Rgs2

Summary

Gene Symbol: Rgs2
Description: regulator of G-protein signaling 2
Alias: GOS8, regulator of G-protein signaling 2
Species: mouse
Products:     Rgs2

Top Publications

  1. Takimoto E, Koitabashi N, Hsu S, Ketner E, Zhang M, Nagayama T, et al. Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J Clin Invest. 2009;119:408-20 pubmed publisher
    ..Here we have shown that this initial adaptation requires regulator of G protein signaling 2 (RGS2)...
  2. Tuomi J, Chidiac P, Jones D. Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse. Am J Physiol Heart Circ Physiol. 2010;298:H554-61 pubmed publisher
    ..b>RGS2 is selective for G(q) and thus may regulate atrial M3R signaling...
  3. Osei Owusu P, Sun X, Drenan R, Steinberg T, Blumer K. Regulation of RGS2 and second messenger signaling in vascular smooth muscle cells by cGMP-dependent protein kinase. J Biol Chem. 2007;282:31656-65 pubmed
    b>RGS2, a GTPase-activating protein (GAP) for G(q)alpha, regulates vascular relaxation and blood pressure. RGS2 can be phosphorylated by type Ialpha cGMP-dependent protein kinase (cGKIalpha), increasing its GAP activity...
  4. Schoeber J, Topala C, Wang X, Diepens R, Lambers T, Hoenderop J, et al. RGS2 inhibits the epithelial Ca2+ channel TRPV6. J Biol Chem. 2006;281:29669-74 pubmed
    ..By yeast two-hybrid and glutathione S-transferase pulldown analysis we identified RGS2 as a novel TRPV6-associated protein...
  5. Tang K, Wang G, Lu P, Karas R, Aronovitz M, Heximer S, et al. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med. 2003;9:1506-12 pubmed
    ..b>Rgs2-/- mice develop marked hypertension, and their blood vessels show enhanced contraction and decreased cGMP-mediated ..
  6. Bernstein L, Ramineni S, Hague C, Cladman W, Chidiac P, Levey A, et al. RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling. J Biol Chem. 2004;279:21248-56 pubmed
    ..We report the novel finding that RGS2 binds directly to the third intracellular (i3) loop of the G(q/11)-coupled M1 muscarinic cholinergic receptor (M1 ..
  7. Sun X, Kaltenbronn K, Steinberg T, Blumer K. RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling. Mol Pharmacol. 2005;67:631-9 pubmed
    ..b>RGS2, a GTPase-activating protein for Gqalpha that is critical for blood pressure homeostasis, has been suggested to ..
  8. Oliveira Dos Santos A, Matsumoto G, Snow B, Bai D, Houston F, Whishaw I, et al. Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci U S A. 2000;97:12272-7 pubmed
    ..The physiological role of mammalian RGS proteins is largely unknown. The RGS family member rgs2 was cloned as an immediate early response gene up-regulated in T lymphocytes after activation...
  9. Hercule H, Tank J, Plehm R, Wellner M, da Costa Goncalves A, Gollasch M, et al. Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice. Exp Physiol. 2007;92:1014-22 pubmed
    ..The regulator of G protein signalling 2 (RGS2) is a negative G protein regulator...

More Information

Publications62

  1. Heximer S, Knutsen R, Sun X, Kaltenbronn K, Rhee M, Peng N, et al. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest. 2003;111:445-52 pubmed
    ..To test this hypothesis, we analyzed mice deficient in RGS2, a GTPase-activating protein that greatly accelerates the deactivation rate of heterotrimeric G proteins in vitro...
  2. Roy A, Nunn C, Ming H, Zou M, Penninger J, Kirshenbaum L, et al. Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts. J Biol Chem. 2006;281:32684-93 pubmed
    Regulator of G protein signaling (RGS) proteins limit G protein signals. In this study, we investigated the role of RGS2 in the control of G protein signaling cascades in osteoblasts, the cells responsible for bone formation...
  3. Zhang W, Anger T, Su J, Hao J, Xu X, Zhu M, et al. Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy. J Biol Chem. 2006;281:5811-20 pubmed
    ..In this study, we report a marked decrease in RGS2 (but not other major cardiac RGS proteins (RGS3-RGS5)) that occurs prior to hypertrophy development in different ..
  4. Obst M, Tank J, Plehm R, Blumer K, Diedrich A, Jordan J, et al. NO-dependent blood pressure regulation in RGS2-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2006;290:R1012-9 pubmed
    ..rate (HR) with telemetry in N(omega)-nitro-l-arginine methyl ester (l-NAME, 5 mg l-NAME/10 ml tap water)-treated RGS2-deficient (RGS2(-/-)) and RGS2-sufficient (RGS2(+/+)) mice and assessed autonomic function...
