Gene Symbol: Rgs5
Description: regulator of G-protein signaling 5
Alias: 1110070A02Rik, regulator of G-protein signaling 5
Species: mouse
Products:     Rgs5

Top Publications

  1. Mitchell T, Bradley J, Robinson G, Shima D, Ng Y. RGS5 expression is a quantitative measure of pericyte coverage of blood vessels. Angiogenesis. 2008;11:141-51 pubmed
    ..vessels by analyzing the expression of the pericyte-specific gene, the regulator of G-protein signaling 5 (RGS5)...
  2. Chen Y, Zhu J, Lum P, Yang X, Pinto S, MacNeil D, et al. Variations in DNA elucidate molecular networks that cause disease. Nature. 2008;452:429-35 pubmed publisher
    ..Our analysis provides direct experimental support that complex traits such as obesity are emergent properties of molecular networks that are modulated by complex genetic loci and environmental factors. ..
  3. Ketsawatsomkron P, Lorca R, Keen H, Weatherford E, Liu X, Pelham C, et al. PPAR? regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. Circ Res. 2012;111:1446-58 pubmed publisher
    ..Gene expression profiling revealed a marked loss of the regulator of G protein signaling 5 (RGS5) mRNA in transgenic MA, which was accompanied by a substantial increase in angiotensin II-..
  4. Bondjers C, Kalén M, Hellstrom M, Scheidl S, Abramsson A, Renner O, et al. Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells. Am J Pathol. 2003;162:721-9 pubmed
    ..The most down-regulated gene present on our microarray was RGS5, a member of the RGS family of GTPase-activating proteins for G proteins...
  5. Holobotovskyy V, Manzur M, Tare M, Burchell J, Bolitho E, Viola H, et al. Regulator of G-protein signaling 5 controls blood pressure homeostasis and vessel wall remodeling. Circ Res. 2013;112:781-91 pubmed publisher
    Regulator of G-protein signaling 5 (RGS5) modulates G-protein-coupled receptor signaling and is prominently expressed in arterial smooth muscle cells...
  6. Cho H, Kozasa T, Bondjers C, Betsholtz C, Kehrl J. Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. FASEB J. 2003;17:440-2 pubmed
    ..in the developing vascular system, in situ hybridization revealed a striking and extensive expression pattern of Rgs5 in the arterial walls of E12.5-E17.5 mouse embryos...
  7. Hamzah J, Jugold M, Kiessling F, Rigby P, Manzur M, Marti H, et al. Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature. 2008;453:410-4 pubmed publisher
    ..Here we identify regulator of G-protein signalling 5 (Rgs5) as a master gene responsible for the abnormal tumour vascular morphology in mice...
  8. Teplyuk N, Galindo M, Teplyuk V, Pratap J, Young D, Lapointe D, et al. Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem. 2008;283:27585-97 pubmed publisher
    ..g. Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13)...
  9. Deng W, Wang X, Xiao J, Chen K, Zhou H, Shen D, et al. Loss of regulator of G protein signaling 5 exacerbates obesity, hepatic steatosis, inflammation and insulin resistance. PLoS ONE. 2012;7:e30256 pubmed publisher
    The effect of regulator of G protein signaling 5 (RGS5) on cardiac hypertrophy, atherosclerosis and angiogenesis has been well demonstrated, but the role in the development of obesity and insulin resistance remains completely unknown...

More Information


  1. Zhang H, Gu S, Al Sabeq B, Wang S, He J, Tam A, et al. Origin-specific epigenetic program correlates with vascular bed-specific differences in Rgs5 expression. FASEB J. 2012;26:181-91 pubmed publisher
    ..We here examined the mechanisms controlling vascular bed-specific differences in Rgs5 expression during development...
  2. Li H, He C, Feng J, Zhang Y, Tang Q, Bian Z, et al. Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload. Proc Natl Acad Sci U S A. 2010;107:13818-23 pubmed publisher
    ..b>Regulator of G protein signaling 5 (Rgs5) is a negative regulator of G protein-mediated signaling by inactivating Galphaq and Galphai, ..
  3. Cho H, Park C, Hwang I, Han S, Schimel D, Despres D, et al. Rgs5 targeting leads to chronic low blood pressure and a lean body habitus. Mol Cell Biol. 2008;28:2590-7 pubmed publisher
    b>RGS5 is a potent GTPase-activating protein for G(ialpha) and G(qalpha) that is expressed strongly in pericytes and is present in vascular smooth muscle cells...
  4. Nisancioglu M, Mahoney W, Kimmel D, Schwartz S, Betsholtz C, Genove G. Generation and characterization of rgs5 mutant mice. Mol Cell Biol. 2008;28:2324-31 pubmed publisher
    ..b>RGS5 has a perivascular expression pattern and was recently identified as a marker for brain pericytes...
