Rps6

Summary

Gene Symbol: Rps6
Description: ribosomal protein S6
Alias: S6R, 40S ribosomal protein S6, phosphoprotein NP33
Species: mouse
Products:     Rps6

Top Publications

  1. Cao R, Lee B, Cho H, Saklayen S, Obrietan K. Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock. Mol Cell Neurosci. 2008;38:312-24 pubmed publisher
    ..Together these data identify a light-responsive mTOR cascade in the SCN, and thus, raise the possibility that inducible translation contributes to the clock entrainment process. ..
  2. Yurttas P, Vitale A, Fitzhenry R, Cohen Gould L, Wu W, Gossen J, et al. Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo. Development. 2008;135:2627-36 pubmed publisher
    ..These results suggest that, in mammals, ribosomal components are stored in the oocyte CPLs and are required for protein translation during early development. ..
  3. Paliouras G, Hamilton L, Aumont A, Joppé S, Barnabe Heider F, Fernandes K. Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain. J Neurosci. 2012;32:15012-26 pubmed publisher
    ..These findings establish fundamental links between mTOR signaling, proliferation, and aging-associated quiescence in the adult forebrain NSC niche. ..
  4. Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich Rain M, Nir T, et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev. 2005;19:2199-211 pubmed
    ..To directly address this issue, we have established viable and fertile knock-in mice, whose rpS6 contains alanine substitutions at all five phosphorylatable serine residues (rpS6(P-/-))...
  5. Ljungberg M, Sunnen C, Lugo J, Anderson A, D ARCANGELO G. Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia. Dis Model Mech. 2009;2:389-98 pubmed publisher
    ..These findings support the possibility that this drug may be developed as a novel antiepileptic treatment for patients with cortical dysplasia and similar disorders. ..
  6. Tuhácková Z, Sloncova E, Vojtechova M, Sovová V. IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells. Int J Mol Med. 2004;13:601-5 pubmed
    ..Here we demonstrate that the phosphorylation of 40S ribosomal protein S6, a physiological substrate p70 S6 kinase, was highly increased by growth-stimulation of the cytolytic T ..
  7. Goorden S, Hoogeveen Westerveld M, Cheng C, van Woerden G, Mozaffari M, Post L, et al. Rheb is essential for murine development. Mol Cell Biol. 2011;31:1672-8 pubmed publisher
    ..Rheb heterozygosity extended the life span of tuberous sclerosis complex 1-deficient (Tsc1(-/-)) embryos, indicating that there is a genetic interaction between the Tsc1 and Rheb genes in mouse. ..
  8. Volarevic S, Stewart M, Ledermann B, Zilberman F, Terracciano L, Montini E, et al. Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science. 2000;288:2045-7 pubmed
    ..To test this possibility, we conditionally deleted the gene encoding 40S ribosomal protein S6 in the liver of adult mice...
  9. Ferrari S, Bandi H, Hofsteenge J, Bussian B, Thomas G. Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites. J Biol Chem. 1991;266:22770-5 pubmed
    ..The low level of phosphorylation of the fifth site in vitro is discussed with regard to known results and to a potential three-dimensional model for the carboxyl terminus of S6. ..

More Information

Publications81

  1. Tavazoie S, Alvarez V, Ridenour D, Kwiatkowski D, Sabatini B. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci. 2005;8:1727-34 pubmed
    ..Thus, the TSC pathway regulates growth and synapse function in neurons, and perturbations of neuronal structure and function are likely to contribute to the pathogenesis of the neurological symptoms of TSC. ..
  2. Chauvin C, Koka V, Nouschi A, Mieulet V, Hoareau Aveilla C, Dreazen A, et al. Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program. Oncogene. 2014;33:474-83 pubmed publisher
    ..S6Ks phosphorylate ribosomal protein S6 (rpS6) and additional proteins involved in the translational machinery, although the functional roles of these ..
  3. Lecomte F, Champagne B, Dasnoy J, Szpirer J, Szpirer C. The mammalian RPS6 gene, homolog of the Drosophila air8 tumor suppressor gene: is it an oncosuppressor gene?. Somat Cell Mol Genet. 1995;21:443-50 pubmed
    ..We assigned the rat Rps6 gene to chromosome 5q22-33...
  4. Feng Q, Di R, Tao F, Chang Z, Lu S, Fan W, et al. PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development. Mol Cell Biol. 2010;30:3711-21 pubmed publisher
    ..Taken together, these results have revealed an essential role of PDK1 in cardiovascular development through activation of Akt and Snail. ..
