Gene Symbol: Rbp1
Description: retinol binding protein 1, cellular
Alias: CRBPI, Crbp, Rbp-1, retinol-binding protein 1, CRBP-I, cellular retinol-binding protein I, mCRBPI
Species: mouse
Products:     Rbp1

Top Publications

  1. Liang X, Sun Y, Schneider J, Ding J, Cheng H, Ye M, et al. Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures. Circ Res. 2007;100:527-35 pubmed
    ..Together, our results demonstrate that Pinch1 plays an essential role in neural crest development, perhaps in part through transforming growth factor-beta signaling. ..
  2. Grondona J, Kastner P, Gansmuller A, Decimo D, Chambon P, Mark M. Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice. Development. 1996;122:2173-88 pubmed
    ..RPE) cells display histological and/or ultrastructural alterations and/or fail to express cellular retinol binding protein I (CRBPI)...
  3. Pravenec M, Kren V, Szpirer C, Szpirer J. Assignment of the cellular retinol binding protein 1 (Rbp1) and hepatic lipase (Lipc) genes to rat chromosome 8. Folia Biol (Praha). 1997;43:97-9 pubmed
    Genes for the cellular retinol binding protein 1 (Rbp1) and hepatic lipase (Lipc) were assigned to chromosome 8 of the rat by the PCR analysis of somatic cell hybrids...
  4. Ghyselinck N, Bavik C, Sapin V, Mark M, Bonnier D, Hindelang C, et al. Cellular retinol-binding protein I is essential for vitamin A homeostasis. EMBO J. 1999;18:4903-14 pubmed
    The gene encoding cellular retinol (ROL, vitA)-binding protein type I (CRBPI) has been inactivated. Mutant mice fed a vitA-enriched diet are healthy and fertile...
  5. Ruberte E, Dolle P, Chambon P, Morriss Kay G. Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos. Development. 1991;111:45-60 pubmed
    ..receptors, RAR-alpha, -beta and -gamma, and the cellular binding proteins for retinoic acid (CRABP I) and retinol (CRBP I), in mouse embryos during the period of early morphogenesis...
  6. Corbin J, Rutlin M, Gaiano N, Fishell G. Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning. Development. 2003;130:4895-906 pubmed
    ..1 dependent specification of oligodendrocytes. Therefore, both integrative and antagonistic interactions between homeodomain-containing transcription factors contribute to the patterning of the telencephalon. ..
  7. Li H, Zhang Z, Wang B, Zhang J, Zhao Y, Jin Y. Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells. Mol Cell Biol. 2007;27:5296-305 pubmed
    ..These results indicate that Wwp2 plays an important role in regulating expression of Rpb1 in normal physiological conditions. ..
  8. Sapin V, Dolle P, Hindelang C, Kastner P, Chambon P. Defects of the chorioallantoic placenta in mouse RXRalpha null fetuses. Dev Biol. 1997;191:29-41 pubmed
    ..Thus, placental defects could represent an extraembryonic cause of lethality for RXRalpha null mutant fetuses, in addition to the previously described embryonic cardiac defects. ..
  9. Saari J, Nawrot M, Garwin G, Kennedy M, Hurley J, Ghyselinck N, et al. Analysis of the visual cycle in cellular retinol-binding protein type I (CRBPI) knockout mice. Invest Ophthalmol Vis Sci. 2002;43:1730-5 pubmed
    ..the visual cycle is affected in mice without a functional gene for cellular retinol-binding protein type I (CRBPI(-/-) mice)...

More Information


  1. Kastner P, Lawrence H, Waltzinger C, Ghyselinck N, Chambon P, Chan S. Positive and negative regulation of granulopoiesis by endogenous RARalpha. Blood. 2001;97:1314-20 pubmed
    ..Thus, the block in granulopoiesis exerted by RARalpha fusion proteins expressed in APL cells may correspond to an amplification of a normal function of unliganded RARalpha. ..
  2. Monroe D, Hawse J, Subramaniam M, Spelsberg T. Retinoblastoma binding protein-1 (RBP1) is a Runx2 coactivator and promotes osteoblastic differentiation. BMC Musculoskelet Disord. 2010;11:104 pubmed publisher
    ..The transcription factor retinoblastoma binding protein-1 (RBP1) was recently identified as an estrogen regulated gene in an osteosarcoma cell model...
  3. Matt N, Schmidt C, Dupé V, Dennefeld C, Nau H, Chambon P, et al. Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development. Dev Dyn. 2005;233:167-76 pubmed
    ..We show that, during development, ROL and retinyl ester levels are decreased in CRBP type 1 (CRBP1) -deficient embryos and fetuses by 50% and 80%, respectively...
