Ret

Summary

Gene Symbol: Ret
Description: ret proto-oncogene
Alias: PTC, RET51, RET9, c-Ret, proto-oncogene c-Ret, proto-oncogene tyrosine-protein kinase receptor Ret
Species: mouse

Top Publications

  1. ncbi A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
    A T Dudley
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 9:2795-807. 1995
  2. pmc Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development
    Sunder Sims-Lucas
    Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA
    Dev Dyn 240:240-9. 2011
  3. pmc C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B
    C L Smith-Hicks
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 W 168th Street, New York, NY 10032, USA
    EMBO J 19:612-22. 2000
  4. pmc Betaglycan is required for the establishment of nephron endowment in the mouse
    Kenneth A Walker
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 6:e18723. 2011
  5. ncbi Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
    Akio Kobayashi
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:2809-23. 2005
  6. ncbi Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis
    Dipa Natarajan
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 129:5151-60. 2002
  7. ncbi Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse
    J P Golden
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Exp Neurol 158:504-28. 1999
  8. ncbi Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease
    Minerva M Carrasquillo
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe St, Jefferson St Bldg, 2 109, Baltimore, Maryland 21287, USA
    Nat Genet 32:237-44. 2002
  9. doi Retrograde signaling onto Ret during motor nerve terminal maturation
    Christel Baudet
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
    J Neurosci 28:963-75. 2008
  10. ncbi GDNF availability determines enteric neuron number by controlling precursor proliferation
    Scott Gianino
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 130:2187-98. 2003

Scientific Experts

Detail Information

Publications139 found, 100 shown here

  1. ncbi A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
    A T Dudley
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 9:2795-807. 1995
    ..Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development...
  2. pmc Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development
    Sunder Sims-Lucas
    Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA
    Dev Dyn 240:240-9. 2011
    ..Beyond E12.5, Fgfr1(Mes-/-)Fgfr2IIIc-/- mice had no renal tissue. In conclusion, Fgfr2IIIc and Fgfr1 in kidney mesenchyme (together) are critical for normal early renal development...
  3. pmc C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B
    C L Smith-Hicks
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 W 168th Street, New York, NY 10032, USA
    EMBO J 19:612-22. 2000
    ..Most cases are caused by substitution of threonine for Met918 in the RET receptor tyrosine kinase, which is believed to convert the RET gene to an oncogene by altering the enzyme's ..
  4. pmc Betaglycan is required for the establishment of nephron endowment in the mouse
    Kenneth A Walker
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 6:e18723. 2011
    ..gene regulatory network that governs metanephric development, including significant increases in Pax2, Eya1, Gdnf, Ret, Wnt4, and Wt1 expression. Conversely, gene expression in null kidneys was normal until e13...
  5. ncbi Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
    Akio Kobayashi
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:2809-23. 2005
    ..We also demonstrate that the nephric duct is essential for the elongation and maintenance of the adjacent Mullerian duct, the anlage of the female reproductive tract...
  6. ncbi Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis
    Dipa Natarajan
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 129:5151-60. 2002
    ..We provide evidence that activation of the receptor tyrosine kinase RET by glial cell line-derived neurotrophic factor (GDNF) is required for the directional migration of ENS progenitors ..
  7. ncbi Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse
    J P Golden
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Exp Neurol 158:504-28. 1999
    ..The receptors for these factors are complexes that include the Ret tyrosine kinase receptor and a GPI-linked, ligand-binding component called GDNF family receptor alpha 1-4 (..
  8. ncbi Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease
    Minerva M Carrasquillo
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe St, Jefferson St Bldg, 2 109, Baltimore, Maryland 21287, USA
    Nat Genet 32:237-44. 2002
    ..13q22 and 16q23; the gene at 13q22 is EDNRB, encoding a G protein-coupled receptor (GPCR) and the gene at 10q11 is RET, encoding a receptor tyrosine kinase (RTK)...
  9. doi Retrograde signaling onto Ret during motor nerve terminal maturation
    Christel Baudet
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
    J Neurosci 28:963-75. 2008
    ..Our results suggest that the Ret tyrosine kinase receptor transmits a signal in motor neuron synapses that contribute to motor neuron survival and ..
  10. ncbi GDNF availability determines enteric neuron number by controlling precursor proliferation
    Scott Gianino
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 130:2187-98. 2003
    To clarify the role of Ret signaling components in enteric nervous system (ENS) development, we evaluated ENS anatomy and intestinal contractility in mice heterozygous for Ret, GFRalpha1 and Ret ligands...
  11. ncbi Essential role of Gata transcription factors in sympathetic neuron development
    Konstantina Tsarovina
    Max Planck Institut für Hirnforschung, Abteilung Neurochemie, Deutschordenstr 46, 60528 Frankfurt Main, Germany
    Development 131:4775-86. 2004
    ..The present data establish Gata2 and Gata3 in the chick and mouse, respectively, as essential members of the transcription factor network controlling sympathetic neuron development...
  12. ncbi Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
    A Schuchardt
    Department of Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Nature 367:380-3. 1994
    ..The RTK encoded by the c-ret proto-oncogene is rearranged and constitutively activated in a large proportion of thyroid papillary carcinomas, ..
