Reck

Summary

Gene Symbol: Reck
Description: reversion-inducing-cysteine-rich protein with kazal motifs
Alias: St15, mRECK, reversion-inducing cysteine-rich protein with Kazal motifs, Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK), membrane-anchored glycoprotein RECK, suppression of tumorigenicity 15
Species: mouse
Products:     Reck

Top Publications

  1. Morioka Y, Monypenny J, Matsuzaki T, Shi S, Alexander D, Kitayama H, et al. The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts. Oncogene. 2009;28:1454-64 pubmed publisher
    Accumulating evidence indicates that Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a membrane-anchored matrix metalloproteinase regulator, plays crucial roles in mammalian development and tumor suppression...
  2. Echizenya M, Kondo S, Takahashi R, Oh J, Kawashima S, Kitayama H, et al. The membrane-anchored MMP-regulator RECK is a target of myogenic regulatory factors. Oncogene. 2005;24:5850-7 pubmed
    The membrane-anchored MMP-regulator RECK is down regulated in many solid tumors; the extent of RECK down regulation correlates with poor prognosis...
  3. Hatta M, Matsuzaki T, Morioka Y, Yoshida Y, Noda M. Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts. Cell Signal. 2009;21:1885-93 pubmed publisher
    b>Reck is a membrane-anchored glycoprotein identified as a transformation suppressor...
  4. Chang H, Liu L, Hung W. Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK. Cell Signal. 2004;16:675-9 pubmed
    b>RECK is a membrane-anchored glycoprotein that may negatively regulate matrix metalloproteinase (MMP) activity and inhibit tumor metastasis...
  5. Kawashima S, Imamura Y, Chandana E, Noda T, Takahashi R, Adachi E, et al. Localization of the membrane-anchored MMP-regulator RECK at the neuromuscular junctions. J Neurochem. 2008;104:376-85 pubmed
    ..Immunohistochemical analyses indicated that the membrane-anchored matrix metalloproteinase regulator RECK was enriched at the NMJ in adult skeletal muscles...
  6. Miki T, Takegami Y, Okawa K, Muraguchi T, Noda M, Takahashi C. The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways. J Biol Chem. 2007;282:12341-52 pubmed
    The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is anchored to the cell surface via glycosylphosphatidylinositol...
  7. Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara R, et al. The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell. 2001;107:789-800 pubmed
    ..We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates MMP-9 and inhibits tumor invasion and metastasis...
  8. Takahashi C, Sheng Z, Horan T, Kitayama H, Maki M, Hitomi K, et al. Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Proc Natl Acad Sci U S A. 1998;95:13221-6 pubmed
    ..One such gene, RECK, encodes a membrane-anchored glycoprotein of about 110 kDa with multiple epidermal growth factor-like repeats and ..
  9. Kondo S, Shukunami C, Morioka Y, Matsumoto N, Takahashi R, Oh J, et al. Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells. J Cell Sci. 2007;120:849-57 pubmed
    ..We previously showed the involvement of a membrane-anchored MMP regulator, RECK (reversion-inducing cysteine-rich protein with Kazal motifs), in vascular development in mice...