  5. Bilger A, Bennett L, Carabeo R, Chiaverotti T, Dvorak C, Liss K, et al. A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines. Genetics. 2004;167:859-66 pubmed
    ..Thus, distal chromosome 1 carries one or more genes that are sufficient to confer susceptibility to liver cancer. ..
  6. Cheng W, Wang P, Wang T, Zhang Y, Du C, Li H, et al. Regulator of G-protein signalling 5 protects against atherosclerosis in apolipoprotein E-deficient mice. Br J Pharmacol. 2015;172:5676-89 pubmed publisher
    ..In this study, we explored the effect of RGS5 on atherosclerosis and the potential underlying mechanisms...
  7. Qin M, Huang H, Wang T, Hu H, Liu Y, Cao H, et al. Absence of Rgs5 prolongs cardiac repolarization and predisposes to ventricular tachyarrhythmia in mice. J Mol Cell Cardiol. 2012;53:880-90 pubmed publisher
    The aim of this study was to elucidate the effects of regulator of G-protein signaling 5 (Rgs5), a negative regulator of G-protein-mediated signaling, on cardiac repolarization and arrhythmia in mice...
  8. Arnold C, Feldner A, Pfisterer L, Hödebeck M, Troidl K, Genove G, et al. RGS5 promotes arterial growth during arteriogenesis. EMBO Mol Med. 2014;6:1075-89 pubmed publisher
    ..In this context, our study revealed that abundance of regulator of G-protein signalling 5 (RGS5) is increased in vascular smooth muscle cells (SMCs) of remodelling collateral arterioles...
  9. Daniel J, Prock A, Dutzmann J, Sonnenschein K, Thum T, Bauersachs J, et al. Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation. Arterioscler Thromb Vasc Biol. 2016;36:317-27 pubmed publisher
    Regulator of G-protein signaling 5 (RGS5) is abundantly expressed in vascular smooth muscle cells (SMCs) and inhibits G-protein signaling by enhancing the guanosine triphosphate-hydrolyzing activity of Gα-subunits...
  10. Balenga N, Jester W, Jiang M, Panettieri R, Druey K. Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation. J Allergy Clin Immunol. 2014;134:451-9 pubmed publisher
    ..We explored the role of a regulator of procontractile GPCR signaling, regulator of G protein signaling 5 (RGS5), in unprovoked and allergen-induced AHR...
  11. Qin M, Liu X, Liu T, Wang T, Huang C. Potential Role of Regulator of G-Protein Signaling 5 in the Protection of Vagal-Related Bradycardia and Atrial Tachyarrhythmia. J Am Heart Assoc. 2016;5:e002783 pubmed publisher
    The regulator of G-protein signaling 5 (Rgs5), which functions as the regulator of G-protein-coupled receptor (GPCR) including muscarinic receptors, has a potential effect on atrial muscarinic receptor-activated IKA ch current...
  12. Qin M, Huang H, Wang T, Hu H, Liu Y, Gu Y, et al. Atrial tachyarrhythmia in Rgs5-null mice. PLoS ONE. 2012;7:e46856 pubmed publisher
    The aim of this study was to elucidate the effects of regulator of G-protein signaling 5 (Rgs5), a negative regulator of G protein-mediated signaling, on atrial repolarization and tachyarrhythmia (ATA) in mice...
  13. de Vries L, Gist Farquhar M. RGS proteins: more than just GAPs for heterotrimeric G proteins. Trends Cell Biol. 1999;9:138-44 pubmed
    ..This review summarizes recent findings on RGS proteins, especially those that implicate RGS proteins in more than just enhancing the GTPase activity of their Galpha subunit targets. ..
  14. Bahrami A, Gunaje J, Hayes B, Riehle K, Kenerson H, Yeung R, et al. Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury. PLoS ONE. 2014;9:e108505 pubmed publisher
    ..Regulator of G-protein signaling-5 (RGS5), an inhibitor of vasoactive GPCR agonists, functions to control GPCR-mediated contraction and hypertrophy in ..
  15. Mahoney W, Gunaje J, Daum G, Dong X, Majesky M. Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling. PLoS ONE. 2013;8:e61421 pubmed publisher
    ..We hypothesize Regulator of G-Protein Signaling (RGS) proteins, and specifically RGS5, are endogenous repressors of Hh signaling via their ability to act as GTPase activating proteins (GAPs) for GTP-..
  16. Liu C, Hu Q, Jing J, Zhang Y, Jin J, Zhang L, et al. Regulator of G protein signaling 5 (RGS5) inhibits sonic hedgehog function in mouse cortical neurons. Mol Cell Neurosci. 2017;83:65-73 pubmed publisher
    b>Regulator of G protein signaling 5 (RGS5) acts as a GTPase-activating protein (GAP) for the G?i subunit and negatively regulates G protein-coupled receptor signaling...
