Genomes and Genes
Gene Symbol: Reln
Alias: reeler, extracellular matrix serine protease
Publications113 found, 100 shown here
- SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in miceXiaochang Zhang
Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
Neuron 64:173-87. 2009..Syne-2 mutants also display severe defects in learning and memory. These results fill an important gap in our understanding of the mechanism of nuclear movement during brain development...
- Fyn tyrosine kinase is a critical regulator of disabled-1 during brain developmentLionel Arnaud
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, WA, USA
Curr Biol 13:9-17. 2003..Mutations in Dab1, its phosphorylation sites, Reelin, or the Reelin receptors cause a common phenotype. However, the molecular mechanism whereby Reelin regulates Dab1 tyrosine phosphorylation is poorly understood...
- Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortexMarta Nieto
Department of Neurology, Harvard Medical School and Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
J Comp Neurol 479:168-80. 2004..The patterns of expression of Cux genes suggest potential roles as determinants of the neuronal fate of the upper cortical layer neurons...
- A protein related to extracellular matrix proteins deleted in the mouse mutant reelerG D'ARCANGELO
Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
Nature 374:719-23. 1995The autosomal recessive mouse mutation reeler leads to impaired motor coordination, tremors and ataxia...
- Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1Hans H Bock
Department of Medicine II, Albert Ludwigs Universitat, Albertstrasse 23, 79104 Freiburg, Germany
J Biol Chem 279:33471-9. 2004....
- Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathwayE S Monuki
Division of Neurogenetics, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Neuron 32:591-604. 2001..These findings provide evidence for the roof plate as an organizing center of the developing cortex and for a roof plate-Lhx2 pathway in cortical patterning...
- ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of ReelinNuno Andrade
Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, A 1030 Vienna, Austria
Proc Natl Acad Sci U S A 104:8508-13. 2007..These data demonstrate a cell-autonomous function of ApoER2, and most likely VLDLR and Dab1, in postnatal migration of neuroblasts in the forebrain, which is suggested to depend on ligands other than Reelin...
- Reelin is a ligand for lipoprotein receptorsG D'ARCANGELO
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Neuron 24:471-9. 1999..In dissociated neurons, apoE reduces the level of Reelin-induced tyrosine phosphorylation of Dab1. These data suggest that Reelin directs neuronal migration by binding to VLDLR and ApoER2...
- Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2M Trommsdorff
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
Cell 97:689-701. 1999..These findings suggest that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1...
- Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylationT Hiesberger
Department of Molecular Genetics, UT Southwestern Dallas, Texas 75235, USA
Neuron 24:481-9. 1999..Taken together, these findings suggest that Reelin acts via VLDLR and ApoER2 to regulate Disabled-1 tyrosine phosphorylation and microtubule function in neurons...
- Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivoShenghui He
Howard Hughes Medical Institute, Department of Internal Medicine, Center for Stem Cell Biology, University of Michigan, 5435 Life Sciences Institute, 210 Washtenaw Ave, Ann Arbor, MI 48109 2216, USA
Dev Biol 328:257-72. 2009..Bmi-1 over-expression therefore has more pronounced effects in culture and does not appear to be sufficient to induce tumorigenesis in vivo...
- Nova2 regulates neuronal migration through an RNA switch in disabled-1 signalingMasato Yano
Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Neuron 66:848-58. 2010..Thus, Nova2 regulates an RNA switch controlling the ability of Dab1 to mediate neuronal responsiveness to reelin signaling and neuronal migration, suggesting new links between splicing regulation, brain disease, and development...
- Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migrationNaoya Yamashita
Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
J Neurosci 26:13357-62. 2006..Loss of crmp1 in a dab1 heterozygous background led to the disruption of hippocampal lamination, a Reeler-like phenotype. In addition to axon guidance, CRMP1 regulates neuronal migration by mediating Reln signaling.
- Relative importance of the tyrosine phosphorylation sites of Disabled-1 to the transmission of Reelin signalingToshifumi Morimura
Ogawa Research Unit, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
Brain Res 1304:26-37. 2009..The results also suggest that phosphorylation of either one of the residues in each pair is sufficient for the transmission of Reelin signaling...
- Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephalyD Hartmann
Anatomisches Institut der CAU Kiel, Otto Hahn Platz 8, D 24 118, Kiel, Germany
Curr Biol 9:719-27. 1999..Physiologically, the presenilins are involved in the Notch and Wnt-beta-catenin signaling pathways...