  13. pmc Kidney development in the absence of Gdnf and Spry1 requires Fgf10
    Odysse Michos
    Department of Genetics and Development, Columbia University, New York, New York, USA
    PLoS Genet 6:e1000809. 2010
    GDNF signaling through the Ret receptor tyrosine kinase (RTK) is required for ureteric bud (UB) branching morphogenesis during kidney development in mice and humans...
  14. ncbi Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction
    M Albert Basson
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, USA
    Dev Cell 8:229-39. 2005
    ..These defects are due to increased sensitivity of the Wolffian duct to GDNF/RET signaling, and reducing Gdnf gene dosage correspondingly rescues the Spry1 null phenotype...
  15. ncbi Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
    Thomas J Carroll
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Dev Cell 9:283-92. 2005
    ..Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system...
  16. ncbi Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development
    R Nishinakamura
    Division of Stem Cell Regulation, Institute of Medical Science, The University of Tokyo, Japan
    Development 128:3105-15. 2001
    ..Sall1 is therefore essential for ureteric bud invasion, the initial key step for metanephros development...
  17. ncbi The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
    A Pattyn
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS INSERM Université de la Méditterranée AP de Marseille, France
    Nature 399:366-70. 1999
    ..nervous system and the sympathetic ganglia, Phox2b is needed for the expression of the GDNF-receptor subunit Ret and for maintaining Mash1 expression...
  18. ncbi Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system
    S Taraviras
    Divisions of Developmental Neurobiology and Neurobiology, MRC, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Development 126:2785-97. 1999
    b>RET is a member of the receptor tyrosine kinase (RTK) superfamily, which can transduce signalling by glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) in cultured cells...
  19. doi Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling
    Steeve Bourane
    INSERM U 583, F34091 Montpellier, France
    Neuron 64:857-70. 2009
    ..of LTMs can be identified shortly after DRG genesis by unique expression of the MafA transcription factor, the Ret receptor and coreceptor GFRalpha2, and find that their specification is Ngn2 dependent...
  20. pmc High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma
    David S Hains
    Division of Nephrology, Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio, USA
    J Urol 183:2077-84. 2010
    ..We determined whether Fgfr2(Mes-/-) mutants developed abnormally positioned ureters predisposing to vesicoureteral reflux...
  21. ncbi IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life
    D C Molliver
    Department of Neurology, Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 19:849-61. 1997
    ..We show that mRNA and protein for the GDNF receptor tyrosine kinase, Ret, are expressed in the DRG in patterns that differ markedly from those of any of the neurotrophin receptors...
  22. pmc Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia
    Sunder Sims-Lucas
    Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15201, USA
    Am J Physiol Renal Physiol 297:F1208-19. 2009
    ..However, Ret and Wnt11 (molecules critical for ureteric branching morphogenesis) mRNA levels were lower in mutants vs. controls...
  23. doi Canonical WNT/beta-catenin signaling is required for ureteric branching
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Dev Biol 317:83-94. 2008
    ..followed by decreased expression of genes downstream of Emx2, including Lim1, Pax2, and the ureteric tip markers, c-ret and Wnt 11...
  24. pmc Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney
    Michelle Self
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    EMBO J 25:5214-28. 2006
    ..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud...
  25. ncbi Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney
    Melina Narlis
    McGill Cancer Centre and Biochemistry Department, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    J Am Soc Nephrol 18:1121-9. 2007
    ..At the ureter tips, the expression of Wnt11, a target of glial cell-derived neurotrophic factor-Ret signaling, is significantly reduced, whereas the expression levels of Ret and GDNF remain normal...
  26. pmc Critical and distinct roles for key RET tyrosine docking sites in renal development
    Sanjay Jain
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genes Dev 20:321-33. 2006
    ..RET signaling in kidney development, we characterized mice that exclusively express either the human RET9 or RET51 isoform, or express these isoforms with individual mutations in docking tyrosines for PTB and SH2-domain-..
  27. ncbi Possible involvement of glial cell line-derived neurotrophic factor and its receptor, GFRalpha1, in survival and maturation of thymocytes
    Sachiko Kondo
    Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Eur J Immunol 33:2233-40. 2003
    ..These results suggested that GDNF/GFRalpha1 are involved in the survival of both the nervous system and DN immature thymocytes...
  28. pmc Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals
    Dario Bonanomi
    Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 148:568-82. 2012
    ..We show that the receptor tyrosine kinase Ret is required for motor axon attraction mediated by ephrin-A reverse signaling...
  29. pmc Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system
    Yuka Morikawa
    Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, New Orleans, LA 70118, USA
    Dev Biol 307:114-26. 2007
    ..Our data suggest that the major role of Hand2 during SNS development is to permit sympathetic neurons to acquire a catecholaminergic phenotype...
  30. pmc Independent roles of Fgfr2 and Frs2alpha in ureteric epithelium
    Sunder Sims-Lucas
    Rangos Research Center, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15201, USA
    Development 138:1275-80. 2011
    ..Taken together, although Fgfr2 and Frs2α have crucial roles in the ureteric lineage, they appear to act separately and additively...
