Gene Symbol: Rgs16
Description: regulator of G-protein signaling 16
Alias: Rgs14, Rgsr, regulator of G-protein signaling 16, A28-RGS14P, RGS-R, retinal-specific RGS, retinally abundant regulator of G-protein signaling
Species: mouse
Products:     Rgs16

Top Publications

  1. Chen C, Zheng B, Han J, Lin S. Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997;272:8679-85 pubmed
    ..isolated from mouse pituitary a full-length cDNA clone encoding a novel member of the RGS protein family, termed RGS16, as well as the full-length cDNA of mRGS5 and mRGS2...
  2. Gerstner J, Vander Heyden W, Lavaute T, Landry C. Profiles of novel diurnally regulated genes in mouse hypothalamus: expression analysis of the cysteine and histidine-rich domain-containing, zinc-binding protein 1, the fatty acid-binding protein 7 and the GTPase, ras-like family member 11b. Neuroscience. 2006;139:1435-48 pubmed
    ..These results demonstrate the ability of gene expression profiling to identify potential candidates important in circadian or homeostatic processes. ..
  3. Snow B, Antonio L, Suggs S, Siderovski D. Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene. Gene. 1998;206:247-53 pubmed
    ..Here, we describe the molecular cloning of the human RGS-r/RGS16 cDNA, encoding a predicted polypeptide of 23kDa that shows 86% identity to mouse RGS-r...
  4. Teplyuk N, Galindo M, Teplyuk V, Pratap J, Young D, Lapointe D, et al. Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem. 2008;283:27585-97 pubmed publisher
    ..g. Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13)...
  5. Stuebe S, Wieland T, Kraemer E, Stritzky A, Schroeder D, Seekamp S, et al. Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene. Naunyn Schmiedebergs Arch Pharmacol. 2008;376:363-73 pubmed
    The expression of the negative Regulator of G protein signaling 16 (RGS16) is rapidly induced in cardiomyocytes by various stimuli. To identify the promoter of the mouse RGS16 gene, a 1...
  6. de Vries L, Gist Farquhar M. RGS proteins: more than just GAPs for heterotrimeric G proteins. Trends Cell Biol. 1999;9:138-44 pubmed
    ..This review summarizes recent findings on RGS proteins, especially those that implicate RGS proteins in more than just enhancing the GTPase activity of their Galpha subunit targets. ..
  7. Nagata Y, Oda M, Nakata H, Shozaki Y, Kozasa T, Todokoro K. A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001;97:3051-60 pubmed
    ..Thus, RGS18 may play an important role in proliferation, differentiation, and/or migration of megakaryocytes. ..
  8. Slep K, Kercher M, Wieland T, Chen C, Simon M, Sigler P. Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation. Proc Natl Acad Sci U S A. 2008;105:6243-8 pubmed publisher
    ..structure of the enigmatic, neuronal G protein Galpha(o) in the GTP hydrolytic transition state, complexed with RGS16. Comparison with the 1...
  9. Hwang I, Park C, Harrison K, Kehrl J. Normal Thymocyte Egress, T Cell Trafficking, and CD4+ T Cell Homeostasis Require Interactions between RGS Proteins and Gαi2. J Immunol. 2017;198:2721-2734 pubmed publisher
    ..This study reveals how RGS proteins modulate Gαi2 signaling to facilitate thymocyte egress and T cell trafficking. ..

