Rbl2

Summary

Gene Symbol: Rbl2
Description: RB transcriptional corepressor like 2
Alias: PRB2, RBR-2, Rb2, p130, retinoblastoma-like protein 2, 130 kDa retinoblastoma-associated protein, retinoblastoma-like 2, retinoblastoma-related protein 2
Species: mouse
Products:     Rbl2

Top Publications

  1. Mantela J, Jiang Z, Ylikoski J, Fritzsch B, Zacksenhaus E, Pirvola U. The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development. 2005;132:2377-88 pubmed
    ..Our findings demonstrate that the pRb pathway is required for hair cell quiescence and that manipulation of the cell cycle machinery disrupts the coordinated development within the inner ear sensory epithelia. ..
  2. Haigis K, Sage J, Glickman J, Shafer S, Jacks T. The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. J Biol Chem. 2006;281:638-47 pubmed
    pRb, p107, and p130 are related proteins that play a central role in the regulation of cell cycle progression and terminal differentiation in mammalian cells...
  3. Dannenberg J, van Rossum A, Schuijff L, te Riele H. Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev. 2000;14:3051-64 pubmed
    The retinoblastoma suppressor pRB belongs to the family of so-called pocket proteins, which also includes p107 and p130. These proteins may functionally overlap in cell cycle control and tumor suppression...
  4. Spencer C, Pajovic S, Devlin H, Dinh Q, Corson T, Gallie B. Distinct patterns of expression of the RB gene family in mouse and human retina. Gene Expr Patterns. 2005;5:687-94 pubmed
    ..Murine retinoblastoma is initiated only when two of the RB family of genes, RB1 and p107 or p130, are inactivated...
  5. Gonzalo S, García Cao M, Fraga M, Schotta G, Peters A, Cotter S, et al. Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol. 2005;7:420-8 pubmed
    ..Mouse embryonic fibroblasts that are triply deficient for RB1 (retinoblastoma 1), RBL1 (retinoblastoma-like 1) and RBL2 (retinoblastoma-like 2) - known as TKO cells - show a marked genomic instability, which is coincidental with ..
  6. Viatour P, Ehmer U, Saddic L, Dorrell C, Andersen J, Lin C, et al. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med. 2011;208:1963-76 pubmed publisher
    ..the RB pathway in the liver of adult mice by deleting the three members of the Rb (Rb1) gene family: Rb, p107, and p130. Rb family triple knockout mice develop liver tumors with histopathological features and gene expression profiles ..
  7. Shin M, Pitot H, Lambert P. Pocket proteins suppress head and neck cancer. Cancer Res. 2012;72:1280-9 pubmed publisher
    ..of mice deficient in the expression of pRb and either of two related "pocket" proteins, p107 and p130, that are also inactivated by E7...
  8. Wirt S, Adler A, Gebala V, Weimann J, Schaffer B, Saddic L, et al. G1 arrest and differentiation can occur independently of Rb family function. J Cell Biol. 2010;191:809-25 pubmed publisher
    ..Here, we tested the requirement for the retinoblastoma (Rb) protein and its family members p107 and p130 in G0/G1 arrest and differentiation in mammalian cells...
  9. Mulligan G, Wong J, Jacks T. p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB. Mol Cell Biol. 1998;18:206-20 pubmed
    The proteins encoded by the retinoblastoma gene family, pRB, p107, and p130, have been implicated in the regulation of cellular proliferation, differentiation, and transformation...

More Information

Publications82

  1. Chen H, Gu X, Liu Y, Wang J, Wirt S, Bottino R, et al. PDGF signalling controls age-dependent proliferation in pancreatic ?-cells. Nature. 2011;478:349-55 pubmed publisher
    ..The discovery of a conserved pathway controlling age-dependent ?-cell proliferation indicates new strategies for ?-cell expansion. ..
  2. Lipinski M, Jacks T. The retinoblastoma gene family in differentiation and development. Oncogene. 1999;18:7873-82 pubmed
    The retinoblastoma (Rb) tumor suppressor gene and its close relatives p107 and p130 are best known for their function in the control of cell cycle progression...
  3. MacPherson D, Sage J, Kim T, Ho D, McLaughlin M, Jacks T. Cell type-specific effects of Rb deletion in the murine retina. Genes Dev. 2004;18:1681-94 pubmed
    ..Conditional Rb mutation in the retina did not result in retinoblastoma formation even in a p53-mutant background. However, on a p107- or p130-deficient background, Rb mutation in the retina caused retinal dysplasia or retinoblastoma.