  5. Zhou Z, Shirakawa T, Ohbo K, Sada A, Wu Q, Hasegawa K, et al. RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells. Dev Cell. 2015;34:96-107 pubmed publisher
    ..This mechanism links mRNA turnover to mTORC1 signaling through Nanos2-containing mRNPs and establishes a post-transcriptional buffering system to facilitate SSC homeostasis in the fluctuating environment within the seminiferous tubule. ..
  6. Foerster P, Daclin M, Asm S, Faucourt M, Boletta A, Genovesio A, et al. mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis. Development. 2017;144:201-210 pubmed publisher
    ..These results suggest that primary cilia regulate ventricle morphogenesis by acting as a brake on the mTORC1 pathway. This opens new avenues for the diagnosis and treatment of hydrocephalus. ..
  7. Fleming M, Vysochan A, Paixão S, Niu J, Klein R, Savitt J, et al. Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors. elife. 2015;4:e06828 pubmed publisher
    ..Taken together, our results suggest that trans and cis RET signaling could function in the same developmental process and that the availability of both forms of activation likely enhances but not diversifies outcomes of RET signaling. ..
  8. Hudon V, Sabourin S, Dydensborg A, Kottis V, Ghazi A, Paquet M, et al. Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin. J Med Genet. 2010;47:182-9 pubmed publisher
    ..In accordance with clinical data showing distinct renal malignancies arising in BHD patients, in this study FLCN is shown as a general tumour suppressor in the kidney. ..
  9. Westmoreland J, Wang Q, Bouzaffour M, Baker S, Sosa Pineda B. Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells. Dev Biol. 2009;334:285-98 pubmed publisher
  10. Kumar N, Srivillibhuthur M, Joshi S, Walton K, Zhou A, Faller W, et al. A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development. 2016;143:3711-3722 pubmed
    ..Our study highlights the still unappreciated role of metabolic regulation during organogenesis, and suggests that it might contribute to neonatal gastrointestinal disorders. ..
  11. Hägglund A, Jones I, Carlsson L. A novel mouse model of anterior segment dysgenesis (ASD): conditional deletion of Tsc1 disrupts ciliary body and iris development. Dis Model Mech. 2017;10:245-257 pubmed publisher
  12. Pui H, Saga Y. Gonocytes-to-spermatogonia transition initiates prior to birth in murine testes and it requires FGF signaling. Mech Dev. 2017;144:125-139 pubmed publisher
    ..Taken together, we defined the precise timing of GST and revealed FGF signaling as a master regulator of GST in the perinatal mouse testes. ..
  13. Moon U, Park J, Park R, Cho J, Hughes L, McKenna J, et al. Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex. Cell Rep. 2015;12:965-78 pubmed publisher
    ..Thus, disrupted Reelin-Dab1 signaling is critically involved in the neuronal migration defects of TSC. ..
  14. Xu J, Chen J, Dong Z, Meyuhas O, Chen J. Phosphorylation of ribosomal protein S6 mediates compensatory renal hypertrophy. Kidney Int. 2015;87:543-56 pubmed publisher
    ..Here we generated congenic ribosomal protein S6 (rpS6) knock-in mice expressing nonphosphorylatable rpS6 and found that uninephrectomy-induced renal hypertrophy was ..
  15. Hegedus B, Dasgupta B, Shin J, Emnett R, Hart Mahon E, Elghazi L, et al. Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms. Cell Stem Cell. 2007;1:443-57 pubmed publisher
    ..Together, these findings demonstrate that neurofibromin is required for normal glial and neuronal development involving separable Ras-dependent and cAMP-dependent mechanisms. ..
  16. Rosner M, Schipany K, Hengstschlager M. Phosphorylation of nuclear and cytoplasmic pools of ribosomal protein S6 during cell cycle progression. Amino Acids. 2013;44:1233-40 pubmed publisher
    Of all known ribosomal proteins, the 40S ribosomal protein S6 is by far the most extensively studied. Still, little is known about some basic aspects of S6 regulation including its cell cycle-related expression and localization...
  17. Barkic M, Crnomarković S, Grabusic K, Bogetić I, Panic L, Tamarut S, et al. The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival. Mol Cell Biol. 2009;29:2489-504 pubmed publisher
    ..Our results imply that activation of a p53-dependent checkpoint mechanism in response to various ribosomal protein deficiencies might also play a role in the pathogenesis of congenital malformations in humans. ..
