Reln

Summary

Gene Symbol: Reln
Description: reelin
Alias: reeler, extracellular matrix serine protease
Species: mouse

Top Publications

  1. ncbi A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    G D'ARCANGELO
    Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Nature 374:719-23. 1995
  2. ncbi Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
    M Trommsdorff
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
    Cell 97:689-701. 1999
  3. pmc Interaction of reelin with amyloid precursor protein promotes neurite outgrowth
    HYANG SOOK HOE
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057 1464, USA
    J Neurosci 29:7459-73. 2009
  4. doi Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration
    Aycan Sentürk
    Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max von Laue Str 9, D 60438, Frankfurt am Main, Germany
    Nature 472:356-60. 2011
  5. ncbi Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
    T Hiesberger
    Department of Molecular Genetics, UT Southwestern Dallas, Texas 75235, USA
    Neuron 24:481-9. 1999
  6. ncbi Neuronal position in the developing brain is regulated by mouse disabled-1
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 389:733-7. 1997
  7. ncbi Reelin is a ligand for lipoprotein receptors
    G D'ARCANGELO
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Neuron 24:471-9. 1999
  8. ncbi Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice
    M Sheldon
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 389:730-3. 1997
  9. ncbi Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci 25:247-51. 2005
  10. pmc SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice
    Xiaochang Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Neuron 64:173-87. 2009

Research Grants

  1. EPILEPTOGENESIS IN THE AGED CNS
    Peter Patrylo; Fiscal Year: 2002
  2. Synapase Modification /Memory Retention /Life Span Model
    Peter Patrylo; Fiscal Year: 2002
  3. In vivo functions of possible tumor suppressor Dab2
    Jonathan Cooper; Fiscal Year: 2004
  4. In vivo functions of possible tumor suppressor Dab2
    Jonathan Cooper; Fiscal Year: 2006
  5. Functions and mechanisms of the endocytic adaptor Dab2
    Jonathan Cooper; Fiscal Year: 2009
  6. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
  7. Molecular Mechanisms of Thalamocortical Development
    NOELLE DWYER; Fiscal Year: 2007
  8. Molecular and Cellular Analysis of Brain Enriched PTP's
    Paul J Lombroso; Fiscal Year: 2010
  9. Functions and mechanisms of the endocytic adaptor Dab2
    Jonathan A Cooper; Fiscal Year: 2010
  10. SRC FAMILY KINASES AND CELL GROWTH REGULATION
    Jonathan A Cooper; Fiscal Year: 2010

Detail Information

Publications152 found, 100 shown here

  1. ncbi A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    G D'ARCANGELO
    Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Nature 374:719-23. 1995
    The autosomal recessive mouse mutation reeler leads to impaired motor coordination, tremors and ataxia...
  2. ncbi Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
    M Trommsdorff
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
    Cell 97:689-701. 1999
    ..These findings suggest that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1...
  3. pmc Interaction of reelin with amyloid precursor protein promotes neurite outgrowth
    HYANG SOOK HOE
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057 1464, USA
    J Neurosci 29:7459-73. 2009
    ..Addition of an alpha3beta1 integrin antibody prevented APP and Reelin-induced neurite outgrowth. These findings demonstrate that Reelin interacts with APP, potentially having important effects on neurite development...
  4. doi Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration
    Aycan Sentürk
    Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max von Laue Str 9, D 60438, Frankfurt am Main, Germany
    Nature 472:356-60. 2011
    ..neuronal migration defects that recapitulate the ones observed in the neocortex, hippocampus and cerebellum of the reeler mouse...
  5. ncbi Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
    T Hiesberger
    Department of Molecular Genetics, UT Southwestern Dallas, Texas 75235, USA
    Neuron 24:481-9. 1999
    ..Taken together, these findings suggest that Reelin acts via VLDLR and ApoER2 to regulate Disabled-1 tyrosine phosphorylation and microtubule function in neurons...
  6. ncbi Neuronal position in the developing brain is regulated by mouse disabled-1
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 389:733-7. 1997
    ..The mdab1 mutant phenotype is very similar to that of the reeler mouse...
  7. ncbi Reelin is a ligand for lipoprotein receptors
    G D'ARCANGELO
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Neuron 24:471-9. 1999
    ..In dissociated neurons, apoE reduces the level of Reelin-induced tyrosine phosphorylation of Dab1. These data suggest that Reelin directs neuronal migration by binding to VLDLR and ApoER2...
  8. ncbi Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice
    M Sheldon
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 389:730-3. 1997
    ..severely disrupted by mutations in reelin which cause widespread misplacement of neurons and associated ataxia in reeler mice...
  9. ncbi Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci 25:247-51. 2005
    ....
  10. pmc SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice
    Xiaochang Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Neuron 64:173-87. 2009
    ..Syne-2 mutants also display severe defects in learning and memory. These results fill an important gap in our understanding of the mechanism of nuclear movement during brain development...