  4. Park K, Martelotto L, Peifer M, Sos M, Karnezis A, Mahjoub M, et al. A crucial requirement for Hedgehog signaling in small cell lung cancer. Nat Med. 2011;17:1504-8 pubmed publisher
  5. Cobrinik D, Lee M, Hannon G, Mulligan G, Bronson R, Dyson N, et al. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 1996;10:1633-44 pubmed
    The p130 protein shares extensive sequence similarity with pRB, the product of the retinoblastoma gene, and is a major E2F-associated protein in quiescent cells...
  6. Hurford R, Cobrinik D, Lee M, Dyson N. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 1997;11:1447-63 pubmed
    ..is controlled by physical association with the retinoblastoma protein (pRB) and two related proteins, p107 and p130. The pRB family members are thought to control different aspects of E2F activity, but it has been unclear what the ..
  7. Shin M, Sage J, Lambert P. Inactivating all three rb family pocket proteins is insufficient to initiate cervical cancer. Cancer Res. 2012;72:5418-27 pubmed publisher
    ..in part by binding and inducing the degradation of pRb and its related pocket protein family members, p107 and p130. The ability of E7 to inactivate the pRb family correlates with its ability to induce head and neck cancers in mice...
  8. Simpson D, Mason Richie N, Gettler C, Wikenheiser Brokamp K. Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis. Cancer Res. 2009;69:8733-41 pubmed publisher
    ..than Rb loss, suggesting that p16 suppresses cancer by regulating Rb as well as the related proteins p107 and p130. However, direct evidence demonstrating that p130 or p107 cooperate with Rb to suppress epithelial cancers ..
  9. Dannenberg J, Schuijff L, Dekker M, van der Valk M, te Riele H. Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev. 2004;18:2952-62 pubmed
    The retinoblastoma gene family consists of three genes: RB, p107, and p130. While loss of pRB causes retinoblastoma in humans and pituitary gland tumors in mice, tumorigenesis in other tissues may be suppressed by p107 and p130...
  10. Jackson M, Agarwal M, Yang J, Bruss P, Uchiumi T, Agarwal M, et al. p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2. J Cell Sci. 2005;118:1821-32 pubmed
    ..Our studies reported here show that p130 and p107 play a key role in transcriptional repression of genes required for G2 and M in response to DNA damage...
  11. Thomas D, Carty S, Piscopo D, Lee J, Wang W, Forrester W, et al. The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Mol Cell. 2001;8:303-16 pubmed
    ..Loss of pRb but not p107 or p130 blocks late osteoblast differentiation...
  12. Lee M, Williams B, Mulligan G, Mukai S, Bronson R, Dyson N, et al. Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 1996;10:1621-32 pubmed
    ..These results provide the first in vivo evidence that p107 and Rb have overlapping functions in some tissues of the developing and adult mouse...
  13. Rossi F, MacLean H, Yuan W, Francis R, Semenova E, Lin C, et al. p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development. Dev Biol. 2002;247:271-85 pubmed
    ..Through analysis of mice lacking the pRB-related p107 and p130 proteins, we found that p107 was required in prechondrogenic condensations for cell cycle withdrawal and for ..
  14. Laplantine E, Rossi F, Sahni M, Basilico C, Cobrinik D. FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest. J Cell Biol. 2002;158:741-50 pubmed
    ..Because mice with targeted mutations of the retinoblastoma (Rb)-related proteins p107 and p130 present severe endochondral bone defects with excessive chondrocyte proliferation, we have investigated the role of ..
  15. Wikenheiser Brokamp K. Retinoblastoma family proteins: insights gained through genetic manipulation of mice. Cell Mol Life Sci. 2006;63:767-80 pubmed
    ..Animals lacking Rb and/or its family members p107 and p130 have led scientists to uncover new and exciting roles for this protein family in development as well as tumor ..
  16. Viatour P, Somervaille T, Venkatasubrahmanyam S, Kogan S, McLaughlin M, Weissman I, et al. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell. 2008;3:416-28 pubmed publisher
    ..Here we employed a conditional knockout strategy to simultaneously inactivate all three members, Rb, p107, and p130, in adult hematopoietic stem cells (HSCs)...
