Rcan1

Summary

Gene Symbol: Rcan1
Description: regulator of calcineurin 1
Alias: Adapt78, CALP1L, CSP1, DSC1, Dscr1, MCIP1, RCN1, calcipressin-1, calcineurin inhibitor, down syndrome critical region protein 1 homolog, myocyte-enriched calcineurin-interacting protein 1
Species: mouse
Products:     Rcan1

Top Publications

  1. Porta S, Marti E, De La Luna S, Arbones M. Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain. Eur J Neurosci. 2007;26:1213-26 pubmed
    ..RT-PCR and Western blot analysis showed that all Rcan mRNAs (Rcan1-1, Rcan1-2, Rcan2-1, Rcan2-3 and Rcan3) and their corresponding protein products (RCAN1-L, RCAN1-S, RCAN2-L, RCAN2-..
  2. Keating D, Dubach D, Zanin M, Yu Y, Martin K, Zhao Y, et al. DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease. Hum Mol Genet. 2008;17:1020-30 pubmed publisher
    ..Regulator of calcineurin activity 1 (RCAN1) is one such gene...
  3. Martin K, Corlett A, Dubach D, Mustafa T, Coleman H, Parkington H, et al. Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory. Hum Mol Genet. 2012;21:3025-41 pubmed publisher
    ..We generated RCAN1-TG mice to study the consequences of RCAN1 over-expression and investigate the contribution of RCAN1 to the brain ..
  4. Esteban V, Méndez Barbero N, Jiménez Borreguero L, Roque M, Novensa L, García Redondo A, et al. Regulator of calcineurin 1 mediates pathological vascular wall remodeling. J Exp Med. 2011;208:2125-39 pubmed publisher
    ..Of these, the most sensitive to CN activation was regulator of CN 1 (Rcan1). Rcan1 was strongly activated by AngII in vitro and in vivo and was required for AngII-induced VSMC migration...
  5. Baek K, Zaslavsky A, Lynch R, Britt C, Okada Y, Siarey R, et al. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature. 2009;459:1126-30 pubmed publisher
    ..One such gene is Down's syndrome candidate region-1 (DSCR1, also known as RCAN1), which encodes a protein that suppresses vascular endothelial growth factor (VEGF)-mediated ..
  6. Yang Y, Chen W, Edgar A, Li B, Molkentin J, Berman J, et al. Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function. J Exp Med. 2009;206:195-207 pubmed publisher
    ..Fc epsilonRI-induced Rcan1 expression was identified by suppression subtractive hybridization and verified by real-time quantitative ..
  7. Abbasi S, Lee J, Su B, Chen X, Alcon J, Yang J, et al. Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1. J Biol Chem. 2006;281:7717-26 pubmed
    ..NFAT) signaling in cardiac myocytes through phosphorylation of modulatory calcineurin-interacting protein 1 (MCIP1)...
  8. Genescà L, Aubareda A, Fuentes J, Estivill X, De La Luna S, Pérez Riba M. Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. Biochem J. 2003;374:567-75 pubmed
    b>Calcipressin 1 is an endogenous inhibitor of calcineurin, which is a serine/threonine phosphatase under the control of Ca(2+) and calmodulin...
  9. Ryeom S, Greenwald R, Sharpe A, McKeon F. The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nat Immunol. 2003;4:874-81 pubmed
    ..assessed the calcineurin-dependent process of T cell activation in mice engineered to lack the gene encoding calcipressin 1 (Csp1)...

More Information

Publications69

  1. Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid P, et al. The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice. J Clin Invest. 2009;119:2257-70 pubmed publisher
    ..gene 1 (DSCR-1) short variant (DSCR-1s) is an inhibitor of calcineurin/NFAT signaling encoded by exons 4-7 of DSCR1. We previously reported that VEGF induces DSCR-1s expression in endothelial cells, which in turn negatively feeds ..
  2. Ryeom S, Baek K, Rioth M, Lynch R, Zaslavsky A, Birsner A, et al. Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth. Cancer Cell. 2008;13:420-31 pubmed publisher
    ..Treatment with the specific pharmacological calcineurin inhibitor cyclosporin A rescues this endothelial defect in DSCR1(-/-) mice, restoring tumor growth.
