Gene Symbol: Rint1
Description: RAD50 interactor 1
Alias: 1500019C06Rik, 2810450M21Rik, Rint-1, RAD50-interacting protein 1
Grigaravicius P, von Deimling A, Frappart P. RINT1 functions as a multitasking protein at the crossroads between genomic stability, ER homeostasis, and autophagy. Autophagy. 2016;12:1413-5 pubmed publisher
b>RINT1 was first identified as an RAD50-interacting protein and its function was therefore linked to the maintenance of genomic stability...
Lin X, Liu C, Gao Q, Zhang X, Wu G, Lee W. RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival. Mol Cell Biol. 2007;27:4905-16 pubmed
Oikarinen S, Cleveland A, Cork K, Bynote K, Rafter J, Gustafsson J, et al
. Genetic mapping of Mom5, a novel modifier of Apc(Min)-induced intestinal tumorigenesis. Carcinogenesis. 2009;30:1591-6 pubmed publisher
..Through in silico analysis and confirmatory sequencing, we have identified the Rad50-interacting protein-1 gene as a strong candidate for Mom5. ..
Grigaravicius P, Kaminska E, HÃ¼bner C, McKinnon P, von Deimling A, Frappart P. Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain. Cell Death Differ. 2016;23:454-68 pubmed publisher
..Here, we reveal the role played by Rint1 in these different biological pathways to ensure normal development of the central nervous system and to prevent ..
Otterpohl K, Gould K. Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk. PLoS ONE. 2017;12:e0172247 pubmed publisher
The Rad50 Interacting Protein 1 (Rint1) influences cellular homeostasis through maintenance of endoplasmic reticulum, Golgi and centrosome integrity and regulation of vesicle transport, autophagy and the G2/M checkpoint...