  31. ncbi A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture
    H M Young
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, 3052, Australia
    Dev Biol 202:67-84. 1998
    ..b>Ret and p75 have also been reported to label migratory-stage enteric neuron precursors...
  32. ncbi Expression of the c-ret proto-oncogene during mouse embryogenesis
    V Pachnis
    Department of Genetics and Development, Columbia University, New York, NY 10032
    Development 119:1005-17. 1993
    The c-ret proto-oncogene encodes a receptor tyrosine kinase whose normal function has yet to be determined...
  33. ncbi Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs
    C A Nosrat
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Exp Brain Res 115:410-22. 1997
    ..GDNFR-alpha), after which the GDNF-GDNFR-alpha associates with and activates the tyrosine kinase receptor Ret. We have localized Ret messenger RNA (mRNA) in the developing and adult rodent and compared with to the expression ..
  34. ncbi Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4
    K Stark
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138
    Nature 372:679-83. 1994
    ..Thus, Wnt-4 appears to act as an autoinducer of the mesenchyme to epithelial transition that underlies nephron development...
  35. pmc Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis
    Xuan Chi
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 17:199-209. 2009
    ..GDNF/RET signaling is required for ureter and kidney development, and cells lacking Ret are excluded from the tips of the ..
  36. ncbi Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3
    Marten P Smidt
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Development 131:1145-55. 2004
    ..However, an overall lower activity was observed. The results suggest that Pitx3 is specifically required for the formation of the SNc subfield at the onset of dopaminergic neuron differentiation...
  37. ncbi Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development
    Lijun Chi
    Biocenter Oulu and Department of Biochemistry, Faculties of Science and Medicine, University of Oulu, PO Box 3000, FIN 90014 Oulu, Finland
    Development 131:3345-56. 2004
    ..Together, these data suggest that Spry genes contribute to reciprocal epithelial-mesenchymal and stromal signalling controlling ureteric branching, which involves the coordination of Ffg/Wnt11/Gdnf pathways...
  38. ncbi Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2
    V Hatini
    Cell Biology Program and Division of Endocrinology, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 10:1467-78. 1996
    ....
  39. pmc The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression
    James M Linton
    Department of Physiology, 1550 Fourth Street, University of California, San Francisco, San Francisco, CA 94143, USA
    Development 134:2501-9. 2007
    ..Our results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development...
  40. ncbi Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney
    Catherine A Schnabel
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5342, USA
    Dev Biol 254:262-76. 2003
    ..Taken together, these data establish a role for Pbx1 in mesenchymal-epithelial signaling and demonstrate that Pbx1 is an essential regulator of mesenchymal function during renal morphogenesis...
  41. ncbi Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development
    Randy S Levinson
    Department of Urology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Development 132:529-39. 2005
    ....
  42. pmc Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter
    Y Miyazaki
    Department of Pediatrics, Department of Pathology, Department of Cell Biology, and Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Clin Invest 105:863-73. 2000
    ..The other is to promote the elongation of the branching ureter within the metanephros, thereby promoting kidney morphogenesis...
  43. ncbi The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis
    S E Quaggin
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Development 126:5771-83. 1999
    ..Defects specific to later specialized cell types where Pod1 is expressed, such as the podocytes, were also observed, suggesting that this transcription factor may play multiple roles in kidney morphogenesis...
  44. ncbi Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development
    A Schuchardt
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, NY 10032, USA
    Development 122:1919-29. 1996
    The c-ret gene encodes a receptor tyrosine kinase that is expressed in the Wolffian duct and ureteric bud of the developing excretory system...
  45. ncbi Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret
    Ekatherina Batourina
    Department of Urology, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Nat Genet 32:109-15. 2002
    ..hypoplasia, hydronephrosis and mega-ureter, abnormalities also seen in mice with mutations in the proto-oncogene Ret. Here we show that ureter maturation depends on formation of the 'trigonal wedge', a newly identified epithelial ..
  46. ncbi A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons
    Wenqin Luo
    The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 54:739-54. 2007
    ..The common receptor for GDNF family ligands, Ret, is highly expressed in nonpeptidergic neurons, but its function during development of these neurons is unclear...
  47. ncbi Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
    Arindam Majumdar
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 130:3175-85. 2003
    ..Gdnf encodes a mesenchymally produced ligand for the Ret tyrosine kinase receptor that is crucial for normal ureteric branching...
  48. ncbi Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene
    P D Brophy
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Development 128:4747-56. 2001
    ..The receptor tyrosine kinase RET and glial cell-derived neurotrophic factor (GDNF) form a signaling complex that is essential for ureteric bud ..
  49. pmc The transcription factors Etv4 and Etv5 mediate formation of the ureteric bud tip domain during kidney development
    Satu Kuure
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Development 137:1975-9. 2010
    Signaling by the Ret receptor tyrosine kinase promotes cell movements in the Wolffian duct that give rise to the first ureteric bud tip, initiating kidney development...