  3. Sanna B, Brandt E, Kaiser R, Pfluger P, Witt S, Kimball T, et al. Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proc Natl Acad Sci U S A. 2006;103:7327-32 pubmed
    ..Here we disrupted the mcip1 and mcip2 genes in the mouse and provide multiple lines of evidence that endogenous MCIP functions as a ..
  4. Mitchell A, Jayakumar L, Koleilat I, Qian J, Sheehan C, Bhoiwala D, et al. Brain expression of the calcineurin inhibitor RCAN1 (Adapt78). Arch Biochem Biophys. 2007;467:185-92 pubmed
    RCAN1 (Adapt78) is an endogenous inhibitor of calcineurin, an important intracellular phosphatase that mediates many cellular responses to calcium. RCAN1 is expressed in multiple organs, especially heart, skeletal muscle and brain...
  5. Rothermel B, Vega R, Yang J, Wu H, Bassel Duby R, Williams R. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem. 2000;275:8719-25 pubmed
    Here we describe a small family of proteins, termed MCIP1 and MCIP2 (for myocyte-enriched calcineurin interacting protein), that are expressed most abundantly in striated muscles and that form a physical complex with calcineurin A...
  6. Sobrado M, Ramirez B, Neria F, Lizasoain I, Arbones M, Minami T, et al. Regulator of calcineurin 1 (Rcan1) has a protective role in brain ischemia/reperfusion injury. J Neuroinflammation. 2012;9:48 pubmed publisher
    ..Here, we have analyzed the role of endogenous regulator of CN 1 (Rcan1) in response to experimental ischemic stroke induced by middle cerebral artery occlusion...
  7. Jung M, Park J, Ryu Y, Choi S, Yoon S, Kwen M, et al. Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation. J Biol Chem. 2011;286:40401-12 pubmed publisher
    ..21, namely dual specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) and regulator of calcineurin 1 (RCAN1), have been implicated in some of the phenotypic characteristics of Down syndrome, including the early onset of ..
  8. Liu Q, Busby J, Molkentin J. Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nat Cell Biol. 2009;11:154-61 pubmed publisher
    ..Here we performed a yeast two-hybrid screen with RCAN1 as bait, identifying TAK1 binding protein 2 (TAB2) as an interacting partner...
  9. Vega R, Rothermel B, Weinheimer C, Kovacs A, Naseem R, Bassel Duby R, et al. Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. Proc Natl Acad Sci U S A. 2003;100:669-74 pubmed
    ..To investigate the involvement of MCIP1 in cardiac hypertrophy in vivo, we generated MCIP1 null mice and subjected them to a variety of stress stimuli ..
  10. Porta S, Serra S, Huch M, Valverde M, Llorens F, Estivill X, et al. RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration. Hum Mol Genet. 2007;16:1039-50 pubmed
    ..Regulator of Calcineurin 1 (RCAN1 or DSCR1) is a dose-sensitive gene whose overexpression has been linked to Down syndrome (DS) and Alzheimer's ..
  11. Davies K, Ermak G, Rothermel B, Pritchard M, Heitman J, Ahnn J, et al. Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J. 2007;21:3023-8 pubmed
  12. Casas C, Martinez S, Pritchard M, Fuentes J, Nadal M, Guimera J, et al. Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis. Mech Dev. 2001;101:289-92 pubmed
    We have demonstrated that DSCR1 acts as a negative regulator of calcineurin-mediated signaling and that its transcript is overexpressed in the Down syndrome (DS) fetal brain...
  13. Strippoli P, Petrini M, Lenzi L, Carinci P, Zannotti M. The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes. Gene. 2000;257:223-32 pubmed
    ..recognized gene family, conserved from yeast to humans, includes Down syndrome candidate region 1 gene (DSCR1), Adapt78 (recognized as the hamster ortholog of the DSCR1 isoform 4), ZAKI-4 (renamed DSCR1-like 1, DSCR1L1) and DSCR1L2 (..
  14. Cho K, Kim Y, Cho Y, Kim S. Upregulation of DSCR1 (RCAN1 or Adapt78) in the peri-infarct cortex after experimental stroke. Exp Neurol. 2008;212:85-92 pubmed publisher
    Down syndrome candidate region 1 (DSCR1; also known as RCAN1 or Adapt78) has been shown to be induced by calcium overload and oxidative stress which are included in the pathogenic hallmarks of the ischemic diseases...
