Gene Symbol: Rdh1
Description: retinol dehydrogenase 1 (all trans)
Alias: retinol dehydrogenase 16, retinol dehydrogenase 1 (11-cis)
Chai X, Zhai Y, Napoli J. cDNA cloning and characterization of a cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase. J Biol Chem. 1997;272:33125-31 pubmed
..These data also illustrate the multifunctional nature of short-chain dehydrogenases and provide a potential mechanism for androgen-retinoid interactions. ..
Ulven S, Gundersen T, Sakhi A, Glover J, Blomhoff R. Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally. Dev Dyn. 2001;222:341-53 pubmed
..It sets definite limits on how much 9-cis-RA potentially is present and demonstrates that at-RA predominates over 9-cis-RA by at least 30- to 180-fold in different spinal cord regions. ..
Zhang M, Thomas B, Napoli J. Gene structure and minimal promoter of mouse rdh1. Gene. 2003;305:121-31 pubmed
Mouse rdh1 encodes retinol dehydrogenase type 1 (RDH1), a short-chain dehydrogenase, which recognizes as substrates all-trans-retinol, 9-cis-retinol, 5alpha-androstan-3,17-diol and 5alpha-androstan-3-ol-17-one...
Zhang M, Hu P, Napoli J. Elements in the N-terminal signaling sequence that determine cytosolic topology of short-chain dehydrogenases/reductases. Studies with retinol dehydrogenase type 1 and cis-retinol/androgen dehydrogenase type 1. J Biol Chem. 2004;279:51482-9 pubmed
..We therefore determined the topology of mouse retinol dehydrogenase type 1 (Rdh1) and cis-retinoid androgen dehydrogenase type 1 (Crad1) in the endoplasmic reticulum of intact mammalian cells...
Zhang M, Hu P, Krois C, KANE M, Napoli J. Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse. FASEB J. 2007;21:2886-96 pubmed
..5 to e18.5) and liver (e12.5 to P2M) display inversely related mRNA expression of an Rodh ortholog, rdh1, and a major retinoic acid catabolic enzyme, cyp26a1, suggesting coordinate modulation of retinoic acid homeostasis...
Driessen C, Winkens H, Kuhlmann L, Janssen B, van Vugt A, Deutman A, et al
. Cloning and structural analysis of the murine GCN5L1 gene. Gene. 1997;203:27-31 pubmed
..The murine GCN5L1, like the human GCN5L1 protein, displays weak homology (27%) to yeast GCN5. The distance between the murine, human and bovine GCN5L1 and 11-cis retinol dehydrogenase genes appeared to be conserved. ..
Ulven S, Gundersen T, Weedon M, Landaas V, Sakhi A, Fromm S, et al
. Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid. Dev Biol. 2000;220:379-91 pubmed
..Therefore, our results suggest that RALDH2 is a key regulator in initiating retinoic acid synthesis sometime between the mid-primitive streak stage and the late allantoic bud stage in mouse embryos. ..
Zhang M, Chen W, Smith S, Napoli J. Molecular characterization of a mouse short chain dehydrogenase/reductase active with all-trans-retinol in intact cells, mRDH1. J Biol Chem. 2001;276:44083-90 pubmed
..in cell culture, and mRNA expression patterns in adult tissues and embryos of a mouse retinol dehydrogenase, RDH1. RDH1 represents a new member of the short chain dehydrogenase/reductase superfamily that differs from other mouse ..
Rout U, Armant D. Expression of genes for alcohol and aldehyde metabolizing enzymes in mouse oocytes and preimplantation embryos. Reprod Toxicol. 2002;16:253-8 pubmed
..The absence of enzymes to convert ethanol to acetaldehyde, coupled with oocyte expression of the acetaldehyde-degrading enzyme, Ahd-5, may be protective for the early embryo. ..