  50. ncbi c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice
    K Burau
    Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, INF 307, D 69120 Heidelberg, Germany
    Eur J Neurosci 20:353-62. 2004
    ..Previous studies have shown that the c-ret receptor and cholinergic properties are coexpressed in chick sympathetic neurons...
  51. pmc Role of fibroblast growth factor receptor 2 in kidney mesenchyme
    David Hains
    Center for Cell and Developmental Biology, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Pediatr Res 64:592-8. 2008
    ..Thus, Fgfr2 is critical in ensuring that there is a single ureteric bud from the nephric duct. The plethora of later stage defects in Fgfr2 conditional knockouts is reminiscent of many human cases of genetic urogenital anomalies...
  52. pmc Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos
    Alexandre Gonçalves
    Developmental Genetics, Department of Biomedicine, University of Basel Medical Faculty, Basel, Switzerland
    PLoS ONE 6:e19370. 2011
    ..Therefore, we investigated whether BMP7 in turn also participates in inhibiting ureteric bud outgrowth during the initiation of metanephric kidney development...
  53. ncbi Overexpression of RET leads to vesicoureteric reflux in mice
    O H Yu
    Department of Pediatrics, Montreal Children s Hospital, McGill University, Montreal, Quebec, Canada
    Am J Physiol Renal Physiol 287:F1123-30. 2004
    b>RET, a tyrosine kinase receptor essential for kidney development, has recently been shown to be important for the formation of the urinary tract...
  54. pmc LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development
    Kenji Mandai
    The Solomon H Snyder Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, PCTB 1015, Baltimore, MD 21205, USA
    Neuron 63:614-27. 2009
    ..Linx, are expressed in subsets of somatosensory and motor neurons, and select members interact with TrkA and Ret RTKs...
  55. pmc Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis
    Satu Kuure
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS Genet 6:e1001176. 2010
    ..The results indicate that ADF activity, provided by either cofilin1 or destrin, is essential in UB epithelial cells for normal growth and branching...
  56. ncbi Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage
    Jason C Clarke
    Department of Pediatrics, University of Michigan, Ann Arbor 48109, USA, and Kolling Institute, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia
    Hum Mol Genet 15:3420-8. 2006
    ..expressed very early in the mammalian nephric duct and both precede the expression of receptor tyrosine kinase, c-Ret. However, in Pax2-/- mutant mice, expression of c-Ret is lost after embryonic day 10.5...
  57. doi Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney
    Nina Perälä
    Institute of Biomedicine Medical Biochemistry and Developmental Biology, Biomedicum Helsinki, PO Box 63, FI 00014 University of Helsinki, Finland
    Differentiation 81:81-91. 2011
    ..As shown by co-immunoprecipitation Plexin B2 interacts with the Ret receptor tyrosine kinase, the receptor of Glial-cell-line-derived neurotrophic factor (Gdnf), in embryonic kidneys...
  58. ncbi Lim 1 is required for nephric duct extension and ureteric bud morphogenesis
    Anissa Pedersen
    Department of Genetics, Cell Biology and Development and University of Minnesota Developmental Biology Center, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Dev Biol 288:571-81. 2005
    ..These results suggest that Lim 1 influences nephric duct extension and ureteric bud outgrowth by regulating and or maintaining the differentiation of the nephric epithelium...
  59. pmc Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system
    Edgar R Kramer
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Martinsried, Germany
    PLoS Biol 5:e39. 2007
    ..We generated mice with regionally selective ablations of the genes encoding the receptors for GDNF (Ret) and BDNF (TrkB)...
  60. pmc Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis
    E de Graaff
    Division of Developmental Neurobiology, Medical Research Council MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Genes Dev 15:2433-44. 2001
    ..Two major isoforms, RET9 and RET51, differ in the amino acid sequence of the C-terminal tail as a result of alternative splicing...
  61. ncbi Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in periphera
    J Widenfalk
    Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Neurosci 17:8506-19. 1997
    ..factor neurturin (NTN) and GDNFR-beta mRNA in developing and adult mice, and comparisons with GDNFR-alpha and RET were made...
  62. pmc Nephric lineage specification by Pax2 and Pax8
    Maxime Bouchard
    Research Institute of Molecular Pathology, Vienna Biocenter, A 1030 Vienna, Austria
    Genes Dev 16:2958-70. 2002
    ..transitions required for nephric duct formation, fails to initiate the kidney-specific expression of Lim1 and c-Ret, and is lost by apoptosis 1 d after failed pronephric induction...
  63. ncbi Pax-2 controls multiple steps of urogenital development
    M Torres
    Abteilung Molekulare Zellbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Development 121:4057-65. 1995
    ..These data show that Pax-2 is required for multiple steps during the differentiation of intermediate mesoderm. In addition, Pax-2 mouse mutants provide an animal model for human hereditary kidney diseases...
  64. ncbi Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts
    P L Durbec
    Division of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, London, UK
    Development 122:349-58. 1996
    c-ret encodes a tyrosine kinase receptor that is necessary for normal development of the mammalian enteric nervous system. Germline mutations in c-ret lead to congenital megacolon in humans, while a loss-of-function allele (ret...