  15. Arron J, Winslow M, Polleri A, Chang C, Wu H, Gao X, et al. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006;441:595-600 pubmed
    ..Here we report that two genes, DSCR1 and DYRK1A , lie within the critical region of human chromosome 21 and act synergistically to prevent nuclear ..
  16. Hoeffer C, Dey A, Sachan N, Wong H, Patterson R, Shelton J, et al. The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling. J Neurosci. 2007;27:13161-72 pubmed
    Regulator of calcineurin 1 (RCAN1/MCIP1/DSCR1) regulates the calmodulin-dependent phosphatase calcineurin...
  17. Zmijewski P, Gao L, Saxena A, Chavannes N, Hushmendy S, Bhoiwala D, et al. Fish oil improves gene targets of Down syndrome in C57BL and BALB/c mice. Nutr Res. 2015;35:440-8 pubmed publisher
    ..One such condition is Down syndrome, which is linked to overexpression of RCAN1 on human chromosome 21 for some phenotypes...
  18. Peiris H, Duffield M, Fadista J, Jessup C, Kashmir V, Genders A, et al. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to ?-Cell Mitochondrial Dysfunction in Type 2 Diabetes. PLoS Genet. 2016;12:e1006033 pubmed publisher
    ..This approach produced a single gene, RCAN1, as a candidate gene linking hyperglycemia and functional changes in T2D ?-cells...
  19. Junkins R, MacNeil A, Wu Z, McCormick C, Lin T. Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. J Immunol. 2013;190:5178-86 pubmed publisher
    ..In this study, we demonstrate that the regulator of calcineurin 1 (RCAN1) is a central negative regulator of inflammation in a mouse model of acute bacterial pneumonia using the ..
  20. Wu Y, Deng Y, Zhang S, Luo Y, Cai F, Zhang Z, et al. Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7. Neurobiol Aging. 2015;36:169-77 pubmed publisher
    ..APP and the regulator of calcineurin 1 (RCAN1) genes on chromosome 21 play a pivotal role in promoting plaque formation and neuronal apoptosis...
  21. Zhou A, Ryeom S. Cyclosporin A promotes tumor angiogenesis in a calcineurin-independent manner by increasing mitochondrial reactive oxygen species. Mol Cancer Res. 2014;12:1663-76 pubmed publisher
    The widely used immunosuppressant cyclosporin A, a potent calcineurin inhibitor, significantly increases the incidence of cancer in organ transplant patients...
  22. Lei Q, Hu G, Chen W, Yu S, Qi S, Du C, et al. RCAN1 deficiency protects against Salmonella intestinal infection by modulating JNK activation. Mol Immunol. 2016;77:26-33 pubmed publisher
    b>RCAN1 (regulator of calcineurin 1) has been shown to be involved in various physiological and pathological processes. However, the biological implications of RCAN1 during gastrointestinal tract infection remain unclear...
  23. Lee M, Garvey S, Baras A, Lemmon J, Gomez M, Schoppee Bortz P, et al. Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells. Hum Mol Genet. 2010;19:468-79 pubmed publisher
    ..Cyclooxygenase 2 (COX2/PTGS2) in SMC phenotypic modulation and uncovered Down Syndrome Candidate Region 1 (DSCR1/RCAN1) as a novel NFAT target gene in SMCs...
  24. Riper D, Jayakumar L, Latchana N, Bhoiwala D, Mitchell A, Valenti J, et al. Regulation of vascular function by RCAN1 (ADAPT78). Arch Biochem Biophys. 2008;472:43-50 pubmed publisher
    RCAN1 (Adapt78) functions mainly, if not exclusively, as a regulator of calcineurin, a phosphatase that mediates many cellular responses to calcium...
  25. Ishihara K, Kanai S, Sago H, Yamakawa K, Akiba S. Comparative proteomic profiling reveals aberrant cell proliferation in the brain of embryonic Ts1Cje, a mouse model of Down syndrome. Neuroscience. 2014;281:1-15 pubmed publisher
  26. Ma Y, Jiang G, Wang Q, Sun Y, Zhao Y, Tong L, et al. Enzymatic and thermodynamic analysis of calcineurin inhibition by RCAN1. Int J Biol Macromol. 2015;72:254-60 pubmed publisher
    Calcineurin (CN) is the target of the immunophilin-immunosuppressant complex, cyclophilin/cyclosporin A (CyP/CsA). RCAN1 has recently been shown to be an endogenous regulator of CN activity...