  17. Cappellari O, Benedetti S, Innocenzi A, Tedesco F, Moreno Fortuny A, Ugarte G, et al. Dll4 and PDGF-BB convert committed skeletal myoblasts to pericytes without erasing their myogenic memory. Dev Cell. 2013;24:586-99 pubmed publisher
    ..Myf5-expressing cells adopt a perithelial position, as occasionally also observed in wild-type (WT) embryos. These data indicate that endothelium, via Dll4 and PDGF-BB, induces a fate switch in adjacent skeletal myoblasts...
  18. Yang Z, Cooper P, Damera G, Mukhopadhyay I, Cho H, Kehrl J, et al. Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness. J Biol Chem. 2011;286:11444-55 pubmed publisher
    ..In contrast, ?-agonists decreased expression of regulator of G protein signaling 5 (RGS5), which is an inhibitor of G-protein-coupled receptor (GPCR) activity...
  19. Feng W, Leach S, Tipney H, Phang T, Geraci M, Spritz R, et al. Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences. PLoS ONE. 2009;4:e8066 pubmed publisher
    ..Overall, our studies provide a valuable resource for probing orofacial development and a robust dataset for bioinformatic analysis of spatial and temporal gene expression changes during embryogenesis. ..
  20. Ang S, Uebersohn A, Spencer C, Huang Y, Lee J, Ge K, et al. KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation. Development. 2016;143:810-21 pubmed publisher
    ..Our findings indicate that KMT2D is essential for regulating cardiac gene expression during heart development primarily via H3K4 di-methylation. ..
  21. Wang Z, Huang H, He W, Kong B, Hu H, Fan Y, et al. Regulator of G-protein signaling 5 protects cardiomyocytes against apoptosis during in vitro cardiac ischemia-reperfusion in mice by inhibiting both JNK1/2 and P38 signaling pathways. Biochem Biophys Res Commun. 2016;473:551-7 pubmed publisher
    ..Regulator of G-protein signaling 5 (RGS5), highly expressed in different cell types of the human adult heart, is a guanosine triphosphatase-activating ..
  22. Lee M, Tasaki T, Moroi K, An J, Kimura S, Davydov I, et al. RGS4 and RGS5 are in vivo substrates of the N-end rule pathway. Proc Natl Acad Sci U S A. 2005;102:15030-5 pubmed
    ..Here, we report that the ATE1 Arg-transferase mediates the in vivo degradation of RGS4 and RGS5, which are negative regulators of specific G proteins whose functions include cardiac growth and angiogenesis...
  23. Nagata Y, Oda M, Nakata H, Shozaki Y, Kozasa T, Todokoro K. A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001;97:3051-60 pubmed
    ..Thus, RGS18 may play an important role in proliferation, differentiation, and/or migration of megakaryocytes. ..
  24. Mould A, Morgan M, Li L, Bikoff E, Robertson E. Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. Genes Dev. 2012;26:2063-74 pubmed publisher
    ..In sum, the transcriptional repressor Blimp1/Prdm1 is required for terminal differentiation of SpA-TGCs and defines a lineage-restricted progenitor cell population contributing to placental growth and morphogenesis. ..
  25. Vrljicak P, Cullum R, Xu E, Chang A, Wederell E, Bilenky M, et al. Twist1 transcriptional targets in the developing atrio-ventricular canal of the mouse. PLoS ONE. 2012;7:e40815 pubmed publisher
    ..Our findings support a role for TWIST1 in the differentiation of AVC mesenchyme post-EMT in the mouse, and suggest that TWIST1 can exert its function by direct DNA binding to activate valve specific gene expression. ..
  26. Svensson A, Özen I, Genové G, Paul G, Bengzon J. Endogenous brain pericytes are widely activated and contribute to mouse glioma microvasculature. PLoS ONE. 2015;10:e0123553 pubmed publisher
    ..implanted in mice expressing green fluorescent protein (GFP) under the pericyte marker regulator of G protein signaling 5 (RGS5)...
  27. Holobotovskyy V, Chong Y, Burchell J, He B, Phillips M, Leader L, et al. Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia. Sci Transl Med. 2015;7:290ra88 pubmed publisher
    ..We identified the role of regulator of G protein (heterotrimeric guanine nucleotide-binding protein) signaling 5 (RGS5) in blood pressure regulation during pregnancy and preeclampsia...
  28. Chen C, Zheng B, Han J, Lin S. Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997;272:8679-85 pubmed
    ..Tissue distribution analysis shows that the novel RGS16 is predominantly expressed in liver and pituitary, and that RGS5 is preferentially expressed in heart and skeletal muscle. In contrast, RGS2 is widely expressed...