  17. Yang Y, Topol L, Lee H, Wu J. Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development. 2003;130:1003-15 pubmed
    ..We find that important cell cycle regulators such as cyclin D1 and p130, a member of the retinoblastoma family, exhibit complimentary expression patterns that correlate with the distinct ..
  18. Sage J, Mulligan G, Attardi L, Miller A, Chen S, Williams B, et al. Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev. 2000;14:3037-50 pubmed
    The retinoblastoma protein, pRB, and the closely related proteins p107 and p130 are important regulators of the mammalian cell cycle...
  19. LeCouter J, Kablar B, Hardy W, Ying C, Megeney L, May L, et al. Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene. Mol Cell Biol. 1998;18:7455-65 pubmed
    ..Mutant embryos expressed approximately twice the normal level of Rb, whereas p130 levels were unaltered...
  20. Schaffer B, Park K, Yiu G, Conklin J, Lin C, Burkhart D, et al. Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. Cancer Res. 2010;70:3877-83 pubmed publisher
    ..Emerging evidence in patients and mouse models suggests that p130, a gene related to RB, may act as a tumor suppressor in SCLC cells...
  21. Ho V, Schaffer B, Karnezis A, Park K, Sage J. The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras. Oncogene. 2009;28:1393-9 pubmed publisher
    ..Emerging evidence also suggests that the RB-related gene p130 is inactivated in a subset of human NSCLCs...
  22. LeCouter J, Kablar B, Whyte P, Ying C, Rudnicki M. Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene. Development. 1998;125:4669-79 pubmed
    The retinoblastoma-related p130 protein is a member of a conserved family, consisting of Rb, p107 and p130, which are believed to play important roles in cell-cycle control and cellular differentiation...
  23. MacLellan W, Garcia A, Oh H, Frenkel P, Jordan M, Roos K, et al. Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb. Mol Cell Biol. 2005;25:2486-97 pubmed
    ..Since both Rb and p130 are expressed in the adult myocardium, we created double-knockout mice (CRbL/L p130-/-) to determine it these ..
  24. Jiang Z, Zacksenhaus E, Gallie B, Phillips R. The retinoblastoma gene family is differentially expressed during embryogenesis. Oncogene. 1997;14:1789-97 pubmed
    We report differential expression of the RB1 tumor suppressor gene and the homologous genes p107 and p130 during embryogenesis...
  25. Burkhart D, Ngai L, Roake C, Viatour P, Thangavel C, Ho V, et al. Regulation of RB transcription in vivo by RB family members. Mol Cell Biol. 2010;30:1729-45 pubmed publisher
    ..Using these reporter mice and mutant alleles for Rb, p107, and p130, we found that RB family members modulate Rb transcription in specific cell populations in vivo and in culture...
  26. Ashe M, Pabon Peña L, Dees E, Price K, Bader D. LEK1 is a potential inhibitor of pocket protein-mediated cellular processes. J Biol Chem. 2004;279:664-76 pubmed
    ..We show that LEK1 interacts with all three pocket proteins, p107, p130, and pRb...
  27. Prince A, May J, Burton G, Lyle R, McGehee R. Proteasomal degradation of retinoblastoma-related p130 during adipocyte differentiation. Biochem Biophys Res Commun. 2002;290:1066-71 pubmed
    ..24 h of hormonally stimulated 3T3-L1 adipocyte differentiation, there are dramatic changes in the protein levels of p130 and p107, two members of the retinoblastoma tumor suppressor gene family...
  28. Chung J, Karkhanis V, Tae S, Yan F, Smith P, Ayers L, et al. Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing. J Biol Chem. 2013;288:35534-47 pubmed publisher
    ..lymphoma cells and that it up-regulates PRC2 expression through inactivation of the retinoblastoma proteins RB1 and RBL2. Although PRMT5 epigenetically controls RBL2 expression, it indirectly promotes RB1 phosphorylation through ..
  29. Vuong L, Brobst D, Saadi A, Ivanovic I, Al Ubaidi M. Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina. Invest Ophthalmol Vis Sci. 2012;53:4821-31 pubmed publisher
    ..Downregulation of p53 in the post-mitotic retina suggests that, although p53 may be involved in ocular and retinal development, it may play a minimal role in healthy adult retinal function. ..