  4. Gustafson A, Dencker L, Eriksson U. Non-overlapping expression of CRBP I and CRABP I during pattern formation of limbs and craniofacial structures in the early mouse embryo. Development. 1993;117:451-60 pubmed
    ..As revealed by immunohistochemistry using antibodies to cellular retinol-binding protein I (CRBP I), retinol accumulates in regions of the embryo expressing CRBP I...
  5. Farias E, Ong D, Ghyselinck N, Nakajo S, Kuppumbatti Y, Mira y Lopez R. Cellular retinol-binding protein I, a regulator of breast epithelial retinoic acid receptor activity, cell differentiation, and tumorigenicity. J Natl Cancer Inst. 2005;97:21-9 pubmed
    ..Cellular retinol-binding protein I (CRBP-I) functions in retinol storage and its expression is lower in human cancers than in normal cells...
  6. Pearsall R, Imai K, Shibata H, Hayashizaki Y, Chapman V, Held W, et al. The Rasgrf1-repeat sequence (D9Ncvs53) maps between Mod1 and Rbp1 on mouse chromosome 9 and may define a putative imprinted region. Mamm Genome. 1998;9:261-2 pubmed
  7. Farjo K, Moiseyev G, Nikolaeva O, Sandell L, Trainor P, Ma J. RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis. Dev Biol. 2011;357:347-55 pubmed publisher
    ..a membrane-bound cellular compartment, which prevents inhibition by the cytosolic cellular retinol-binding protein (RBP1)...
  8. Wongsiriroj N, Jiang H, Piantedosi R, Yang K, Kluwe J, Schwabe R, et al. Genetic dissection of retinoid esterification and accumulation in the liver and adipose tissue. J Lipid Res. 2014;55:104-14 pubmed publisher
    ..stressed by feeding a 25-fold excess retinol diet or upon ablation of cellular retinol-binding protein type I (CRBPI), which is proposed to limit retinol availability to ARATs...
  9. Mark M, Bloch Zupan A, Wolf C, Ruberte E, Ruch J. Involvement of cellular retinoic acid-binding proteins I and II (CRABPI and CRABPII) and of the cellular retinol-binding protein I (CRBPI) in odontogenesis in the mouse. Differentiation. 1991;48:89-98 pubmed
    ..We have analyzed, by in situ hybridization, the distribution patterns of CRABPI, CRABPII and CRBPI transcripts during odontogenesis in the mouse...
  10. KANE M, Folias A, Pingitore A, Perri M, Krois C, Ryu J, et al. CrbpI modulates glucose homeostasis and pancreas 9-cis-retinoic acid concentrations. Mol Cell Biol. 2011;31:3277-85 pubmed publisher
    Cellular retinol-binding protein type I (CrbpI), encoded by Rpb1, serves as a chaperone of retinol homeostasis, but its physiological effects remain incompletely understood...
  11. Toresson H, Potter S, Campbell K. Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2. Development. 2000;127:4361-71 pubmed
  12. Toresson H, Mata De Urquiza A, Fagerstrom C, Perlmann T, Campbell K. Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation. Development. 1999;126:1317-26 pubmed
    ..These findings, therefore, strongly support the notion that local retinoid signalling within the lateral ganglionic eminence regulates striatal neuron differentiation. ..
  13. Timmons P, Rigby P, Poirier F. The murine seminiferous epithelial cycle is pre-figured in the Sertoli cells of the embryonic testis. Development. 2002;129:635-47 pubmed
  14. Miner L, Marley R. Chromosomal mapping of the psychomotor stimulant effects of cocaine in BXD recombinant inbred mice. Psychopharmacology (Berl). 1995;122:209-14 pubmed
    ..The largest associations for baseline activity were observed on chromosomes 5 and 9 and the largest associations for cocaine's psychomotor stimulant effects on chromosomes 3 and 17. ..
  15. Wendler C, Schmoldt A, Flentke G, Case L, Quadro L, Blaner W, et al. Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice. Circ Res. 2003;92:920-8 pubmed
    ..This murine model may have relevance to fetal development in human populations with inadequate retinoid intake. ..
  16. Villarroya F, Giralt M, Iglesias R. Retinoids and adipose tissues: metabolism, cell differentiation and gene expression. Int J Obes Relat Metab Disord. 1999;23:1-6 pubmed
    ..Retinoic acid (RA) has a specific effect on brown adipose tissue, because it activates transcription of the gene for uncoupling protein-1, responsible for brown fat thermogenesis. ..
