Rhog

Summary

Gene Symbol: Rhog
Description: ras homolog family member G
Alias: 2810426G09Rik, Arhg, Sid10750, rho-related GTP-binding protein RhoG, aplysia ras-related homolog G (RhoG), ras homolog G (RhoG), ras homolog gene family, member G, sid 10750
Species: mouse
Products:     Rhog

Top Publications

  1. Elfenbein A, Rhodes J, Meller J, Schwartz M, Matsuda M, Simons M. Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. J Cell Biol. 2009;186:75-83 pubmed publisher
    ..In this study, we show that Rac1 activation downstream of S4 is mediated by the RhoG activation pathway...
  2. Wennerberg K, Ellerbroek S, Liu R, Karnoub A, Burridge K, Der C. RhoG signals in parallel with Rac1 and Cdc42. J Biol Chem. 2002;277:47810-7 pubmed
    b>RhoG is a member of the Rho family of small GTPases and shares high sequence identity with Rac1 and Cdc42. Previous studies suggested that RhoG mediates its effects through activation of Rac1 and Cdc42...
  3. Vigorito E, Bell S, Hebeis B, Reynolds H, McAdam S, Emson P, et al. Immunological function in mice lacking the Rac-related GTPase RhoG. Mol Cell Biol. 2004;24:719-29 pubmed
    b>RhoG is a low-molecular-weight GTPase highly expressed in lymphocytes that activates gene transcription and promotes cytoskeletal reorganization in vitro...
  4. Yang H, Shin M, Lee S, Kim J, Park W, Cho K, et al. Cooperative activation of PI3K by Ras and Rho family small GTPases. Mol Cell. 2012;47:281-90 pubmed publisher
    ..GTPases activated PI3K by an indirect cooperative positive feedback that required a combination of Rac, CDC42, and RhoG small GTPase activities...
  5. Meller J, Vidali L, Schwartz M. Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration. J Cell Sci. 2008;121:1981-9 pubmed publisher
    ..Based mainly on overexpression of dominant-negative mutants, RhoG has been proposed to mediate integrin-dependent Rac activation upstream of ELMO and Dock180...
  6. Fujimoto S, Negishi M, Katoh H. RhoG promotes neural progenitor cell proliferation in mouse cerebral cortex. Mol Biol Cell. 2009;20:4941-50 pubmed publisher
    ..Here we found that RhoG, a member of Rho family GTPases, was expressed in the VZ at early stages of cortical development...
  7. Damoulakis G, Gambardella L, Rossman K, Lawson C, Anderson K, Fukui Y, et al. P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils. J Cell Sci. 2014;127:2589-600 pubmed publisher
    ..been attributed to its GEF activity towards Rac1, we show that P-Rex1 also acts as a GEF for the Rac-related GTPase RhoG, both in vitro and in GPCR-stimulated primary mouse neutrophils...
  8. Kim S, Dangelmaier C, Bhavanasi D, Meng S, Wang H, Goldfinger L, et al. RhoG protein regulates glycoprotein VI-Fc receptor ?-chain complex-mediated platelet activation and thrombus formation. J Biol Chem. 2013;288:34230-8 pubmed publisher
    We investigated the mechanism of activation and functional role of a hitherto uncharacterized signaling molecule, RhoG, in platelets. We demonstrate for the first time the expression and activation of RhoG in platelets...
  9. Ho E, Irvine T, Vilk G, Lajoie G, Ravichandran K, D Souza S, et al. Integrin-linked kinase interactions with ELMO2 modulate cell polarity. Mol Biol Cell. 2009;20:3033-43 pubmed publisher
    ..We also demonstrate the presence of RhoG in ILK-ELMO2 complexes, and the localization of this multiprotein species specifically to the leading lamellipodia ..