  11. ncbi Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain
    D S Rice
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Development 125:3719-29. 1998
    ..or disabled-1 (Dab1) results in widespread abnormalities in laminar structures throughout the brain and ataxia in reeler and scrambler mice...
  12. ncbi Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling
    Victor Borrell
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Nat Neurosci 9:1284-93. 2006
    ..Thus, the meningeal membranes are fundamental in the development of Cajal-Retzius cells and, hence, in the normal development of the cerebral cortex...
  13. ncbi Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway
    Sanyong Niu
    The Cain Foundation Laboratories, Houston, TX 77030, USA
    Neuron 41:71-84. 2004
    ..In addition to cellular disorganization, dendrite abnormalities are present in the brain of reeler mice lacking Reelin...
  14. ncbi Reelin is a detachment signal in tangential chain-migration during postnatal neurogenesis
    Iris Hack
    NMDA IBDM, CNRS INSERM Université Méditerranée, Campus de Luminy, 13288 Marseille Cedex 9, France
    Nat Neurosci 5:939-45. 2002
    ..Furthermore, we found that in reeler mutant mice, neuronal precursors accumulated in the olfactory bulb and remained in clusters, indicating that they ..
  15. ncbi The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development
    Yves Jossin
    Developmental Genetics Unit, University of Louvain Medical School, B1200 Brussels, Belgium
    J Neurosci 24:514-21. 2004
    ..receptor (CNR1) as reported previously; (3) Reelin and its central fragment are equally able to rescue the reeler phenotype in a slice culture assay; and (4) anti-receptor antibodies can induce Dab1 phosphorylation but do not ..
  16. ncbi Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway
    E S Monuki
    Division of Neurogenetics, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neuron 32:591-604. 2001
    ..These findings provide evidence for the roof plate as an organizing center of the developing cortex and for a roof plate-Lhx2 pathway in cortical patterning...
  17. pmc Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation
    Jost Leemhuis
    Center for Neuroscience, Albert Ludwigs University, 79104 Freiburg, Germany
    J Neurosci 30:14759-72. 2010
    ..Our data link the observation that defects in Rho GTPases and Reelin signaling are responsible for developmental defects leading to neurological and psychiatric disorders...
  18. ncbi Age-related accumulation of Reelin in amyloid-like deposits
    Irene Knuesel
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Neurobiol Aging 30:697-716. 2009
    ..Our findings suggest that elevated Reelin plaque load creates a precursor condition for senile plaque deposition and may represent a critical risk factor for sporadic AD...
  19. ncbi Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cereb Cortex 18:1604-17. 2008
    ..In Sall1-mutant animals, these patterns of neurogenesis were disrupted. These findings suggest a role for Sall1 in regulating neuronal differentiation and maturation in developing neural structures...
  20. ncbi Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons
    Iris Hack
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    Development 134:3883-91. 2007
    ..b>Reeler mice lacking the reelin protein show altered radial neuronal migration resulting in an inversion of cortical ..
  21. ncbi Reelin regulates neuronal progenitor migration in intact and epileptic hippocampus
    Chao Gong
    Department of Neurology and Program for Neuroscience, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:1803-11. 2007
    ..Loss of Reelin expression in the epileptic adult hippocampus, moreover, likely contributes to ectopic chain migration and aberrant integration of newborn DGCs...
  22. pmc Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment
    Tohru Matsuki
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Cell 143:826-36. 2010
    ....
  23. ncbi A key role for the HLH transcription factor EBF2COE2,O/E-3 in Purkinje neuron migration and cerebellar cortical topography
    Laura Croci
    San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Development 133:2719-29. 2006
    ....
  24. pmc DeltaNp73 regulates neuronal survival in vivo
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology Unit, Brussels, Belgium
    Proc Natl Acad Sci U S A 106:16871-6. 2009
    ..that express DeltaNp73 and Wnt3a did neither remove all CRc, nor did they abolish Reelin secretion or generate a reeler-like cortical phenotype...
  25. ncbi Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip
    Andrew J Fink
    Department of Pathology Neuropathology, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 26:3066-76. 2006
    ..Tbr1 expression persists to adulthood in a subset of medial DCN projection neurons. In reeler mutant mice, which have a severe cerebellar malformation, rhombic lip-derived cells migrated to the NTZ, despite ..
  26. ncbi The reeler mouse as a model of brain development
    C Lambert de Rouvroit
    Neurobiology Unit, University of Namur Medical School, Belgium
    Adv Anat Embryol Cell Biol 150:1-106. 1998
  27. pmc Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 USA
    Genes Dev 13:643-8. 1999
    The reelin (reln) and disabled 1 (dab1) genes both ensure correct neuronal positioning during brain development. We have found that the intracellular Dab1 protein receives a tyrosine phosphorylation signal from extracellular Reln protein...
