Ren2

Summary

Gene Symbol: Ren2
Description: renin 2 tandem duplication of Ren1
Alias: Ren, Ren-2, Ren-B, Rn-2, Rnr, renin-2, angiotensinogenase, submandibular gland renin
Species: mouse
Products:     Ren2

Top Publications

  1. Cheng Z, Tikkanen I, Vapaatalo H, Mervaala E. Vascular effects of COX inhibition and AT1 receptor blockade in transgenic rats harboring mouse renin-2 gene. J Physiol Pharmacol. 2002;53:597-613 pubmed
    ..The present study also demonstrated that COX does not play a central role in the pathogenesis of Ang II-induced endothelial dysfunction in mREN2 rats. ..
  2. Mitchell K, Bagatell S, Miller C, Mouton C, Seth D, Mullins J. Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats. J Renin Angiotensin Aldosterone Syst. 2006;7:74-86 pubmed
    Transgenic rats with inducible angiotensin II (Ang II)-dependent hypertension (strain name: TGR[Cyp1a1-Ren2]) were generated by inserting the mouse Ren2 renin gene, fused to the cytochrome P450 1a1 (Cyp1a1) promoter, into the genome of ..
  3. Sharp M, Fettes D, Brooker G, Clark A, Peters J, Fleming S, et al. Targeted inactivation of the Ren-2 gene in mice. Hypertension. 1996;28:1126-31 pubmed
    ..Wild mouse strains and some inbred laboratory strains have a duplicated renin gene (Ren-2), the physiological significance of which is unclear...
  4. Szymura J, Taylor B, Klein J. Upg-2: a urinary pepsinogen variant located on chromosome 1 of the mouse. Biochem Genet. 1982;20:1211-9 pubmed
    ..Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus.
  5. Copeland N, Silan C, Kingsley D, Jenkins N, Cannizzaro L, Croce C, et al. Chromosomal location of murine and human IL-1 receptor genes. Genomics. 1991;9:44-50 pubmed
    ..The murine Il-1r1 gene has thus been separated from the IL-1 genes, which lie on murine chromosome 2. ..
  6. Cervenka L, Bibova J, Husková Z, Vanourková Z, Kramer H, Herget J, et al. Combined suppression of the intrarenal and circulating vasoconstrictor renin-ACE-ANG II axis and augmentation of the vasodilator ACE2-ANG 1-7-Mas axis attenuates the systemic hypertension in Ren-2 transgenic rats exposed to chronic hypoxia. Physiol Res. 2015;64:11-24 pubmed
    The aim of the present study was to test the hypothesis that chronic hypoxia would aggravate hypertension in Ren-2 transgenic rats (TGR), a well-defined monogenetic model of hypertension with increased activity of endogenous renin-..
  7. Fowler J, Johnson N, Haroldson T, Brintnall J, Herrera J, Katz S, et al. Regulated renin release from 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 2009;296:E1383-91 pubmed publisher
    ..In conclusion, the expression and secretion of renin are regulated under a complex series of hormonal and metabolic determinants in mature 3T3-L1 adipocytes. ..
  8. Moseley W, Seldin M. Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1. Genomics. 1989;5:899-905 pubmed
    ..These studies provide a model for examination of specific evolutionary events. ..
  9. Cohen J, Lindsey S, Pirro N, Brosnihan K, Gallagher P, Chappell M. Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain. Am J Physiol Renal Physiol. 2010;299:F35-42 pubmed publisher
    ..We conclude that the increase in uAGT with estrogen depletion or HS likely may be a biomarker for glomerular damage reflecting filtration of the circulating protein in the mRen2...
  10. Wiggins K, Tiauw V, Zhang Y, Gilbert R, Langham R, Kelly D. Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats. Nephrology (Carlton). 2008;13:721-9 pubmed publisher
    ..Female Sprague-Dawley rats heterozygous for the Ren-2 gene were randomized to three groups (n = 8 per group)--controls, diabetes or diabetes + perindopril...

Detail Information

Publications62

  1. Cheng Z, Tikkanen I, Vapaatalo H, Mervaala E. Vascular effects of COX inhibition and AT1 receptor blockade in transgenic rats harboring mouse renin-2 gene. J Physiol Pharmacol. 2002;53:597-613 pubmed
    ..The present study also demonstrated that COX does not play a central role in the pathogenesis of Ang II-induced endothelial dysfunction in mREN2 rats. ..