- Reelin binds alpha3beta1 integrin and inhibits neuronal migrationL Dulabon
Department of Biology and Neuroscience, Pennsylvania State University, University Park 16802, USA
Neuron 27:33-44. 2000..Thus, Reelin may arrest neuronal migration and promote normal cortical lamination by binding alpha3beta1 integrin and modulating integrin-mediated cellular adhesion...
- Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic miceO Wirths
Department of Psychiatry, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Neurosci Lett 316:145-8. 2001..This observation gives the first evidence for the association of reelin with amyloid deposits...
- Rescue of the reeler phenotype in the dentate gyrus by wild-type coculture is mediated by lipoprotein receptors for Reelin and Disabled 1Shanting Zhao
Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
J Comp Neurol 495:1-9. 2006Reelin is a positional signal for the lamination of the dentate gyrus. In the reeler mutant lacking Reelin, granule cells are scattered all over the dentate gyrus...
- Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deploymentTohru Matsuki
Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Cell 143:826-36. 2010....
- Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3betaUwe Beffert
Department of Molecular Genetics, Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
J Biol Chem 277:49958-64. 2002....
- Reelin activates SRC family tyrosine kinases in neuronsHans H Bock
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 75390, Dallas, TX, USA
Curr Biol 13:18-26. 2003..However, the kinases that mediate Dab1 tyrosine phosphorylation and the intracellular pathways that are triggered by this event remain unknown...
- Reelin is a detachment signal in tangential chain-migration during postnatal neurogenesisIris Hack
NMDA IBDM, CNRS INSERM Université Méditerranée, Campus de Luminy, 13288 Marseille Cedex 9, France
Nat Neurosci 5:939-45. 2002..Furthermore, we found that in reeler mutant mice, neuronal precursors accumulated in the olfactory bulb and remained in clusters, indicating that they ..
- Multiple dose-dependent effects of Lis1 on cerebral cortical developmentMichael J Gambello
Department of Pediatrics and Medicine, University of California, San Diego, La Jolla, California 92093 0627, USA
J Neurosci 23:1719-29. 2003..These studies reveal the importance of LIS1 levels in orderly cerebral cortical morphogenesis and suggest new insights into the pathogenesis of type I lissencephaly...
- Neuronal position in the developing brain is regulated by mouse disabled-1B W Howell
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Nature 389:733-7. 1997..The mdab1 mutant phenotype is very similar to that of the reeler mouse...
- The role of the first postmitotic cortical cells in the development of thalamocortical innervation in the reeler mouseZ Molnar
University Laboratory of Physiology, Oxford OX1 3PT, United Kingdom
J Neurosci 18:5746-65. 1998In the mutant mouse reeler, the tangential distribution of thalamocortical fibers is essentially normal, even though neurons of the cortical plate accumulate below the entire early-born preplate population (Caviness et al., 1998)...
- SOX5 controls the sequential generation of distinct corticofugal neuron subtypesTina Lai
MGH HMS Center for Nervous System Repair, Department of Neurosurgery, Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA
Neuron 57:232-47. 2008..These data indicate that SOX5 controls the timing of critical fate decisions during corticofugal neuron production and thus subtype-specific differentiation and neocortical neuron diversity...
- Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitroMélanie Sinagra
Institut F Magendie des Neurosciences, 33077 Bordeaux Cedex, France
J Neurosci 25:6127-36. 2005..These data reveal a new role for Reelin and LDL receptors and reinforce the idea of a prominent role of extracellular matrix proteins in postnatal maturation...
- Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsyInma Cobos
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
Nat Neurosci 8:1059-68. 2005..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss...
- Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neuronsMary Wines-Samuelson
Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Dev Biol 277:332-46. 2005..These findings show a cell-autonomous role for PS1 in cortical lamination and radial glial development, and a non-cell-autonomous role for PS1 in CR neuron survival...
- Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transductionPeggy C Stolt
Department of Pathology, Harvard Medical School, Brigham and Womens Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 280:9671-7. 2005....
- Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neuronsBryan A Ballif
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Curr Biol 14:606-10. 2004..secreted protein Reelin controls the locations of many types of neurons, and its absence causes the classic "Reeler" phenotype...
- The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fateTeresa H Chae
Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center and Department of Neurology and Program in Neuroscience, Harvard Medical School, HIM 816, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
Nat Genet 36:264-70. 2004..Apical localization of the SNARE Vamp7 is also disrupted. Thus, alpha Snap is essential for apical protein localization and cell fate determination in neuroepithelial cells...
- Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathwaySanyong Niu
The Cain Foundation Laboratories, Houston, TX 77030, USA
Neuron 41:71-84. 2004..In addition to cellular disorganization, dendrite abnormalities are present in the brain of reeler mice lacking Reelin...
- Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler miceSusan Magdaleno
Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
Neuron 33:573-86. 2002The gene mutated in reeler (reelin) encodes a protein secreted by neurons in the developing brain that controls laminar positioning of migrating cells in the CNS by an unknown mechanism...
- Expression of coiled-coil protein 1, a novel gene downstream of FGF2, in the developing brainFrancesca Pellicano
Beatson Laboratories for Cancer Research, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
Gene Expr Patterns 6:285-93. 2006..We observed that the expressed ccp1 protein was localised to endo/lysosomal compartment in the cell body as well as to vesicles present in the processes of primary cortical neurons and oligodendrocyte cell line...
- Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3Xuejun Chai
Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
J Neurosci 29:288-99. 2009..Immunostaining for phospho-cofilin in dissociated reeler neurons is significantly increased after incubation in Reelin-containing medium compared with control medium...
- Expression of Disabled 1 suppresses astroglial differentiation in neural stem cellsIl Sun Kwon
Department of Anatomy, School of Medicine, Ajou University, Suwon, 443 749, South Korea
Mol Cell Neurosci 40:50-61. 2009..Our results suggest that Dab1 participates in the differentiation of NSCs into a specific cell lineage, thereby maintaining a balance between neurogenesis and gliogenesis...
- Regulation of neural migration by the CREB/CREM transcription factors and altered Dab1 levels in CREB/CREM mutantsCarmen Díaz-Ruiz
Institute for Research in Biomedicine Barcelona IRB, Department of Cell Biology and CIBERNED ISCIII, University of Barcelona, Barcelona Science Park, Lab A1 S1, Josep Samitier 1 5, Barcelona 08028, Spain
Mol Cell Neurosci 39:519-28. 2008....
- Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signalingRita De Gasperi
Research and Development James J Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA
Dev Dyn 237:2405-14. 2008..Prior studies have commented on similarities between Psen1-/- and reeler mice. Reelin induces phosphorylation of Dab1 and activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway...
- Chemokine signaling controls intracortical migration and final distribution of GABAergic interneuronsGuillermina López-Bendito
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
J Neurosci 28:1613-24. 2008....
- Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-type cortexTadashi Nomura
Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTTAR, Tohoku University School of Medicine, Sendai, Japan
PLoS ONE 3:e1454. 2008..These lines of evidence shed light on the developmental programs underlying the evolution of the mammalian specific laminated cortex...
- Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathwaysJulie A Siegenthaler
Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
Dev Biol 313:35-46. 2008..Thus, TGFbeta and Foxo3a may work in concert to regulate expression of p21 during CR neuronal generation...
- Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortexToshio Ohshima
Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
Development 134:2273-82. 2007..In addition, proper radial neuronal migration generates an inside-out pattern of cerebral cortex formation and normal axonal trajectories of cortical pyramidal neurons...
- Hippocampal dendritic arbor growth in vitro: regulation by Reelin-Disabled-1 signalingSarah A MacLaurin
Novartis Institutes for BioMedical Research, Inc Cambridge, MA 02139, USA
Brain Res 1172:1-9. 2007..Moreover, experiments that incorporated a Reelin-neutralizing antibody support the hypothesis that the role(s) Reelin-signaling plays in dendritic maturation is different than the one it has in neuronal positioning...
- Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cordS A Villeda
Department of Physiological Science, UCLA, Los Angeles, CA 90095 1606, USA
Neuroscience 139:1385-96. 2006Mutations in reeler, the gene coding for the Reelin protein, result in pronounced motor deficits associated with positioning errors (i.e. ectopic locations) in the cerebral and cerebellar cortices...
- Expression of Cux-1 and Cux-2 in the developing somatosensory cortex of normal and barrel-defective miceArnaud Ferrere
INSERM U616, Hopital de la Pitie Salpetriere, Paris, France
Anat Rec A Discov Mol Cell Evol Biol 288:158-65. 2006..Conversely, in Reeler mice, Cux-1 and Cux-2 had a distinct laminar distribution: the Cux-1-positive neurons had an inverted deep ..
- Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stagesTakayuki Uchida
Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya, Aichi 467 8603, Japan
J Neurosci 29:10653-62. 2009..It is thus strongly suggested that Reelin exerts critical actions on migrating projection neurons at their early/premigratory stages en route to their final destinations, in the developing cerebral cortex and cerebellum...