  30. Han X, Li F, Fang Z, Gao Y, Li F, Fang R, et al. Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. Nat Commun. 2014;5:3261 pubmed publisher
    ..Collectively, our findings demonstrate the de novo transdifferentiation of lung ADC to SCC in mice and provide mechanistic insight that may have important implications for lung cancer treatment. ..
  31. Iyirhiaro G, Zhang Y, Estey C, O Hare M, Safarpour F, Parsanejad M, et al. Regulation of ischemic neuronal death by E2F4-p130 protein complexes. J Biol Chem. 2014;289:18202-13 pubmed publisher
    ..Following stress exposure, E2F4-p130 complexes are lost rapidly along with the presence of E2F4 at E2F-containing B-Myb promoter sites...
  32. Blanchette P, Gilchrist C, Baker R, Gray D. Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130. Oncogene. 2001;20:5533-7 pubmed
    ..these proteins interact with the retinoblastoma gene product pRb, as well as the related 'pocket proteins' p107 and p130. We have explored the possibility that UNP interacts with pocket proteins, and report here that such associations ..
  33. Harrington E, Bruce J, Harlow E, Dyson N. pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc Natl Acad Sci U S A. 1998;95:11945-50 pubmed
    ..In contrast, the pRB related proteins p107 and p130 do not play an essential part in the DNA damage response...
  34. El Naggar S, Liu Y, Dean D. Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation. Mol Cell Biol. 2009;29:5710-7 pubmed publisher
    ..These studies link inactivation of the Rb1 pathway, a hallmark of cancer, to accumulation of Akt-473, resistance to anoikis, and a block in c-Raf/Erk activation. ..
  35. Tonks I, Mukhopadhyay P, Schroder W, Sorolla A, Mould A, Handoko H, et al. Melanocyte transformation requires complete loss of all pocket protein function via a mechanism that mitigates the need for MAPK pathway activation. Oncogene. 2017;36:3789-3795 pubmed publisher
    ..However, there are also two other PPs, p107 and p130, which, when phosphorylated by CDK-cyclin complexes, play a role in permitting cell progression...
  36. Chen Q, Liang D, Overbeek P. Overexpression of E2F5/p130, but not E2F5 alone, can inhibit E2F-induced cell cycle entry in transgenic mice. Mol Vis. 2008;14:602-14 pubmed
    The retinoblastoma (Rb) gene family member p130 binds preferentially to the E2F5 transcription factor and forms a repressive E2F5/p130 complex that inhibits cell cycle progression and tumor growth...
  37. Ajioka I, Martins R, Bayazitov I, Donovan S, Johnson D, Frase S, et al. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell. 2007;131:378-90 pubmed
    ..The Rb family of proteins (Rb, p107, and p130) regulates cell-cycle exit and differentiation during retinogenesis...
  38. Spiller C, Wilhelm D, Jans D, Bowles J, Koopman P. Mice Lacking Hbp1 Function Are Viable and Fertile. PLoS ONE. 2017;12:e0170576 pubmed publisher
    ..Lastly, in a model of defective germ cell G1/G0 arrest, the Rb1-knockout model, we found no evidence for Hbp1 mis-regulation, suggesting that the reported RB1-HBP1 interaction is not critical in the germline, despite co-expression. ..
  39. Sindermann J, Smith J, Köbbert C, Plenz G, Skaletz Rorowski A, Solomon J, et al. Direct evidence for the importance of p130 in injury response and arterial remodeling following carotid artery ligation. Cardiovasc Res. 2002;54:676-83 pubmed
    ..Carotid artery ligation was applied to mice with targeted disruption of the p130 gene (p130 -/-)...
  40. Tarangelo A, Lo N, Teng R, Kim E, Le L, Watson D, et al. Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. Nat Commun. 2015;6:10028 pubmed publisher
    ..These data indicate that both the physiological and the oncogenic activities of E2f result in distinct transcriptional responses, which could be exploited to target E2f oncogenic activity for therapy. ..
  41. Miles W, Korenjak M, Griffiths L, Dyer M, Provero P, Dyson N. Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. EMBO J. 2014;33:2201-15 pubmed publisher
    ..Our data suggest that NANOS increases in importance in pRb-deficient cells and helps to maintain homeostasis by repressing the translation of transcripts containing PUM Regulatory Elements (PRE). ..
  42. Saeed M, Schwarze F, Loidl A, Meraner J, Lechner M, Loidl P. In vitro phosphorylation and acetylation of the murine pocket protein Rb2/p130. PLoS ONE. 2012;7:e46174 pubmed publisher
    The retinoblastoma protein (pRb) and the related proteins Rb2/p130 and 107 represent the "pocket protein" family of cell cycle regulators...