  28. doi Mechanism and significance of specific proteolytic cleavage of Reelin
    Shiori Kohno
    Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Biochem Biophys Res Commun 380:93-7. 2009
    ..The N-t cleavage splits Reelin into two distinct fragments and virtually abolishes its signaling activity. These findings provide an important biochemical basis for the function of Reelin proteolysis in brain development and function...
  29. ncbi The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons
    M Ogawa
    Department of Physiology, Kochi Medical School, Japan
    Neuron 14:899-912. 1995
    In the neurological mutant mouse reeler, the histological organization of the neocortex develops abnormally and essentially results in an inversion of the relative positions of the cortical layers...
  30. pmc Dab1 (Disable homolog-1) reelin adaptor protein is overexpressed in the olfactory bulb at early postnatal stages
    Eduardo Martín-López
    Department of Molecular, Cellular, and Developmental Neurobiology, Instituto Cajal CSIC, Madrid, Spain
    PLoS ONE 6:e26673. 2011
    ..bulb undergoes a prominent layering reorganization, but shows not apparent differences between wild type and reeler in the layer organization...
  31. pmc Functional importance of covalent homodimer of reelin protein linked via its central region
    Norihisa Yasui
    Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 286:35247-56. 2011
    ....
  32. doi Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala
    Maureen P Boyle
    Allen Institute for Brain Science, Seattle, Washington 98103, USA
    J Comp Neurol 519:2061-89. 2011
    The disrupted cortical lamination phenotype in reeler mice and subsequent identification of the Reelin signaling pathway have strongly informed models of cortical development...
  33. pmc Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum
    Takaki Miyata
    Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neural Dev 5:23. 2010
    ..Furthermore, it is not known what nascent Purkinje cells look like in vivo. When and how Purkinje cells start axonogenesis must also be elucidated...
  34. ncbi Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons
    Bryan A Ballif
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Curr Biol 14:606-10. 2004
    ..The secreted protein Reelin controls the locations of many types of neurons, and its absence causes the classic "Reeler" phenotype...
  35. ncbi The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells
    Qin Shen
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Nat Neurosci 9:743-51. 2006
    ..Our data demonstrate that neural stem cells change neuropotency during development and have a window of plasticity when restrictions can be reversed...
  36. ncbi Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1
    Hans H Bock
    Department of Medicine II, Albert Ludwigs Universitat, Albertstrasse 23, 79104 Freiburg, Germany
    J Biol Chem 279:33471-9. 2004
    ....
  37. ncbi Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons
    Mireille Rossel
    EPHE Quantitative Cell Biology, INSERM EMI 343, IFR 122, University Montpellier 2, 34090 Montpellier, France
    Development 132:1175-85. 2005
    ..We identified two cell populations not previously known to be affected in reeler mutants that show a common migratory defect: the olivocochlear efferent neurons and the facial visceral motor ..
  38. pmc Reelin secreted by GABAergic neurons regulates glutamate receptor homeostasis
    Cecilia Gonzalez Campo
    INSERM U862, Neurocentre Magendie, Pathophysiology of Synaptic Plasticity, Bordeaux, France
    PLoS ONE 4:e5505. 2009
    ..The phenotype of neurons that bind secreted reelin and whether the continuous secretion of reelin is required for physiological functions at postnatal stages remain unknown...
  39. ncbi Reelin, the extracellular matrix protein deficient in reeler mutant mice, is processed by a metalloproteinase
    C Lambert de Rouvroit
    Neurobiology Unit, University of Namur Medical School, 61 rue de Bruxelles, B 5000 Namur, Belgium
    Exp Neurol 156:214-7. 1999
    Reelin is the extracellular protein defective in reeler mice. It is believed that reelin acts via the extracellular matrix to influence the development of nearby neurons, but the mechanism remains thus far unknown...
  40. ncbi Absence of Fyn and Src causes a reeler-like phenotype
    Gloria Kuo
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 25:8578-86. 2005
    ..This implies that Src and Fyn are needed for Reelin-dependent events during brain development...
  41. pmc ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin
    Nuno Andrade
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 104:8508-13. 2007
    ..These data demonstrate a cell-autonomous function of ApoER2, and most likely VLDLR and Dab1, in postnatal migration of neuroblasts in the forebrain, which is suggested to depend on ligands other than Reelin...
  42. ncbi Birthdate and cell marker analysis of scrambler: a novel mutation affecting cortical development with a reeler-like phenotype
    J L Gonzalez
    Division of Neurogenetics, Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 17:9204-11. 1997
    The reeler mutation in mice produces an especially well characterized disorder, with systematically abnormal migration of cerebral cortical neurons...
  43. pmc Reelin promotes neuronal orientation and dendritogenesis during preplate splitting
    Anna J Nichols
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Cereb Cortex 20:2213-23. 2010
    ..The absence of detectable L6 ectopia in "reeler" cortices at this developmental time point indicates that Reelin-signaling might not regulate L6 neuron migration ..