  5. Reif K, Cyster J. RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines. J Immunol. 2000;164:4720-9 pubmed
    ..Following in vivo activation by Ag, B cells rapidly up-regulate expression of RGS1 and RGS2 while simultaneously decreasing expression of RGS3 and RGS14...
  6. Chakir K, Zhu W, Tsang S, Woo A, Yang D, Wang X, et al. RGS2 is a primary terminator of ??-adrenergic receptor-mediated G(i) signaling. J Mol Cell Cardiol. 2011;50:1000-7 pubmed publisher
    ..Here we demonstrate that regulator of G protein signaling 2 (RGS2) is a primary terminator of the ?(2)AR-G(i) signaling...
  7. Osei Owusu P, Sabharwal R, Kaltenbronn K, Rhee M, Chapleau M, Dietrich H, et al. Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling. J Biol Chem. 2012;287:12541-9 pubmed publisher
    b>Regulator of G protein signaling 2 (RGS2) is a GTPase-activating protein for G(q/11)? and G(i/o)? subunits. RGS2 deficiency is linked to hypertension in mice and humans, although causative mechanisms are not understood...
  8. Nunn C, Zhao P, Zou M, Summers K, Guglielmo C, Chidiac P. Resistance to age-related, normal body weight gain in RGS2 deficient mice. Cell Signal. 2011;23:1375-86 pubmed publisher
    RGS2 (regulator of G protein signaling 2) is known to limit signals mediated via Gq- and Gs-coupled GPCRs (G protein coupled receptors), and it has been implicated in the differentiation of several cells types...
  9. Papakonstantinou M, Karoussiotis C, Georgoussi Z. RGS2 and RGS4 proteins: New modulators of the κ-opioid receptor signaling. Cell Signal. 2015;27:104-14 pubmed publisher
    ..Results from pull down experiments indicated that RGS2 and RGS4 directly interact within different domains of the κ-CT...
  10. Lee H, Park D, Bae J, Kim H, Shin D, Park J, et al. RGS2 is a negative regulator of STAT3-mediated Nox1 expression. Cell Signal. 2012;24:803-9 pubmed publisher
    ..We find that regulator of G-protein signaling 2 (RGS2) inhibits STAT3-mediated Nox1 transcription, and can itself be repressed by TLR2; Nox1 induction upon RGS2 down-..
  11. Salim S, Asghar M, Taneja M, Hovatta I, Wu Y, Saha K, et al. Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells. FEBS Lett. 2011;585:1375-81 pubmed publisher
    ..Also, RGS2 expression is reported to be induced by oxidative stress...
  12. Smalley M, Iravani M, Leao M, Grigoriadis A, Kendrick H, Dexter T, et al. Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers. Breast Cancer Res. 2007;9:R85 pubmed
    ..Analysis of the gene expression data identified the gene Rgs2 (regulator of G-protein signalling 2) as being highly expressed in the Sca-1- 33A10Low/- population, which included ..
  13. Boelte K, Gordy L, Joyce S, Thompson M, Yang L, Lin P. Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1. PLoS ONE. 2011;6:e18534 pubmed publisher
    ..for molecular mediators responsible for pro-tumor functions, we found that regulator of G protein signaling-2 (Rgs2) is highly increased in tumor-derived MDSCs compared to control MDSCs...
  14. Jie L, Owens E, Plante L, Fang Z, Rensing D, Moeller K, et al. RGS2 squelches vascular Gi/o and Gq signaling to modulate myogenic tone and promote uterine blood flow. Physiol Rep. 2016;4: pubmed publisher
    ..The etiology of abnormal UABF is not known. Here, we determined whether deficiency or loss of RGS2, a GTPase-activating protein for Gq/11 and Gi/o class G proteins, affects UABF in nonpregnant mice...
  15. Yuan X, Cao J, Liu T, Li Y, Scannapieco F, He X, et al. Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss. Cell Death Differ. 2015;22:2046-57 pubmed publisher
    ..Thus our findings demonstrate that Rgs12 is an important regulator in OC differentiation and function and identify Rgs12 as a potential therapeutic target for osteoporosis and inflammation-induced bone loss. ..
