Gene Symbol: Ric3
Description: RIC3 acetylcholine receptor chaperone
Alias: E130307J04Rik, protein RIC-3, resistance to inhibitors of cholinesterase 3 homolog, resistant to inhibitor of cholinesterase 3
Osman A, Schrader A, Hawkes A, Akil O, Bergeron A, Lustig L, et al
. Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear. Mol Cell Neurosci. 2008;38:153-69 pubmed publisher
..Our data suggest that RIC-3 facilitates receptor function, while rapsyn enhances receptor clustering at the cell surface. ..
Wang Y, Yao Y, Tang X, Wang Z. Mouse RIC-3, an endoplasmic reticulum chaperone, promotes assembly of the alpha7 acetylcholine receptor through a cytoplasmic coiled-coil domain. J Neurosci. 2009;29:12625-35 pubmed publisher
..We suggest that efficient assembly of the homomeric alpha7 nAChR may thus require mRIC-3 self-association through the cytoplasmic coiled-coil domain and suggest a model by which this may occur. ..
Alexander J, Sagher D, Krivoshein A, Criado M, Jefford G, Green W. Ric-3 promotes alpha7 nicotinic receptor assembly and trafficking through the ER subcompartment of dendrites. J Neurosci. 2010;30:10112-26 pubmed publisher
..In neurons, Ric-3 ER retention appears to promote transport within the dendritic ER subcompartment, thereby restricting alpha7 trafficking to dendrites and preventing axonal transport. ..
Ben David Y, Mizrachi T, Kagan S, Krisher T, Cohen E, Brenner T, et al
. RIC-3 expression and splicing regulate nAChR functional expression. Mol Brain. 2016;9:47 pubmed publisher
..Specifically, in immune cells such regulation via effects on ?7 nicotinic acetylcholine receptor, known to function in the cholinergic anti-inflammatory pathway, may have a role in neuroinflammatory diseases. ..