  18. Nelson D, Manhardt C, Kamath V, Sui Y, Santamaria Pang A, Can A, et al. Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation. Biol Open. 2013;2:439-47 pubmed publisher
    ..The data suggest that there are temporally and spatially discreet progenitor populations that contribute to salivary gland development and homeostasis. ..
  19. Calamaras T, Lee C, Lan F, Ido Y, Siwik D, Colucci W. The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling. Free Radic Biol Med. 2015;82:137-46 pubmed publisher
    ..HNE inhibited the downstream kinase AMPK, increased hypertrophic mTOR-p70S6K-RPS6 signaling, and stimulated protein synthesis by 27.1 ± 3.5%...
  20. Shah O, Hunter T. Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex. J Biol Chem. 2004;279:20816-23 pubmed
    ..These results also highlight the importance of dual control of T-loop and H-motif phosphorylation of S6K1 by the Tsc1-Tsc2 complex. ..
  21. Dharaneeswaran H, Abid M, Yuan L, Dupuis D, Beeler D, Spokes K, et al. FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis. Circ Res. 2014;115:238-251 pubmed publisher
    ..Moreover, FoxO1-mediated feedback activation of Akt maintains growth factor responsive Akt/mTORC1 activity within a homeostatic range. ..
  22. Hughes J, Dawson R, Tea M, McAninch D, Piltz S, Jackson D, et al. Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling. Sci Rep. 2017;7:12618 pubmed publisher
  23. Plaks V, Gershon E, Zeisel A, Jacob Hirsch J, Neeman M, Winterhager E, et al. Blastocyst implantation failure relates to impaired translational machinery gene expression. Reproduction. 2014;148:87-98 pubmed publisher
    ..This information could be implicated to diagnosis and treatment of infertility, particularly to IVF. ..
  24. Hsieh A, Costa M, Zollo O, Davis C, Feldman M, Testa J, et al. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell. 2010;17:249-61 pubmed publisher
    ..While phosphorylation of rpS6 is dispensable for cancer formation, 4EBP-eIF4E exerts significant control over cap-dependent translation, cell ..
  25. Panic L, Tamarut S, Sticker Jantscheff M, Barkic M, Solter D, Uzelac M, et al. Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol. 2006;26:8880-91 pubmed
    ..Thus, a p53-dependent checkpoint is activated during gastrulation in response to ribosome insufficiency to prevent improper execution of the developmental program. ..
  26. Buaas F, Gardiner J, Clayton S, Val P, Swain A. In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland. Development. 2012;139:4561-70 pubmed publisher
    ..This study is the first to show the in vivo requirements of SF1 in steroidogenesis and provides novel data on the cellular consequences of the loss of this protein specifically within steroid-producing cells. ..
  27. Ka M, Condorelli G, Woodgett J, Kim W. mTOR regulates brain morphogenesis by mediating GSK3 signaling. Development. 2014;141:4076-86 pubmed publisher
    ..Our findings reveal that the interaction between mTOR and GSK3 signaling plays an essential role in dynamic homeostasis of neural progenitors during brain development. ..
  28. Bandi H, Ferrari S, Krieg J, Meyer H, Thomas G. Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum. J Biol Chem. 1993;268:4530-3 pubmed
    ..The results show that the phosphorylated peptide extends from Arg231 to Lys249 and that the sites of phosphorylation in vivo are Ser235, Ser240, Ser244, and Ser247...
  29. Granot Z, Swisa A, Magenheim J, Stolovich Rain M, Fujimoto W, Manduchi E, et al. LKB1 regulates pancreatic beta cell size, polarity, and function. Cell Metab. 2009;10:296-308 pubmed publisher
    ..Insulin secretion and content are restricted by LKB1, at least in part, via AMPK. These results expose a molecular mechanism, orchestrated by LKB1, for the coordinated maintenance of beta cell size, form, and function. ..
  30. Cortez Toledo O, Schnair C, Sangngern P, Metzger D, Chao L. Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice. PLoS ONE. 2017;12:e0171268 pubmed publisher
    ..Collectively, the findings presented here demonstrate Nur77 as an important regulator of muscle growth both during prenatal and postnatal myogenesis. ..
