Gene Symbol: Rbp3
Description: retinol binding protein 3, interstitial
Alias: Irbp, Rbp-3, retinol-binding protein 3, interphotoreceptor retinoid-binding protein
Species: mouse
Products:     Rbp3

Top Publications

  1. Liao R, Gonzalez Fernandez F. Albumin is not present in the murine interphotoreceptor matrix, or in that of transgenic mice lacking IRBP. Mol Vis. 2004;10:1038-46 pubmed
    ..Some components, such as interphotoreceptor retinoid binding protein (IRBP), are virtually unique to the interphotoreceptor matrix...
  2. Avichezer D, Grajewski R, Chan C, Mattapallil M, Silver P, Raber J, et al. An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms. J Exp Med. 2003;198:1665-76 pubmed
    ..deficiency versus sufficiency of a uveitogenic retinal antigen, interphotoreceptor retinoid-binding protein (IRBP). IRBP-knockout (KO) and wild-type (WT) mice on a highly EAU-susceptible background were challenged with IRBP...
  3. Parker R, Fan J, Nickerson J, Liou G, Crouch R. Normal cone function requires the interphotoreceptor retinoid binding protein. J Neurosci. 2009;29:4616-21 pubmed publisher
    ..The interphotoreceptor retinoid-binding protein (IRBP) is a proposed retinoid transporter in the visual cycle, but rods in Irbp(-/-) mice have a normal visual cycle...
  4. Grajewski R, Silver P, Agarwal R, Su S, Chan C, Liou G, et al. Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity. J Exp Med. 2006;203:851-6 pubmed
    ..a model for human uveitis induced in mice with the retinal antigen interphotoreceptor retinoid-binding protein (IRBP), is controlled by "natural" CD4+CD25+ regulatory T (T reg) cells...
  5. Liou G, Wang M, Matragoon S. Timing of interphotoreceptor retinoid-binding protein (IRBP) gene expression and hypomethylation in developing mouse retina. Dev Biol. 1994;161:345-56 pubmed
    ..there is a retina-specific hypomethylation of the mouse gene encoding interphotoreceptor retinoid-binding protein (IRBP) that is associated with its activation...
  6. Wisard J, Faulkner A, Chrenek M, Waxweiler T, Waxweiler W, Donmoyer C, et al. Exaggerated eye growth in IRBP-deficient mice in early development. Invest Ophthalmol Vis Sci. 2011;52:5804-11 pubmed publisher
    Because interphotoreceptor retinoid-binding protein (IRBP) is expressed before being needed in its presumptive role in the visual cycle, we tested whether it controls eye growth during development...
  7. Parker R, Wang J, Kefalov V, Crouch R. Interphotoreceptor retinoid-binding protein as the physiologically relevant carrier of 11-cis-retinol in the cone visual cycle. J Neurosci. 2011;31:4714-9 pubmed publisher
    ..Interphotoreceptor retinoid-binding protein (IRBP) is a retinoid-binding protein in the subretinal space that binds 11-cis-retinol endogenously...
  8. Jin M, Li S, Nusinowitz S, Lloyd M, Hu J, Radu R, et al. The role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors. J Neurosci. 2009;29:1486-95 pubmed publisher
    ..Interphotoreceptor retinoid-binding protein (IRBP) is present in the extracellular space between photoreceptors and the RPE. IRBP is known to bind visual retinoids...
  9. Liou G, Fei Y, Peachey N, Matragoon S, Wei S, Blaner W, et al. Early onset photoreceptor abnormalities induced by targeted disruption of the interphotoreceptor retinoid-binding protein gene. J Neurosci. 1998;18:4511-20 pubmed
    ..It has been proposed that the interphotoreceptor retinoid-binding protein (IRBP) is essential for this intercellular exchange, and that it serves to prevent the potentially cytotoxic effects of ..

Scientific Experts

More Information


  1. Ripps H, Peachey N, Xu X, Nozell S, Smith S, Liou G. The rhodopsin cycle is preserved in IRBP "knockout" mice despite abnormalities in retinal structure and function. Vis Neurosci. 2000;17:97-105 pubmed
    ..of retinoids between these cellular compartments is mediated by the interphotoreceptor retinoid-binding protein (IRBP), a large glycoprotein synthesized in the photoreceptors and extruded into the interphotoreceptor matrix (IPM) that ..
  2. Sato K, Li S, Gordon W, He J, Liou G, Hill J, et al. Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein. J Neurosci. 2013;33:17458-68 pubmed publisher
    Interphotoreceptor retinoid-binding protein (IRBP) secreted by photoreceptors plays a pivotal role in photoreceptor survival with an unknown mechanism...