  27. Shin J, Lee J, Baek K. A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis. Cancer Lett. 2014;342:70-81 pubmed publisher
    ..with three copies of the Down syndrome critical region-1 (Dscr1) gene, a chromosome 21-encoded endogenous calcineurin inhibitor. These data indicate that upregulated Dscr1 contributes to broad cancer protection by suppressing tumor ..
  28. Lee E, Kim S, Lee S, Baek K, Seo S. Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation. J Biol Chem. 2015;290:21019-31 pubmed publisher
    ..Here we report that PACAP induces the expression of regulator of calcineurin 1 (RCAN1, also known as DSCR1), which is abnormally expressed in the brains of Down syndrome patients...
  29. Gurda G, Crozier S, Ji B, Ernst S, Logsdon C, Rothermel B, et al. Regulator of calcineurin 1 controls growth plasticity of adult pancreas. Gastroenterology. 2010;139:609-19, 619.e1-6 pubmed publisher
    ..Exocrine pancreas-specific overexpression of CN inhibitor Regulator of Calcineurin 1 (Rcan1) was achieved by breeding elastase-Cre(estrogen receptor [ER]) transgenics with "flox-on" Rcan1 mice...
  30. Peiris H, Raghupathi R, Jessup C, Zanin M, Mohanasundaram D, Mackenzie K, et al. Increased expression of the glucose-responsive gene, RCAN1, causes hypoinsulinemia, ?-cell dysfunction, and diabetes. Endocrinology. 2012;153:5212-21 pubmed publisher
    b>RCAN1 is a chromosome 21 gene that controls secretion in endocrine cells, regulates mitochondrial function, and is sensitive to oxidative stress...
  31. To K, Church J, O Connor T. Combined activation of calpain and calcineurin during ligand-induced growth cone collapse. Mol Cell Neurosci. 2007;36:425-34 pubmed
    ..We thus show for the first time that ligand-induced growth cone collapse can activate both calcineurin- and calpain-mediated pathways concurrently. ..
  32. Rotter D, Grinsfelder D, Parra V, Pedrozo Z, Singh S, Sachan N, et al. Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion. J Mol Cell Cardiol. 2014;74:103-11 pubmed publisher
    ..In vitro, cardiomyocytes depleted of RCAN1 were more sensitive to simulated I/R and the calcineurin inhibitor, FK506, restored protection. FK506 also conferred protection to PM-infarcted WT animals...
  33. Méndez Barbero N, Esteban V, Villahoz S, Escolano A, Urso K, Alfranca A, et al. A major role for RCAN1 in atherosclerosis progression. EMBO Mol Med. 2013;5:1901-17 pubmed publisher
    ..As RCAN1 is implicated in cell migration, we investigated its contribution to atherosclerosis...
  34. Patel A, Yamashita N, Ascaño M, Bodmer D, Boehm E, Bodkin Clarke C, et al. RCAN1 links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in Down syndrome. Nat Commun. 2015;6:10119 pubmed publisher
    ..We show that excess regulator of calcineurin 1 (RCAN1), an endogenous inhibitor of the calcineurin phosphatase that is triplicated in Down syndrome, impairs ..
  35. Wang W, Rai A, Hur E, Smilansky Z, Chang K, MIN K. DSCR1 is required for both axonal growth cone extension and steering. J Cell Biol. 2016;213:451-62 pubmed publisher
    ..Here, we show that Down syndrome critical region 1 protein (DSCR1) controls axon outgrowth by modulating growth cone actin dynamics through regulation of cofilin activity (phospho/..
  36. Kluetzman K, Perez A, Crawford D. DSCR1 (ADAPT78) lethality: evidence for a protective effect of trisomy 21 genes?. Biochem Biophys Res Commun. 2005;337:595-601 pubmed
    Over the last several years, suggestive evidence has accrued supporting a possible involvement for DSCR1 (ADAPT78) in Down syndrome. Toward testing this, we attempted to generate DSCR1 transgenic mice...
  37. Yang Y, MacNeil A, Junkins R, Carrigan S, Tang J, Forward N, et al. Regulator of calcineurin 1 (Rcan1) is required for the development of pulmonary eosinophilia in allergic inflammation in mice. Am J Pathol. 2011;179:1199-210 pubmed publisher
    ..Here, we report that deficiency in the regulator of calcineurin 1 gene (Rcan1) leads to a near-complete absence of eosinophilia in ovalbumin-induced allergic asthma in mice...
