Gene Symbol: Rin
Description: Ras-like without CAAX 2
Alias: RIBA, Rin, Roc2, GTP-binding protein Rit2, GTP-binding protein Roc2, RAS-like protein expressed in neuron, ras-like protein expressed in neurons, ras-like without CAAX protein 2
Species: mouse
Products:     Rin

Top Publications

  1. Shao H, Kadono Okuda K, Finlin B, Andres D. Biochemical characterization of the Ras-related GTPases Rit and Rin. Arch Biochem Biophys. 1999;371:207-19 pubmed
    We report the biochemical characterization of Rit and Rin, two members of the Ras superfamily identified by expression cloning. Recombinant Rit and Rin bind GTP and exhibit intrinsic GTPase activity...
  2. Spencer M, Shao H, Tucker H, Andres D. Nerve growth factor-dependent activation of the small GTPase Rin. J Biol Chem. 2002;277:17605-15 pubmed
    The Rit and Rin proteins comprise a distinct and evolutionarily conserved subfamily of Ras-related small GTPases...
  3. Hoshino M, Nakamura S. The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation. Biochem Biophys Res Commun. 2002;295:651-6 pubmed
    A novel 25 K Ras-like protein, Rin, binds calmodulin in a Ca2+-dependent manner and is considered to participate in a calcium/calmodulin-mediated signaling pathway. However, little is known about Rin signaling mechanism...
  4. Calissano M, Latchman D. Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor. Oncogene. 2003;22:5408-14 pubmed
    ..By using the N-terminal of Brn-3a as the bait, we have repeatedly isolated a protein named Rin, an incompletely characterized small GTP-binding protein expressed only in neurons...
  5. Hoshino M, Nakamura S. Small GTPase Rin induces neurite outgrowth through Rac/Cdc42 and calmodulin in PC12 cells. J Cell Biol. 2003;163:1067-76 pubmed
    The novel Ras-like small GTPase Rin is expressed prominently in adult neurons, and binds calmodulin (CaM) through its COOH-terminal-binding motif...
  6. Hartwig C, Veske A, Krejcova S, Rosenberger G, Finckh U. Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. BMC Neurosci. 2005;6:53 pubmed
    ..Using yeast two-hybrid analysis, we identified the neuron-specific and calmodulin-binding Ras-related GTPase Rin as an interaction partner of the intracellular part of B3, but not of B2...
  7. Shi G, Jin L, Andres D. Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation. Mol Cell Biol. 2008;28:4940-51 pubmed publisher
    ..Here we show that the Ras-related Rin GTP-binding protein, a GTPase that is expressed predominantly in neurons, is regulated by PACAP38 signaling, and ..
  8. Lee C, Della N, Chew C, Zack D. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. J Neurosci. 1996;16:6784-94 pubmed
    cDNAs encoding two novel 25 kDa Ras-like proteins, Rit and Rin, were isolated from mouse retina using a degenerate PCR-based cloning strategy. Using the expressed sequence tag database, human orthologs were also obtained and sequenced...
  9. Hoshino M, Yoshimori T, Nakamura S. Small GTPase proteins Rin and Rit Bind to PAR6 GTP-dependently and regulate cell transformation. J Biol Chem. 2005;280:22868-74 pubmed
    The novel small GTPases Rin and Rit are close relatives of Ras, and recent studies show that they play a role in mediating neuronal differentiation. However, the direct effectors of Rin and Rit have yet to be fully characterized...

More Information


  1. Zhang L, Wahlin K, Li Y, Masuda T, Yang Z, Zack D, et al. RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. Mol Vis. 2013;19:1371-86 pubmed
  2. Shao H, Andres D. A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras. J Biol Chem. 2000;275:26914-24 pubmed
    ..These data suggest that RGL3 functions as an exchange factor for Ral and may serve as a downstream effector for both Rit and Ras. ..