  17. Mulligan M, Ponomarev I, Hitzemann R, Belknap J, Tabakoff B, Harris R, et al. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc Natl Acad Sci U S A. 2006;103:6368-73 pubmed
    ..locus on chromosome 9 were identified: Arhgef12, Carm1, Cryab, Cox5a, Dlat, Fxyd6, Limd1, Nicn1, Nmnat3, Pknox2, Rbp1, Sc5d, Scn4b, Tcf12, Vps11, and Zfp291 and four ESTs...
  18. Schubert S, Lamoureux N, Kilian K, Klein Hitpass L, Hashemolhosseini S. Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1. J Biol Chem. 2008;283:5460-5 pubmed publisher
    ..5. Our data demonstrate for the first time that genes encoding key regulators of placental tissue formation and architecture are regulated by GCMa. ..
  19. Johansson S, Gustafson A, Donovan M, Romert A, Eriksson U, Dencker L. Retinoid binding proteins in mouse yolk sac and chorio-allantoic placentas. Anat Embryol (Berl). 1997;195:483-90 pubmed
    ..binding proteins such as the plasma retinol binding protein (RBP), the cellular retinol binding protein type I (CRBP I), and also the cellular receptors for RBP are thought to regulate transport and metabolism of retinol (vitamin A)...
  20. Kasahara M, Matsumura E, Webb G, Board P, Figueroa F, Klein J. Mapping of class alpha glutathione S-transferase 2 (GST-2) genes to the vicinity of the d locus on mouse chromosome 9. Genomics. 1990;8:90-6 pubmed
    ..The fact that the syntenic group extends across the centromere of human chromosome 6 can best be explained by a pericentric inversion postulated to have taken place in the primate lineage leading to Catarhini. ..
  21. Turkoz M, Townsend R, Kopan R. The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development. J Invest Dermatol. 2016;136:1106-1115 pubmed publisher
    ..Minimal amounts of the Notch intracellular domain were sufficient for rescue, which was not mediated by transcription, suggesting that the Notch intracellular domain is acting through a novel mechanism. ..
  22. Farias E, Marzan C, Mira y Lopez R. Cellular retinol-binding protein-I inhibits PI3K/Akt signaling through a retinoic acid receptor-dependent mechanism that regulates p85-p110 heterodimerization. Oncogene. 2005;24:1598-606 pubmed
    Downregulation of the cellular retinol-binding protein-I (CRBP-I) occurs in breast and other human cancers, but its significance is not well understood...
  23. Rubin W, LaMantia A. Age-dependent retinoic acid regulation of gene expression distinguishes the cervical, thoracic, lumbar, and sacral spinal cord regions during development. Dev Neurosci. 1999;21:113-25 pubmed
    ..These observations suggest that the local availability of RA establishes absolute differences in gene expression that distinguish the thoracic and sacral cord from the cervical and lumbar cord during midgestation. ..
  24. Gustafson A, Eriksson U, Dencker L. CRBP I and CRABP I localisation during olfactory nerve development. Brain Res Dev Brain Res. 1999;114:121-6 pubmed
    ..Immunohistochemistry was used to localise the cellular retinoid binding-proteins for retinol (CRBP I) and retinoic acid (CRABP I) in the embryonic and adult olfactory system...
  25. Ruberte E, Friederich V, Morriss Kay G, Chambon P. Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis. Development. 1992;115:973-87 pubmed
    ..Interestingly, the expression of the three genes, RAR-beta, CRABP II and CRBP I, is induced by retinoic acid, which suggests a link between the synthesis of RA from retinol and the control of ..
  26. Berry D, O Byrne S, Vreeland A, Blaner W, Noy N. Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6. Mol Cell Biol. 2012;32:3164-75 pubmed publisher
    ..by STRA6-mediated translocation of retinol from serum RBP to an intracellular acceptor, the retinol-binding protein CRBP-I...
  27. Pierzchalski K, Yu J, Norman V, KANE M. CrbpI regulates mammary retinoic acid homeostasis and the mammary microenvironment. FASEB J. 2013;27:1904-16 pubmed publisher
    Cellular retinol-binding protein, type I (CrbpI), encoded by retinol-binding protein, type 1 (Rbp1), is a chaperone of vitamin A (retinol) that is epigenetically silenced in ~25% of human breast cancers...
  28. Billings S, Pierzchalski K, Butler Tjaden N, Pang X, Trainor P, KANE M, et al. The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J. 2013;27:4877-89 pubmed publisher
    ..These data demonstrate that the reduction of retinaldehyde by DHRS3 is critical for preventing formation of excess ATRA during embryonic development...