More Information

Publications37

  1. Muraguchi T, Takegami Y, Ohtsuka T, Kitajima S, Chandana E, Omura A, et al. RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity. Nat Neurosci. 2007;10:838-45 pubmed
    ..that during cortical development in the mouse embryo, reversion-inducing cysteine-rich protein with Kazal motifs (RECK) critically regulates Notch signaling by antagonizing the ectodomain shedding of Notch ligands, which is mediated ..
  2. Kitajima S, Miki T, Takegami Y, Kido Y, Noda M, Hara E, et al. Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling. Oncogene. 2011;30:737-50 pubmed publisher
    The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) gene had been isolated as an antagonist to RAS signaling; however, the mechanism of its action is not clear...
  3. Loayza Puch F, Yoshida Y, Matsuzaki T, Takahashi C, Kitayama H, Noda M. Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs. Oncogene. 2010;29:2638-48 pubmed publisher
    ..The membrane-anchored protease regulator RECK is downregulated in many cancers, and forced expression of RECK in tumor cells results in decreased malignancy in ..
  4. Chandana E, Maeda Y, Ueda A, Kiyonari H, Oshima N, Yamamoto M, et al. Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice. BMC Dev Biol. 2010;10:84 pubmed publisher
    ..Mice lacking the membrane-anchored metalloproteinase regulator Reck die in utero around embryonic day 10...
  5. Peng X, Wu W, Zhu B, Sun Z, Ji L, Ruan Y, et al. Activation of farnesoid X receptor induces RECK expression in mouse liver. Biochem Biophys Res Commun. 2014;443:211-6 pubmed publisher
    ..In the present study, we identified RECK, a membrane-anchored inhibitor of matrix metalloproteinases, as a novel target gene of FXR in mouse liver...
  6. Noda M. [Roles of an extracellular matrix regulator RECK in mouse development]. Tanpakushitsu Kakusan Koso. 2008;53:324-30 pubmed
  7. Siddesha J, Valente A, Sakamuri S, Gardner J, Delafontaine P, Noda M, et al. Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK. J Cell Physiol. 2014;229:845-55 pubmed publisher
    ..Here we investigated the role of RECK (reversion-inducing-cysteine-rich protein with Kazal motifs), a unique membrane-anchored MMP regulator, on IL-18-..
  8. Gutiérrez J, Droppelmann C, Contreras O, Takahashi C, Brandan E. RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice. PLoS ONE. 2015;10:e0135005 pubmed publisher
    ..Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is a key regulator of ECM homeostasis and turnover. However, its role in wound contraction is presently unknown...
  9. Kim C, Kumar S, Son D, Jang I, Griendling K, Jo H. Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice. Arterioscler Thromb Vasc Biol. 2014;34:1412-21 pubmed publisher
    ..tissue inhibitor of metalloproteinase 3 (TIMP3) and reversion-inducing cysteine-rich protein with kazal motifs (RECK)...
  10. Hu S, Ren G, Liu J, Zhao Z, Yu Y, Su R, et al. MicroRNA expression and regulation in mouse uterus during embryo implantation. J Biol Chem. 2008;283:23473-84 pubmed publisher
    ..Furthermore, we showed that Reck was the target gene of miR-21. Our data suggest that miR-21 may play a key role during embryo implantation.
  11. Pan Y, Liang H, Chen W, Zhang H, Wang N, Wang F, et al. microRNA-200b and microRNA-200c promote colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs. RNA Biol. 2015;12:276-89 pubmed publisher
    ..colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs (RECK). Firstly, bioinformatics analysis predicted RECK as a conserved target of miR-200b/c...
  12. De Oliveira Demarchi A, Zambuzzi W, Paiva K, da Silva Valenzuela M, Nunes F, De Cássia Savio Figueira R, et al. Development of secondary palate requires strict regulation of ECM remodeling: sequential distribution of RECK, MMP-2, MMP-3, and MMP-9. Cell Tissue Res. 2010;340:61-9 pubmed publisher
    We have evaluated RECK (reversion-inducing-cysteine-rich protein with Kazal motifs), MMP-2 (matrix metalloproteinase-2), MMP-3, and MMP-9 involvement during palate development in mice by using various techniques...
  13. Wang H, Imamura Y, Ishibashi R, Chandana E, Yamamoto M, Noda M. The Reck tumor suppressor protein alleviates tissue damage and promotes functional recovery after transient cerebral ischemia in mice. J Neurochem. 2010;115:385-98 pubmed publisher
    ..Reversion-inducing cysteine-rich protein with Kazal motifs (Reck) is a membrane-anchored MMP-regulator implicated in coordinated regulation of pericellular proteolysis...
  14. Zambuzzi W, Yano C, Cavagis A, Peppelenbosch M, Granjeiro J, Ferreira C. Ascorbate-induced osteoblast differentiation recruits distinct MMP-inhibitors: RECK and TIMP-2. Mol Cell Biochem. 2009;322:143-50 pubmed publisher
    ..Accordingly, we demonstrated that, during the osteoblastic differentiation, TIMP-2 and RECK presented differential expressions, where RECK expression was downregulated from the 14th day in contrast with an ..