More Information


  1. Chen C, Wieland T, Simon M. RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996;93:12885-9 pubmed
    ..We show that a novel retinal specific RGS-motif protein specifically binds to an intermediate conformation involved in GTP hydrolysis by transducin ..
  2. Karim Z, Alshbool F, Vemana H, Conlon C, Druey K, Khasawneh F. CXCL12 regulates platelet activation via the regulator of G-protein signaling 16. Biochim Biophys Acta. 2016;1863:314-21 pubmed publisher
    ..One of the members of this family, RGS16, is highly expressed in megakaryocytes and platelets...
  3. Druey K, Ugur O, Caron J, Chen C, Backlund P, Jones T. Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling. J Biol Chem. 1999;274:18836-42 pubmed
    ..We investigated the function of palmitoylation for RGS16, which shares conserved amino-terminal cysteines with RGS4 and RGS5...
  4. Buckbinder L, Velasco Miguel S, Chen Y, Xu N, Talbott R, Gelbert L, et al. The p53 tumor suppressor targets a novel regulator of G protein signaling. Proc Natl Acad Sci U S A. 1997;94:7868-72 pubmed
    ..Herein we report on the identification of a novel p53 target gene (A28-RGS14) that is induced in response to genotoxic stress and encodes a novel member of a family of regulators of G protein ..
  5. Lippert E, Yowe D, Gonzalo J, Justice J, Webster J, Fedyk E, et al. Role of regulator of G protein signaling 16 in inflammation-induced T lymphocyte migration and activation. J Immunol. 2003;171:1542-55 pubmed
    ..To explore the role of RGS16 in T lymphocyte-dependent immune responses in a whole-organism model, we generated transgenic (Tg) mice expressing ..
  6. Gohlke J, Armant O, Parham F, Smith M, Zimmer C, Castro D, et al. Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biol. 2008;6:15 pubmed publisher
    ..Together, these data shed light on the molecular pathways regulated by proneural genes and demonstrate that the integration of experimentation with bioinformatics can guide both hypothesis testing and hypothesis generation. ..
  7. Hiol A, Davey P, Osterhout J, Waheed A, Fischer E, Chen C, et al. Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue. J Biol Chem. 2003;278:19301-8 pubmed
    ..For RGS16, mutation of Cys-2 and Cys-12 blocks its incorporation of [3H]palmitate and ability to turn-off Gi and Gq ..
  8. Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, et al. RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes. Biochem J. 2001;359:109-18 pubmed
    ..RGS1, RGS2 and RGS16, other members of the R4 subfamily, were expressed in distinct progenitor and mature myeloerythroid and lymphoid ..
  9. Hayasaka N, Aoki K, Kinoshita S, Yamaguchi S, Wakefield J, Tsuji Kawahara S, et al. Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice. PLoS ONE. 2011;6:e17655 pubmed publisher
    ..Previous studies have demonstrated that the Rgs16 transcripts exhibit robust circadian rhythms both in the suprachiasmatic nucleus (SCN), the master circadian light-..
  10. Shankar S, Wilson M, DiVietro J, Mentink Kane M, Xie Z, Wynn T, et al. RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol. 2012;188:6347-56 pubmed publisher
    ..b>RGS16 is enriched in activated/effector T lymphocytes...
  11. Xie S, Li J, Wang J, Wu Q, Yang P, Hsu H, et al. IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16. J Immunol. 2010;184:2289-96 pubmed publisher
    ..Inhibition of p65 phosphorylation downregulated RGS16 expression and abrogated the IL-17-induced chemotactic arrest of B cells in response to CXCL12...
  12. Ding Y, Li J, Wu Q, Yang P, Luo B, Xie S, et al. IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells. J Immunol. 2013;191:1614-24 pubmed publisher
    ..IL-17 upregulated the expression of regulator of G-protein signaling 16 (RGS16) to promote the ability of TFH to form conjugates with B cells, which was abolished in TFH cells from BXD2-Rgs16(-/..
  13. Doi M, Ishida A, Miyake A, Sato M, Komatsu R, Yamazaki F, et al. Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus. Nat Commun. 2011;2:327 pubmed publisher
    ..Here we show that the amount of RGS16 (regulator of G protein signalling 16), a protein known to inactivate G?i, increases at a selective circadian time ..
  14. Pehrson J, Changolkar L, Costanzi C, Leu N. Mice without macroH2A histone variants. Mol Cell Biol. 2014;34:4523-33 pubmed publisher
    ..MacroH2A-dependent gene regulation changes substantially in postnatal development and can be strongly affected by fasting. We propose that macroH2As produce adaptive changes to gene expression, which in the liver focus on metabolism. ..
  15. Hidvegi T, Mirnics K, Hale P, Ewing M, Beckett C, Perlmutter D. Regulator of G Signaling 16 is a marker for the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency. J Biol Chem. 2007;282:27769-80 pubmed
    ..Of several distinct gene expression profiles, marked up-regulation of regulator of G signaling (RGS16) was particularly notable...
  16. Villasenor A, Wang Z, Rivera L, Ocal O, Asterholm I, Scherer P, et al. Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes. Dis Model Mech. 2010;3:567-80 pubmed publisher
    ..Here, we show that the regulators of G protein signaling Rgs16 and Rgs8 are expressed in pancreatic progenitor and endocrine cells during development, then extinguished in ..
  17. Pashkov V, Huang J, Parameswara V, Kedzierski W, Kurrasch D, Tall G, et al. Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner. J Biol Chem. 2011;286:15116-25 pubmed publisher
    ..Herein we determined the role of Rgs16 in GPCR regulation of liver metabolism...