- Detection of the reelin breakpoint in reeler miceG D'ARCANGELO
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38103, USA
Brain Res Mol Brain Res 39:234-6. 1996Disruption of the reelin gene by partial deletion causes the neurological phenotype known as reeler. Here we report the cloning and sequencing of the reelin breakpoint region from the Jackson reeler strain (rl)...
- Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfindingKathie M Bishop
Molecular Neurobiology Lab, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Comp Neurol 457:345-60. 2003..The more severe phenotypes in Emx double mutants suggest that Emx1 and Emx2 cooperate to regulate multiple features of cortical development...
- Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler miceT Miyata
Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
J Comp Neurol 372:215-28. 1996We have immunohistochemically investigated the expression of a reeler gene-related antigen in the mouse cerebellum by using a monoclonal antibody, CR-50...
- Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascadeNobutaka Ohkubo
Department of Physiology, School of Medicine, Ehime University, Onsen gun, Ehime 791 0295, Japan
FASEB J 17:295-7. 2003..Mice lacking Reelin (Reln), double-knockouts lacking the VLDL receptor (VLDLR) and ApoE receptor2 (ApoER2), and mice lacking disabled-1 (Dab1)..
- Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neuronsYoshinobu Sugitani
Department of Cell Biology, JFCR Cancer Institute, Tokyo 170 8455, Japan
Genes Dev 16:1760-5. 2002..These data indicate that Brn-1 and Brn-2 share roles in the production and positioning of neocortical neuron development...
- Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient miceKarl Heinz Weiss
Anatomisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
J Comp Neurol 460:56-65. 2003We studied the postnatal development of the radial glial scaffold in the dentate gyrus of reeler mice, lacking the extracellular matrix protein Reelin, in scrambler mice, deficient in the intracellular adaptor protein disabled1 (Dab1), ..
- Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouseS Alcantara
Department of Animal and Plant Cell Biology, Faculty of Biology, University of Barcelona, Barcelona 08028, Spain
J Neurosci 18:7779-99. 1998..This complex pattern of cellular and regional expression is consistent with Reelin having multiple roles in brain development and adult brain function...
- Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cellsIn Kyung Park
Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Nature 423:302-5. 2003..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs...
- Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesisPetur H Petersen
Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, Connecticut 06520, USA
Nat Neurosci 7:803-11. 2004....
- Obstructed migration of Purkinje cells in the developing cerebellum of the reeler mutant mouseS Yuasa
Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
Anat Embryol (Berl) 188:317-29. 1993It has been considered that cortical malformation in the brain of the reeler mutant mouse is due to a defect in the process of neuroblast migration during development...
- Regulation of protein tyrosine kinase signaling by substrate degradation during brain developmentLionel Arnaud
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
Mol Cell Biol 23:9293-302. 2003..Our data provide the first evidence for how Reelin down-regulates Dab1 protein expression in vivo. Dab1 degradation may be important for ensuring a transient Reelin response and may play a role in normal brain development...
- Reelin controls position of autonomic neurons in the spinal cordJ W Yip
Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Proc Natl Acad Sci U S A 97:8612-6. 2000Mutation of the reeler gene (Reln) disrupts neuronal migration in several brain regions and gives rise to functional deficits such as ataxic gait and trembling in the reeler mutant mouse...
- Interaction of reelin signaling and Lis1 in brain developmentAmir H Assadi
Cain Foundation Laboratories and Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Genet 35:270-6. 2003..In the mouse, homozygous mutations in Reln result in the reeler phenotype, characterized by ataxia and disrupted cortical layers...
- Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalonSusana Nery
Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
Cereb Cortex 13:895-903. 2003..This recovery may be, at least in part, a result of the late migration of Dlx2 progenitors from the caudal ganglionic eminences (CGE), which, based on our previous work, does not appear to require Nkx2.1 gene function...
- Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibodyG D'ARCANGELO
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
J Neurosci 17:23-31. 1997The neurological mouse mutant strain reeler displays abnormal laminar organization of several brain structures as a consequence of a defect in cell migration during neurodevelopment...
- Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulbSusan J Harrison
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Cereb Cortex 18:1604-17. 2008..In Sall1-mutant animals, these patterns of neurogenesis were disrupted. These findings suggest a role for Sall1 in regulating neuronal differentiation and maturation in developing neural structures...
- Role of reelin in the control of brain developmentT Curran
Department of Developmental Neural Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Brain Res Brain Res Rev 26:285-94. 1998b>Reeler is an autosomal recessive mutation in mice that results in widespread disruption of laminated regions of the brain. We isolated a gene, reelin, that is mutated in reeler mice...