  38. Serrano Candelas E, Alemán Muench G, Solé Sánchez S, Aubareda A, Martínez Høyer S, Adán J, et al. RCAN 1 and 3 proteins regulate thymic positive selection. Biochem Biophys Res Commun. 2015;460:295-301 pubmed publisher
    ..Overexpression of human RCAN3 and RCAN1 can modulate T cell development by increasing positive selection-related surface markers, as well as the "Erk(hi) ..
  39. Strippoli P, Lenzi L, Petrini M, Carinci P, Zannotti M. A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). Genomics. 2000;64:252-63 pubmed
    ..has been identified on the basis of in-depth bioinformatics analysis of the Down syndrome candidate region 1 (DSCR1) gene, located on 21q22.1...
  40. Blazek J, Malik A, Tischbein M, Arbones M, Moore C, Roper R. Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner. Mech Dev. 2015;136:133-42 pubmed publisher
    ..5 and E17.5 in trisomic embryos. Taken together, these data suggest that the dosage imbalance of genes other than Dyrk1a is involved in the development of the prenatal bone phenotype in Ts65Dn embryos. ..
  41. Fric J, Lim C, Mertes A, Lee B, Viganò E, Chen J, et al. Calcium and calcineurin-NFAT signaling regulate granulocyte-monocyte progenitor cell cycle via Flt3-L. Stem Cells. 2014;32:3232-44 pubmed publisher
  42. Brait V, Martin K, Corlett A, Broughton B, Kim H, Thundyil J, et al. Over-expression of DSCR1 protects against post-ischemic neuronal injury. PLoS ONE. 2012;7:e47841 pubmed publisher
    The Down syndrome candidate region 1 (DSCR1) gene is located on human chromosome 21 and its protein is over-expressed in brains of Down syndrome individuals...
  43. Lange A, Molkentin J, Yutzey K. DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice. Dev Biol. 2004;266:346-60 pubmed
    The Down syndrome critical region 1 (DSCR1) gene is present in the region of human chromosome 21 and the syntenic region of mouse chromosome 16, trisomy of which is associated with congenital heart defects observed in Down syndrome...
  44. Oh M, Rybkin I, Copeland V, Czubryt M, Shelton J, van Rooij E, et al. Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers. Mol Cell Biol. 2005;25:6629-38 pubmed
    ..approach to obtain muscle-specific overexpression of the modulatory calcineurin-interacting protein 1 (MCIP1/DSCR1), an inhibitor of calcineurin...
  45. Wang W, Zhu J, Chang K, MIN K. DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis. EMBO J. 2012;31:3655-66 pubmed publisher
    ..Here, we show that Down syndrome critical region1 (DSCR1) interacts with Fragile X mental retardation protein (FMRP) and regulates both dendritic spine morphogenesis and ..
  46. Rakowski Anderson T, Wong H, Rothermel B, Cain P, Lavilla C, Pullium J, et al. Fecal corticosterone levels in RCAN1 mutant mice. Comp Med. 2012;62:87-94 pubmed
    Regulator of calcineurin 1 (RCAN1) is related to the expression of human neurologic disorders such as Down syndrome, Alzheimer disease, and chromosome 21q deletion syndrome...
  47. Lee E, Kim S, Seo S. Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction. Biochem Pharmacol. 2017;143:107-117 pubmed publisher
    ..In this study, we report that regulator of calcineurin activity 1 (RCAN1) expression is induced by PDTC treatment and that increased RCAN1 expression is dependent on the generation of ..
  48. Ma L, Tang H, Ren Y, Deng H, Wu J, Wang Z. p38? MAP kinase phosphorylates RCAN1 and regulates its interaction with calcineurin. Sci China Life Sci. 2012;55:559-66 pubmed publisher
    RCAN1, also known as DSCR1, is an endogenous regulator of calcineurin, a serine/threonine protein phosphatase that plays a critical role in many physiological processes...
  49. Wu H, Kao S, Barrientos T, Baldwin S, Olson E, Crabtree G, et al. Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development. J Biol Chem. 2007;282:30673-9 pubmed
    ..region 1 (DSCR1) gene, identified at the conserved trisomic 21 region in those patients, encodes a calcineurin inhibitor that inactivates nuclear factor of activated T cells (NFATc) activity...