  44. pmc Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration
    Sergi Simo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 30:5668-76. 2010
    ..Correct layering requires an extracellular protein, Reelin (Reln), an intracellular signaling molecule, Disabled-1 (Dab1), and an E3 ubiquitin ligase, Cullin-5 (Cul5)...
  45. ncbi Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody
    G D'ARCANGELO
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Neurosci 17:23-31. 1997
    The neurological mouse mutant strain reeler displays abnormal laminar organization of several brain structures as a consequence of a defect in cell migration during neurodevelopment...
  46. ncbi CXCR4 regulates interneuron migration in the developing neocortex
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurosci 23:5123-30. 2003
    ..Thus, our findings suggest that SDF-1, which is highly expressed in the embryonic leptomeninx, selectively regulates migration and layer-specific integration of CXCR4-expressing interneurons during neocortical development...
  47. ncbi Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex
    Marta Nieto
    Department of Neurology, Harvard Medical School and Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Comp Neurol 479:168-80. 2004
    ..The patterns of expression of Cux genes suggest potential roles as determinants of the neuronal fate of the upper cortical layer neurons...
  48. ncbi Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration
    Naoya Yamashita
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 26:13357-62. 2006
    ..Loss of crmp1 in a dab1 heterozygous background led to the disruption of hippocampal lamination, a Reeler-like phenotype. In addition to axon guidance, CRMP1 regulates neuronal migration by mediating Reln signaling.
  49. ncbi Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
    Nat Neurosci 8:1059-68. 2005
    ..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss...
  50. pmc Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling
    Masato Yano
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 66:848-58. 2010
    ..Thus, Nova2 regulates an RNA switch controlling the ability of Dab1 to mediate neuronal responsiveness to reelin signaling and neuronal migration, suggesting new links between splicing regulation, brain disease, and development...
  51. pmc Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo
    Shenghui He
    Howard Hughes Medical Institute, Department of Internal Medicine, Center for Stem Cell Biology, University of Michigan, 5435 Life Sciences Institute, 210 Washtenaw Ave, Ann Arbor, MI 48109 2216, USA
    Dev Biol 328:257-72. 2009
    ..Bmi-1 over-expression therefore has more pronounced effects in culture and does not appear to be sufficient to induce tumorigenesis in vivo...
  52. pmc Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination
    Ashley S Pawlisz
    Department of Neurology and Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, 303 E Superior Street, Chicago, IL 60611, USA
    Hum Mol Genet 17:2441-55. 2008
    ..Our data suggest that maintaining the shape and cell-cell interactions of radial glial neuroepithelial progenitors by the Lis1-Nde1 complex is essential for their self renewal during the early phase of corticogenesis...
  53. doi SOX5 controls the sequential generation of distinct corticofugal neuron subtypes
    Tina Lai
    MGH HMS Center for Nervous System Repair, Department of Neurosurgery, Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA
    Neuron 57:232-47. 2008
    ..These data indicate that SOX5 controls the timing of critical fate decisions during corticofugal neuron production and thus subtype-specific differentiation and neocortical neuron diversity...
  54. pmc Sall3 is required for the terminal maturation of olfactory glomerular interneurons
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Comp Neurol 507:1780-94. 2008
    ..Our data suggest that Sall3 is required for the terminal maturation of neurons destined for the glomerular layer...
  55. pmc The role of Robo3 in the development of cortical interneurons
    Melissa Barber
    Department of Cell and Developmental Biology, University College London, London, UK
    Cereb Cortex 19:i22-31. 2009
    ..These observations and the results of other recent studies suggest a complex interplay between the 3 Robo receptors in regulating the number, migration and morphological differentiation of cortical interneurons...
  56. pmc Reconstitution of the Reelin signaling pathway in fibroblasts demonstrates that Dab1 phosphorylation is independent of receptor localization in lipid rafts
    Harald Mayer
    Max F Perutz Laboratories, Department of Medical Biochemistry, University Department at the Vienna Biocenter, Medical University of Vienna, Vienna, Austria
    Mol Cell Biol 26:19-27. 2006
    ....
  57. doi Reelin sets the pace of neocortical neurogenesis
    Jarmila Lakomá
    Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, Campus de San Juan s n, E 03550 San Juan de Alicante, Spain
    Development 138:5223-34. 2011
    ..These results indicate that reelin and Notch signaling cooperate to set the pace of neocortical neurogenesis, a prerequisite for proper neuronal migration and cortical layering...
  58. pmc Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling
    Guangnan Li
    Department of Neurology, UCSF School of Medicine, San Francisco, CA 94158, USA
    Development 136:327-35. 2009
    ..These results demonstrate that the relocation of neural precursors in the dentate gyrus consists of discrete steps regulated by multiple pathways...