More Information

Publications26

  1. Sauzeau V, Sevilla M, Montero M, Bustelo X. The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells. J Clin Invest. 2010;120:315-30 pubmed publisher
  2. Zalcman G, Closson V, Camonis J, Honore N, Rousseau Merck M, Tavitian A, et al. RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J Biol Chem. 1996;271:30366-74 pubmed
    ..system, RhoGDI-3 interacts specifically with GDP- and GTP-bound forms of post-translationally processed RhoB and RhoG proteins, both of which show a growth-regulated expression in mammalian cells...
  3. Bass M, Williamson R, Nunan R, Humphries J, Byron A, Morgan M, et al. A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis. Dev Cell. 2011;21:681-93 pubmed publisher
    ..Association of syndecan-4 with PKC? was found to trigger RhoG activation and subsequent dynamin- and caveolin-dependent integrin uptake...
  4. Fujiwara K, Fujita Y, Kasai A, Onaka Y, Hashimoto H, Okada H, et al. Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse. Transl Psychiatry. 2016;6:e766 pubmed publisher
    ..Our findings provide evidence for the involvement of histone demethylation in the formation of functional neural networks during development. ..
  5. Prieto Sánchez R, Bustelo X. Structural basis for the signaling specificity of RhoG and Rac1 GTPases. J Biol Chem. 2003;278:37916-25 pubmed
    b>RhoG is a new GTPase that has high sequence similarity with members of the Rac subfamily (Rac1, Rac2, and Rac3), including the regions involved in effector recognition and binding...
  6. Backer S, Hidalgo Sanchez M, Offner N, Portales Casamar E, Debant A, Fort P, et al. Trio controls the mature organization of neuronal clusters in the hindbrain. J Neurosci. 2007;27:10323-32 pubmed
    ..We report that the absence of the Rho-guanine exchange factor Trio, which can activate both RhoG and Rac1 in vivo, prevents the proper formation of ION and fMN subnuclei...
  7. Kwiatkowska A, Didier S, Fortin S, Chuang Y, White T, Berens M, et al. The small GTPase RhoG mediates glioblastoma cell invasion. Mol Cancer. 2012;11:65 pubmed publisher
    ..Both Trio and Vav3 act on the small GTPase RhoG. We therefore examined the role of RhoG in the invasive behavior of glioblastoma cells...
  8. Condliffe A, Webb L, Ferguson G, Davidson K, Turner M, Vigorito E, et al. RhoG regulates the neutrophil NADPH oxidase. J Immunol. 2006;176:5314-20 pubmed
    b>RhoG is a Rho family small GTPase implicated in cytoskeletal regulation, acting either upstream of or in parallel to Rac1. The precise function(s) of RhoG in vivo has not yet been defined...
  9. Miki T, Smith C, Long J, Eva A, Fleming T. Oncogene ect2 is related to regulators of small GTP-binding proteins. Nature. 1993;362:462-5 pubmed
    ..Thus ect2 is a new member of an expanding family, whose products have transforming properties and interact with Rho-like proteins of the Ras superfamily. ..
  10. Martínez Martín N, Fernández Arenas E, Cemerski S, Delgado P, Turner M, Heuser J, et al. T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis. Immunity. 2011;35:208-22 pubmed publisher
    ..with the TCR to the IS and is necessary for TCR internalization from the IS through a mechanism dependent on RhoG, a small GTPase previously associated with phagocytosis...
  11. Monypenny J, Zicha D, Higashida C, Oceguera Yanez F, Narumiya S, Watanabe N. Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis. Mol Cell Biol. 2009;29:2730-47 pubmed publisher
    ..chemotaxis assay that of all of the Cdc42/Rac1-related GTPases expressed in primary fibroblasts, Cdc42, Rac1, and RhoG are required for efficient migration towards platelet-derived growth factor (PDGF)...
  12. Franke K, Otto W, Johannes S, Baumgart J, Nitsch R, Schumacher S. miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling. EMBO J. 2012;31:2908-21 pubmed publisher
    The small GTPase RhoG plays a central role in actin remodelling during diverse biological processes such as neurite outgrowth, cell migration, phagocytosis of apoptotic cells, and the invasion of pathogenic bacteria...
  13. Namekata K, Watanabe H, Guo X, Kittaka D, Kawamura K, Kimura A, et al. Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG. Genes Cells. 2012;17:688-97 pubmed publisher
    ..We show that Dock3 forms a complex with Elmo and activated RhoG downstream of BDNF-TrkB signaling and induces neurite outgrowth via Rac1 activation in PC12 cells...
  14. Jackson B, Ivanova I, Dagnino L. An ELMO2-RhoG-ILK network modulates microtubule dynamics. Mol Biol Cell. 2015;26:2712-25 pubmed publisher
    ..ELMO2 can simultaneously bind integrin-linked kinase (ILK) and RhoG, forming tripartite ERI complexes...
  15. Fritsch R, de Krijger I, Fritsch K, George R, Reason B, Kumar M, et al. RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell. 2013;153:1050-63 pubmed publisher
    ..These findings revise our understanding of the regulation of type I PI3K by showing that both RAS and RHO family GTPases directly regulate distinct ubiquitous PI3K isoforms and that RAC activates p110? downstream of GPCRs. ..
  16. Goggs R, Harper M, Pope R, Savage J, Williams C, Mundell S, et al. RhoG protein regulates platelet granule secretion and thrombus formation in mice. J Biol Chem. 2013;288:34217-29 pubmed publisher
    Rho GTPases such as Rac, RhoA, and Cdc42 are vital for normal platelet function, but the role of RhoG in platelets has not been studied...
  17. Samson T, van Buul J, Kroon J, Welch C, Bakker E, Matlung H, et al. The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis. PLoS ONE. 2013;8:e55202 pubmed publisher
    ..Previously, we showed in vitro that the RhoG guanine nucleotide exchange factor SGEF (Arhgef26) contributes to the formation of ICAM-1-induced endothelial ..