Gene Symbol: Reg2
Description: regenerating islet-derived 2
Alias: PSP, PTP, REG-2, lithostathine-2, islet of Langerhans regenerating protein 2, pancreatic stone protein 2, pancreatic thread protein 2, regenerating islet-derived, mouse homolog 2
Species: mouse
Products:     Reg2

Top Publications

  1. van Ampting M, Loonen L, Schonewille A, Konings I, Vink C, Iovanna J, et al. Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice. Infect Immun. 2012;80:1115-20 pubmed publisher
    ..Reg3b plays a protective role against intestinal translocation of the gram-negative bacterium S. enteritidis in mice but not against the gram-positive bacterium L. monocytogenes. ..
  2. Wilding Crawford L, Tweedie Ables E, Oh Y, Boone B, Levy S, Gannon M. Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis. PLoS ONE. 2008;3:e1611 pubmed publisher
    ..This study provides a unique dataset that can act as a starting point for other investigators to explore the role of the identified genes in pancreatogenesis, islet morphogenesis and mature beta cell function. ..
  3. Baeza N, Moriscot C, Renaud W, Okamoto H, Figarella C, Vialettes B. Pancreatic regenerating gene overexpression in the nonobese diabetic mouse during active diabetogenesis. Diabetes. 1996;45:67-70 pubmed
    ..All of these data suggest that there is a strong correlation between reg gene expression in the pancreas of the NOD mouse and the likelihood of developing diabetes. ..
  4. Li Q, Li B, Miao X, Ramgattie C, Gao Z, Liu J. Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet-Induced Obesity. Endocrinology. 2017;158:1634-1644 pubmed publisher
    ..Regenerating islet-derived 2 (Reg2, Reg II, human ortholog Reg1B) gene is normally expressed in pancreatic acinar cells and is significantly induced ..
  5. Huszarik K, Wright B, Keller C, Nikoopour E, Krougly O, Lee Chan E, et al. Adjuvant immunotherapy increases beta cell regenerative factor Reg2 in the pancreas of diabetic mice. J Immunol. 2010;185:5120-9 pubmed publisher
    ..The Regeneration (Reg) gene family is known to be involved in regeneration of various tissues including ? cells. Reg2 expression was found to be upregulated in pancreatic islets both during diabetes development and as a result of ..
  6. Lieu H, Simon M, Nguyen Khoa T, Kebede M, Cortes A, Tebar L, et al. Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice. Hepatology. 2006;44:1452-64 pubmed
    b>Reg2/RegIIIbeta is the murine homologue of the human secreted HIP/PAP C-type lectin. HIP/PAP transgenic mice were protected against acetaminophen-induced acute liver failure and were stimulated to regenerate post-hepatectomy...
  7. Abe M, Nata K, Akiyama T, Shervani N, Kobayashi S, Tomioka Kumagai T, et al. Identification of a novel Reg family gene, Reg IIIdelta, and mapping of all three types of Reg family gene in a 75 kilobase mouse genomic region. Gene. 2000;246:111-22 pubmed
    ..Possible roles of Reg IIIdelta and the widespread occurrence of the Reg IIIdelta gene in mammalian genomes are discussed. ..
  8. Narushima Y, Unno M, Nakagawara K, Mori M, Miyashita H, Suzuki Y, et al. Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma. Gene. 1997;185:159-68 pubmed
    ..These results suggest that genes of the mouse Reg family are derived from a common ancestor gene by several gene duplications, and have obtained divergency in expression and function in the process of genetic evolution. ..
  9. Luo C, Li B, Liu L, Yin H, Wang M, Liu J. Transcriptional activation of Reg2 and Reg3? genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells. Mol Cell Endocrinol. 2013;365:187-96 pubmed publisher
    ..Dexamethasone (DEX) significantly increased the promoter expression of Reg2 and Reg3? genes and the levels of endogenous Reg3? mRNA and protein in AR42J cells...