  16. Pang A, Taylor H, Johnson W, Alexander S, Chen Y, Su Y, et al. Identification of differentially expressed genes in mouse spermatogenesis. J Androl. 2003;24:899-911 pubmed
    ..Many of the genes identified were not previously characterized. This study highlights new targets for manipulation to unravel the molecular mechanism of spermatogenesis. ..
  17. Huang Z, Ni H, Yang Z, Wang J, Tso J, Shen Q. Expression of regulator of G-protein signalling protein 2 (RGS2) in the mouse uterus at implantation sites. Reproduction. 2003;126:309-16 pubmed
    ..sequence tag of the genes identified showed 92% identity to the regulator of G-protein signalling protein 2 (RGS2). The full cDNA sequence of this gene was amplified by PCR and subsequently registered in GenBank...
  18. Wolff D, Xie Y, Deng C, Gatalica Z, Yang M, Wang B, et al. Epigenetic repression of regulator of G-protein signaling 2 promotes androgen-independent prostate cancer cell growth. Int J Cancer. 2012;130:1521-31 pubmed publisher
    ..Oncogene 2006;25:3719-34). Here, we show reduced RGS2 protein expression in human prostate cancer specimens compared to adjacent normal or hyperplastic tissue...
  19. Beckers J, Herrmann F, Rieger S, Drobyshev A, Horsch M, Hrabe de Angelis M, et al. Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis. Int J Cancer. 2005;114:590-7 pubmed
    ..Supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html.) ..
  20. Han J, Mark M, Li X, Xie M, Waka S, Rettig J, et al. RGS2 determines short-term synaptic plasticity in hippocampal neurons by regulating Gi/o-mediated inhibition of presynaptic Ca2+ channels. Neuron. 2006;51:575-86 pubmed
    b>RGS2, one of the small members of the regulator of G protein signaling (RGS) family, is highly expressed in brain and regulates G(i/o) as well as G(q)-coupled receptor pathways...
  21. Gross V, Tank J, Obst M, Plehm R, Blumer K, Diedrich A, et al. Autonomic nervous system and blood pressure regulation in RGS2-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2005;288:R1134-42 pubmed
    Regulator of G protein signaling (RGS2) deletion in mice prolongs signaling by G protein-coupled vasoconstrictor receptors and increases blood pressure. However, the exact mechanism of the increase in blood pressure is unknown...
  22. Momen A, Afroze T, Sadi A, Khoshbin A, Zhang H, Choi J, et al. Enhanced proliferation and altered calcium handling in RGS2-deficient vascular smooth muscle cells. J Recept Signal Transduct Res. 2014;34:476-83 pubmed publisher
    Regulator of G-protein signaling-2 (RGS2) inhibits Gq-mediated regulation of Ca(2+) signalling in vascular smooth muscle cells (VSMC). RGS2 knockout (RGS2KO) mice are hypertensive and show arteriolar remodeling...
  23. James C, Appleton C, Ulici V, Underhill T, Beier F. Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy. Mol Biol Cell. 2005;16:5316-33 pubmed
    ..One gene that was up-regulated at later stages of chondrocyte differentiation was Rgs2. Overexpression of Rgs2 in the chondrogenic cell line ATDC5 resulted in accelerated hypertrophic differentiation, ..
  24. Klaiber M, Kruse M, Völker K, Schröter J, Feil R, Freichel M, et al. Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Res Cardiol. 2010;105:583-95 pubmed publisher
    ..The selectivity of this interaction is determined by PKG I and RGS2-dependent modulation of Ang II/AT(1) signalling...
  25. Nguyen C, Ming H, Zhao P, Hugendubler L, Gros R, Kimball S, et al. Translational control by RGS2. J Cell Biol. 2009;186:755-65 pubmed publisher
    ..We have discovered a novel function for RGS2 in the control of protein synthesis...
  26. Jiang H, Xie Y, Abel P, Wolff D, Toews M, Panettieri R, et al. Regulator of G-protein signaling 2 repression exacerbates airway hyper-responsiveness and remodeling in asthma. Am J Respir Cell Mol Biol. 2015;53:42-9 pubmed publisher
    ..Because RGS2 protein levels in airway cells were significantly lower in patients with asthma compared with patients without ..
  27. Xie Y, Jiang H, Zhang Q, Mehrotra S, Abel P, Toews M, et al. Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis. Respir Res. 2016;17:103 pubmed publisher
    ..We identified Regulator of G-protein Signaling 2 (RGS2) as an early pirfenidone-induced gene...