  3. Xu H, Wawrousek E, Redmond T, Nickerson J, Wiggert B, Chan C, et al. Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis. Eur J Immunol. 2000;30:272-8 pubmed
    Interphotoreceptor retinoid-binding protein (IRBP) is an immunologically privileged retinal antigen that can elicit experimental autoimmune uveitis (EAU)...
  4. Kolesnikov A, Tang P, Parker R, Crouch R, Kefalov V. The mammalian cone visual cycle promotes rapid M/L-cone pigment regeneration independently of the interphotoreceptor retinoid-binding protein. J Neurosci. 2011;31:7900-9 pubmed publisher
    ..In addition, it is not clear what role, if any, the abundant interphotoreceptor retinoid-binding protein (IRBP) presumed to facilitate the traffic of chromophore, plays in accelerating mammalian cone pigment regeneration...
  5. Redmond T, Yu S, Lee E, Bok D, Hamasaki D, Chen N, et al. Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet. 1998;20:344-51 pubmed
    ..Disruption of the RPE-based metabolism of all-trans-retinyl esters to 11-cis-retinal thus appears to underlie the Rpe65-/- phenotype, although cone pigment regeneration may be dependent on a separate pathway. ..
  6. Zhou R, Horai R, Silver P, Mattapallil M, Zárate Bladés C, Chong W, et al. The living eye "disarms" uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition. J Immunol. 2012;188:1742-50 pubmed publisher
    ..These findings shed new light on the phenomenon of immune privilege and on its role, as well as its limitations, in actively controlling immune responses in the tissue. ..
  7. Zhu L, Shen W, Lyons B, Wang Y, Zhou F, Gillies M. Dysregulation of inter-photoreceptor retinoid-binding protein (IRBP) after induced Müller cell disruption. J Neurochem. 2015;133:909-18 pubmed publisher
    ..chromatography followed by Tandem mass spectrometry identified it as Inter-photoreceptor retinoid-binding protein (IRBP)...
  8. Borst D, Boatright J, Si J, Stodulkova E, Remaley N, Pallansch L, et al. Structural characterization and comparison of promoter activity of mouse and bovine interphotoreceptor retinoid-binding protein (IRBP) gene 5' flanking regions in WERI, Y79, chick retina cells, and transgenic mice. Curr Eye Res. 2001;23:20-32 pubmed
    To determine the sequences of the mouse and bovine interphotoreceptor retinoid-binding protein (IRBP) 5' flanking regions and whether these 5' flanking regions contain functional IRBP promoter activity in multiple cell types using both ..
  9. Serizawa K, Suzuki H, Tsuchiya K. A phylogenetic view on species radiation in Apodemus inferred from variation of nuclear and mitochondrial genes. Biochem Genet. 2000;38:27-40 pubmed
    ..We examined the cytochrome b (cyt b) gene in mitochondrial DNA (1140 bp) and the interphotoreceptor retinoid binding protein (IRBP) gene in nuclear DNA (1152 bp) in nine species of Apodemus...
  10. Threadgill D, Womack J. Mapping HSA10 homologous loci in cattle. Cytogenet Cell Genet. 1991;57:123-6 pubmed
    ..aminotransferase (OAT) on HSA10 and MMU7; hexokinase 1 (HK1) on HSA10 and MMU10; retinol-binding protein 3 (RBP3) on HSA10 and MMU14; plasminogen activator, urokinase type (PLAU) on HSA10 and MMU14; and alpha-2-adrenergic ..
  11. Palczewski K, Van Hooser J, Garwin G, Chen J, Liou G, Saari J. Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry. 1999;38:12012-9 pubmed
    ..Interphotoreceptor retinoid-binding protein (IRBP) has been postulated to play a role in intercellular retinoid transfer in the retina; however, the rates of ..
  12. Boldison J, Khera T, Copland D, Stimpson M, Crawford G, Dick A, et al. A novel pathogenic RBP-3 peptide reveals epitope spreading in persistent experimental autoimmune uveoretinitis. Immunology. 2015;146:301-11 pubmed publisher
    ..The 629-643 RBP-3 peptide is a major uveitogenic peptide for the induction of EAU in C57BL/6J mice and the persistent clinical disease induced with one peptide leads to epitope spreading. ..
  13. Vasudevan K, Raber J, Sztein J. Fertility comparison between wild type and transgenic mice by in vitro fertilization. Transgenic Res. 2010;19:587-94 pubmed publisher
    ..For the WT the average fertility rate ranged from 80% (C57BL/6), 90% (FVB/N), 45% (129Sv/J x C57Bl/6)F1 and 43% (CD1). For transgenic mice it was 52% (C57BL/6), 65% (FVB/N), 22% (129Sv/J x C57Bl/6)F1 and 25% (CD1). ..
