Rbm17

Summary

Gene Symbol: Rbm17
Description: RNA binding motif protein 17
Alias: 2700027J02Rik, splicing factor 45, 45 kDa-splicing factor
Species: mouse
Products:     Rbm17

Top Publications

  1. Lim J, Crespo Barreto J, Jafar Nejad P, Bowman A, Richman R, Hill D, et al. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature. 2008;452:713-8 pubmed publisher
    ..Polyglutamine expansion in ATXN1 favours the formation of a particular protein complex containing RBM17, contributing to SCA1 neuropathology by means of a gain-of-function mechanism...
  2. Lai S, O Callaghan B, Zoghbi H, Orr H. 14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus. J Biol Chem. 2011;286:34606-16 pubmed publisher
    ..a region of ATXN1 that harbors several functional motifs including binding sites for 14-3-3, and splicing factors RBM17 and U2AF65...
  3. Tan Q, Yalamanchili H, Park J, De Maio A, Lu H, Wan Y, et al. Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models. Hum Mol Genet. 2016;25:5083-5093 pubmed publisher
    ..Here we report that constitutive deletion of Rbm17, which encodes an RBP with a putative role in splicing, causes early embryonic lethality in mice and that its loss ..