  29. Rühl R, Krzyżosiak A, Niewiadomska Cimicka A, Rochel N, Szeles L, Vaz B, et al. 9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice. PLoS Genet. 2015;11:e1005213 pubmed publisher
    ..We show here that mice lacking cellular retinol binding protein (Rbp1-/-) display memory deficits reflecting compromised RXR signaling...
  30. Makita T, Duncan S, Sucov H. Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol. 2005;280:59-72 pubmed
    ..5 onward is enhancer-independent, and is driven instead by basal promoter elements that provide a sufficient level of expression to support further erythropoietic differentiation. ..
  31. Smith W, Nakshatri H, Leroy P, Rees J, Chambon P. A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter. EMBO J. 1991;10:2223-30 pubmed
    Genomic and cDNA sequences for the mouse cellular retinol binding protein I (mCRBPI) are presented. A specific cis-acting element responsible for retinoic acid (RA) inducibility of the mCRBPI promoter was identified and characterized...
  32. Thompson C, Selby C, Van Gelder R, Blaner W, Lee J, Quadro L, et al. Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice. J Biol Rhythms. 2004;19:504-17 pubmed
    ..These data demonstrate that both cryptochromes and opsins regulate nonvisual photoresponses. ..
  33. Maden M, Ong D, Chytil F. Retinoid-binding protein distribution in the developing mammalian nervous system. Development. 1990;109:75-80 pubmed
    We have analysed the distribution of cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP) in the day 8.5-day 12 mouse and rat embryo...
  34. Wei L, Blaner W, Goodman D, Nguyen Huu M. Regulation of the cellular retinoid-binding proteins and their messenger ribonucleic acids during P19 embryonal carcinoma cell differentiation induced by retinoic acid. Mol Endocrinol. 1989;3:454-63 pubmed
    ..of expression of the genes for cellular retinoic acid-binding protein (CRABP) and cellular retinol-binding protein (CRBP) in P19 cells induced to differentiate by RA...
  35. Dolle P, Ruberte E, Leroy P, Morriss Kay G, Chambon P. Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis. Development. 1990;110:1133-51 pubmed
    ..beta and gamma (RAR-alpha, -beta and -gamma), and the cellular binding proteins for retinol and retinoic acid (CRBP, CRABP) in non-neural tissues of mouse embryos during the period of organogenesis...
  36. Yamamoto M, Drager U, Ong D, McCaffery P. Retinoid-binding proteins in the cerebellum and choroid plexus and their relationship to regionalized retinoic acid synthesis and degradation. Eur J Biochem. 1998;257:344-50 pubmed
    The expression of cellular retinoic-acid-binding protein (CRABP) and cellular retinol-binding protein (CRBP), as well as their relationship to retinoic acid (RA) synthesis and degradation were examined in the developing mouse cerebellum ..
  37. Romand R, Sapin V, Ghyselinck N, Avan P, Le Calvez S, Dolle P, et al. Spatio-temporal distribution of cellular retinoid binding protein gene transcripts in the developing and the adult cochlea. Morphological and functional consequences in CRABP- and CRBPI-null mutant mice. Eur J Neurosci. 2000;12:2793-804 pubmed
    ..The cellular retinoic acid binding protein II (CRABPII) and cellular retinol binding protein I (CRBPI) were present in a widespread and abundant pattern in cochlear structures during ..
  38. Werten P, Roll B, van Aalten D, de Jong W. Gecko iota-crystallin: how cellular retinol-binding protein became an eye lens ultraviolet filter. Proc Natl Acad Sci U S A. 2000;97:3282-7 pubmed
    ..This protein is related to cellular retinol-binding protein type I (CRBP I) but has 3,4-didehydroretinol, rather than retinol, as a ligand...
  39. Sapin V, Ward S, Bronner S, Chambon P, Dolle P. Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse. Dev Dyn. 1997;208:199-210 pubmed
    ..of transcripts from genes encoding the retinol binding protein (RBP), the cellular retinol binding proteins (CRBP I, II) and retinoic acid binding proteins (CRABP I, II), the retinaldehyde dehydrogenase type 2 (RALDH-2), the ..
  40. Toyofuku T, Nojima S, Ishikawa T, Takamatsu H, Tsujimura T, Uemura A, et al. Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival. Genes Dev. 2012;26:816-29 pubmed publisher
    ..Our findings therefore indicate that Sema4A regulates two distinct endosomal-sorting pathways that are critical for photoreceptor survival and phototransduction during the transition between daylight and darkness. ..
  41. Kwong J, Lo K, Chow L, To K, Choy K, Chan F, et al. Epigenetic silencing of cellular retinol-binding proteins in nasopharyngeal carcinoma. Neoplasia. 2005;7:67-74 pubmed
    ..Apart from RARbeta2, transcriptional silencing of two CRBPs, CRBPI and CRBPIV, was observed in NPC cell lines and xenografts...
