Gene Symbol: Rpl11
Description: ribosomal protein L11
Alias: 2010203J19Rik, 60S ribosomal protein L11
Itahana K, Mao H, Jin A, Itahana Y, Clegg H, Lindström M, et al
. Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell. 2007;12:355-66 pubmed
Zhou X, Hao Q, Zhang Q, Liao J, Ke J, Liao P, et al
. Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition. Cell Death Differ. 2015;22:755-66 pubmed publisher
..Herein, we report that RPL5 and RPL11 can also enhance the transcriptional activity of a p53 homolog TAp73, but through a distinct mechanism...
Bernardi R, Scaglioni P, Bergmann S, Horn H, Vousden K, Pandolfi P. PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat Cell Biol. 2004;6:665-72 pubmed
..These findings demonstrate an unexpected role of PML in the nucleolar network for tumour suppression. ..
Yuan X, Zhou Y, Casanova E, Chai M, Kiss E, Grone H, et al
. Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell. 2005;19:77-87 pubmed
..The striking correlation between perturbation of nucleolar function, elevated levels of p53, and induction of cell suicide supports the view that the nucleolus is a stress sensor that regulates p53 activity. ..
Macias E, Jin A, Deisenroth C, Bhat K, Mao H, Lindström M, et al
. An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Cancer Cell. 2010;18:231-43 pubmed publisher
..cysteine-to-phenylalanine substitution in the zinc finger of Mdm2 that disrupted its binding to RPL5 and RPL11. Mice harboring this mutation, retain normal p53 response to DNA damage, but lack of p53 response to perturbations ..
Morgado Palacin L, Llanos S, Serrano M. Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells. Cell Cycle. 2012;11:503-10 pubmed publisher
..These results extend to pluripotent cells the functionality of the ribosomal stress pathway and we speculate that this could be a relevant cellular checkpoint during early embryogenesis. ..
Kamio T, Gu B, Olson T, Zhang Y, Mason P, Bessler M. Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis. PLoS ONE. 2016;11:e0152263 pubmed publisher
..that the ubiquitination of p53 by MDM2 can be inhibited when certain ribosomal proteins, including RPL5 and RPL11, bind to MDM2...
Panic L, Tamarut S, Sticker Jantscheff M, Barkic M, Solter D, Uzelac M, et al
. Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol. 2006;26:8880-91 pubmed
..Thus, a p53-dependent checkpoint is activated during gastrulation in response to ribosome insufficiency to prevent improper execution of the developmental program. ..
Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, et al
. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med. 2011;17:944-51 pubmed publisher
..Pict1-deficient cells accumulated p53, owing to impaired Mdm2 function. Pict1 binds Rpl11, and Rpl11 is released from nucleoli in the absence of Pict1...