  2. Mitchell K, Bagatell S, Miller C, Mouton C, Seth D, Mullins J. Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats. J Renin Angiotensin Aldosterone Syst. 2006;7:74-86 pubmed
    Transgenic rats with inducible angiotensin II (Ang II)-dependent hypertension (strain name: TGR[Cyp1a1-Ren2]) were generated by inserting the mouse Ren2 renin gene, fused to the cytochrome P450 1a1 (Cyp1a1) promoter, into the genome of ..
  3. Sharp M, Fettes D, Brooker G, Clark A, Peters J, Fleming S, et al. Targeted inactivation of the Ren-2 gene in mice. Hypertension. 1996;28:1126-31 pubmed
    ..Wild mouse strains and some inbred laboratory strains have a duplicated renin gene (Ren-2), the physiological significance of which is unclear...
  4. Szymura J, Taylor B, Klein J. Upg-2: a urinary pepsinogen variant located on chromosome 1 of the mouse. Biochem Genet. 1982;20:1211-9 pubmed
    ..Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus.
  5. Copeland N, Silan C, Kingsley D, Jenkins N, Cannizzaro L, Croce C, et al. Chromosomal location of murine and human IL-1 receptor genes. Genomics. 1991;9:44-50 pubmed
    ..The murine Il-1r1 gene has thus been separated from the IL-1 genes, which lie on murine chromosome 2. ..
  6. Cervenka L, Bibova J, Husková Z, Vanourková Z, Kramer H, Herget J, et al. Combined suppression of the intrarenal and circulating vasoconstrictor renin-ACE-ANG II axis and augmentation of the vasodilator ACE2-ANG 1-7-Mas axis attenuates the systemic hypertension in Ren-2 transgenic rats exposed to chronic hypoxia. Physiol Res. 2015;64:11-24 pubmed
    The aim of the present study was to test the hypothesis that chronic hypoxia would aggravate hypertension in Ren-2 transgenic rats (TGR), a well-defined monogenetic model of hypertension with increased activity of endogenous renin-..
  7. Fowler J, Johnson N, Haroldson T, Brintnall J, Herrera J, Katz S, et al. Regulated renin release from 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 2009;296:E1383-91 pubmed publisher
    ..In conclusion, the expression and secretion of renin are regulated under a complex series of hormonal and metabolic determinants in mature 3T3-L1 adipocytes. ..
  8. Moseley W, Seldin M. Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1. Genomics. 1989;5:899-905 pubmed
    ..These studies provide a model for examination of specific evolutionary events. ..
  9. Cohen J, Lindsey S, Pirro N, Brosnihan K, Gallagher P, Chappell M. Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain. Am J Physiol Renal Physiol. 2010;299:F35-42 pubmed publisher
    ..We conclude that the increase in uAGT with estrogen depletion or HS likely may be a biomarker for glomerular damage reflecting filtration of the circulating protein in the mRen2...
  10. Wiggins K, Tiauw V, Zhang Y, Gilbert R, Langham R, Kelly D. Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats. Nephrology (Carlton). 2008;13:721-9 pubmed publisher
    ..Female Sprague-Dawley rats heterozygous for the Ren-2 gene were randomized to three groups (n = 8 per group)--controls, diabetes or diabetes + perindopril...
  11. Elliott R, Barlow D, Hogan B. Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse. In Vitro Cell Dev Biol. 1985;21:477-84 pubmed
    ..4 +/- 3.2 cM distal to the Pep-3 locus. There is no evidence in the mouse for pseudogenes for these proteins. ..
  12. Seldin M, Morse H, LeBoeuf R, Steinberg A. Establishment of a molecular genetic map of distal mouse chromosome 1: further definition of a conserved linkage group syntenic with human chromosome 1q. Genomics. 1988;2:48-56 pubmed
    ..seven probes on Southern hybridization combined with data from previous studies suggest the gene order Cfh, Pep-3/Ren-1,2, Ly-5, Lamb-2, At-3, Apoa-2/Ly-17,Spna-1...
  13. Field L, Philbrick W, Howles P, Dickinson D, McGowan R, Gross K. Expression of tissue-specific Ren-1 and Ren-2 genes of mice: comparative analysis of 5'-proximal flanking regions. Mol Cell Biol. 1984;4:2321-31 pubmed
    All inbred strains of mice carry the Ren-1 structural gene, which encodes the renin-1 isozyme, the classical renin activity found in kidneys...