  65. ncbi Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract
    T Kume
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 127:1387-95. 2000
    ..Here, we show that most compound heterozygotes have hypoplastic kidneys and a single hydroureter, while all heterozygotes are normal. This provides evidence that the two genes interact in kidney as well as heart development...
  66. ncbi Crosstalk between Jagged1 and GDNF/Ret/GFRalpha1 signalling regulates ureteric budding and branching
    Satu Kuure
    Developmental Biology, Institute of Biomedicine, P O Box 63, Haartmaninkatu 8, University of Helsinki, Helsinki FIN 00014, Finland
    Mech Dev 122:765-80. 2005
    ..The ligand activates on the ureteric bud epithelium a receptor complex composed of Ret and GFRalpha1. The upstream regulators of the GDNF receptors are poorly known...
  67. ncbi Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code
    J E Pitera
    Gastroenterology Unit, Institute of Child Health, University College London, London, England
    Gastroenterology 117:1339-51. 1999
    ..We have studied the expression domains of these genes in the gut both spatially and temporally...
  68. ncbi Stromal cells mediate retinoid-dependent functions essential for renal development
    C Mendelsohn
    Columbia University, Department of Urology, New York, NY 10032, USA
    Development 126:1139-48. 1999
    ..Analysis of genes important for ureteric bud morphogenesis revealed that the proto-oncogene c-ret was downregulated...
  69. ncbi Regulation of metanephric kidney development by growth/differentiation factor 11
    Aurora F Esquela
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Biol 257:356-70. 2003
    ..Our studies suggest that Gdf11 may be important in directing the initial outgrowth of the ureteric bud from the Wolffian duct by controlling the expression of Gdnf in the metanephric mesenchyme...
  70. ncbi Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney
    David Grote
    McGill Cancer Centre and Biochemistry Department, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    Development 133:53-61. 2006
    ..At the molecular level, the nephric duct of Gata3(-/-) embryos is characterized by the loss of Ret expression and signaling, which may contribute to the guidance defect of the nephric duct...
  71. ncbi Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain
    Chih Li Chen
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Neuron 49:365-77. 2006
    ..development but in adult mice, becomes restricted to nociceptors marked by expression of the neurotrophin receptor Ret. In these neurons, Runx1 regulates the expression of many ion channels and receptors, including TRP class thermal ..
  72. ncbi A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification
    Ina Kramer
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Neuron 49:379-93. 2006
    ..Together, our findings suggest that Runx transcription factor signaling plays a key role in sensory neuron diversification...
  73. pmc POU domain factor Brn-3a controls the differentiation and survival of trigeminal neurons by regulating Trk receptor expression
    E J Huang
    Program in Neuroscience, Department of Physiology, and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0723 USA
    Development 126:2869-82. 1999
    ..Approximately 70% of these express the GDNF receptor subunit, c-ret; many can be sustained by GDNF, but not by NGF in culture...
  74. ncbi Spatial gene expression in the T-stage mouse metanephros
    Georgina Caruana
    Department of Anatomy and Cell Biology, Monash University, Clayton, Vic, Australia
    Gene Expr Patterns 6:807-25. 2006
    ..This study has identified genes spatially expressed in regions of the developing kidney involved in branching morphogenesis, nephrogenesis and the development of the collecting duct system, calyces, renal pelvis and ureter...
  75. pmc A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia
    Mayumi Jijiwa
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Mol Cell Biol 24:8026-36. 2004
    The Ret receptor tyrosine kinase plays a crucial role in the development of the enteric nervous system and the kidney...
  76. pmc Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation
    J Grimm
    Max Delbrueck Center for Molecular Medicine, 13092 Berlin, Germany
    J Cell Biol 154:345-54. 2001
    ..Here we found that p62dok family members act as substrates for the c-Ret receptor tyrosine kinase...
  77. pmc Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction
    David Grote
    Goodman Cancer Centre, McGill University, Quebec, Canada
    PLoS Genet 4:e1000316. 2008
    ..Central to this process, GDNF secreted from the metanephric mesenchyme induces ureter budding by activating the Ret receptor expressed in the nephric duct epithelium...
  78. ncbi Defects of urogenital development in mice lacking Emx2
    N Miyamoto
    Department of Morphogenesis, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University School of Medicine, Honjo, Japan
    Development 124:1653-64. 1997
    ..Pax-2 and c-ret expressions in the Wolffian duct and WT-1 and GDNF expressions in the metanephric blastema were initially normal in ..
  79. doi Dynamic regulation of the expression of neurotrophin receptors by Runx3
    Souichiro Nakamura
    Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8577, Japan
    Development 135:1703-11. 2008
    ..Moreover, we show that the number of TrkA-positive DRG neurons is reduced in Runx3(-/-) mice, as compared with the wild type. These results suggest that Runx3 positively regulates the expression of TrkC and TrkA in DRG neurons...
  80. ncbi Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET
    Amanda Barlow
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Neuron 40:905-16. 2003
    ..Two signaling systems mediated by RET and EDNRB have been identified as critical players in enteric neurogenesis...
