski R, Leonard W. Critical role for Rsk2 in T-lymphocyte activation. Blood. 2008;111:525-33 pubmed
    ..We now report that interleukin 2 (IL-2) and IL-15, but not IL-7, rapidly activate the p90 ribosomal S6 kinases, Rsk1 and Rsk2, in human T lymphocytes...
  2. Mieulet V, Roceri M, Espeillac C, Sotiropoulos A, Ohanna M, Oorschot V, et al. S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover. Am J Physiol Cell Physiol. 2007;293:C712-22 pubmed
    ..Our results do not support a role for global translational control in the growth defect due to S6K deletion, suggesting specific modes of growth control and translational target regulation downstream of mTOR. ..
  3. Wang Y, Wang F, Sun T, Trostinskaia A, Wygle D, Puscheck E, et al. Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos. Dev Dyn. 2004;231:72-87 pubmed
    ..gene products was present: FRS2 alpha, GRB2, GAB1, SOS1, Ha-ras, Raf1/RafB, MEK1,2,5, MAPK/ERK1,2, MAPK/ERK5, and RSK1,2,3 (see abbreviations). These proteins were detected in trophoblasts in embryonic day (E) 3...
  4. Kawasome H, Papst P, Webb S, Keller G, Johnson G, Gelfand E, et al. Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity. Proc Natl Acad Sci U S A. 1998;95:5033-8 pubmed
    ..This study localizes the function of p70(s6k) to ribosomal biogenesis by regulating ribosomal protein synthesis at the level of mRNA translation. ..
  5. Pan X, Kane L, Van Eyk J, Coulombe P. Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion. J Biol Chem. 2011;286:42403-13 pubmed publisher
    ..We show that p90 RSK1, an AGC kinase involved in the regulation of cell survival and proliferation, phosphorylates K17-Ser(44) in skin ..
  6. Spring D, Krebs E. Deletion of 11 amino acids in p90(rsk-mo-1) abolishes kinase activity. Mol Cell Biol. 1999;19:317-20 pubmed
    p90(rsk) is a distal member of the mitogen-activated protein kinase signaling pathway. It has been cloned from a variety of species including Xenopus laevis, mouse, chicken, rat, and human...
  7. Le N, Heo K, Takei Y, Lee H, Woo C, Chang E, et al. A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation. 2013;127:486-99 pubmed publisher
    ..Here, we report the critical role of the p90 ribosomal S6 kinase (p90RSK)/ERK5 complex in EC dysfunction in diabetes mellitus and atherosclerosis...
  8. Pereira A, Zhang B, Malcolm P, Sugiharto Winarno A, Sundram S. Quetiapine and aripiprazole signal differently to ERK, p90RSK and c-Fos in mouse frontal cortex and striatum: role of the EGF receptor. BMC Neurosci. 2014;15:30 pubmed publisher
    ..the second generation atypical APDs aripiprazole and quetiapine affect the EGFR-ERK pathway and its substrates p90RSK and c-Fos in mouse brain, given their divergent agonist and antagonist properties on dopaminergic transmission, ..
  9. Alcorta D, Crews C, Sweet L, Bankston L, Jones S, Erikson R. Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Mol Cell Biol. 1989;9:3850-9 pubmed
    ..We propose that this family of genes be named rsk, for ribosomal S6 kinase.
  10. Butcher G, Lee B, Hsieh F, Obrietan K. Light- and clock-dependent regulation of ribosomal S6 kinase activity in the suprachiasmatic nucleus. Eur J Neurosci. 2004;19:907-15 pubmed
    ..In this study, we examined light-induced regulation of RSK-1 in the SCN...
  11. Zaru R, Matthews S, Edgar A, Prescott A, Gomez Nicola D, Hanauer A, et al. The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning. J Immunol. 2015;195:4264-72 pubmed publisher
    ..Deletion of the phosphoinositide-dependent kinase 1 target kinases, ribosomal S6 kinase 1 (Rsk1) and Rsk2, produced a striking perturbation in the LC network: LC density was reduced 2-fold, but LC size was ..
  12. Buck M, Poli V, van der Geer P, Chojkier M, Hunter T. Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. Mol Cell. 1999;4:1087-92 pubmed
    We report that TGF alpha induces activation of the p90 ribosomal S kinase (RSK), which results in the phosphorylation of rat C/EBP beta on Ser-105 and of mouse C/EBP beta on Thr-217 and concomitantly stimulates proliferation in ..