  14. Wei Y, Clark S, Morris E, Thyfault J, Uptergrove G, Whaley Connell A, et al. Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats. J Hepatol. 2008;49:417-28 pubmed publisher
    ..We employed the transgenic TG(mRen2)27(Ren2) hypertensive rat, harboring the mouse renin gene with elevated tissue Angiotensin II (Ang II)...
  15. Whaley Connell A, Nistala R, Habibi J, Hayden M, Schneider R, Johnson M, et al. Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat. Am J Physiol Renal Physiol. 2010;298:F655-61 pubmed publisher
    ..an ARB on renal oxidative stress and associated glomerular structural and functional changes in the transgenic Ren2 rat, which manifests hypertension, albuminuria, and increased tissue RAS activity...
  16. Wilson C, Erdos E, Wilson J, Taylor B. Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse. Proc Natl Acad Sci U S A. 1978;75:5623-6 pubmed
    ..Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a ..
  17. Garcia Espinosa M, Shaltout H, Gallagher P, Chappell M, Diz D. In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats. J Cardiovasc Pharmacol. 2012;60:150-7 pubmed publisher
  18. Pendergrass K, Pirro N, Westwood B, Ferrario C, Brosnihan K, Chappell M. Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis rats. Am J Physiol Heart Circ Physiol. 2008;295:H10-20 pubmed publisher
    ..The enhanced activity of the RAAS in male congenics may contribute to the higher pressure and tissue injury evident in the strain. ..
  19. Kim J, Brannan C, Copeland N, Jenkins N, Khan T, Moore K. Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes. J Immunol. 1992;148:3618-23 pubmed
    ..The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1. ..
  20. Zhao Y, Peters J, Ganten D, Bader M. Expression of the mouse ren-2 gene in the small intestine is regulated by food intake. Pflugers Arch. 1993;424:199-202 pubmed
    ..We demonstrate the presence of ren-2 transcripts in the small intestine of DBA/2 mice...
  21. Elliott R, Romejko C, Hohman C. Mapping the gene for LTW-4, a 26,000 molecular weight major protein of mouse liver and kidney. Mol Gen Genet. 1980;180:17-22 pubmed
    ..The gene order is Dip-1 Rnr - (Sas-1, ald) - Ltw-4 - Mls. The map distance between (Dip-1, Rnr) and Ltw-4 is estimated to be 12.2 +/- 4...
  22. Schwab K, Patterson L, Hartman H, Song N, Lang R, Lin X, et al. Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol. 2007;5:15 pubmed
    ..Microarray analysis showed changed expression of several genes, including Cxcl13, Slc5a2, Klk5, Ren2 and Timeless, which represent candidate Wnt targets in kidney development...
  23. Field L, McGowan R, Dickinson D, Gross K. Tissue and gene specificity of mouse renin expression. Hypertension. 1984;6:597-603 pubmed
    The Ren-1 locus of mice encodes the protease renin, which with converting enzyme processes angiotensinogen to the potent vasopressor angiotensin II...
  24. Piccini N, Knopf J, Gross K. A DNA polymorphism, consistent with gene duplication, correlates with high renin levels in the mouse submaxillary gland. Cell. 1982;30:205-13 pubmed
    The renin regulatory locus (Rnr) is a genetic element governing mouse submaxillary gland (SMG) renin levels...
  25. Wilson C, Erdos E, Dunn J, Wilson J. Genetic control of renin activity in the submaxillary gland of the mouse. Proc Natl Acad Sci U S A. 1977;74:1185-9 pubmed
    ..Studies with the various hybrids indicate that the difference in renin activity between the two strains is apparently due to a single regulatory gene. ..
  26. Hill R, Hall A, Sime C, Hastie N. A mouse homeo box-containing gene maps near a developmental mutation. Cytogenet Cell Genet. 1987;44:171-4 pubmed
    ..This gene maps to mouse chromosome 1 near or at the dominant hemimelia locus which is a known mouse developmental mutation. ..
  27. Wilson C, Cherry M, Taylor B, Wilson J. Genetic and endocrine control of renin activity in the submaxillary gland of the mouse. Biochem Genet. 1981;19:509-23 pubmed
  28. Sigmund C, Jones C, Mullins J, Kim U, Gross K. Expression of murine renin genes in subcutaneous connective tissue. Proc Natl Acad Sci U S A. 1990;87:7993-7 pubmed
    ..blot analysis of tumor RNA indicated that most of the tumors expressed both T antigen and the endogenous renin gene Ren-1c...