  15. Zhao W, Dong Y, Wu C, Ma Y, Jin Y, Ji Y. MiR-21 overexpression improves osteoporosis by targeting RECK. Mol Cell Biochem. 2015;405:125-33 pubmed publisher
    ..Expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) which is a predicted target of miR-21 was inhibited by miR-21 mimics...
  16. Zhang X, Healy C, Nothnick W. Estrogen suppresses expression of the matrix metalloproteinase inhibitor reversion-inducing cysteine-rich protein with Kazal motifs (RECK) within the mouse uterus. Endocrine. 2012;42:97-106 pubmed
    b>RECK (reversion-inducing cysteine-rich protein with Kazal motifs) is a membrane-anchored glycoprotein which regulates MMP2 and MMP9 activity and has been proposed to play a role in embryo implantation while misexpression of RECK has been ..
  17. Park S, Lee C, Sabharwal P, Zhang M, Meyers C, Sockanathan S. GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Science. 2013;339:324-8 pubmed publisher
    ..GDE2 GDPD activity inactivates the Notch activator RECK (reversion-inducing cysteine-rich protein with kazal motifs) by releasing it from the membrane through GPI-anchor ..
  18. de Almeida G, Yamamoto M, Morioka Y, Ogawa S, Matsuzaki T, Noda M. Critical roles for murine Reck in the regulation of vascular patterning and stabilization. Sci Rep. 2015;5:17860 pubmed publisher
    ..b>RECK, a tumor suppressor downregulated in a wide variety of cancers, encodes a membrane-anchored matrix-..
  19. Cho C, Smallwood P, Nathans J. Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron. 2017;95:1056-1073.e5 pubmed publisher
    b>Reck, a GPI-anchored membrane protein, and Gpr124, an orphan GPCR, have been implicated in Wnt7a/Wnt7b signaling in the CNS vasculature...
  20. Lee Y, Lee S, Lee K, Nguyen M, Lee M, Park G, et al. Silencing of reversion-inducing cysteine-rich protein with Kazal motifs stimulates hyperplastic phenotypes through activation of epidermal growth factor receptor and hypoxia-inducible factor-2?. PLoS ONE. 2013;8:e84520 pubmed publisher
    Reversion-inducing cysteine-rich protein with Kazal motifs (RECK, a tumor suppressor) is down-regulated by the oncogenic signals and hypoxia, but the biological function of RECK in early tumorigenic hyperplastic phenotypes is largely ..
  21. Miki T, Shamma A, Kitajima S, Takegami Y, Noda M, Nakashima Y, et al. The ß1-integrin-dependent function of RECK in physiologic and tumor angiogenesis. Mol Cancer Res. 2010;8:665-76 pubmed publisher
    ..A glycosylphosphatidylinositol-anchored glycoprotein, reversion-inducing cysteine-rich protein with Kazal motifs (RECK), has been shown to attenuate MMP-2 maturation by directly interacting with MT1-MMP...
  22. Takahashi C, Muraguchi T, Takegami Y, Miki T. [Regulation of Notch signaling and its polarity mediated by ectodomain shedding of DSL ligands]. Tanpakushitsu Kakusan Koso. 2009;54:1742-6 pubmed
  23. Hsu M, Chang H, Hung W. HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion. J Biol Chem. 2006;281:4718-25 pubmed
    ..In this study, we demonstrate that the HER-2/neu oncogene inhibits the expression of the MMP inhibitor RECK to promote cell invasion...
  24. Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, et al. The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs. Biol Open. 2012;1:458-66 pubmed publisher
    The membrane-anchored metalloproteinase-regulator RECK has been characterized as a tumor suppressor...
  25. Xu Z, Gao J, Sun Y, Zhang Z, Ge J, Xu C, et al. [Nonsteroidal anti-inflammatory drug NS398 induces RECK expression in the animal model of prostate cancer]. Zhonghua Nan Ke Xue. 2010;16:1079-82 pubmed
    To investigate the regulatory effect of the nonsteroidal anti-inflammatory drug NS398 on the expression of the RECK gene in the animal model of prostate cancer...
  26. Mori T, Moriuchi R, Okazaki E, Yamada K, Katamine S. Tgat oncoprotein functions as a inhibitor of RECK by association of the unique C-terminal region. Biochem Biophys Res Commun. 2007;355:937-43 pubmed
    We identified RECK, a membrane-anchored glycoprotein negatively regulating the activities of MMPs, as a molecule interacting with Tgat oncoprotein consisting of RhoGEF domain and the unique C-terminal 15 amino acids...
  27. Siddesha J, Valente A, Sakamuri S, Yoshida T, Gardner J, Somanna N, et al. Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK. J Mol Cell Cardiol. 2013;65:9-18 pubmed publisher
    ..The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is a unique membrane-anchored endogenous MMP regulator...
  28. Nuttall R, Sampieri C, Pennington C, Gill S, Schultz G, Edwards D. Expression analysis of the entire MMP and TIMP gene families during mouse tissue development. FEBS Lett. 2004;563:129-34 pubmed
    ..We profiled the RNA levels of every MMP, several ADAMs, and inhibitors of metalloproteinases (TIMPs and RECK) in numerous mouse tissues during development and in the uterus during pregnancy...