  31. McGowan K, Li J, Park C, Beaudry V, Tabor H, Sabnis A, et al. Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet. 2008;40:963-70 pubmed publisher
  32. Kim E, Wang Y, Kim S, Bornhorst M, Jecrois E, Anthony T, et al. Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1. elife. 2014;3: pubmed publisher
  33. Park K, Liu K, Hu Y, Smith P, Wang C, Cai B, et al. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 2008;322:963-6 pubmed publisher
    ..Thus, our results suggest the manipulation of intrinsic growth control pathways as a therapeutic approach to promote axon regeneration after CNS injury. ..
  34. Hashimoto M, Sato T, Muroyama Y, Fujimura L, Hatano M, Saito T. Nepro is localized in the nucleolus and essential for preimplantation development in mice. Dev Growth Differ. 2015;57:529-38 pubmed publisher
    ..Furthermore, at the morula stage, whereas 18S rRNA and ribosomal protein S6 (rpS6), which are components of the ribosome, were distributed to the cytoplasm in WT embryos, they were mainly localized ..
  35. Yano T, Ferlito M, Aponte A, Kuno A, Miura T, Murphy E, et al. Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling. Circ Res. 2014;114:1268-80 pubmed publisher
    ..preconditioning and other Akt activators (insulin and opioids) result in phosphorylation of ribosomal protein S6 (Rps6) at Ser235/236 in mouse hearts and neonatal rat ventricular myocytes...
  36. Kim S, Lehtinen M, Sessa A, Zappaterra M, Cho S, Gonzalez D, et al. The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron. 2010;66:69-84 pubmed publisher
    ..These data highlight unexpected roles of the apical complex protein Pals1 in cell survival through interactions with mTOR signaling. ..
  37. Nguyen H, Hinman M, Guo X, Sharma A, Arakawa H, Luo G, et al. Neurofibromatosis type 1 alternative splicing is a key regulator of Ras/ERK signaling and learning behaviors in mice. Hum Mol Genet. 2017;26:3797-3807 pubmed publisher
    ..Therefore, the regulated alternative splicing of Nf1 is an important mechanism for fine-tuning Ras/ERK signaling as well as learning and memory in mice. ..
  38. Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, et al. Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep. 2014;7:1626-1639 pubmed publisher
    ..Our findings demonstrate that mTORC1 plays different roles in developmental and adult stages and contributes to human neurological diseases. ..
  39. Khalaileh A, Dreazen A, Khatib A, Apel R, Swisa A, Kidess Bassir N, et al. Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer. Cancer Res. 2013;73:1811-20 pubmed publisher
    ..Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implicated previously in cancer...
  40. Puighermanal E, Biever A, Pascoli V, Melser S, Pratlong M, Cutando L, et al. Ribosomal Protein S6 Phosphorylation Is Involved in Novelty-Induced Locomotion, Synaptic Plasticity and mRNA Translation. Front Mol Neurosci. 2017;10:419 pubmed publisher
    The phosphorylation of the ribosomal protein S6 (rpS6) is widely used to track neuronal activity...
  41. Pollizzi K, Malinowska Kolodziej I, Doughty C, Betz C, Ma J, Goto J, et al. A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles. Hum Mol Genet. 2009;18:2378-87 pubmed publisher
    ..Tsc2-del3 mice also serve as a model for hypomorphic TSC2 missense mutations reported in TSC patients. ..
  42. Rosner M, Fuchs C, Dolznig H, Hengstschlager M. Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236. Amino Acids. 2011;40:595-600 pubmed publisher
    ..Our findings provide new insights into the regulation of S6 phosphorylation and S6 protein localization in mammalian cells. ..
  43. Wittenberg A, Azar S, Klochendler A, Stolovich Rain M, Avraham S, Birnbaum L, et al. Phosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-Cells. PLoS ONE. 2016;11:e0149995 pubmed publisher
    ..To determine which functions of Akt are mediated by ribosomal protein S6 (rpS6), an Akt effector, we generated mice that express constitutive Akt in β-cells in the background of ..
  44. Kimball S, Horetsky R, Ron D, Jefferson L, Harding H. Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. Am J Physiol Cell Physiol. 2003;284:C273-84 pubmed
    ..Finally, we also show that stress granules contain many, if not all, of the components of the 48S preinitiation complex, but not 60S ribosomal subunits, suggesting that they represent stalled translation initiation complexes. ..
  45. Hernandez O, Way S, McKenna J, Gambello M. Generation of a conditional disruption of the Tsc2 gene. Genesis. 2007;45:101-6 pubmed
    ..Using this Tsc2(flox) allele we have generated a null allele using Cre recombination. This allele will be useful in investigating TSC pathology with appropriate cell and organ specific Cre-transgenic mice. ..