  29. Seldin M, Morse H, Reeves J, Scribner C, LeBoeuf R, Steinberg A. Genetic analysis of autoimmune gld mice. I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group. J Exp Med. 1988;167:688-93 pubmed
    ..The gene order was: (centromere) C4bp, Ren-1,2, Ly-5, [At-3/gld], Apoa-2/Ly-17, Spna-1 (telomere)...
  30. Hampl V, Herget J, Bibova J, Banasová A, Husková Z, Vanourková Z, et al. Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia. Physiol Res. 2015;64:25-38 pubmed
    ..type 2 (ACE2)/angiotensin 1-7 (ANG 1-7)/Mas receptor axis, in the development of hypoxic pulmonary hypertension in Ren-2 transgenic rats (TGR). Transgene-negative Hannover Sprague-Dawley (HanSD) rats served as controls...
  31. Isa K, Garcia Espinosa M, Arnold A, Pirro N, Tommasi E, Ganten D, et al. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2009;297:R111-5 pubmed publisher
    ..The antihypertensive effects produced by endogenous neutralization of brain ANG-(1-12) suggest that ANG-(1-12) is functionally active in brain pathways regulating blood pressure. ..
  32. Holland P, Pannozzo M, Bastin M, McNeilly A, Ferguson K, Caughey S, et al. Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats. J Cereb Blood Flow Metab. 2015;35:188-92 pubmed publisher
    ..Herein we show that moderate hypertension alone or with additional risk factors has minimal impact on white matter integrity in this model. ..
  33. Seldin M, Morse H, Steinberg A. A molecular genetic approach to gld "autoimmune" disease. Curr Top Microbiol Immunol. 1988;137:227-32 pubmed
  34. Burt D, Reith A, Brammar W. A retroviral provirus closely associated with the Ren-2 gene of DBA/2 mice. Nucleic Acids Res. 1984;12:8579-93 pubmed
    We have determined the entire nucleotide sequence of an intra-cisternal A particle (IAP) genome, associated with the Ren-2 gene of DBA/2 mice. This genome (MIARN) displays features common to other IAP retroviral-like genomes...
  35. Epstein D, Bardeesy N, Vidal S, Malo D, Weith A, Vekemans M, et al. Characterization of a region-specific library of microclones in the vicinity of the Bcg and splotch loci on mouse chromosome 1. Genomics. 1994;19:163-6 pubmed
    ..mapping of 27 microclones from this library, we divided a 56-cM segment of chromosome 1 between the Col3a1 and Ren 1,2 genes into eight intervals defined by anchor loci...
  36. Perera E, Martin H, Seeherunvong T, Kos L, Hughes I, Hawkins J, et al. Tescalcin, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, Col9a3, and renin are expressed in the mouse testis during the early stages of gonadal differentiation. Endocrinology. 2001;142:455-63 pubmed
    ..5 dpc. RENIN: mRNA was localized in cells of the interstitium and cells at the border between the gonad and mesonephros. Expression of RENIN: in the ovary was not detected using standard conditions. ..
  37. Honetschlägerová Z, Husková Z, Vanourková Z, Sporkova A, Kramer H, Hwang S, et al. Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension. J Physiol. 2011;589:207-19 pubmed publisher
    ..and on renal function in transgenic rats with inducible expression of the mouse renin gene (strain name Cyp1a1-Ren-2). Hypertension was induced in these rats by indole-3-carbinol (I3C; 0.3% in the diet) for 12 days...
  38. Misono K, Chang J, Inagami T. Amino acid sequence of mouse submaxillary gland renin. Proc Natl Acad Sci U S A. 1982;79:4858-62 pubmed
    ..Residues identical in renin and pepsin are distributed throughout the length of the molecules, suggesting a similarity in their overall structures. ..
  39. Field L, Gross K. Ren-1 and Ren-2 loci are expressed in mouse kidney. Proc Natl Acad Sci U S A. 1985;82:6196-200 pubmed
    ..absence or presence of a duplicated copy of the renin structural gene; one-gene strains carry a single renin gene (Ren-1), whereas two-gene strains carry two renin genes (Ren-1 and Ren-2)...
  40. Springate J, Feld L, Ganten D. Renal function in hypertensive rats transgenic for mouse renin gene. Am J Physiol. 1994;266:F731-7 pubmed
    The recent development of a transgenic rat strain carrying the mouse ren-2 renin gene [TGR(mRen2)27] has provided a new model of hypertension characterized by suppressed plasma renin levels and marked hyperproreninemia...