  43. Tonini T, Bagella L, D Andrilli G, Claudio P, Giordano A. Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A. Oncogene. 2004;23:4930-7 pubmed
    ..We observed that Ezh2 binds to pRb2/p130, a member of the retinoblastoma family; as such, we were led to consider the possible ability of Ezh2 to ..
  44. Rocha Sanchez S, Scheetz L, Contreras M, Weston M, Korte M, McGee J, et al. Mature mice lacking Rbl2/p130 gene have supernumerary inner ear hair cells and supporting cells. J Neurosci. 2011;31:8883-93 pubmed publisher
    ..The retinoblastoma (pRB) family of cell cycle regulators, Rb1, Rbl1 (p107), and Rbl2 (p130), regulate the G(1)- to S-phase transition in proliferating cells...
  45. Anjos Afonso F, Loizou J, Bradburn A, Kanu N, Purewal S, Da Costa C, et al. Perturbed hematopoiesis in mice lacking ATMIN. Blood. 2016;128:2017-2021 pubmed publisher
    ..ATMIN, therefore, has multiple roles in different cell types, and its absence results in perturbed hematopoiesis, especially during stress conditions and aging. ..
  46. Garfin P, Min D, Bryson J, Serwold T, Edris B, Blackburn C, et al. Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. J Exp Med. 2013;210:1087-97 pubmed publisher
    ..Thus, the RB family promotes thymic involution and controls T cell production via a bone marrow-independent mechanism, identifying a novel pathway to target to increase thymic function in patients...
  47. Petrenko O, Moll U. Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway. Mol Cell. 2005;17:225-36 pubmed
    ..A proinflammatory molecule interfering with tumor suppression and DNA replication provides a compelling molecular link for the association of chronic inflammation and tumorigenesis. ..
  48. Konishi M, Asaki T, Koike N, Miwa H, Miyake A, Itoh N. Role of Fgf10 in cell proliferation in white adipose tissue. Mol Cell Endocrinol. 2006;249:71-7 pubmed
    ..Both cyclin D2 expression and p130 phosphorylation were impaired in the Fgf10(-/-) WAT...
  49. Peters T, Ausmeier K, Dildrop R, Ruther U. The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb deletion including the entire Iroquois B gene cluster. Mamm Genome. 2002;13:186-8 pubmed
    ..6 Mb of genomic sequences on mouse Chromosome 8. Owing to this deletion, six genes, including the entire IroquoisB (IrxB) gene cluster, are directly affected by the Ft mutation. ..
  50. Lesche R, Peetz A, van der Hoeven F, Ruther U. Ft1, a novel gene related to ubiquitin-conjugating enzymes, is deleted in the Fused toes mouse mutation. Mamm Genome. 1997;8:879-83 pubmed
    ..of the longest Ft1 transcripts are identical to the reverse complement of the 3'-most sequences of the Rb-related p130 gene. Both genes are transcribed in opposite directions and overlap in their 3' UTRs...
  51. Lazaro S, Perez Crespo M, Enguita A, Hernandez P, Martínez Palacio J, Oteo M, et al. Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation. Oncotarget. 2017;8:4373-4386 pubmed publisher
    ..reported in lung cancer, mainly in small cell lung carcinoma, the tumor suppressive role of its relatives p107 and p130 is still a matter of debate...
  52. Benetti R, Gonzalo S, Jaco I, Muñoz P, Gonzalez S, Schoeftner S, et al. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol. 2008;15:268-79 pubmed publisher
    ..We identify the retinoblastoma-like 2 protein (Rbl2) as responsible for decreased Dnmt expression in Dicer1-null cells, suggesting the existence of Dicer-dependent ..
  53. Macaluso M, Caracciolo V, Rizzo V, Sun A, Montanari M, Russo G, et al. Integrating role of T antigen, Rb2/p130, CTCF and BORIS in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by chronic ER stress in mouse medulloblastoma. Cell Cycle. 2012;11:1841-50 pubmed publisher
    ..The diversity of these responses may be due, at least in part, to distinct activities of Rb2/p130, CTCF and BORIS proteins in response to an altered network of signaling evoked by the T-Ag presence...