  14. Parker R, Crouch R. The interphotoreceptor retinoid binding (IRBP) is essential for normal retinoid processing in cone photoreceptors. Adv Exp Med Biol. 2010;664:141-9 pubmed publisher
    ..The interphotoreceptor retinoid-binding protein (IRBP) is a proposed retinoid transporter in the visual cycle, but rods in Irbp ( -/- ) mice have a normal visual cycle...
  15. Avichezer D, Liou G, Chan C, Lewis G, Wiggert B, Donoso L, et al. Interphotoreceptor retinoid-binding protein (IRBP)-deficient C57BL/6 mice have enhanced immunological and immunopathogenic responses to IRBP and an altered recognition of IRBP epitopes. J Autoimmun. 2003;21:185-94 pubmed
    ..responses of mice deficient in the retinal autoantigen interphotoreceptor retinoid-binding protein (IRBP). The consequences of IRBP deficiency on the T-cell repertoire were also investigated...
  16. Danciger M, Kozak C, Nickerson J, Redmond T, Farber D. Localization of the gene for interphotoreceptor retinoid-binding protein to mouse chromosome 14 near Np-1. Genomics. 1990;8:727-31 pubmed
    Interphotoreceptor retinoid-binding protein (IRBP) is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells...
  17. Suzuki H, Shimada T, Terashima M, Tsuchiya K, Aplin K. Temporal, spatial, and ecological modes of evolution of Eurasian Mus based on mitochondrial and nuclear gene sequences. Mol Phylogenet Evol. 2004;33:626-46 pubmed
    We sequenced mitochondrial (cytochrome b, 12S rRNA) and nuclear (IRBP, RAG1) genes for 17 species of the Old World murine genus Mus, drawn primarily from the Eurasian subgenus Mus...
  18. Suzuki H, Tsuchiya K, Takezaki N. A molecular phylogenetic framework for the Ryukyu endemic rodents Tokudaia osimensis and Diplothrix legata. Mol Phylogenet Evol. 2000;15:15-24 pubmed
    ..and Apodemus, Micromys, Mus, and Rattus, using an analysis of mitochondrial cytochrome b gene (1140 bp) and nuclear IRBP gene (782 bp) sequences...
  19. Vooijs M, te Riele H, van der Valk M, Berns A. Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells. Oncogene. 2002;21:4635-45 pubmed
    ..Our results highlight the important differences that exist in tumor susceptibility between mice and man (e.g pineal gland) and question the photoreceptor cell origin of human retinoblastoma. ..
  20. Barber S, Fultz M, Salkowski C, Vogel S. Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages. Infect Immun. 1995;63:601-8 pubmed
    ..Thus, the IRFs may represent yet an additional molecular pathway in the complex response to LPS. ..
  21. Li S, Yang Z, Hu J, Gordon W, Bazan N, Haas A, et al. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). J Biol Chem. 2013;288:11395-406 pubmed publisher
    Interphotoreceptor retinoid-binding protein (IRBP) secreted by photoreceptors plays a pivotal role in photoreceptor survival and function...
  22. Fernandez M, Copeland N, Gilbert D, Jenkins N, Morgan R. The genetic origin of mouse annexin VIII. Mamm Genome. 1998;9:8-14 pubmed
    ..Despite their synteny, the combined proximity and segregation of these three annexins diminished the likelihood that they were mutual gene duplication products. ..
  23. Arranz V, Dreuillet C, Crisanti P, Tillit J, Kress M, Ernoult Lange M. The zinc finger transcription factor, MOK2, negatively modulates expression of the interphotoreceptor retinoid-binding protein gene, IRBP. J Biol Chem. 2001;276:11963-9 pubmed
    ..MOK2-binding site was found within introns 7 and 2 of human PAX3 and interphotoreceptor retinoid-binding protein (IRBP) genes, respectively...
  24. Cui Y, Shao H, Lan C, Nian H, O Brien R, Born W, et al. Major role of gamma delta T cells in the generation of IL-17+ uveitogenic T cells. J Immunol. 2009;183:560-7 pubmed publisher
    We show that in vitro activation of interphotoreceptor retinoid-binding protein (IRBP)-specific T cells from C57BL/6 mice immunized with an uveitogenic IRBP peptide (IRBP(1-20)) under TH17-polarizing conditions is associated with ..
  25. Boatright J, Borst D, Peoples J, Bruno J, Edwards C, Si J, et al. A major cis activator of the IRBP gene contains CRX-binding and Ret-1/PCE-I elements. Mol Vis. 1997;3:15 pubmed
    b>Interphotoreceptor retinoid binding protein (IRBP) is expressed exclusively and to high levels in photoreceptive cells...
  26. Stanhope M, Czelusniak J, Si J, Nickerson J, Goodman M. A molecular perspective on mammalian evolution from the gene encoding interphotoreceptor retinoid binding protein, with convincing evidence for bat monophyly. Mol Phylogenet Evol. 1992;1:148-60 pubmed
    ..on mammalian phylogeny deduced from the coding sequence of the single-copy nuclear gene for the interphotoreceptor retinoid binding protein (IRBP)...