  41. Panthier J, Dreyfus M, Roux T, Rougeon F. Mouse kidney and submaxillary gland renin genes differ in their 5' putative regulatory sequences. Proc Natl Acad Sci U S A. 1984;81:5489-93 pubmed
    ..The Ren1 and Ren2 genes, encoding the kidney and submaxillary renins, respectively, span about 9.5 kilobases each...
  42. Neubauer B, Machura K, Schnermann J, Wagner C. Renin expression in large renal vessels during fetal development depends on functional beta1/beta2-adrenergic receptors. Am J Physiol Renal Physiol. 2011;301:F71-7 pubmed publisher
    ..Furthermore, ?-adrenergic receptor input is critical for the expression of renin in large renal vessels during early fetal development. ..
  43. Burt D, Mullins L, George H, Smith G, Brooks J, Pioli D, et al. The nucleotide sequence of a mouse renin-encoding gene, Ren-1d, and its upstream region. Gene. 1989;84:91-104 pubmed
    The renin-encoding genes have been cloned from high (Ren-1d, Ren-2d)- and low (Ren-1c)-renin-producing strains of mice (DBA/2J and C57BL/10). Each of the genes is approx. 9.6 kb in length and consists of nine exons and eight introns...
  44. Gomez R, Pentz E, Jin X, Cordaillat M, Sequeira Lopez M. CBP and p300 are essential for renin cell identity and morphological integrity of the kidney. Am J Physiol Heart Circ Physiol. 2009;296:H1255-62 pubmed publisher
    ..Results show that the histone acetyltransferases CBP and p300 are necessary for maintenance of renin cell identity and structural integrity of the kidney. ..
  45. Hartner A, Porst M, Klanke B, Cordasic N, Veelken R, Hilgers K. Angiotensin II formation in the kidney and nephrosclerosis in Ren-2 hypertensive rats. Nephrol Dial Transplant. 2006;21:1778-85 pubmed
    b>Ren-2 transgenic hypertensive rats develop malignant hypertensive nephrosclerosis despite low to normal plasma angiotensin II and suppressed renal renin...
  46. Panthier J, Rougeon F. Kidney and submaxillary gland renins are encoded by two non-allelic genes in Swiss mice. EMBO J. 1983;2:675-8 pubmed
    ..Comparison of these sequences with the sequence of Swiss mouse SMG renin mRNA we have previously reported, demonstrates that Swiss mice express the two non-allelic genes, Rn1 and Rn2. ..
  47. Pentz E, Lopez M, Kim H, Carretero O, Smithies O, Gomez R. Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1d. Physiol Genomics. 2001;6:45-55 pubmed
    To distinguish the contributions of Ren1(d) and Ren2 to kidney development and blood pressure homeostasis, we placed green fluorescent protein (GFP) under control of the Ren1(d) renin locus by homologous recombination in mice...
  48. Dickinson D, Gross K, Piccini N, Wilson C. Evolution and variation of renin genes in mice. Genetics. 1984;108:651-67 pubmed
    Inbred strains of mice carry Ren-1, a gene encoding the thermostable Renin-1 isozyme. Ren-1 is expressed at relatively low levels in mouse submandibular gland and kidney...
  49. Baltatu O, Cayla C, Iliescu R, Andreev D, Jordan C, Bader M. Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene. J Am Soc Nephrol. 2002;13:2681-7 pubmed
    ..androgen receptors in the development of hypertension and end-organ damage in transgenic rats harboring the mouse Ren-2 renin gene [TGR(mREN2)27] was studied...
  50. Hinrichs S, Heger J, Schreckenberg R, Wenzel S, Euler G, Arens C, et al. Controlling cardiomyocyte length: the role of renin and PPAR-{gamma}. Cardiovasc Res. 2011;89:344-52 pubmed publisher
    ..This type of cell size modification differs from that of any other known pro-hypertrophic agonists. ..
  51. Martin G, Richman M, Reinsch S, Nadeau J, Joyner A. Mapping of the two mouse engrailed-like genes: close linkage of En-1 to dominant hemimelia (Dh) on chromosome 1 and of En-2 to hemimelic extra-toes (Hx) on chromosome 5. Genomics. 1990;6:302-8 pubmed
    ..Instead, we suggest that En-1-Dh and En-2-Hx represent paralogous linkage groups that evolved following duplication of a common ancestral chromosome segment. ..