  81. ncbi Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons
    R O Heuckeroth
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 22:253-63. 1999
    Neurturin (NTN) is a neuronal survival factor that activates the Ret tyrosine kinase in the presence of a GPI-linked coreceptor (either GFR alpha1 or GFR alpha2)...
  82. pmc Loss of Sprouty1 rescues renal agenesis caused by Ret mutation
    Esteban J Rozen
    Cell Signaling and Apoptosis Group, Institut de Recerca Biomedica de Lleida, Lleida, Spain
    J Am Soc Nephrol 20:255-9. 2009
    ..a balance between positive and negative signals, which are provided in part by the receptor tyrosine kinase Ret and the putative tumor suppressor Sprouty1, respectively...
  83. ncbi Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis
    Odysse Michos
    Developmental Genetics, Dept of Clinical Biological Sciences DKBW University of Basel Medical School, c o Anatomy Institute, Pestalozzistrasse 20, CH 4056 Basel, Switzerland
    Development 131:3401-10. 2004
    ..essential to induce metanephric kidney development as initiation of ureter growth, branching and establishment of RET/GDNF feedback signaling are disrupted in Grem1-deficient embryos...
  84. ncbi Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb
    Edgar R Kramer
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    Neuron 50:35-47. 2006
    ..Here, we implicate glial-cell-line-derived neurotrophic factor (GDNF) and its receptor, Ret, in the same guidance decision...
  85. ncbi The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons
    C Fode
    IGBMC, CNRS INSERM Universite Louis Pasteur, Illkirch, C U de Strasbourg, France
    Neuron 20:483-94. 1998
    ..Interestingly, the homeobox gene Phox2a is activated independently of ngn2 in epibranchial placodes, suggesting that neuronal fate and neuronal subtype identity may be specified independently in cranial sensory ganglia...
  86. pmc Non-cell-autonomous effects of Ret deletion in early enteric neurogenesis
    Silvia Bogni
    Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 135:3007-11. 2008
    ..in chick embryos, and genetic studies in mice have identified genes crucial for ENS development, including Ret. Here, we have combined mouse embryo and organotypic gut culture to monitor and experimentally manipulate the ..
  87. pmc Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases
    Noriko Uetani
    Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Clin Invest 119:924-35. 2009
    ..In cell culture, Ptprs bound and negatively regulated the phosphorylation and signaling of the Ret receptor tyrosine kinase, whereas Ptprs-induced apoptosis was inhibited by Ret expression...
  88. doi The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes
    Thomas W Gould
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    J Neurosci 28:2131-46. 2008
    ..and synapse elimination, and mice lacking either GDNF or its receptors GDNF family receptor alpha1 (GFRalpha1) and Ret exhibit a 25% reduction of lumbar MNs at postnatal day 0 (P0)...
  89. ncbi Constitutive Ret activity in knock-in multiple endocrine neoplasia type B mice induces profound elevation of brain dopamine concentration via enhanced synthesis and increases the number of TH-positive cells in the substantia nigra
    Jelena Mijatovic
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
    J Neurosci 27:4799-809. 2007
    b>Ret is the common signaling receptor for glial cell line-derived neurotrophic factor (GDNF) and other ligands of the GDNF family that have potent effects on brain dopaminergic neurons...
  90. pmc Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice
    Toshihiro Uesaka
    Laboratory for Neuronal Differentiation and Regeneration and Laboratory for Cellular Morphogenesis, RIKEN Center for Developmental Biology, Kobe, Japan
    J Clin Invest 118:1890-8. 2008
    Mutations in the RET gene are the primary cause of Hirschsprung disease (HSCR), or congenital intestinal aganglionosis. However, how RET malfunction leads to HSCR is not known...
  91. doi Development of satellite glia in mouse sympathetic ganglia: GDNF and GFR alpha 1 are not essential
    Thomas Callahan
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria 3010, Australia
    Glia 56:1428-37. 2008
    ..5-E15.5 mice also expressed the GDNF-binding molecule, GFRalpha1. B-FABP immunoreactive cells did not express Ret or NCAM, two potential signaling molecules for GDNF/GFRalpha1. In E12.5 and E18...
  92. doi Disturbances of colonic motility in mouse models of Hirschsprung's disease
    Rachael R Roberts
    Dept of Physiology, Univ of Melbourne, Parkville, VIC 3010, Australia
    Am J Physiol Gastrointest Liver Physiol 294:G996-G1008. 2008
    ..GDNF signals through Ret, a receptor tyrosine kinase, and Et-3 signals through endothelin receptor B (Ednrb)...
  93. doi Impact of connexin32 deletion on E7 or RET/PTC3 oncogene-driven growth and neoplastic transformation of the thyroid gland
    Gaëlle Prost
    Institut National de Santé et de Recherche Médicale, UMR 664, Lyon F 69372, France
    Endocr Relat Cancer 16:873-84. 2009
    ..Cx32-KO) mice were crossed with transgenic mice expressing, selectively in the thyroid gland, either the E7 or RET/PTC3 (RP3) oncogene...