  59. ncbi Reelin activates SRC family tyrosine kinases in neurons
    Hans H Bock
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 75390, Dallas, TX, USA
    Curr Biol 13:18-26. 2003
    ..However, the kinases that mediate Dab1 tyrosine phosphorylation and the intracellular pathways that are triggered by this event remain unknown...
  60. doi Ectopic Reelin induces neuronal aggregation with a normal birthdate-dependent "inside-out" alignment in the developing neocortex
    Ken ichiro Kubo
    Department of Anatomy, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    J Neurosci 30:10953-66. 2010
    ..MZ), is crucial for this "inside-out" layering, because the layers are inverted in the Reelin-deficient mouse, reeler (Reln(rl))...
  61. doi Go or stop? Divergent roles of Reelin in radial neuronal migration
    Shanting Zhao
    Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany
    Neuroscientist 16:421-34. 2010
    ..Different Reelin fragments and different Reelin receptors suggest multiple functions of Reelin. In this review, the authors focus on Reelin effects on the actin cytoskeleton of migrating neurons...
  62. ncbi Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development
    Lionel Arnaud
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, WA, USA
    Curr Biol 13:9-17. 2003
    ..Mutations in Dab1, its phosphorylation sites, Reelin, or the Reelin receptors cause a common phenotype. However, the molecular mechanism whereby Reelin regulates Dab1 tyrosine phosphorylation is poorly understood...
  63. pmc Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons
    Alessandro Sessa
    Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy
    Genes Dev 24:1816-26. 2010
    ..We thus propose that INPs are able to control simultaneously the increase of glutamatergic and GABAergic neuronal pools, thereby creating a simple way to intrinsically balance their relative accumulation...
  64. ncbi A truncated Reelin protein is produced but not secreted in the 'Orleans' reeler mutation (Reln[rl-Orl])
    V de Bergeyck
    Department of Physiology, FUNDP Medical School, Namur, Belgium
    Brain Res Mol Brain Res 50:85-90. 1997
    Reelin is the protein defective in reeler mutant mice [I. Bar, C. Lambert de Rouvroit, I. Royaux, D.B. Krizman, C. Dernoncourt, D. Ruelle, M.C. Beckers, A.M...
  65. doi Impaired reelin processing and secretion by Cajal-Retzius cells contributes to granule cell dispersion in a mouse model of temporal lobe epilepsy
    Venceslas Duveau
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Hippocampus 21:935-44. 2011
    ..This phenotype resembled the morphology of Cajal-Retzius cells in reeler Orleans (reln (orl/orl) ) mice, which express a secretion-deficient 310-kDa reelin fragment...
  66. ncbi Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons
    S J Pleasure
    Neurodevelopmental Disorders Laboratory, Department of Neurology, University of California, San Francisco, CA 94143, USA
    Neuron 28:727-40. 2000
    ..Loss of hippocampal interneurons does not appear to have major effects on the early development of hippocampal projection neurons nor on the pathfinding of afferrent tracts...
  67. pmc Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells
    Celine Zimmer
    National Institute for Medical Research NIMR, Medical Research Council MRC, Department of Molecular Neurobiology, London NW7 1AA, UK
    Development 137:293-302. 2010
    ..Together, our results shed light on the mechanisms specifying rostral CR cells and further emphasise the crucial role of telencephalic signalling centres in the generation of distinct CR cell populations...
  68. ncbi Rescue of the reeler phenotype in the dentate gyrus by wild-type coculture is mediated by lipoprotein receptors for Reelin and Disabled 1
    Shanting Zhao
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 495:1-9. 2006
    Reelin is a positional signal for the lamination of the dentate gyrus. In the reeler mutant lacking Reelin, granule cells are scattered all over the dentate gyrus...
  69. doi Relative importance of the tyrosine phosphorylation sites of Disabled-1 to the transmission of Reelin signaling
    Toshifumi Morimura
    Ogawa Research Unit, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Brain Res 1304:26-37. 2009
    ..The results also suggest that phosphorylation of either one of the residues in each pair is sufficient for the transmission of Reelin signaling...
  70. ncbi Reelin binds alpha3beta1 integrin and inhibits neuronal migration
    L Dulabon
    Department of Biology and Neuroscience, Pennsylvania State University, University Park 16802, USA
    Neuron 27:33-44. 2000
    ..Thus, Reelin may arrest neuronal migration and promote normal cortical lamination by binding alpha3beta1 integrin and modulating integrin-mediated cellular adhesion...
  71. ncbi Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice
    O Wirths
    Department of Psychiatry, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 316:145-8. 2001
    ..This observation gives the first evidence for the association of reelin with amyloid deposits...
  72. ncbi Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly
    D Hartmann
    Anatomisches Institut der CAU Kiel, Otto Hahn Platz 8, D 24 118, Kiel, Germany
    Curr Biol 9:719-27. 1999
    ..Physiologically, the presenilins are involved in the Notch and Wnt-beta-catenin signaling pathways...