  13. Engel K, Plath K, Gaestel M. The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain. FEBS Lett. 1993;336:143-7 pubmed
    ..However, the functional consequences of the nuclear targeting sequence present in MAPKAP kinase 2 suggest the existence of further substrates for the enzyme in the nucleus. ..
  14. Shi X, Yan C, Nadtochiy S, Abe J, Brookes P, Berk B. p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury. J Mol Cell Cardiol. 2011;51:272-5 pubmed publisher
    ..Elevated p90 ribosomal S6 kinase (RSK) activity has been observed in diabetic animal, as well as in human failing hearts...
  15. Manhas N, Shi Y, Taunton J, Sun D. p90 activation contributes to cerebral ischemic damage via phosphorylation of Na+/H+ exchanger isoform 1. J Neurochem. 2010;114:1476-86 pubmed publisher
    ..in ischemic brains is regulated by extracellular signal-regulated kinase (ERK)/90-kDa ribosomal S6 kinase (p90(RSK)) signaling pathways...
  16. Luo J, Kintner D, Shull G, Sun D. ERK1/2-p90RSK-mediated phosphorylation of Na+/H+ exchanger isoform 1. A role in ischemic neuronal death. J Biol Chem. 2007;282:28274-84 pubmed
    ..We further examined the ERK/90-kDa ribosomal S6 kinase (p90(RSK)) signaling pathways...
  17. Gao X, Chaturvedi D, Patel T. Localization and retention of p90 ribosomal S6 kinase 1 in the nucleus: implications for its function. Mol Biol Cell. 2012;23:503-15 pubmed publisher
    Ribosomal S6 kinase 1 (RSK1) belongs to a family of proteins with two kinase domains...
  18. McPhee J, Mena P, Bliska J. Delineation of regions of the Yersinia YopM protein required for interaction with the RSK1 and PRK2 host kinases and their requirement for interleukin-10 production and virulence. Infect Immun. 2010;78:3529-39 pubmed publisher
    ..YopM has previously been shown to contain leucine-rich repeats (LRRs) and to interact with two host kinases, RSK1 and PRK2, although the consequence of these interactions is unknown...
  19. Cuello F, Bardswell S, Haworth R, Ehler E, Sadayappan S, Kentish J, et al. Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation. J Biol Chem. 2011;286:5300-10 pubmed publisher
    In myocardium, the 90-kDa ribosomal S6 kinase (RSK) is activated by diverse stimuli and regulates the sarcolemmal Na(+)/H(+) exchanger through direct phosphorylation...
  20. Yamaguchi N, Chakraborty A, Pasek D, Molkentin J, Meissner G. Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. Am J Physiol Heart Circ Physiol. 2011;300:H2187-95 pubmed publisher
    ..5 hearts; rather increased Erk1/2 and p90RSK phosphorylation levels likely leading to reduced GSK-3? activity were found to precede development of cardiac ..
  21. Rawashdeh O, Jilg A, Maronde E, Fahrenkrug J, Stehle J. Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK. J Neurochem. 2016;138:731-45 pubmed publisher
    ..Magnification: 100X, inset 400X. Read the Editorial Highlight for this article on page 650. Cover image for this issue: doi: 10.1111/jnc.13332. ..
  22. Xing L, Larsen R, Bjorklund G, Li X, Wu Y, Philpot B, et al. Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex. elife. 2016;5: pubmed publisher
    ..These data demonstrate selective requirements for ERK/MAPK signaling in layer 5 circuit development and general effects on cortical pyramidal neuron excitability. ..
  23. McMullen J, Shioi T, Zhang L, Tarnavski O, Sherwood M, Dorfman A, et al. Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy. Mol Cell Biol. 2004;24:6231-40 pubmed
    ..These studies suggest that S6Ks alone are not essential for the development of cardiac hypertrophy. ..
  24. Huo L, Fan H, Zhong Z, Chen D, Schatten H, Sun Q. Ubiquitin-proteasome pathway modulates mouse oocyte meiotic maturation and fertilization via regulation of MAPK cascade and cyclin B1 degradation. Mech Dev. 2004;121:1275-87 pubmed
    ..When UPP was inhibited, mitogen-activated protein kinase (MAPK)/p90rsk phosphorylation was not affected, but the cyclin B1 degradation that occurs during normal metaphase-anaphase ..