  94. doi The murine Fgfrl1 receptor is essential for the development of the metanephric kidney
    Simon D Gerber
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Dev Biol 335:106-19. 2009
    ..We also observed a loss of Pax2 positive nephron precursor cells and an increase of apoptosis in the cortical zone of the remnant kidney. Fgfrl1 is therefore essential for mesenchymal differentiation in the early steps of nephrogenesis...
  95. doi Sorafenib potently inhibits papillary thyroid carcinomas harboring RET/PTC1 rearrangement
    Ying C Henderson
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:4908-14. 2008
    Papillary thyroid carcinomas (PTC) are the most common type of thyroid malignancy with one of the two mutations, RET/PTC rearrangement or BRAF mutation...
  96. pmc RET signaling is required for survival and normal function of nonpeptidergic nociceptors
    Judith P Golden
    Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:3983-94. 2010
    ..of unmyelinated nociceptors express the NGF receptor TrkA, and half express the GDNF family ligand (GFL) receptor Ret. The function of NGF/TrkA signaling in the TrkA population of nociceptors has been extensively studied, and NGF/..
  97. ncbi C620R mutation of the murine ret proto-oncogene: loss of function effect in homozygotes and possible gain of function effect in heterozygotes
    Luo Yin
    International Agency for Research on Cancer IARC, Lyon, France
    Int J Cancer 121:292-300. 2007
    Germline RET mutations are responsible for different inherited disorders: Hirschsprung disease (congenital aganglionic megacolon), caused by loss of function mutations, familial medullary thyroid carcinoma and multiple endocrine ..
  98. ncbi RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice
    Sanjay Jain
    Department of Medicine, Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:11230-8. 2006
    Glial cell-line derived neurotrophic factor (GDNF)-mediated RET tyrosine kinase signaling is implicated in the survival of several PNS and CNS neuronal populations that are important in the pathogenesis of several disorders including ..
  99. ncbi Genetic mapping of the RET protooncogene on rat chromosome 4
    F Canzian
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Mamm Genome 6:433-5. 1995
  100. ncbi YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis
    A W Moore
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Development 126:1845-57. 1999
    ..These data demonstrate a variety of new functions for WT1 and suggest a general requirement for this protein in the formation of organs derived from the intermediate mesoderm...
  101. ncbi Transgenic mouse models for tumors of melanocytes and retinal pigment epithelium
    F Beermann
    Swiss Institute for Experimental Cancer Research ISREC, Epalinges
    Pigment Cell Res 12:71-80. 1999
    ..past years, transgenic mouse lines have been generated using different oncogenes - Ha-ras, SV40 T antigen (Tag), ret - which develop benign lesions of melanocytes, melanoma, and/or eye tumors...

Research Grants54

  1. NEW INSIGHTS INTO ROLE OF RET IN UROGENITAL DEVELOPMENT AND ANOMALIES
    Sanjay Jain; Fiscal Year: 2009
    ..Glial cell line-derived neurotrophic factor (GDNF), its coreceptor GFR11 and receptor tyrosine kinase RET constitute a signaling system that is critical for development of the kidneys and the urinary tract...
  2. DECIPHERING ROLES OF GDNF-GFRA1 RET SIGNALING IN NORMAL AND INJURED KIDNEY
    Sanjay Jain; Fiscal Year: 2010
    ..Glial cell line-derived neurotrophic factor (GDNF), its coreceptor Gfra1 and receptor Ret constitute a signaling system that is critical for kidney development...
  3. Functional Dissection of Ret Signaling Pathways
    Sanjay Jain; Fiscal Year: 2007
    b>RET is a single membrane tyrosine kinase receptor that mediates signaling of GDNF family ligands (GFLs) in association with GFRalpha coreceptors...
  4. NEW INSIGHTS INTO ROLE OF RET IN UROGENITAL DEVELOPMENT AND ANOMALIES
    Sanjay Jain; Fiscal Year: 2010
    ..Glial cell line-derived neurotrophic factor (GDNF), its coreceptor GFR11 and receptor tyrosine kinase RET constitute a signaling system that is critical for development of the kidneys and the urinary tract...
  5. DECIPHERING ROLES OF GDNF-GFRA1 RET SIGNALING IN NORMAL AND INJURED KIDNEY
    Sanjay Jain; Fiscal Year: 2011
    ..Glial cell line-derived neurotrophic factor (GDNF), its coreceptor Gfra1 and receptor Ret constitute a signaling system that is critical for kidney development...
  6. Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease
    Hoon Ryu; Fiscal Year: 2009
    ..These studies will provide novel mechanisms for preventing mitochondrial transcriptional dysfunction and help in the design of applicable compounds that modulate mitochondrial function. ..
  7. Genetic analysis of Pea3 transcription factors and kidney development
    FRANKLIN D COSTANTINI; Fiscal Year: 2010
    While GDNF signaling through the Ret receptor tyrosine kinase is essential for renal development in mice and in humans, the events that occur downstream of Ret to promote ureteric bud (UB) branching morpho- genesis remain largely ..