  28. Endale M, Kim S, Lee W, Kim S, Suk K, Cho J, et al. Ischemia induces regulator of G protein signaling 2 (RGS2) protein upregulation and enhances apoptosis in astrocytes. Am J Physiol Cell Physiol. 2010;298:C611-23 pubmed publisher
    Regulator of G protein signaling (RGS) family members, such as RGS2, interact with Galpha subunits of heterotrimeric G proteins, accelerating the rate of GTP hydrolysis and attenuating the intracellular signaling triggered by the G ..
  29. Thirunavukkarasu K, Halladay D, Miles R, Geringer C, Onyia J. Analysis of regulator of G-protein signaling-2 (RGS-2) expression and function in osteoblastic cells. J Cell Biochem. 2002;85:837-50 pubmed
    ..In summary, our data suggest that PTH treatment results in a direct transcriptional stimulation of RGS-2 that in turn may play a role in modulating the duration/intensity of PTH receptor signaling. ..
  30. Adebiyi A. RGS2 regulates urotensin II-induced intracellular Ca2+ elevation and contraction in glomerular mesangial cells. J Cell Physiol. 2014;229:502-11 pubmed publisher
    ..In situ proximity ligation assay indicated molecular proximity between endogenous RGS2 and UTR in the cells. Treatment of GMCs with mUII elevated plasma membrane expression of RGS2 by ?2-fold...
  31. Jiang M, Shi Y, Sun Z, Zhang Z, Zhu Y. Inhibition of the Binding between RGS2 and ?-Tubulin Interferes with Spindle Formation and Chromosome Segregation during Mouse Oocyte Maturation In Vitro. PLoS ONE. 2016;11:e0159535 pubmed publisher
    b>RGS2 is a negative regulator of G protein signaling that contains a GTPase-activating domain and a ?-tubulin binding region. This study aimed to determine the localization and function of RGS2 during mouse oocyte maturation in vitro...
  32. Nagata Y, Oda M, Nakata H, Shozaki Y, Kozasa T, Todokoro K. A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001;97:3051-60 pubmed
    ..Thus, RGS18 may play an important role in proliferation, differentiation, and/or migration of megakaryocytes. ..
  33. Holden N, Bell M, Rider C, King E, Gaunt D, Leigh R, et al. ?2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids. Proc Natl Acad Sci U S A. 2011;108:19713-8 pubmed publisher
    ..glucocorticoid/LABA combinations synergistically induce the expression of regulator of G-protein signaling 2 (RGS2), a GTPase-activating protein that attenuates G(q) signaling...
  34. Tsingotjidou A, Nervina J, Pham L, Bezouglaia O, Tetradis S. Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3',5'-monophosphate-mediated pathway in primary neonatal murine osteoblasts. Bone. 2002;30:677-84 pubmed
    ..We conclude that RGS-2 is a PTH-induced primary response gene in murine osteoblasts that is induced mainly through the cAMP-PKA pathway and specifically inhibits Galphaq-coupled receptors. ..
  35. Song Y, Altarejos J, Goodarzi M, Inoue H, Guo X, Berdeaux R, et al. CRTC3 links catecholamine signalling to energy balance. Nature. 2010;468:933-9 pubmed publisher
    ..in response to catecholamine signals, when it reduced adenyl cyclase activity by upregulating the expression of Rgs2, a GTPase-activating protein that also inhibits adenyl cyclase activity...
  36. Cheng Y, Lee T, Hsu H, Kou Y, Wu Y. Characterization of the transcriptional regulation of the regulator of G protein signaling 2 (RGS2) gene during 3T3-L1 preadipocyte differentiation. J Cell Biochem. 2008;105:922-30 pubmed publisher
    ..genes at the early stage of preadipocyte differentiation have been identified, including the regulator of G protein signaling 2 (RGS2), a member of the RGS protein superfamily...
  37. Teplyuk N, Galindo M, Teplyuk V, Pratap J, Young D, Lapointe D, et al. Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem. 2008;283:27585-97 pubmed publisher
    ..g. Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13)...
  38. Lifschytz T, Broner E, Zozulinsky P, Slonimsky A, Eitan R, Greenbaum L, et al. Relationship between Rgs2 gene expression level and anxiety and depression-like behaviour in a mutant mouse model: serotonergic involvement. Int J Neuropsychopharmacol. 2012;15:1307-18 pubmed publisher
    b>RGS2 is a member of a family of proteins that negatively modulate G-protein coupled receptor transmission. Variations in the RGS2 gene were found to be associated in humans with anxious and depressive phenotypes...
