Gene Symbol: Rnf11
Description: ring finger protein 11
Alias: RING finger protein 11, NEDD4 WW domain-binding protein 2, sid 1669
Jolliffe C, Harvey K, Haines B, Parasivam G, Kumar S. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Biochem J. 2000;351 Pt 3:557-65 pubmed
..These results provide evidence that Nedd4 can potentially interact with multiple proteins, possibly simultaneously, through its WW domains. ..
Liu W, Rui H, Wang J, Lin S, He Y, Chen M, et al
. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 2006;25:1646-58 pubmed
..However, coexpression of Wnt-1 reduced Smad7 ubiquitination by downregulating Axin levels, underscoring the importance of Axin as an intrinsic regulator in TGF-beta signaling. ..
Shembade N, Ma A, Harhaj E. Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science. 2010;327:1135-9 pubmed publisher
..These findings suggest mechanism of A20 action in the inhibition of inflammatory signaling pathways. ..
Rorick N, Kinoshita A, Weirather J, Peyrard Janvid M, de Lima R, Dunnwald M, et al
. Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome. Am J Med Genet A. 2011;155A:1314-21 pubmed publisher
..The expression and mutation data were consistent with the hypothesis that WDR65 was a novel gene involved in oral clefting. ..
Dalal N, Pranski E, TANSEY M, Lah J, Levey A, BETARBET R. RNF11 modulates microglia activation through NF-?B signalling cascade. Neurosci Lett. 2012;528:174-9 pubmed publisher
..b>RING finger protein 11 (RNF11), in association with A20 ubiquitin-editing complex, is one of the key negative regulators of NF-?B ..
Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, et al
. Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein. Biochim Biophys Acta. 1999;1489:421-7 pubmed
..The genes were designated as RNF11/Rnf11 for RING finger protein 11. A single 2...
Dumitriu B, Bhattaram P, Dy P, Huang Y, Quayum N, Jensen J, et al
. Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions. PLoS ONE. 2010;5:e12088 pubmed publisher
..It is primarily involved in enhancing the survival rate and maturation process of erythroid cells and acts at least in part by upregulating Bcl2l1. ..
Shembade N, Pujari R, Harhaj N, Abbott D, Harhaj E. The kinase IKK? inhibits activation of the transcription factor NF-?B by phosphorylating the regulatory molecule TAX1BP1. Nat Immunol. 2011;12:834-43 pubmed publisher
..cytokines, the deubiquitinase A20 inducibly interacts with the regulatory molecules TAX1BP1, Itch and RNF11 to form the A20 ubiquitin-editing complex...
Sun H, Hunter T. Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. J Biol Chem. 2012;287:42071-83 pubmed publisher
..We suggest that the clustered SIMs in these proteins form distinct SUMO binding domains to recognize diverse forms of protein sumoylation. ..