  73. ncbi The role of the first postmitotic cortical cells in the development of thalamocortical innervation in the reeler mouse
    Z Molnar
    University Laboratory of Physiology, Oxford OX1 3PT, United Kingdom
    J Neurosci 18:5746-65. 1998
    In the mutant mouse reeler, the tangential distribution of thalamocortical fibers is essentially normal, even though neurons of the cortical plate accumulate below the entire early-born preplate population (Caviness et al., 1998)...
  74. ncbi Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta
    Uwe Beffert
    Department of Molecular Genetics, Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Biol Chem 277:49958-64. 2002
    ....
  75. ncbi Multiple dose-dependent effects of Lis1 on cerebral cortical development
    Michael J Gambello
    Department of Pediatrics and Medicine, University of California, San Diego, La Jolla, California 92093 0627, USA
    J Neurosci 23:1719-29. 2003
    ..These studies reveal the importance of LIS1 levels in orderly cerebral cortical morphogenesis and suggest new insights into the pathogenesis of type I lissencephaly...
  76. ncbi Obstructed migration of Purkinje cells in the developing cerebellum of the reeler mutant mouse
    S Yuasa
    Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
    Anat Embryol (Berl) 188:317-29. 1993
    It has been considered that cortical malformation in the brain of the reeler mutant mouse is due to a defect in the process of neuroblast migration during development...
  77. doi Regulation of neural migration by the CREB/CREM transcription factors and altered Dab1 levels in CREB/CREM mutants
    Carmen Díaz-Ruiz
    Institute for Research in Biomedicine Barcelona IRB, Department of Cell Biology and CIBERNED ISCIII, University of Barcelona, Barcelona Science Park, Lab A1 S1, Josep Samitier 1 5, Barcelona 08028, Spain
    Mol Cell Neurosci 39:519-28. 2008
    ....
  78. pmc Expression of Disabled 1 suppresses astroglial differentiation in neural stem cells
    Il Sun Kwon
    Department of Anatomy, School of Medicine, Ajou University, Suwon, 443 749, South Korea
    Mol Cell Neurosci 40:50-61. 2009
    ..Our results suggest that Dab1 participates in the differentiation of NSCs into a specific cell lineage, thereby maintaining a balance between neurogenesis and gliogenesis...
  79. pmc Reelin controls position of autonomic neurons in the spinal cord
    J W Yip
    Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 97:8612-6. 2000
    Mutation of the reeler gene (Reln) disrupts neuronal migration in several brain regions and gives rise to functional deficits such as ataxic gait and trembling in the reeler mutant mouse...
  80. ncbi Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Development 134:2273-82. 2007
    ..In addition, proper radial neuronal migration generates an inside-out pattern of cerebral cortex formation and normal axonal trajectories of cortical pyramidal neurons...
  81. pmc Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-type cortex
    Tadashi Nomura
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTTAR, Tohoku University School of Medicine, Sendai, Japan
    PLoS ONE 3:e1454. 2008
    ..These lines of evidence shed light on the developmental programs underlying the evolution of the mammalian specific laminated cortex...
  82. pmc Hippocampal dendritic arbor growth in vitro: regulation by Reelin-Disabled-1 signaling
    Sarah A MacLaurin
    Novartis Institutes for BioMedical Research, Inc Cambridge, MA 02139, USA
    Brain Res 1172:1-9. 2007
    ..Moreover, experiments that incorporated a Reelin-neutralizing antibody support the hypothesis that the role(s) Reelin-signaling plays in dendritic maturation is different than the one it has in neuronal positioning...
  83. pmc Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling
    Rita De Gasperi
    Research and Development James J Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Dev Dyn 237:2405-14. 2008
    ..Prior studies have commented on similarities between Psen1-/- and reeler mice. Reelin induces phosphorylation of Dab1 and activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway...
  84. ncbi Detection of the reelin breakpoint in reeler mice
    G D'ARCANGELO
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38103, USA
    Brain Res Mol Brain Res 39:234-6. 1996
    Disruption of the reelin gene by partial deletion causes the neurological phenotype known as reeler. Here we report the cloning and sequencing of the reelin breakpoint region from the Jackson reeler strain (rl)...
  85. pmc Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathways
    Julie A Siegenthaler
    Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Dev Biol 313:35-46. 2008
    ..Thus, TGFbeta and Foxo3a may work in concert to regulate expression of p21 during CR neuronal generation...
  86. ncbi Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice
    T Miyata
    Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    J Comp Neurol 372:215-28. 1996
    We have immunohistochemically investigated the expression of a reeler gene-related antigen in the mouse cerebellum by using a monoclonal antibody, CR-50...