  39. Mederos y Schnitzler M, Storch U, Meibers S, Nurwakagari P, Breit A, Essin K, et al. Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction. EMBO J. 2008;27:3092-103 pubmed publisher
    ..This inhibitory effect is enhanced in blood vessels of mice deficient in the regulator of G-protein signalling-2. These findings suggest that G(q/11)-coupled receptors function as sensors of membrane stretch in VSM cells. ..
  40. Xie Y, Jiang H, Nguyen H, Jia S, Berro A, Panettieri R, et al. Regulator of G protein signaling 2 is a key modulator of airway hyperresponsiveness. J Allergy Clin Immunol. 2012;130:968-76.e3 pubmed publisher
    ..b>Regulator of G protein signaling 2 (RGS2), an intracellular selective inhibitor of multiple bronchoconstrictor receptors, may play a ..
  41. Kim D, Lim J, Lee J, Kim D, Lee H, Min W, et al. RGS2-mediated intracellular Ca2+ level plays a key role in the intracellular replication of Brucella abortus within phagocytes. J Infect Dis. 2012;205:445-52 pubmed publisher
    ..However, the intracellular survival mechanism and factors of virulence are not fully understood...
  42. Jang H, Kim J, Noh M, Rhee M, Park K. Regulator of G protein signaling 2 (RGS2) deficiency accelerates the progression of kidney fibrosis. Biochim Biophys Acta. 2014;1842:1733-41 pubmed publisher
    The regulator of G protein signaling 2 (RGS2) is a potent negative regulator of Gq protein signals including the angiotensin II (AngII)/AngII receptor signal, which plays a critical role in the progression of fibrosis...
  43. Le T, Coffman T. RGS2: a "turn-off" in hypertension. J Clin Invest. 2003;111:441-3 pubmed
  44. Sjögren B, Swaney S, Neubig R. FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. PLoS ONE. 2015;10:e0123581 pubmed publisher
    ..Among these, Regulator of G Protein Signaling 2 (RGS2) is a target for rapid proteasomal degradation, however, the specific enzymes involved are not ..
  45. Park Windhol C, Zhang P, Zhu M, Su J, Chaves L, Maldonado A, et al. Gq/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2. PLoS ONE. 2012;7:e40048 pubmed publisher
    ..We previously showed that among Regulators of G protein Signaling, RGS2 selectively inhibits G(q/11) signaling and its hypertrophic effects in isolated CM...
  46. Wang X, Huang G, Luo X, Penninger J, Muallem S. Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells. J Biol Chem. 2004;279:41642-9 pubmed
    ..b>RGS2 is an RGS protein that shows preference toward Galpha(q)...
  47. Wilson L, Ross S, Lepore D, Wada T, Penninger J, Thomas P. Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary. Gene Expr Patterns. 2005;5:305-11 pubmed
    ..Analysis of the data using the R program revealed that the Regulator of G Protein Signaling 2 (Rgs2) gene was 3.9-fold more abundant in the 14.5 dpc pituitary...
  48. Wang X, Zeng W, Kim M, Allen P, Greengard P, Muallem S. Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors. EMBO J. 2007;26:2768-76 pubmed
    ..Thus, SPL and NRB bind all members of the R4 subfamily of RGS proteins tested (RGS1, RGS2, RGS4, RGS16) and GAIP...
  49. Zuber A, Singer D, Penninger J, Rossier B, Firsov D. Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice. J Am Soc Nephrol. 2007;18:1672-8 pubmed
    ..This study provides evidence that V2R signaling is negatively regulated by regulator of G protein signaling 2 (RGS2), a member of the family of RGS proteins...
  50. Yalcin B, Willis Owen S, Fullerton J, Meesaq A, Deacon R, Rawlins J, et al. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet. 2004;36:1197-202 pubmed
    ..We also show that this locus can be subdivided into three regions, one of which contains Rgs2, which encodes a regulator of G protein signaling...
  51. Yalcin B, Flint J, Mott R. Using progenitor strain information to identify quantitative trait nucleotides in outbred mice. Genetics. 2005;171:673-81 pubmed
  52. Bernhardt M, Lowther K, Padilla Banks E, McDonough C, Lee K, Evsikov A, et al. Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs. Development. 2015;142:2633-40 pubmed publisher
    ..Here, we show that regulator of G-protein signaling 2 (RGS2) suppresses Ca(2+) release in MII eggs...
  53. de Vries L, Gist Farquhar M. RGS proteins: more than just GAPs for heterotrimeric G proteins. Trends Cell Biol. 1999;9:138-44 pubmed
    ..This review summarizes recent findings on RGS proteins, especially those that implicate RGS proteins in more than just enhancing the GTPase activity of their Galpha subunit targets. ..