Gene Symbol: Reep1
Description: receptor accessory protein 1
Alias: D6Ertd253e, receptor expression-enhancing protein 1
Saito H, Kubota M, Roberts R, Chi Q, Matsunami H. RTP family members induce functional expression of mammalian odorant receptors. Cell. 2004;119:679-91 pubmed
..Similar although weaker effects were seen with a third protein, REEP1. These findings suggest that RTP1 and RTP2 in particular play significant roles in the translocation of ORs to the ..
Beetz C, Koch N, Khundadze M, Zimmer G, Nietzsche S, Hertel N, et al
. A spastic paraplegia mouse model reveals REEP1-dependent ER shaping. J Clin Invest. 2013;123:4273-82 pubmed publisher
..We identified a heterozygous receptor accessory protein 1 (REEP1) exon 2 deletion in a patient suffering from the autosomal dominantly inherited HSP variant SPG31...
Björk S, Hurt C, Ho V, Angelotti T. REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity. PLoS ONE. 2013;8:e76366 pubmed publisher
..By utilizing several REEP family members (REEP1, REEP2, and REEP6) and model GPCRs (?2A and ?2C adrenergic receptors), we examined REEP regulation of GPCR plasma ..
Falk J, Rohde M, Bekhite M, Neugebauer S, Hemmerich P, Kiehntopf M, et al
. Functional mutation analysis provides evidence for a role of REEP1 in lipid droplet biology. Hum Mutat. 2014;35:497-504 pubmed publisher
..Which of the many ER functions are pathologically relevant, however, remains to be determined. REEP1 is an ER protein mutated in hereditary spastic paraplegia (HSP) and hereditary motor neuropathy (HMN)...
Hashimoto Y, Shirane M, Matsuzaki F, Saita S, Ohnishi T, Nakayama K. Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia. J Biol Chem. 2014;289:12946-61 pubmed publisher
..to interact with other HSP-related proteins including myelin proteolipid protein 1 (SPG2), atlastin-1 (SPG3A), REEP1 (SPG31), REEP5 (similar to REEP1), Kif5A (SPG10), Kif5B, Kif5C, and reticulon 1, 3, and 4 (similar to reticulon 2, ..
Renvoisé B, Malone B, Falgairolle M, Munasinghe J, Stadler J, Sibilla C, et al
. Reep1 null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulation. Hum Mol Genet. 2016;25:5111-5125 pubmed publisher
..autosomal dominant forms are caused by mutations in genes that encode the spastin (SPG4), atlastin-1 (SPG3A) and REEP1 (SPG31) proteins...