More Information


  1. Liu L, Chowdhury S, Uppal S, Fang X, Liu J, Srikant C. mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells. Growth Factors. 2015;33:1-7 pubmed publisher
    ..On the other hand, mReg2 induced the expression of hsp70 which is known to promote cytosolic retention of AIF. We conclude that mReg2 inhibits AIF-mediated apoptosis by promoting the nuclear presence of Scythe and inducing hsp70. ..
  2. Aden K, Rehman A, Falk Paulsen M, Secher T, Kuiper J, Tran F, et al. Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation. Cell Rep. 2016;16:2208-2218 pubmed publisher
    ..The study identifies a critical barrier-protective immune pathway that originates from, and is orchestrated by, IL-23R signaling in intestinal epithelial cells. ..
  3. Zhong B, Strnad P, Toivola D, Tao G, Ji X, Greenberg H, et al. Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation. Mol Biol Cell. 2007;18:4969-78 pubmed
    ..Thus, Reg-II is a likely mouse exocrine pancreas cytoprotective candidate protein whose expression is regulated by keratin filament organization and phosphorylation. ..
  4. Perfetti R, Raygada M, Wang Y, Zenilman M, Egan J, Denno K, et al. Regenerating (reg) and insulin genes are expressed in prepancreatic mouse embryos. J Mol Endocrinol. 1996;17:79-88 pubmed
    ..Differential expression of reg-I and -II suggests that they may be induced by different and independent stimuli and have distinct functions. ..
  5. Liu L, Liu J, Srikant C. Reg2 protects mouse insulinoma cells from streptozotocin-induced mitochondrial disruption and apoptosis. Growth Factors. 2010;28:370-8 pubmed publisher
    ..that pancreas-specific ablation of IGF-I in mice induced an increased expression of regenerating family proteins Reg2 and Reg3β in the pancreas and protected them from streptozotocin (Stz)-induced β-cell damage...
  6. Gironella M, Calvo C, Fernandez A, Closa D, Iovanna J, Rosello Catafau J, et al. Reg3? deficiency impairs pancreatic tumor growth by skewing macrophage polarization. Cancer Res. 2013;73:5682-94 pubmed publisher
    ..Our studies reveal a novel role for Reg3? as a tumor promoter in pancreatic adenocarcinoma through the regulation of tumor stroma. Thus, inhibition of this protein may be a useful strategy in treatment of pancreatic cancer. ..
  7. Liu L, Chowdhury S, Fang X, Liu J, Srikant C. Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells. FEBS Lett. 2014;588:2016-24 pubmed publisher
    ..Knockdown of GRP78 sensitized the cells overexpressing mReg2 to UPR without affecting its ability to activate Akt-mTORC1 signaling. Induced expression of mReg2 may protect insulin producing cells from ER stress in diabetes. ..
  8. Unno M, Yonekura H, Nakagawara K, Watanabe T, Miyashita H, Moriizumi S, et al. Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome. J Biol Chem. 1993;268:15974-82 pubmed
    ..It is remarkable that in the gallbladder reg I is expressed, but reg II is not. ..
  9. Gurr W, Shaw M, Li Y, Sherwin R. RegII is a beta-cell protein and autoantigen in diabetes of NOD mice. Diabetes. 2007;56:34-40 pubmed
    ..In conclusion, RegII is a novel beta-cell-derived autoantigen in NOD mice. The autoimmune response against this protein may convert a regenerative into an islet-destructive process accelerating development of type 1 diabetes. ..
  10. Li B, Wang X, Liu J. Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2010;299:G413-21 pubmed publisher
    ..Recent reports suggest that Reg2 is an autoantigen normally expressed in islet beta-cells...
  11. Perfetti R, Egan J, Zenilman M, Shuldiner A. Differential expression of reg-I and reg-II genes during aging in the normal mouse. J Gerontol A Biol Sci Med Sci. 1996;51:B308-15 pubmed
    ..Differential regulation of reg-I and reg-II genes may explain the presence of conflicting data in the current literature. ..
  12. Tebar L, GĂ©ranton S, Parsons Perez C, Fisher A, Bayne R, Smith A, et al. Deletion of the mouse RegIIIbeta (Reg2) gene disrupts ciliary neurotrophic factor signaling and delays myelination of mouse cranial motor neurons. Proc Natl Acad Sci U S A. 2008;105:11400-5 pubmed publisher
    ..RegIIIbeta, also known as Reg2 in rat and HIP/PAP1 in humans, is a member of a family of growth factors found in many areas of the body and ..
  13. Wang Y, Jacovetti C, Li B, Siddique T, Xiong X, Yin H, et al. Coordinated age-dependent and pancreatic-specific expression of mouse Reg2Reg3?, and Reg3? genes. Growth Factors. 2011;29:72-81 pubmed publisher
    ..Recent reports further suggest similar roles to be played by new members such as Reg2, Reg3?, and Reg3?. We have studied their age-, isoform-, and tissue-specific expressions...