  50. Chen H, Chen W, Yan W, Huang Y, Chang S, Fu W, et al. NRIP is newly identified as a Z-disc protein, activating calmodulin signaling for skeletal muscle contraction and regeneration. J Cell Sci. 2015;128:4196-209 pubmed publisher
    ..In conclusion, NRIP is a novel Z-disc protein that is important for skeletal muscle strength and regenerative capacity. ..
  51. Chen S, Law C, Grigsby C, Olsen K, Hong T, Zhang Y, et al. Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation. 2011;124:1838-47 pubmed publisher
    ..alpha skeletal actin gene expression), and increased expression of modulatory calcineurin inhibitory protein 1 (MCIP1), a direct downstream target of calcineurin/nuclear factor of activated T cell signaling...
  52. McElyea S, Starbuck J, Tumbleson Brink D, Harrington E, Blazek J, Ghoneima A, et al. Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome. Hum Mol Genet. 2016;25:4856-4869 pubmed publisher
    ..These results suggest that a temporally specific prenatal therapy may be an effective way to ameliorate some craniofacial anatomical changes associated with DS. ..
  53. Lee J, Shin J, Baek K. Trisomy of the Dscr1 gene suppresses early progression of pancreatic intraepithelial neoplasia driven by oncogenic Kras. Biochem Biophys Res Commun. 2013;440:50-5 pubmed publisher
    ..cancer, we demonstrate that trisomy of the Down syndrome critical region-1 (Dscr1), an endogenous calcineurin inhibitor localized on chromosome 21, suppresses the progression of pancreatic intraepithelial neoplasia-1A (PanIN-..
  54. Zanin M, Mackenzie K, Peiris H, Pritchard M, Keating D. RCAN1 regulates vesicle recycling and quantal release kinetics via effects on calcineurin activity. J Neurochem. 2013;124:290-9 pubmed publisher
    We have previously shown that Regulator of Calcineurin 1 (RCAN1) regulates multiple stages of vesicle exocytosis. However, the mechanisms by which RCAN1 affects secretory vesicle exocytosis and quantal release kinetics remain unknown...
  55. Chan B, Greenan G, McKeon F, Ellenberger T. Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo. Proc Natl Acad Sci U S A. 2005;102:13075-80 pubmed
    ..One such inhibitor, Down Syndrome Critical Region 1 (DSCR1), functions in T cell activation, cardiac hypertrophy, and angiogenesis...
  56. Noh E, Hwang H, Hwang H, Min B, Im E, Chung K. Covalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin. PLoS ONE. 2012;7:e48315 pubmed publisher
    ..However, NEDD8 targets and their functional alterations are not well known. Regulator of calcineurin 1 (RCAN1/DSCR1P1) is located near the Down syndrome critical region on the distal part of chromosome 21, and its gene ..
  57. Minami T, Jiang S, Schadler K, Suehiro J, Osawa T, Oike Y, et al. The calcineurin-NFAT-angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases. Cell Rep. 2013;4:709-23 pubmed publisher
    ..Upregulation of the calcineurin pathway via deletion of its endogenous inhibitor Dscr1 leads to a significant increase in lung metastases due to increased expression of a newly identified NFAT target, ..
  58. Dierssen M, Arqué G, McDonald J, Andreu N, Martinez Cue C, Flórez J, et al. Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1. PLoS ONE. 2011;6:e17010 pubmed publisher
    b>DSCR1/ RCAN1 is a chromosome 21 gene found to be overexpressed in the brains of Down syndrome (DS) and postulated as a good candidate to contribute to mental disability...
  59. Wu Z, Li Y, MacNeil A, Junkins R, Berman J, Lin T. Calcineurin-Rcan1 interaction contributes to stem cell factor-mediated mast cell activation. J Immunol. 2013;191:5885-94 pubmed publisher
    ..In this study, we identified calcineurin and regulator of calcineurin 1 (Rcan1) as novel components in SCF signaling...
  60. Oh M, Dey A, Gerard R, Hill J, Rothermel B. The CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4. J Biol Chem. 2010;285:16623-31 pubmed publisher
    Regulator of calcineurin 1 (RCAN1) inhibits the protein phosphatase calcineurin and is required for appropriate immune responses, synaptic plasticity, vascular tone, angiogenesis, and cardiac remodeling...