- Cortical malformations and epilepsy: new insights from animal modelsN Chevassus-au-Louis
INSERM U29, Paris, France
Epilepsia 40:811-21. 1999..In agreement with clinical evidence, these experimental data suggest that cortical malformations can both form epileptogenic foci and alter brain development in a manner that causes a diffuse hyperexcitability of the cortical network...
- Cerebellar disorganization characteristic of reeler in scrambler mutant mice despite presence of reelinD Goldowitz
Department of Anatomy and Neurobiology, University of Tennessee College of Medicine, Memphis, Tennessee 38163, USA
J Neurosci 17:8767-77. 1997..The scrambler mutation results in ataxic mice that exhibit several neuroanatomic defects reminiscent of reeler. The most obvious of these lies in the cerebellum, which is small and lacks foliation...
- The evolution of cortical development. An hypothesis based on the role of the Reelin signaling pathwayI Bar
Neurobiology Unit, University of Namur, School of Medicine, 61 rue de Bruxelles, B 5000, Namur, Belgium
Trends Neurosci 23:633-8. 2000..Thus, the Reelin pathway played a key role in cortical architectonic evolution in mammalian and squamate lineages...
- Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor poolNina Solberg
Section for Cellular and Genetic Therapy, Institute of Microbiology, Rikshospitalet, Oslo, Norway
Dev Dyn 237:1799-811. 2008..The lower number of progenitors in the dentate gyrus was not rescued after migration to the subgranular zone and thus the dentate gyrus lacked the entire internal blade and a part of the external blade from postnatal to adult stages...
- Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expressionMarta Pascual
Institut de Recerca Biomèdica, Parc Cientific de Barcelona, Universitat de Barcelona, Josep Samitier 1 5, E 08028 Barcelona, Spain
Proc Natl Acad Sci U S A 104:5193-8. 2007..Moreover, our results suggest that Ptf1a is also required for the suppression of the granule cell specification program in cerebellar ventricular zone precursors...
- The hippocampus of the reeler mutant mouse: fiber segregation in area CA1 depends on the position of the postsynaptic target cellsT Deller
Institute of Anatomy, University of Freiburg, Freiburg, D 79001, Germany
Exp Neurol 156:254-67. 1999..this hypothesis, entorhinal and commissural/associational afferents to Ammon's horn were investigated in the adult reeler mutant mouse, in which developmental cell migration defects have disrupted the normal array of cells...
- Ectopic corticospinal tract and corticothalamic tract neurons in the cerebral cortex of yotari and reeler miceTatsuro Yamamoto
Division of Anatomy and Developmental Neurobiology, Department of Neuroscience, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
J Comp Neurol 461:61-75. 2003b>Reeler and yotari mice, which are mutant for Reelin or Dab1, respectively, show disorders of cerebral cortical lamination...
- Estimation of genetic distances between "reeler" and nearby loci on mouse chromosome 5C Dernoncourt
Department of Physiology, FUNDP School of Medicine, Namur, Belgium
Genomics 11:1167-9. 1991Genetic distances between reeler (gene symbol rl) and the adjacent loci Pgy-1, Sor, and En-2 on proximal chromosome 5 were estimated using a backcross panel between rlOrl/rlOrl BALB/c and C57 mice...
- Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesisA Hirschberg
Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
Mol Cell Biol 30:764-80. 2010..These results suggest that Sema4D-plexin-B2 interactions regulate mechanisms underlying cell specification, differentiation, and migration during corticogenesis...
- Developmental expression and intracellular location of P400 protein characteristic of Purkinje cells in the mouse cerebellumN Maeda
Division of Regulation of Macromolecular Function, Osaka University, Japan
Dev Biol 133:67-76. 1989..Immunohistochemistry of the cerebella of neurological mutant mice indicated that the Purkinje cells of reeler, weaver, and pcd mutant mice retain the ability to produce a large amount of P400 protein...
- Reelin signaling antagonizes beta-amyloid at the synapseMurat S Durakoglugil
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 106:15938-43. 2009..We propose a model in which Abeta, Reelin, and ApoE receptors modulate neurotransmission and thus synaptic stability as opposing regulators of synaptic gain control...
- Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signallingMasaaki Torii
Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
Nature 461:524-8. 2009....
- Interaction of reelin with amyloid precursor protein promotes neurite outgrowthHYANG SOOK HOE
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057 1464, USA
J Neurosci 29:7459-73. 2009..Addition of an alpha3beta1 integrin antibody prevented APP and Reelin-induced neurite outgrowth. These findings demonstrate that Reelin interacts with APP, potentially having important effects on neurite development...