  46. Goller T, Seibold U, Kremmer E, Voos W, Kolanus W. Atad3 function is essential for early post-implantation development in the mouse. PLoS ONE. 2013;8:e54799 pubmed publisher
    ..At the biochemical level, we report here that ATAD3 is present in five native mitochondrial protein complexes of different sizes, indicating complex roles of the protein in mitochondrial architecture and function. ..
  47. Um S, Sticker Jantscheff M, Chau G, Vintersten K, Mueller M, Gangloff Y, et al. S6K1 controls pancreatic ? cell size independently of intrauterine growth restriction. J Clin Invest. 2015;125:2736-47 pubmed publisher
    ..of S6K1 in ? cells of S6K1-/- mice restored embryonic ? cell size, insulin levels, glucose tolerance, and RPS6 phosphorylation, without rescuing IUGR...
  48. Salmond R, Emery J, Okkenhaug K, Zamoyska R. MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J Immunol. 2009;183:7388-97 pubmed publisher
    Ribosomal protein S6 (rpS6) is a key component of the translational machinery in eukaryotic cells and is essential for ribosome biogenesis...
  49. Wang C, Cigliano A, Jiang L, Li X, Fan B, Pilo M, et al. 4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice. Hepatology. 2015;61:200-13 pubmed publisher
    ..mTORC1 functions by regulating p70S6K/ribosomal protein S6 (RPS6) and eukaryotic translation initiation factor 4E-binding protein 1/ eukaryotic translation initiation factor 4E (..
  50. Figlia G, Norrmen C, Pereira J, Gerber D, Suter U. Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system. elife. 2017;6: pubmed publisher
    ..An ensuing decline in mTORC1 activity is crucial to allow myelination to start, while remaining mTORC1 activity drives myelin growth. ..
  51. Han S, Kim S, Bahl S, Li L, Burande C, Smith N, et al. The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains. J Biol Chem. 2012;287:30063-72 pubmed publisher
    ..The ubiquitin ligase complex containing Pam-Fbxo45 likely targets additional synaptic and axonal proteins, which may explain the overlapping neurodevelopmental defects observed in Phr1 and Fbxo45 deficiency. ..
  52. Unhavaithaya Y, Hao Y, Beyret E, Yin H, Kuramochi Miyagawa S, Nakano T, et al. MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem. 2009;284:6507-19 pubmed publisher
    ..These observations indicate that MILI may positively regulate translation and that such regulation is required for germ line stem cell self-renewal. ..
  53. Lai L, Lilley B, Sanes J, McMahon A. Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation. Proc Natl Acad Sci U S A. 2013;110:19450-5 pubmed publisher
    ..These findings highlight a critical requirement for integration of mammalian target of rapamycin activity into developmental decision-making during mammalian skeletogenesis. ..
  54. Gong Y, Ishida Takahashi R, Villanueva E, Fingar D, Munzberg H, Myers M. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem. 2007;282:31019-27 pubmed
    ..Dissecting the contributions of these individual pathways to leptin action will be important for our ultimate understanding of the processes that regulate energy balance in vivo. ..
  55. Chen J, Tu X, Esen E, Joeng K, Lin C, Arbeit J, et al. WNT7B promotes bone formation in part through mTORC1. PLoS Genet. 2014;10:e1004145 pubmed publisher
    ..Genetic disruption of mTORC1 signaling by deleting Raptor in the osteoblast lineage alleviated the WNT7B-induced high-bone-mass phenotype. Thus, WNT7B promotes bone formation in part through mTORC1 activation. ..
  56. Lalanne J, Lucero M, Le Moullec J. Complete sequence of mouse S6 ribosomal protein. Nucleic Acids Res. 1987;15:4990 pubmed
  57. Klingebiel M, Dinekov M, Kohler C. Analysis of ribosomal protein S6 baseline phosphorylation and effect of tau pathology in the murine brain and human hippocampus. Brain Res. 2017;1659:121-135 pubmed publisher
  58. Grego Bessa J, Bloomekatz J, Castel P, Omelchenko T, Baselga J, Anderson K. The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium. elife. 2016;5:e12034 pubmed publisher
    ..The data suggest that appropriate levels of membrane-associated PDPK1 are required for stabilization of apical junctions, which promotes cell elongation, during epithelial morphogenesis. ..
  59. Patursky Polischuk I, Stolovich Rain M, Hausner Hanochi M, Kasir J, Cybulski N, Avruch J, et al. The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Mol Cell Biol. 2009;29:640-9 pubmed publisher
    ..This conclusion is further supported by the observation that raptor knockout renders the translation of TOP mRNAs rapamycin hypersensitive. ..