  87. ncbi Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse
    S Alcantara
    Department of Animal and Plant Cell Biology, Faculty of Biology, University of Barcelona, Barcelona 08028, Spain
    J Neurosci 18:7779-99. 1998
    ..This complex pattern of cellular and regional expression is consistent with Reelin having multiple roles in brain development and adult brain function...
  88. doi Chemokine signaling controls intracortical migration and final distribution of GABAergic interneurons
    Guillermina López-Bendito
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 28:1613-24. 2008
    ....
  89. ncbi Expression of Cux-1 and Cux-2 in the developing somatosensory cortex of normal and barrel-defective mice
    Arnaud Ferrere
    INSERM U616, Hopital de la Pitie Salpetriere, Paris, France
    Anat Rec A Discov Mol Cell Evol Biol 288:158-65. 2006
    ..Conversely, in Reeler mice, Cux-1 and Cux-2 had a distinct laminar distribution: the Cux-1-positive neurons had an inverted deep ..
  90. ncbi Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord
    S A Villeda
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1606, USA
    Neuroscience 139:1385-96. 2006
    Mutations in reeler, the gene coding for the Reelin protein, result in pronounced motor deficits associated with positioning errors (i.e. ectopic locations) in the cerebral and cerebellar cortices...
  91. doi Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3
    Xuejun Chai
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    J Neurosci 29:288-99. 2009
    ..Immunostaining for phospho-cofilin in dissociated reeler neurons is significantly increased after incubation in Reelin-containing medium compared with control medium...
  92. ncbi Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction
    Peggy C Stolt
    Department of Pathology, Harvard Medical School, Brigham and Womens Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 280:9671-7. 2005
    ....
  93. ncbi Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons
    Mary Wines-Samuelson
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 277:332-46. 2005
    ..These findings show a cell-autonomous role for PS1 in cortical lamination and radial glial development, and a non-cell-autonomous role for PS1 in CR neuron survival...
  94. ncbi Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs...
  95. ncbi Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis
    Petur H Petersen
    Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, Connecticut 06520, USA
    Nat Neurosci 7:803-11. 2004
    ....
  96. ncbi Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon
    Susana Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Cereb Cortex 13:895-903. 2003
    ..This recovery may be, at least in part, a result of the late migration of Dlx2 progenitors from the caudal ganglionic eminences (CGE), which, based on our previous work, does not appear to require Nkx2.1 gene function...
  97. ncbi Interaction of reelin signaling and Lis1 in brain development
    Amir H Assadi
    Cain Foundation Laboratories and Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 35:270-6. 2003
    ..In the mouse, homozygous mutations in Reln result in the reeler phenotype, characterized by ataxia and disrupted cortical layers...
  98. pmc Regulation of protein tyrosine kinase signaling by substrate degradation during brain development
    Lionel Arnaud
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Mol Cell Biol 23:9293-302. 2003
    ..Our data provide the first evidence for how Reelin down-regulates Dab1 protein expression in vivo. Dab1 degradation may be important for ensuring a transient Reelin response and may play a role in normal brain development...
  99. ncbi The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate
    Teresa H Chae
    Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center and Department of Neurology and Program in Neuroscience, Harvard Medical School, HIM 816, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    Nat Genet 36:264-70. 2004
    ..Apical localization of the SNARE Vamp7 is also disrupted. Thus, alpha Snap is essential for apical protein localization and cell fate determination in neuroepithelial cells...
  100. ncbi Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice
    Karl Heinz Weiss
    Anatomisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 460:56-65. 2003
    We studied the postnatal development of the radial glial scaffold in the dentate gyrus of reeler mice, lacking the extracellular matrix protein Reelin, in scrambler mice, deficient in the intracellular adaptor protein disabled1 (Dab1), ..
  101. doi Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stages
    Takayuki Uchida
    Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    J Neurosci 29:10653-62. 2009
    ..It is thus strongly suggested that Reelin exerts critical actions on migrating projection neurons at their early/premigratory stages en route to their final destinations, in the developing cerebral cortex and cerebellum...

Research Grants64

  1. EPILEPTOGENESIS IN THE AGED CNS
    Peter Patrylo; Fiscal Year: 2002
    ..Thus, by examining synaptic reorganization within the aged CNS they may also provide insight into the basic mechanisms of epilepsy and learning and memory within the overall population. ..
  2. Synapase Modification /Memory Retention /Life Span Model
    Peter Patrylo; Fiscal Year: 2002
    ..abstract_text> ..
  3. In vivo functions of possible tumor suppressor Dab2
    Jonathan Cooper; Fiscal Year: 2004
    ..These studies will provide insights into the molecular mechanisms of action of Dab2 and into the role of a single gene in receptor trafficking and signal transduction. ..
  4. In vivo functions of possible tumor suppressor Dab2
    Jonathan Cooper; Fiscal Year: 2006
    ..We've also found that Dab2 is phosphorylated in mitogen-stimulated cells by MAP kinase, and will investigate the significance of Dab2 phosphorylation in regulating biological responses. ..