- Course and collaterals of corticospinal fibers arising from the sensorimotor cortex of the reeler mouseT Terashima
Department of Anatomy, Tokyo Metropolitan Institute for Neuroscience, Fuchu City, Japan
Dev Neurosci 17:8-19. 1995The reeler genetic mutation, occurring spontaneously in mice, affects migration of neuroblasts in the central nervous system at its last stage, causing severe cytoarchitectonic abnormalities in laminated structures, such as the cerebral ..
- The role of Robo3 in the development of cortical interneuronsMelissa Barber
Department of Cell and Developmental Biology, University College London, London, UK
Cereb Cortex 19:i22-31. 2009..These observations and the results of other recent studies suggest a complex interplay between the 3 Robo receptors in regulating the number, migration and morphological differentiation of cortical interneurons...
- Neonatal vestibular stimulation and mating in cerebellar mutantsJ M Guastavino
Laboratoire de Biologie du Comportement et Physiologie, Universite de Nancy 1, CNRS URA 1293, Vandoeuvre les Nancy, France
Behav Genet 23:265-9. 1993Two cerebellar mutants, staggerer and reeler, and their congenic nonmutants were used in this experiment...
- Specific glial populations regulate hippocampal morphogenesisGuy Barry
The University of Queensland, Queensland Brain Institute, and School of Biomedical Sciences, Brisbane, 4067, Australia
J Neurosci 28:12328-40. 2008..These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis...
- SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neuronsKenneth Y Kwan
Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 105:16021-6. 2008..Thus, SOX5 postmitotically regulates the migration, postmigratory differentiation, and subcortical projections of subplate and deep-layer neurons...
- Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneuronsS J Pleasure
Neurodevelopmental Disorders Laboratory, Department of Neurology, University of California, San Francisco, CA 94143, USA
Neuron 28:727-40. 2000..Loss of hippocampal interneurons does not appear to have major effects on the early development of hippocampal projection neurons nor on the pathfinding of afferrent tracts...
- Behavioral phenotype of the reeler mutant mouse: effects of RELN gene dosage and social isolationWalter L Salinger
Department of Psychology, University of North Carolina at Greensboro, 27402 6170, USA
Behav Neurosci 117:1257-75. 2003b>Reeler (rl/rl) and reeler/wild-type (+/rl) mice synthesize Reln at subnormal rates, as do patients with schizophrenia, bipolar disorder, and autism, thereby forming the basis for a Reln hypothesis for vulnerability to these ..
- Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous systemFriedrich Laub
Laboratory of Genetics and Organogenesis, Research Division of the Hospital for Special Surgery, and Department of Physiology and Biophysics at Weill Medical College of Cornell University, 535 East 70th St, New York, New York 10021, USA
Mol Cell Biol 25:5699-711. 2005..KLF7 activity might therefore control neuronal morphogenesis in part by optimizing the levels of molecules that promote axon outgrowth...
- Id4 is required for the correct timing of neural differentiationLynn Bedford
Institute of Genetics, Queen s Medical Centre, School of Biology, The University of Nottingham, UK
Dev Biol 280:386-95. 2005..Together, these in vivo and in vitro data suggest a crucial role for Id4 in regulating NPC proliferation and differentiation...
- Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNSOlga Britanova
Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, 37075 Goettingen, Germany
Eur J Neurosci 21:658-68. 2005..In the Lbx1 mutants Satb2 expression is greatly reduced. We suggest that Satb2 may regulate differentiation of subsets of neurons at the level of higher order chromatin structure via binding to MARs...
- Neuronal migration and the role of reelin during early development of the cerebral cortexYves Jossin
Developmental Neurobiology Unit, University of Louvain Medical School, Brussels, Belgium
Mol Neurobiol 30:225-51. 2004....
- Cajal-Retzius cells in the mouse: transcription factors, neurotransmitters, and birthdays suggest a pallial originRobert F Hevner
Department of Pathology, University of Washington, Harborview Medical Center, Box 359630, 325 Ninth Ave, Seattle, WA 98104 2499, USA
Brain Res Dev Brain Res 141:39-53. 2003..5. Our results suggest that the marginal zone contains two main types of neurons: Cajal-Retzius cells derived from the pallium, and migrating interneurons derived from the subpallium...
- A role of MAP1B in Reelin-dependent neuronal migrationChristian Gonzalez-Billault
Centro de Biologia Molecular, Universidad Autonoma de Madrid CSIC, Madrid 28049, Spain
Cereb Cortex 15:1134-45. 2005..Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration...
- MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisionsNoriyuki Kishi
MGH HMS Center for Nervous System Repair, Department of Neurosurgery, and Program in Neuroscience, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Cell Neurosci 27:306-21. 2004..Taken together, our results indicate that MECP2 is involved in the maturation and maintenance of neurons, including dendritic arborization, rather than in cell fate decisions...
- Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neuronsElena Colombo
Stem Cell Research Institute, DIBIT, San Raffaele Science Park, Via Olgettina 58, 20132 Milan, Italy
Dev Dyn 231:631-9. 2004..In conclusion, our mouse Arx expression data provide important further insights into the puzzling complexity of the human ARX mutation pleiotropy...
- High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neuronsTara M Herrick
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Brain Res Mol Brain Res 126:121-8. 2004..The Dab1(F158V) allele adds to a series of Dab1 alleles that demonstrates cell type-specific variation in the Reelin-Dab1 pathway...
- Dynamics of Cux2 expression suggests that an early pool of SVZ precursors is fated to become upper cortical layer neuronsCeline Zimmer
Developmental Biology Institute of Marseille, NMDA, Campus de Luminy Case 907, 13288 Marseille Cedex 9, France
Cereb Cortex 14:1408-20. 2004..This suggests that laminar determination of upper cortical layer neurons occurs during the earliest stages of corticogenesis...
- Expression of the chemokine receptor Cxcr4 mRNA during mouse brain developmentFadel Tissir
Developmental Genetics Unit, University of Louvain Medical School, avenue E Mounier, 73 Box DENE 7382, B1200 Brussels, Belgium
Brain Res Dev Brain Res 149:63-71. 2004..This expression pattern suggests that Sdf1 and its receptor Cxcr4 may exert trophic influences on precursor cell proliferation and some neuronal targets that remain to be identified and studied further...
- The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate developmentYves Jossin
Developmental Genetics Unit, University of Louvain Medical School, B1200 Brussels, Belgium
J Neurosci 24:514-21. 2004..receptor (CNR1) as reported previously; (3) Reelin and its central fragment are equally able to rescue the reeler phenotype in a slice culture assay; and (4) anti-receptor antibodies can induce Dab1 phosphorylation but do not ..
- BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2Fernando Aguado
Department of Cell Biology Faculty of Biology, and Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
Development 130:1267-80. 2003..Given that BDNF itself is regulated by neuronal activity, we suggest that BDNF acts as a homeostatic factor controlling the emergence, complexity and networking properties of spontaneous networks...
- Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3Vassiliki Fotaki
Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
J Neurosci 26:9282-92. 2006..We propose that Gli3 is indispensable for formation of an intact telencephalic-diencephalic boundary and for preventing the abnormal positioning of diencephalic cells in the dorsal telencephalon...
- Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matterChris Englund
Department of Pathology, University of Washington, Seattle, Washington 98104, USA
J Neurosci 26:9184-95. 2006..In reeler mutant mice, Tbr2+ UBCs accumulated near the rhombic lip, consistent with impaired migration through developing ..
- A key role for the HLH transcription factor EBF2COE2,O/E-3 in Purkinje neuron migration and cerebellar cortical topographyLaura Croci
San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Development 133:2719-29. 2006....
- Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formationBart L T Vaes
Department of Applied Biology FNWI, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Bone 39:724-38. 2006..In conclusion, our data show that a comparative genome-wide expression analysis of wild-type and mutant mouse models allows the examination of mutant phenotypes in complex tissues...
- EPILEPTOGENESIS IN THE AGED CNSPeter Patrylo; Fiscal Year: 2002..Thus, by examining synaptic reorganization within the aged CNS they may also provide insight into the basic mechanisms of epilepsy and learning and memory within the overall population. ..
- Synapase Modification /Memory Retention /Life Span ModelPeter Patrylo; Fiscal Year: 2002..abstract_text> ..
- In vivo functions of possible tumor suppressor Dab2Jonathan Cooper; Fiscal Year: 2004..These studies will provide insights into the molecular mechanisms of action of Dab2 and into the role of a single gene in receptor trafficking and signal transduction. ..
- In vivo functions of possible tumor suppressor Dab2Jonathan Cooper; Fiscal Year: 2006..We've also found that Dab2 is phosphorylated in mitogen-stimulated cells by MAP kinase, and will investigate the significance of Dab2 phosphorylation in regulating biological responses. ..