  60. Keel S, Phelps S, Sabo K, O Leary M, Kirn Safran C, Abkowitz J. Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis. Exp Hematol. 2012;40:290-4 pubmed publisher
    ..The mice have an erythroid phenotype similar to both Diamond-Blackfan anemia and the 5q- syndrome and lenalidomide therapy improves their anemia. ..
  61. Ruvinsky I, Katz M, Dreazen A, Gielchinsky Y, Saada A, Freedman N, et al. Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit. PLoS ONE. 2009;4:e5618 pubmed publisher
    ..protein S6 cannot be phosphorylated due to replacement of all five phosphorylatable serine residues by alanines (rpS6(P-/-)), are viable and fertile...
  62. Hartman A, Santos P, Dolce A, Hardwick J. The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice. PLoS ONE. 2012;7:e45156 pubmed publisher
    ..Furthermore, the combined pattern of acute seizure test results places rapamycin in a third category distinct from both fasting and the ketogenic diet, and which is more similar to drugs acting on sodium channels. ..
  63. Ma A, Wang L, Gao Y, Chang Z, Peng H, Zeng N, et al. Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality. Hum Mol Genet. 2014;23:693-705 pubmed publisher
    ..We postulated that disruption of normal angiogenic pathways through hyperactive mTOR signaling maybe the mechanism that lead to deranged vascular pathogenesis in the tuberous sclerosis complex. ..
  64. Jones I, Hägglund A, Törnqvist G, Nord C, Ahlgren U, Carlsson L. A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development. Dis Model Mech. 2015;8:1517-29 pubmed publisher
  65. Stiles B, Kuralwalla Martinez C, Guo W, Gregorian C, Wang Y, Tian J, et al. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol. 2006;26:2772-81 pubmed
    ..Our data demonstrate that PTEN loss in beta cells is not tumorigenic but beneficial. This suggests that modulating the PTEN-controlled signaling pathway is a potential approach for beta-cell protection and regeneration therapies. ..
  66. Sulic S, Panic L, Barkic M, Mercep M, Uzelac M, Volarevic S. Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. Genes Dev. 2005;19:3070-82 pubmed
    ..the effect of impaired ribosome functions in vivo, we conditionally deleted one or two alleles of the 40S ribosomal protein S6 gene in T cells in the mouse...
  67. Marshall K, Tomasini A, Makky K, N Kumar S, Mayer A. Dynamic Lkb1-TORC1 signaling as a possible mechanism for regulating the endoderm-intestine transition. Dev Dyn. 2010;239:3000-12 pubmed publisher
    ..These data suggest that programmed localization of Lkb1 could represent a novel mechanism for regulating the EIT during intestinal development in vertebrates. ..
  68. Hasumi Y, Baba M, Ajima R, Hasumi H, Valera V, Klein M, et al. Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2. Proc Natl Acad Sci U S A. 2009;106:18722-7 pubmed publisher
  69. Cloëtta D, Thomanetz V, Baranek C, Lustenberger R, Lin S, Oliveri F, et al. Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis. J Neurosci. 2013;33:7799-810 pubmed publisher
    ..Together, our results show that postnatal survival, overall brain growth, and specific aspects of brain development critically depend on mTORC1 function. ..
  70. Díaz Alonso J, Aguado T, de Salas Quiroga A, Ortega Z, Guzman M, Galve Roperh I. CB1 Cannabinoid Receptor-Dependent Activation of mTORC1/Pax6 Signaling Drives Tbr2 Expression and Basal Progenitor Expansion in the Developing Mouse Cortex. Cereb Cortex. 2015;25:2395-408 pubmed publisher
  71. Fumagalli S, Di Cara A, Neb Gulati A, Natt F, Schwemberger S, Hall J, et al. Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction. Nat Cell Biol. 2009;11:501-8 pubmed publisher
    ..Previously, we demonstrated that deletion of the 40S rpS6 gene in mouse liver prevents hepatocytes from re-entering the cell cycle after partial hepatectomy...
  72. Jeon Y, Kim I, Hong S, Nan H, Kim H, Lee H, et al. Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling. Oncogene. 2008;27:4344-52 pubmed publisher
    ..performed a functional genetic screening and rescued TRAIL-resistant Jurkat clones harboring ribosomal protein S6 (rpS6) cDNA in anti-sense frame...