Gene Symbol: Rph3a
Description: rabphilin 3A
Alias: 2900002P20Rik, AU022689, AW108370, rabphilin-3A, Doc2 family, exophilin-1
Species: mouse
Products:     Rph3a

Top Publications

  1. Mashimo T, Glaser P, Lucas M, Simon Chazottes D, Ceccaldi P, Montagutelli X, et al. Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine 2',5'-oligoadenylate synthetases. Genomics. 2003;82:537-52 pubmed
    ..For all these eight genes a specific inducible promoter controls transcription. The possible functions of this family of proteins are discussed. ..
  2. Inagaki N, Mizuta M, Seino S. Cloning of a mouse Rabphilin-3A expressed in hormone-secreting cells. J Biochem. 1994;116:239-42 pubmed
    ..These results suggest that Rabphilin-3A might be involved in the exocytosis of secretory vesicles in hormone-secreting cells as well as in neurons. ..
  3. Ostermeier C, Brunger A. Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A. Cell. 1999;96:363-74 pubmed
    ..RabCDRs could be major determinants of effector specificity during vesicle trafficking and fusion. ..
  4. Fenster S, Chung W, Zhai R, Cases Langhoff C, Voss B, Garner A, et al. Piccolo, a presynaptic zinc finger protein structurally related to bassoon. Neuron. 2000;25:203-14 pubmed
    ..These data suggest that Piccolo plays a role in the trafficking of synaptic vesicles (SVs) at the active zone. ..
  5. Brozzi F, Lajus S, Diraison F, Rajatileka S, Hayward K, Regazzi R, et al. MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway. Mol Biol Cell. 2012;23:4444-55 pubmed publisher
    ..These data suggest that MyRIP only forms a functional protein complex with BR-MyoVa on SGs when cAMP is elevated and under this condition facilitates phosphorylation of SG-associated proteins, which in turn can enhance secretion. ..
  6. Liu Z, Li H, Hu X, Yu L, Liu H, Han R, et al. Control of precerebellar neuron development by Olig3 bHLH transcription factor. J Neurosci. 2008;28:10124-33 pubmed publisher
    ..Therefore, Olig3 plays an important role in the fate specification and differentiation of caudal RL-derived neurons. ..
  7. Deak F, Shin O, Tang J, Hanson P, Ubach J, Jahn R, et al. Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion. EMBO J. 2006;25:2856-66 pubmed
  8. Dalfo E, Gomez Isla T, Rosa J, Nieto Bodelón M, Cuadrado Tejedor M, Barrachina M, et al. Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice. J Neuropathol Exp Neurol. 2004;63:302-13 pubmed
    ..This rationale is consistent with previous data showing that short-term hippocampal synaptic plasticity is altered and that alpha-synuclein accumulates in the cytoplasm of neurons in Tg mice. ..
  9. Capron B, Wattiez R, Sindic C, Godaux E, Ris L. Tyrosine phosphorylation of rabphilin during long-lasting long-term potentiation. Neurosci Lett. 2007;414:257-62 pubmed
    ..Our results suggest that rabphilin, a protein present in presynaptic terminals, could play a role in the late phase of L-LTP. ..

