Gene Symbol: Recql5
Description: RecQ protein-like 5
Alias: RecQ5, Recq5b, Recql5b, ATP-dependent DNA helicase Q5, DNA helicase, RecQ-like type 5, RECQL5beta
Hu Y, Raynard S, Sehorn M, Lu X, Bussen W, Zheng L, et al
. RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev. 2007;21:3073-84 pubmed
..RECQL and RECQL5 have not been associated with a human disease...
Hu Y, Lu X, Barnes E, Yan M, Lou H, Luo G. Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers. Mol Cell Biol. 2005;25:3431-42 pubmed
..show here that in mouse embryonic stem (ES) cells, mutations in either the Bloom syndrome homologue (Blm) or the Recql5 genes result in a significant increase in the frequency of sister chromatid exchange (SCE), whereas deleting both ..
Hu Y, Lu X, Zhou G, Barnes E, Luo G. Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment. Mol Biol Cell. 2009;20:114-23 pubmed publisher
..Here, we report that the deletion of RecQ helicase Recql5 in mouse ES cells and embryonic fibroblast (MEF) cells resulted in a significant increase in CPT sensitivity and a ..
Ohhata T, Araki R, Fukumura R, Kuroiwa A, Matsuda Y, Abe M. Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RECQL5beta. Gene. 2001;280:59-66 pubmed
Five members of the RecQ helicase family, RECQL, WRN, BLM, RTS and RECQL5, have been found in human and three of them (WRN, BLM and RTS) were disclosed to be the genes responsible for Werner, Bloom and Rothmund-Thomson syndromes, ..
Hu Y, Lu X, Luo G. Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc(min) mice. World J Gastroenterol. 2010;16:1482-6 pubmed
To investigate whether Recql5, a DNA helicase that plays an important role in the maintenance of genome integrity, is a tumor suppressor in the gastrointestinal tract in mice...
Liao W, Qi Y, Wang L, Dong X, Xu T, Ding C, et al
. Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice. World J Gastroenterol. 2015;21:10375-84 pubmed publisher
To investigate the effects of Recql5 deficiency on liver injury induced by lipopolysaccharide/D-galactosamine (LPS/D-Gal)...
Bachrati C, Hickson I. RecQ helicases: suppressors of tumorigenesis and premature aging. Biochem J. 2003;374:577-606 pubmed
..We will discuss models in which RecQ helicases are required to protect against replication fork demise, either through prevention of fork breakdown or restoration of productive DNA synthesis...
Kim T, Son M, Dodds S, Hu L, Luo G, Hasty P. RECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathway. Nucleic Acids Res. 2015;43:893-903 pubmed publisher
..Two RecQ helicases, RECQL5 and Bloom syndrome mutated (BLM) suppress HR through nonredundant mechanisms...