  8. Role of GDNF Family Ligands in Photoreceptor Rescue
    MILAM BRANTLEY; Fiscal Year: 2007
    ..in conjunction with their respective GDNF family receptors (GFRas) activate intracellular signaling through the Ret tyrosine kinase...
  9. Genetic Control of Ureter and Kidney Development
    FRANKLIN COSTANTINI; Fiscal Year: 2009
    ..GDNF is a mesenchymally-derived growth factor that signals to the ureteric bud epithelium via the Ret receptor tyrosine kinase and the co-receptor Gfr11...
  10. Branching Morphogenesis of Urinary Epithelia: from Genes to Cellular Behaviors
    FRANKLIN D COSTANTINI; Fiscal Year: 2010
    ..project will focus on the cellular events that are regulated by the secreted factor GDNF, which signals through the Ret receptor tyrosine kinase...
  11. Molecular Events in Urinary Tract Formation
    Cathy L Mendelsohn; Fiscal Year: 2010
    ..we have shown that ureter insertion depends on retinoic acid and that retinoids act by inducing transcription of Ret, a gene required for kidney development and for ureter insertion...
  12. Genetic analysis of Pea3 transcription factors and kidney development
    FRANKLIN COSTANTINI; Fiscal Year: 2009
    While GDNF signaling through the Ret receptor tyrosine kinase is essential for renal development in mice and in humans, the events that occur downstream of Ret to promote ureteric bud (UB) branching morpho- genesis remain largely obscure...
  13. Genetic analysis of Pea3 transcription factors and kidney development
    FRANKLIN D COSTANTINI; Fiscal Year: 2010
    While GDNF signaling through the Ret receptor tyrosine kinase is essential for renal development in mice and in humans, the events that occur downstream of Ret to promote ureteric bud (UB) branching morpho- genesis remain largely ..
  14. Genetic Control of Ureter and Kidney Development
    FRANKLIN COSTANTINI; Fiscal Year: 2009
    ..Cells expressing the Ret receptor, located at the tips of the ureteric bud, are the major progenitors of collecting ducts, while metanephric ..
  15. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2009
    ..we have shown that ureter insertion depends on retinoic acid (RA) and that RA acts by inducing transcription of Ret, a gene that when mutated in humans causes renal malformations and vesico-ureteral reflux...
  16. Genetic Control of Ureter and Kidney Development
    FRANKLIN D COSTANTINI; Fiscal Year: 2010
    ..GDNF is a mesenchymally-derived growth factor that signals to the ureteric bud epithelium via the Ret receptor tyrosine kinase and the co-receptor Gfr11...
  17. The Role of RET in Spermatogenesis
    Cathy Naughton; Fiscal Year: 2005
    ..of this application are to support my training as a physician-scientist and to establish the importance of RET tyrosine kinase and its coreceptors and ligands in spermatogenesis...
  18. CORE--ANIMAL FACILITY
    Cathy Mendelsohn; Fiscal Year: 2002
    ..To facilitate the sharing of animals, data and ideas between the individual research projects. ..
  19. SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESIS
    FRANKLIN COSTANTINI; Fiscal Year: 2002
    ..abstract_text> ..
  20. SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESIS
    FRANKLIN COSTANTINI; Fiscal Year: 2001
    ..Finally, new types of mutants and transgenic mice will be generated to study the role of Fused in mouse embryogenesis. ..
  21. Optimizing Testis Transplantation to Study RET Signaling
    Cathy Naughton; Fiscal Year: 2005
    The overall purpose of this study is to optimize whole testes transplantation technology to study Ret-mediated spermatogenesis...
  22. Transcription Factor P53 in Terminal Nephron Different
    Zubaida Saifudeen; Fiscal Year: 2004
    ..The results of this work will provide information on what determines terminal renal differentiation. In addition, these data will advance our understanding of the role the tumor suppressor p53 in kidney development...
  23. Function of Ret-GFL signaling in sensory neurons
    Judith Golden; Fiscal Year: 2007
    ..One population continues to express TrkA. The other population down-regulates TrkA expression and expresses Ret, the receptor for the neurotrophic factors belonging to the GDNF family...
  24. Molecular Events in Urinary Tract Formation
    Cathy Mendelsohn; Fiscal Year: 2007
    ..the base of the Wolffian ducts that we call the wedge, and that wedge outgrowth depends on Vitamin A and the RTK Ret. We will use mouse models of Vitamin A deficiency and time-lapse photography in organ culture studies to ..
  25. Estrogenic Regulation of Mitochondrial Transcription in Huntington's Disease
    Hoon Ryu; Fiscal Year: 2007
    ..These studies will provide novel mechanisms for preventing mitochondrial transcriptional dysfunction and help in the design of applicable compounds that modulate mitochondrial function. ..
  26. SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESIS
    FRANKLIN COSTANTINI; Fiscal Year: 2007
    ..abstract_text> ..
  27. SIGNAL TRANSDUCTION IN VERTEBRATE EMBRYOGENESIS
    FRANKLIN COSTANTINI; Fiscal Year: 2006
    ..abstract_text> ..