  27. Cunningham N, Jenkins N, Gilbert D, Copeland N, Reddi A, Lee S. Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3. Growth Factors. 1995;12:99-109 pubmed
    ..Gdf10 was mapped to the proximal region of mouse chromosome 14 close to a region known to contain a spontaneous recessive mutation that is associated with a craniofacial defect. ..
  28. DeVoss J, Hou Y, Johannes K, Lu W, Liou G, Rinn J, et al. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med. 2006;203:2727-35 pubmed
    ..as a result of loss of thymic expression of a single eye antigen, interphotoreceptor retinoid-binding protein (IRBP)...
  29. Shuler R, Gross E, He W, Liou G, Nickerson J. Sequence analysis of the mouse IRBP gene and cDNA. Curr Eye Res. 2002;24:354-67 pubmed
    To understand the structure of the mouse interphotoreceptor retinoid-binding protein (IRBP) gene and to compare the predicted primary structure within each repeat of IRBP with its relatives...
  30. Darby K, Eyre H, Lapsys N, Copeland N, Gilbert D, Couzens M, et al. Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14. Genomics. 1997;46:513-5 pubmed
    ..The human Y4 subtype is most closely related to the Y1-receptor subtype (42%), suggesting that it evolved from an ancestral Y1-like receptor via an RNA-mediated transpositional event. ..
  31. Cortes L, Mattapallil M, Silver P, Donoso L, Liou G, Zhu W, et al. Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice. Invest Ophthalmol Vis Sci. 2008;49:1946-56 pubmed publisher
    b>Interphotoreceptor retinoid binding protein (IRBP) is the major uveitogenic retinal antigen eliciting experimental autoimmune uveoretinitis (EAU) in mice. The most frequently used mouse strains are B10...
  32. Yeung R, Hino O, Vilensky M, Buetow K, Szpirer C, Szpirer J, et al. Assignment of 22 loci in the rat by somatic hybrid and linkage analysis. Mamm Genome. 1993;4:585-8 pubmed
    ..Results of this study further support the extensive conservation of synteny between the rat and mouse and, to a lesser degree, between rat and human. ..
  33. Kutty G, Duncan T, Nickerson J, Si J, van Veen T, Chader G, et al. Light deprivation profoundly affects gene expression of interphotoreceptor retinoid-binding protein in the mouse eye. Exp Eye Res. 1994;58:65-75 pubmed
    ..appears to play a role in regulating gene and protein expression of interphotoreceptor retinoid-binding protein (IRBP), a protein that facilitates the transport of retinoids between the neural retina and pigment epithelium in the ..
  34. Boatright J, Dalal N, Chrenek M, Gardner C, Ziesel A, Jiang Y, et al. Methodologies for analysis of patterning in the mouse RPE sheet. Mol Vis. 2015;21:40-60 pubmed
    ..Subtle differences between the RPE sheet characteristics of young and old mice were identified. The IRBP(-/-) mouse RPE sheet did not differ from C57BL/6J (wild type, WT), suggesting that IRBP does not play a direct role ..
  35. Taniguchi R, DeVoss J, Moon J, Sidney J, Sette A, Jenkins M, et al. Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A. 2012;109:7847-52 pubmed publisher
    ..T cells specific for the Aire-dependent tissue-specific antigen interphotoreceptor retinoid-binding protein (IRBP), in the polyclonal repertoire...
  36. Bibb L, Holt J, Tarttelin E, Hodges M, Gregory Evans K, Rutherford A, et al. Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development. Hum Mol Genet. 2001;10:1571-9 pubmed
    ..c., implying that it would be unable to transactivate PDEB, IRBP and arrestin, which were all expressed before 15 weeks...
  37. Rutherford A, Dhomen N, Smith H, Sowden J. Delayed expression of the Crx gene and photoreceptor development in the Chx10-deficient retina. Invest Ophthalmol Vis Sci. 2004;45:375-84 pubmed
    ..rhodopsin, peripherin, rod phosphodiesterase beta (Pdeb), and arrestin, with the exception of interphotoreceptor retinoid binding protein (Irbp), was delayed in the Chx10(or-J/or-J) retina...
  38. Horai R, Zárate Bladés C, Dillenburg Pilla P, Chen J, Kielczewski J, Silver P, et al. Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity. 2015;43:343-53 pubmed publisher
  39. Mishina Y, Suzuki A, Gilbert D, Copeland N, Jenkins N, Ueno N, et al. Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor. Biochem Biophys Res Commun. 1995;206:310-7 pubmed
    ..4-kb. The BMP-2/4 receptor gene (Bmpr) was mapped to mouse chromosome 14. Bmpr is closely linked to Rbp3 in the region containing pugnose, a mutation that alters bone development...