  25. Gao X, Lin B, Sadayappan S, Patel T. Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis. Mol Pharmacol. 2014;85:357-67 pubmed publisher
    ..apoptosis is accompanied by a decrease in the type I PKA regulatory subunit (PKARI?) and activation of RSK1. As previously described by us for other cell types, in cardiomyocytes, inactive RSK1 also interacts with PKARI?, ..
  26. Hatano N, Mori Y, Oh Hora M, Kosugi A, Fujikawa T, Nakai N, et al. Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells. 2003;8:847-56 pubmed
    ..These observations indicate that ERK2 is essential for placental development and suggest that ERK2 in the trophoblast compartment may be indispensable for the vascularization of the labyrinth. ..
  27. Pelosi M, De Rossi M, Barberi L, Musaro A. IL-6 impairs myogenic differentiation by downmodulation of p90RSK/eEF2 and mTOR/p70S6K axes, without affecting AKT activity. Biomed Res Int. 2014;2014:206026 pubmed publisher
    ..Our study revealed that IL-6 induces the activation of the Stat3 signaling and promotes the downmodulation of the p90RSK/eEF2 and mTOR/p70S6K axes, while it does not affect the activation of AKT...
  28. Ohguchi K, Banno Y, Nakagawa Y, Akao Y, Nozawa Y. Negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells. J Cell Physiol. 2005;205:444-51 pubmed
    ..The results obtained here provide possible evidence that PLD1 exerts a negative regulatory role in the melanogenic process through mTOR/S6K1 signaling. ..
  29. Liu J, Puscheck E, Wang F, Trostinskaia A, Barisic D, Maniere G, et al. Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction. 2004;128:643-54 pubmed
    ..complex during M phase, but one (p38MAPK) associated with the spindle pole and five (Cdx2, MEK1, 2, p27, and RSK1) associated with the DNA...
  30. Casar B, Arozarena I, Sanz Moreno V, Pinto A, Agudo Ibáñez L, Marais R, et al. Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins. Mol Cell Biol. 2009;29:1338-53 pubmed publisher
    ..and cytosolic phospholipase A(2) (cPLA(2)) is most prominent when ERK1/2 are activated from lipid rafts, whereas RSK1 is mainly activated by Ras signals from the disordered membrane...
  31. Xifro X, Anglada Huguet M, Rue L, Saavedra A, Pérez Navarro E, Alberch J. Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity. Mol Neurodegener. 2011;6:74 pubmed publisher
    ..We observed increased protein levels of Rsk1 and Rsk2 in the striatum of Hdh(Q111/Q111) and R6/1 mice, STHdh(Q111/Q111) cells and striatal cells transfected ..
  32. Pan Z, Devaux Y, Ray P. Ribosomal S6 kinase as a mediator of keratinocyte growth factor-induced activation of Akt in epithelial cells. Mol Biol Cell. 2004;15:3106-13 pubmed
    ..Using the yeast two-hybrid assay, we have identified ribosomal S6 kinase (RSK) to be a protein that associates with the cytoplasmic domain of the KGFR...
  33. Cheatham L, Monfar M, Chou M, Blenis J. Structural and functional analysis of pp70S6k. Proc Natl Acad Sci U S A. 1995;92:11696-700 pubmed
    ..Our results indicate that both the N and C termini participate in the complex regulation of pp70S6k activity. ..
  34. Heffron D, Mandell J. Differential localization of MAPK-activated protein kinases RSK1 and MSK1 in mouse brain. Brain Res Mol Brain Res. 2005;136:134-41 pubmed
    b>RSK1 and MSK1 are closely related members of the MAP kinase-activated kinase family and are direct substrates and effectors of the well-studied mitogen-activated protein kinases...
  35. Schuck S, Soloaga A, Schratt G, Arthur J, Nordheim A. The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells. BMC Mol Biol. 2003;4:6 pubmed
    ..In addition, they indicate that MSK1 could act through CRE binding proteins to achieve c-fos promoter activation. Thus, they further our understanding of the complex regulation of the model immediate-early gene c-fos. ..