  42. Piantedosi R, Ghyselinck N, Blaner W, Vogel S. Cellular retinol-binding protein type III is needed for retinoid incorporation into milk. J Biol Chem. 2005;280:24286-92 pubmed
    The physiologic role(s) of cellular retinol-binding protein (CRBP)-III, an intracellular retinol-binding protein that is expressed solely in heart, muscle, adipose, and mammary tissue, remains to be elucidated...
  43. Schrick J, Lingrel J. cDNA cloning, mapping and expression of the mouse propionyl CoA carboxylase beta (pccb), the gene for human type II propionic acidaemia. Gene. 2001;264:147-52 pubmed
    ..Northern blots of adult tissue show that the pccb gene is broadly expressed in the mouse. The approximately 2.3 kb transcript is most abundantly expressed in the kidney, liver, small intestine and stomach tissues. ..
  44. Ruberte E, Friederich V, Chambon P, Morriss Kay G. Retinoic acid receptors and cellular retinoid binding proteins. III. Their differential transcript distribution during mouse nervous system development. Development. 1993;118:267-82 pubmed
    ..retinoic acid binding proteins type I and II (CRABP I and CRABP II) and cellular retinol binding protein type I (CRBP I), were widely distributed in developing neural structures...
  45. Huang P, Ceccatelli S, Hoegberg P, Sten Shi T, Hakansson H, Rannug A. TCDD-induced expression of Ah receptor responsive genes in the pituitary and brain of cellular retinol-binding protein (CRBP-I) knockout mice. Toxicol Appl Pharmacol. 2003;192:262-74 pubmed
    ..TCDD exposure in wild-type 129/SV/C57BL/6 mice and in mice deficient in cellular retinol-binding protein type I (CRBP-I) of the same mixed genetic background. A single oral dose of TCDD (50 or 250 mug/kg) was administrated by gavage...
  46. Vogel S, Mendelsohn C, Mertz J, Piantedosi R, Waldburger C, Gottesman M, et al. Characterization of a new member of the fatty acid-binding protein family that binds all-trans-retinol. J Biol Chem. 2001;276:1353-60 pubmed
    Cellular retinol-binding protein, type I (CRBP-I) and type II (CRBP-II) are the only members of the fatty acid-binding protein (FABP) family that process intracellular retinol...
  47. Graham A, Maden M, Krumlauf R. The murine Hox-2 genes display dynamic dorsoventral patterns of expression during central nervous system development. Development. 1991;112:255-64 pubmed
    ..The cellular retinol binding protein (CRBP) shows a complementary ventral staining pattern, suggesting that a number of genes are dorsoventrally restricted ..
  48. Bojanic D, Tarr P, Gale G, Smith D, Bok D, Chen B, et al. Differential expression and function of ABCG1 and ABCG4 during development and aging. J Lipid Res. 2010;51:169-81 pubmed publisher
    ..Finally, behavioral tests show that Abcg4(-/-) mice have a general deficit in associative fear memory. Together, these data indicate that loss of ABCG1 and/or ABCG4 from the CNS results in changes in metabolic pathways and in behavior...
  49. Whitesides J, Hall M, Anchan R, LaMantia A. Retinoid signaling distinguishes a subpopulation of olfactory receptor neurons in the developing and adult mouse. J Comp Neurol. 1998;394:445-61 pubmed
  50. Acuna C, Liu X, Sudhof T. How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs. Neuron. 2016;91:792-807 pubmed publisher
    ..Thus, RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions. ..
  51. Ulven S, Gundersen T, Weedon M, Landaas V, Sakhi A, Fromm S, et al. Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid. Dev Biol. 2000;220:379-91 pubmed
    ..Therefore, our results suggest that RALDH2 is a key regulator in initiating retinoic acid synthesis sometime between the mid-primitive streak stage and the late allantoic bud stage in mouse embryos. ..
  52. Santos J, Cole Y, Pellicer A. Phylogenetic relationships among laboratory and wild-origin Mus musculus strains on the basis of genomic DNA RFLPs. Mamm Genome. 1993;4:485-92 pubmed
    ..Natural. 106,283, 1972) and unbiased minimum (Genetics 89,583, 1978), Edwards (Biometrics 27,873, 1971; Genetic Distance, p. 41, 1974) and Rogers modified (1986). ..
  53. Molotkov A, Ghyselinck N, Chambon P, Duester G. Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation. Biochem J. 2004;383:295-302 pubmed