Gene Symbol: Rgs14
Description: regulator of G-protein signaling 14
Alias: RPIP1, regulator of G-protein signaling 14, RAP1/RAP2-interacting protein, rap1/rap2 interacting protein
Species: mouse
Products:     Rgs14

Top Publications

  1. Mittal V, Linder M. The RGS14 GoLoco domain discriminates among Galphai isoforms. J Biol Chem. 2004;279:46772-8 pubmed
    ..b>RGS14 regulates G protein nucleotide exchange and hydrolysis by acting as a GAP through its RGS domain and as a guanine ..
  2. Cho H, Kim D, Kehrl J. RGS14 is a centrosomal and nuclear cytoplasmic shuttling protein that traffics to promyelocytic leukemia nuclear bodies following heat shock. J Biol Chem. 2005;280:805-14 pubmed
    b>RGS14, a member of the regulator of G-protein signaling (RGS) protein family, possesses an N-terminal RGS domain, two Raf-like Ras-binding domains, and a GoLoco motif, which has GDP dissociation inhibitor activity...
  3. Martin McCaffrey L, Willard F, Oliveira dos Santos A, Natale D, Snow B, Kimple R, et al. RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell. 2004;7:763-9 pubmed
    ..elegans and D. melanogaster. Here we show that "regulator of G protein signaling-14" (RGS14) is expressed by the mouse embryonic genome immediately prior to the first mitosis, where it colocalizes with the ..
  4. Traver S, Bidot C, Spassky N, Baltauss T, de Tand M, Thomas J, et al. RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Biochem J. 2000;350 Pt 1:19-29 pubmed
    ..This protein was identified as RGS14, a member of the recently discovered family of RGS ('regulators of G-protein signalling') proteins that stimulate ..
  5. Vellano C, Shu F, Ramineni S, Yates C, Tall G, Hepler J. Activation of the regulator of G protein signaling 14-G?i1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A. Biochemistry. 2011;50:752-62 pubmed publisher
    b>RGS14 is a brain scaffolding protein that integrates G protein and MAP kinase signaling pathways. Like other RGS proteins, RGS14 is a GTPase activating protein (GAP) that terminates G?i/o signaling...
  6. Kukimoto Niino M, Takagi T, Akasaka R, Murayama K, Uchikubo Kamo T, Terada T, et al. Crystal structure of the RUN domain of the RAP2-interacting protein x. J Biol Chem. 2006;281:31843-53 pubmed
    ..In the crystal the putative Rap2 binding site of the RPIPx RUN domain interacts with the extended segment in a segment-swapping manner. ..
  7. Siletti K, Tarchini B, Hudspeth A. Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles. Proc Natl Acad Sci U S A. 2017;114:E11170-E11179 pubmed publisher
    ..Our results suggest that the primary cilium or an associated structure influences the domain of cell-intrinsic signals that shape the hair bundle. Daple is therefore essential to orient and pattern sensory hair bundles. ..
  8. Branch M, Hepler J. Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus. PLoS ONE. 2017;12:e0184497 pubmed publisher
    b>Regulator of G protein signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates G protein and H-Ras/MAPkinase signaling pathways to regulate synaptic plasticity important for hippocampal learning and memory...
  9. Vellano C, Brown N, Blumer J, Hepler J. Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by G?i1 and G?i-linked G protein-coupled receptors. J Biol Chem. 2013;288:3620-31 pubmed publisher
    b>Regulator of G protein signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates heterotrimeric G protein and H-Ras signaling pathways...

More Information


  1. Lee S, Simons S, Heldt S, Zhao M, Schroeder J, Vellano C, et al. RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. Proc Natl Acad Sci U S A. 2010;107:16994-8 pubmed publisher
    ..Here we demonstrate that the signaling protein RGS14 is highly enriched in CA2 pyramidal neurons and plays a role in suppression of both synaptic plasticity at these ..
  2. Rodríguez Muñoz M, de la Torre Madrid E, Gaitan G, Sánchez Blázquez P, Garzón J. RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons. Cell Signal. 2007;19:2558-71 pubmed
    ..The regulator of G-protein signaling, the RGS14 protein, associates with MORs in periaqueductal gray matter (PAG) neurons, and when RGS14 is silenced morphine ..
  3. Martin McCaffrey L, Hains M, Pritchard G, Pajak A, Dagnino L, Siderovski D, et al. Differential expression of regulator of G-protein signaling R12 subfamily members during mouse development. Dev Dyn. 2005;234:438-44 pubmed
    ..The mammalian R12 RGS protein subfamily is composed of RGS12 and RGS14, two proteins characterized by their multidomain architecture of hallmark RGS domain, tandem Ras-binding domains (..
  4. Martin McCaffrey L, Willard F, Pajak A, Dagnino L, Siderovski D, D Souza S. RGS14 is a microtubule-associated protein. Cell Cycle. 2005;4:953-60 pubmed
    ..elegans, D. melanogaster and mammals. We recently demonstrated that RGS14 is required for completion of the first mitotic division of the mouse embryo, and that it regulates microtubule ..
  5. Cho H, Kehrl J. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007;178:245-55 pubmed
    ..Fluorescence resonance energy transfer analysis confirms a direct interaction between RGS14 and G(ialpha1) in centrosomes...
  6. Mittal V, Linder M. Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A. Biochem J. 2006;394:309-15 pubmed
    ..b>RGS14 accelerates GTP hydrolysis by G(ialpha) family members through its RGS domain and suppresses guanine nucleotide ..
  7. Nagata Y, Oda M, Nakata H, Shozaki Y, Kozasa T, Todokoro K. A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood. 2001;97:3051-60 pubmed
    ..Thus, RGS18 may play an important role in proliferation, differentiation, and/or migration of megakaryocytes. ..
  8. Evans P, Lee S, Smith Y, Hepler J. Postnatal developmental expression of regulator of G protein signaling 14 (RGS14) in the mouse brain. J Comp Neurol. 2014;522:186-203 pubmed publisher
    b>Regulator of G protein signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates G protein and mitogen-activated protein kinase (MAPK) signaling pathways...