Gene Symbol: Rcan2
Description: regulator of calcineurin 2
Alias: Csp2, Dscr1l1, MCIP2, ZAKI-4, calcipressin-2, Down syndrome critical region gene 1-like 1, calcineurin inhibitory protein ZAKI-4, down syndrome candidate region 1-like protein 1, myocyte-enriched calcineurin interactin protein 2, myocyte-enriched calcineurin-interacting protein 2
Species: mouse
Products:     Rcan2

Top Publications

  1. Mizuno Y, Kanou Y, Rogatcheva M, Imai T, Refetoff S, Seo H, et al. Genomic organization of mouse ZAKI-4 gene that encodes ZAKI-4 alpha and beta isoforms, endogenous calcineurin inhibitors, and changes in the expression of these isoforms by thyroid hormone in adult mouse brain and heart. Eur J Endocrinol. 2004;150:371-80 pubmed
    ..These results indicate that expression of ZAKI-4 alpha and beta isoforms is regulated by thyroid hormone in vivo, and the regulation is isoform- and tissue-specific. ..
  2. Sanna B, Brandt E, Kaiser R, Pfluger P, Witt S, Kimball T, et al. Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proc Natl Acad Sci U S A. 2006;103:7327-32 pubmed
    ..Here we disrupted the mcip1 and mcip2 genes in the mouse and provide multiple lines of evidence that endogenous MCIP functions as a calcineurin ..
  3. Davies K, Ermak G, Rothermel B, Pritchard M, Heitman J, Ahnn J, et al. Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J. 2007;21:3023-8 pubmed
  4. Gelpi R, Gao S, Zhai P, Yan L, Hong C, Danridge L, et al. Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload. Am J Physiol Heart Circ Physiol. 2009;297:H1814-9 pubmed publisher
    ..Thus genetic calcineurin inhibition reveals a new mechanism regulating LV diastolic function. ..
  5. Fouillade C, Baron Menguy C, Domenga Denier V, Thibault C, Takamiya K, Huganir R, et al. Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler Thromb Vasc Biol. 2013;33:76-86 pubmed publisher
    ..Notch3-regulated transcriptome provides potential for modulating myogenic response in the cerebrovasculature. ..
  6. Strippoli P, Lenzi L, Petrini M, Carinci P, Zannotti M. A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). Genomics. 2000;64:252-63 pubmed
    ..a 241-amino-acid protein highly similar to products of the human genes DSCR1 and ZAKI-4 (HGMW-approved symbol DSCR1L1)...
  7. Liu Q, Busby J, Molkentin J. Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nat Cell Biol. 2009;11:154-61 pubmed publisher
  8. Bassett J, Logan J, Boyde A, Cheung M, Evans H, Croucher P, et al. Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function. Endocrinology. 2012;153:3537-48 pubmed publisher
    ..controls the differentiation and function of osteoclasts and osteoblasts, and regulator of calcineurin-2 (Rcan2) is a physiological inhibitor of this pathway...
  9. Zhao J, Li S, Gong Q, Ding L, Jin Y, Zhang J, et al. A disputed evidence on obesity: comparison of the effects of Rcan2(-/-) and Rps6kb1(-/-) mutations on growth and body weight in C57BL/6J mice. J Zhejiang Univ Sci B. 2016;17:657-71 pubmed publisher
    ..However, in C57BL/6J mice, we found that Rcan2 increases food intake and plays an important role in the development of age- and diet-induced obesity through a ..

More Information


  1. Ding L, Gong Q, Li S, Fu X, Jin Y, Zhang J, et al. Rcan2 and estradiol independently regulate body weight in female mice. Oncotarget. 2017;8:48098-48109 pubmed publisher
    b>Rcan2 increases food intake and plays an important role in the development of age- and diet- induced obesity in male mice...
  2. Rothermel B, Vega R, Yang J, Wu H, Bassel Duby R, Williams R. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem. 2000;275:8719-25 pubmed
    Here we describe a small family of proteins, termed MCIP1 and MCIP2 (for myocyte-enriched calcineurin interacting protein), that are expressed most abundantly in striated muscles and that form a physical complex with calcineurin A...
  3. Strippoli P, Petrini M, Lenzi L, Carinci P, Zannotti M. The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes. Gene. 2000;257:223-32 pubmed
    ..gene (DSCR1), Adapt78 (recognized as the hamster ortholog of the DSCR1 isoform 4), ZAKI-4 (renamed DSCR1-like 1, DSCR1L1) and DSCR1L2 (a novel gene on human chromosome 1), along with yeast and C. elegans single members (Strippoli P...
  4. Vega R, Rothermel B, Weinheimer C, Kovacs A, Naseem R, Bassel Duby R, et al. Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. Proc Natl Acad Sci U S A. 2003;100:669-74 pubmed
    ..These opposing roles of MCIP have important implications for therapeutic strategies to regulate cardiac hypertrophy through modulation of calcineurin-MCIP activity. ..
  5. Sun X, Hayashi Y, Xu S, Kanou Y, Takagishi Y, Tang Y, et al. Inactivation of the Rcan2 gene in mice ameliorates the age- and diet-induced obesity by causing a reduction in food intake. PLoS ONE. 2011;6:e14605 pubmed publisher
    ..The genetic factors predisposing to obesity are little understood. Rcan2 was originally identified as a thyroid hormone-responsive gene...