- Functions and mechanisms of the endocytic adaptor Dab2Jonathan Cooper; Fiscal Year: 2009..This application proposes to understand the mechanisms by which cell surface proteins are recognized for internalization. The results will be informative regarding changes in cancer cells that affect cell survival and motility. ..
- Regulation of Laminar Fate in Cerebral CortexRobert Hevner; Fiscal Year: 2006..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
- Molecular Mechanisms of Thalamocortical DevelopmentNOELLE DWYER; Fiscal Year: 2007..Combining the expertise in mouse genetics with the previous training in mouse neuroanatomy and nematode genetics will significantly add to the Candidate's potential to make a strong impact on the field. ..
- Molecular and Cellular Analysis of Brain Enriched PTP'sPaul J Lombroso; Fiscal Year: 2010..The proposed studies examine the molecular mechanisms that regulate STEP activity and will clarify how this important family of regulatory proteins are involved in synaptic plasticity, cell death, and human disease. ..
- Functions and mechanisms of the endocytic adaptor Dab2Jonathan A Cooper; Fiscal Year: 2010..This application proposes to understand the mechanisms by which cell surface proteins are recognized for internalization. The results will be informative regarding changes in cancer cells that affect cell survival and motility. ..
- SRC FAMILY KINASES AND CELL GROWTH REGULATIONJonathan A Cooper; Fiscal Year: 2010..By further study of this signaling process, we expect to identify principles of signal complex formation and regulation that may be relevant to other tyrosine kinase signaling pathways. ..
- Biological Role of the FE65 Protein/APP InteractionsSuzanne Guenette; Fiscal Year: 2009..In addition, we will gain insight into the role of the FE65 proteins in cellular signaling events that are critical for brain function. ..
- SRC FAMILY KINASES AND CELL GROWTH REGULATIONJonathan Cooper; Fiscal Year: 2009..By further study of this signaling process, we expect to identify principles of signal complex formation and regulation that may be relevant to other tyrosine kinase signaling pathways. ..
- MOLECULAR AND CELLULAR ANALYSIS OF BRAIN ENRICHED PTPSPaul Lombroso; Fiscal Year: 2007..abstract_text> ..
- Chromosome Metabolism and Cancer Training GrantJonathan Cooper; Fiscal Year: 2007..It is hoped that this program will create young scientists with in-depth understanding of chromosome metabolism and commitment to explore its various links to cancer cause, cure and prevention. ..
- Biological Role of the FE65 Protein/APP InteractionsSuzanne Guenette; Fiscal Year: 2007..In addition, we will gain insight into the role of the FE65 proteins in cellular signaling events that are critical for brain function. ..
- Investigating the nature of prestin-associated proteinsJing Zheng; Fiscal Year: 2007..This knowledge may make it possible to manipulate OHC function for therapeutic purposes. ..
- Role of the JIP-1-p190RhoGEF Complex In Neuron FunctionWILLIAM ARTHUR; Fiscal Year: 2004..Furthermore, the importance of the JIP-l-p190RhoGEF association in brain development and neuronal migration will be investigated by disrupting this complex in mutant mice . ..
- INTEGRATION OF STRESS AND MITOGEN SIGNALINGJonathan Cooper; Fiscal Year: 2001..4) To map the interactions between ERK and Msk using approaches such at the two-hybrid system. 5) To clone Mapkip108 using conventional techniques. ..
- MOLECULAR CONTROL OF CELL MIGRATION IN THE SPINAL CORDJOSEPH YIP; Fiscal Year: 2004..A gene that has been found to influence neuronal migration in the brain of the mouse is the reeler gene (reln)...
- MOLECULAR AND CELLULAR ANALYSIS OF BRAIN ENRICHED PTPSPaul Lombroso; Fiscal Year: 2003..We will identify the physiological substrates of STEP, one of which is proposed to be the NMDA receptor. We will these these hypotheses using biochemical, molecular, and electrophysiological techniques. ..
- ROLE OF HFE65 PROTEINS IN ALZHEIMER'S DISEASE.Suzanne Guenette; Fiscal Year: 2003..of hFE65L to LRP contribute to the extracellular pool of APPs and Abeta? Does the FE65L-APP interaction have an effect on intracellular Abeta42 production? Does FE65L act as an adaptor protein form a tripartite complex with APP and LRP? ..
- STRUCTURAL AND FUNCTIONAL ANALYSES OF NEURONAL PTPSPaul Lombroso; Fiscal Year: 2007..STEP knock-out mice will also be characterized. The proposed investigations will be done in the supportive environment of the Child Study Center with its commitment to cliniclaly informed basic science research. ..