  5. Functions and mechanisms of the endocytic adaptor Dab2
    Jonathan Cooper; Fiscal Year: 2009
    ..This application proposes to understand the mechanisms by which cell surface proteins are recognized for internalization. The results will be informative regarding changes in cancer cells that affect cell survival and motility. ..
  6. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
    ..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
  7. Molecular Mechanisms of Thalamocortical Development
    NOELLE DWYER; Fiscal Year: 2007
    ..Combining the expertise in mouse genetics with the previous training in mouse neuroanatomy and nematode genetics will significantly add to the Candidate's potential to make a strong impact on the field. ..
  8. Molecular and Cellular Analysis of Brain Enriched PTP's
    Paul J Lombroso; Fiscal Year: 2010
    ..The proposed studies examine the molecular mechanisms that regulate STEP activity and will clarify how this important family of regulatory proteins are involved in synaptic plasticity, cell death, and human disease. ..
  9. Functions and mechanisms of the endocytic adaptor Dab2
    Jonathan A Cooper; Fiscal Year: 2010
    ..This application proposes to understand the mechanisms by which cell surface proteins are recognized for internalization. The results will be informative regarding changes in cancer cells that affect cell survival and motility. ..
  10. SRC FAMILY KINASES AND CELL GROWTH REGULATION
    Jonathan A Cooper; Fiscal Year: 2010
    ..By further study of this signaling process, we expect to identify principles of signal complex formation and regulation that may be relevant to other tyrosine kinase signaling pathways. ..
  11. Biological Role of the FE65 Protein/APP Interactions
    Suzanne Guenette; Fiscal Year: 2009
    ..In addition, we will gain insight into the role of the FE65 proteins in cellular signaling events that are critical for brain function. ..
  12. SRC FAMILY KINASES AND CELL GROWTH REGULATION
    Jonathan Cooper; Fiscal Year: 2009
    ..By further study of this signaling process, we expect to identify principles of signal complex formation and regulation that may be relevant to other tyrosine kinase signaling pathways. ..
  13. MOLECULAR AND CELLULAR ANALYSIS OF BRAIN ENRICHED PTPS
    Paul Lombroso; Fiscal Year: 2007
    ..abstract_text> ..
  14. Chromosome Metabolism and Cancer Training Grant
    Jonathan Cooper; Fiscal Year: 2007
    ..It is hoped that this program will create young scientists with in-depth understanding of chromosome metabolism and commitment to explore its various links to cancer cause, cure and prevention. ..
  15. Biological Role of the FE65 Protein/APP Interactions
    Suzanne Guenette; Fiscal Year: 2007
    ..In addition, we will gain insight into the role of the FE65 proteins in cellular signaling events that are critical for brain function. ..
  16. Investigating the nature of prestin-associated proteins
    Jing Zheng; Fiscal Year: 2007
    ..This knowledge may make it possible to manipulate OHC function for therapeutic purposes. ..
  17. Role of the JIP-1-p190RhoGEF Complex In Neuron Function
    WILLIAM ARTHUR; Fiscal Year: 2004
    ..Furthermore, the importance of the JIP-l-p190RhoGEF association in brain development and neuronal migration will be investigated by disrupting this complex in mutant mice . ..
  18. INTEGRATION OF STRESS AND MITOGEN SIGNALING
    Jonathan Cooper; Fiscal Year: 2001
    ..4) To map the interactions between ERK and Msk using approaches such at the two-hybrid system. 5) To clone Mapkip108 using conventional techniques. ..
  19. MOLECULAR CONTROL OF CELL MIGRATION IN THE SPINAL CORD
    JOSEPH YIP; Fiscal Year: 2004
    ..A gene that has been found to influence neuronal migration in the brain of the mouse is the reeler gene (reln)...
  20. MOLECULAR AND CELLULAR ANALYSIS OF BRAIN ENRICHED PTPS
    Paul Lombroso; Fiscal Year: 2003
    ..We will identify the physiological substrates of STEP, one of which is proposed to be the NMDA receptor. We will these these hypotheses using biochemical, molecular, and electrophysiological techniques. ..
  21. ROLE OF HFE65 PROTEINS IN ALZHEIMER'S DISEASE.
    Suzanne Guenette; Fiscal Year: 2003
    ..of hFE65L to LRP contribute to the extracellular pool of APPs and Abeta? Does the FE65L-APP interaction have an effect on intracellular Abeta42 production? Does FE65L act as an adaptor protein form a tripartite complex with APP and LRP? ..
  22. STRUCTURAL AND FUNCTIONAL ANALYSES OF NEURONAL PTPS
    Paul Lombroso; Fiscal Year: 2007
    ..STEP knock-out mice will also be characterized. The proposed investigations will be done in the supportive environment of the Child Study Center with its commitment to cliniclaly informed basic science research. ..