  52. Schurr E, Skamene E, Morgan K, Chu M, Gros P. Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1 identifies conserved linkage of structural protein genes between murine chromosome 1 and human chromosome 2q. Genomics. 1990;8:477-86 pubmed
    ..The loci investigated were NEB/Neb, ELN/Eln, COL3A1/Col3a1, CRYG/Len-2, FN1/Fn-1, VIL/Vil, and COL6A3/Col6a3. Ren-1,2 and Acrg were included as two proximal mouse chromosome 1 anchor loci...
  53. Wilkinson Berka J, Tan G, Jaworski K, Ninkovic S. Valsartan but not atenolol improves vascular pathology in diabetic Ren-2 rat retina. Am J Hypertens. 2007;20:423-30 pubmed
    ..therapy per se, attenuates acellular capillaries and proliferating endothelial cells in the retina of diabetic Ren-2 rats. Eight-week-old hypertensive Ren-2 rats were made diabetic (streptozotocin, 55 mg/kg) or nondiabetic (0...
  54. Schuhmacher A, Guerra C, Sauzeau V, Canamero M, Bustelo X, Barbacid M. A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. J Clin Invest. 2008;118:2169-79 pubmed publisher
    ..In addition, it partially alleviated the observed cardiomyopathies. These mice should help in elucidating the etiology of CS symptoms, identifying additional defects, and evaluating potential therapeutic strategies. ..
  55. Lavoie J, Liu X, Bianco R, Beltz T, Johnson A, Sigmund C. Evidence supporting a functional role for intracellular renin in the brain. Hypertension. 2006;47:461-6 pubmed
    ..These data support the concept of an intracellular form of renin in the brain, which may provoke functional changes in fluid homeostasis and BP regulation. ..
  56. Mock B, Givol D, D Hoostelaere L, Huppi K, Seldin M, Gurfinkel N, et al. Mapping of the bcl-2 oncogene on mouse chromosome 1. Cytogenet Cell Genet. 1988;47:11-5 pubmed
    ..The co-segregation of bcl-2 alleles with allelic forms of two other chromosome 1 loci, Ren-1,2 and Spna-1, in a set of back-cross progeny, positions bcl-2 7.8 cM centromeric from Ren-1,2.
  57. Abel K, Gross K. Close physical linkage of the murine Ren-1 and Ren-2 loci. Nucleic Acids Res. 1988;16:2111-26 pubmed
    In addition to the Ren-1 gene common to all mice, some inbred strains carry a second copy of the renin structural gene, Ren-2. These two loci are tightly linked genetically on mouse chromosome one...
  58. Matsusaka T, Kon V, Takaya J, Katori H, Chen X, Miyazaki J, et al. Dual renin gene targeting by Cre-mediated interchromosomal recombination. Genomics. 2000;64:127-31 pubmed
    ..Our study began with the establishment of two lines of mice carrying different mutations in either Ren1 or Ren2. These two genes, both encoding renin, span over 40 kb in tandem on chromosome 1...
  59. Barnum S, Kristensen T, Chaplin D, Seldin M, Tack B. Molecular analysis of the murine C4b-binding protein gene. Chromosome assignment and partial gene organization. Biochemistry. 1989;28:8312-7 pubmed
    ..These sequences may play a role in 3' cleavage of the precursor RNA prior to polyadenylation.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  60. Xia Y, Wen H, Prashner H, Chen R, Inagami T, Catanzaro D, et al. Pregnancy-induced changes in renin gene expression in mice. Biol Reprod. 2002;66:135-43 pubmed
    ..These results were obtained using ICR mice that have 2 related renin genes, Ren1 and Ren2. We also examined renin gene expression in C57Bl/6 mice that have only the Ren1 gene...
  61. Sporkova A, Jíchová S, Husková Z, Kopkan L, Nishiyama A, Hwang S, et al. Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats. Clin Exp Pharmacol Physiol. 2014;41:1003-13 pubmed publisher
    ..administration of indole-3-carbinol (I3C), a natural xenobiotic that activates the mouse renin gene in Cyp1a1-Ren-2 transgenic rats. BP was monitored by radiotelemetry...
  62. Dhanaraj V, Dealwis C, Frazao C, Badasso M, Sibanda B, Tickle I, et al. X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins. Nature. 1992;357:466-72 pubmed