More Information


  1. Schlüter O, Schnell E, Verhage M, Tzonopoulos T, Nicoll R, Janz R, et al. Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release. J Neurosci. 1999;19:5834-46 pubmed
    ..Our data thus demonstrate that rabphilin is endowed with the properties of a rab3 effector but is not essential for the regulatory functions of rab3 in synaptic transmission. ..
  2. Tanaka M, Miyoshi J, Ishizaki H, Togawa A, Ohnishi K, Endo K, et al. Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction. Mol Biol Cell. 2001;12:1421-30 pubmed
    ..Thus, Rab3 GEP is essential for neurotransmitter release and probably for formation and trafficking of the synaptic vesicles. ..
  3. Stanic J, Carta M, Eberini I, Pelucchi S, Marcello E, Genazzani A, et al. Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex. Nat Commun. 2015;6:10181 pubmed publisher
    ..Here, we identify Rabphilin 3A (Rph3A) as a new GluN2A subunit-binding partner...
  4. Kanadia R, Clark V, Punzo C, Trimarchi J, Cepko C. Temporal requirement of the alternative-splicing factor Sfrs1 for the survival of retinal neurons. Development. 2008;135:3923-33 pubmed publisher
    ..Our results highlight the requirement of Sfrs1-mediated alternative splicing for the survival of retinal neurons, with sensitivity defined by the window of time in which the neuron was generated. ..
  5. Yuan Q, Ren C, Xu W, Petri B, Zhang J, Zhang Y, et al. PKN1 Directs Polarized RAB21 Vesicle Trafficking via RPH3A and Is Important for Neutrophil Adhesion and Ischemia-Reperfusion Injury. Cell Rep. 2017;19:2586-2597 pubmed publisher
    ..We show that the protein kinase PKN1 phosphorylates RPH3A, which enhances binding of RPH3A to guanosine triphosphate (GTP)-bound RAB21...
  6. Baldini G, Martelli A, Tabellini G, Horn C, Machaca K, Narducci P, et al. Rabphilin localizes with the cell actin cytoskeleton and stimulates association of granules with F-actin cross-linked by {alpha}-actinin. J Biol Chem. 2005;280:34974-84 pubmed
    ..These results suggest that rabphilin, by interacting with alpha-actinin, organizes the cell cytoskeleton to facilitate granule localization within F-actin-rich regions. ..
  7. Perelygin A, Scherbik S, Zhulin I, Stockman B, Li Y, Brinton M. Positional cloning of the murine flavivirus resistance gene. Proc Natl Acad Sci U S A. 2002;99:9322-7 pubmed
    ..Expression of the resistant allele of Oas1b in susceptible embryo fibroblasts resulted in partial inhibition of the replication of a flavivirus but not of an alpha togavirus. ..
  8. Ozaki N, Shibasaki T, Kashima Y, Miki T, Takahashi K, Ueno H, et al. cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000;2:805-11 pubmed
    ..Accordingly, cAMP-GEFII is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, PKA-independent exocytosis. ..
  9. Landsberg R, Awatramani R, Hunter N, Farago A, DiPietrantonio H, Rodriguez C, et al. Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6. Neuron. 2005;48:933-47 pubmed
    ..These studies suggest that underlying the diversity and proportions of fates produced by the LRL is a precise suborganization regulated by Pax6. ..
  10. Yao I, Takagi H, Ageta H, Kahyo T, Sato S, Hatanaka K, et al. SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell. 2007;130:943-57 pubmed
    ..Thus, SCRAPPER has an essential function in regulating proteasome-mediated degradation of RIM1 required for synaptic tuning. ..
  11. Smith R, Petersen A, Bates G, Brundin P, Li J. Depletion of rabphilin 3A in a transgenic mouse model (R6/1) of Huntington's disease, a possible culprit in synaptic dysfunction. Neurobiol Dis. 2005;20:673-84 pubmed
    ..We observed that the levels of rabphilin 3A, a protein involved in exocytosis, is substantially decreased in synapses of most brain regions in R6/1 mice...
  12. Pang Z, Bacaj T, Yang X, Zhou P, Xu W, Sudhof T. Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism. Neuron. 2011;70:244-51 pubmed publisher
    ..Thus, our data suggest that Doc2s are modulators of spontaneous synaptic transmission that act by a Ca(2+)-independent mechanism. ..
  13. Rastaldi M, Armelloni S, Berra S, Li M, Pesaresi M, Poczewski H, et al. Glomerular podocytes possess the synaptic vesicle molecule Rab3A and its specific effector rabphilin-3a. Am J Pathol. 2003;163:889-99 pubmed
    ..The altered expression observed in mouse and human proteinuric diseases suggests a possible role for these molecules in glomerulopathies. ..
  14. Fukuda M, Kanno E, Yamamoto A. Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells. J Biol Chem. 2004;279:13065-75 pubmed