  54. Chen G, Guy C, Chen H, Hu N, Lee E, Lee W. Molecular cloning and developmental expression of mouse p130, a member of the retinoblastoma gene family. J Biol Chem. 1996;271:9567-72 pubmed
    With sequence homology to the SV40 T antigen-binding domain of the retinoblastoma protein (Rb), p107 and p130 constitute two additional members of the Rb family...
  55. Farago A, Snyder E, Jacks T. SnapShot: Lung cancer models. Cell. 2012;149:246-246.e1 pubmed publisher
  56. Reed C, Mayhew C, McClendon A, Knudsen E. Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control. J Biol Chem. 2010;285:1089-96 pubmed publisher
    ..Although these findings indicated compensatory effects from the RB-related proteins p107 and p130, even the dual deletion of RB with p107 or p130 failed to deregulate hepatic proliferation...
  57. Park J, Shin M, Pitot H, Lambert P. High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins. PLoS ONE. 2013;8:e75056 pubmed publisher
    ..We also found that deficiency of pocket proteins, pRb, p107, and p130 that are well-established targets of E7, could recapitulate E7's induction of DNA damage...
  58. Caracciolo V, Reiss K, Crozier Fitzgerald C, De Pascali F, Macaluso M, Khalili K, et al. Interplay between the retinoblastoma related pRb2/p130 and E2F-4 and -5 in relation to JCV-TAg. J Cell Physiol. 2007;212:96-104 pubmed
    ..if the distribution between nucleus and cytoplasm of the transcription factors E2F4 and E2F5 is mediated by pRb2/p130 and if the presence of JCV T-antigen may impair this shuttling by sequestering pRb2/p130...
  59. Han J, Ito Y, Yeo J, Sucov H, Maas R, Chai Y. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol. 2003;261:183-96 pubmed
    ..Genetic mutation of Msx1 may alternatively instruct the fate of these progenitor cells during craniofacial development. ..
  60. Vormer T, Wojciechowicz K, Dekker M, de Vries S, van der Wal A, Delzenne Goette E, et al. RB family tumor suppressor activity may not relate to active silencing of E2F target genes. Cancer Res. 2014;74:5266-76 pubmed publisher
    The retinoblastoma protein pRB and its two homologs p130 and p107 form the family of pocket proteins and play a major role in cell-cycle regulation and suppression of human and mouse tumorigenesis...
  61. MacLean H, Guo J, Knight M, Zhang P, Cobrinik D, Kronenberg H. The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes. J Clin Invest. 2004;113:1334-43 pubmed
    ..These studies suggest that the effects of PTHrP on both the rate and extent of chondrocyte proliferation are mediated, at least in part, through suppression of p57 expression. ..
  62. Yeung R, Bell D, Testa J, Mayol X, Baldi A, Grana X, et al. The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19. Oncogene. 1993;8:3465-8 pubmed
    A retinoblastoma-related human gene, referred to as RB2, has been cloned based on sequence homology of the E1A-binding domain of the retinoblastoma gene...
  63. Kim E, Cheng Y, Bolton Gillespie E, Cai X, Ma C, Tarangelo A, et al. Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression. J Exp Med. 2017;214:1901-1912 pubmed publisher
    ..Therefore, Rb proteins act as a central hub of quiescence and homeostasis by coordinating the regulation of both cell cycle and Jak2 signaling in HSCs. ..
  64. Sen T, Tong P, Stewart C, Cristea S, Valliani A, Shames D, et al. CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib. Cancer Res. 2017;77:3870-3884 pubmed publisher
    ..Our findings provide a preclinical proof of concept supporting the initiation of a clinical efficacy trial in patients with platinum-sensitive or platinum-resistant relapsed SCLC. Cancer Res; 77(14); 3870-84. ©2017 AACR. ..
  65. Pertile P, Baldi A, De Luca A, Bagella L, Virgilio L, Pisano M, et al. Molecular cloning, expression, and developmental characterization of the murine retinoblastoma-related gene Rb2/p130. Cell Growth Differ. 1995;6:1659-64 pubmed
    The product of the retinoblastoma-related human gene Rb2/p130 is highly homologous with the product of the retinoblastoma tumor suppressor gene (pRb) and Rb-related p107...
  66. Slack R, el Bizri H, Wong J, Belliveau D, Miller F. A critical temporal requirement for the retinoblastoma protein family during neuronal determination. J Cell Biol. 1998;140:1497-509 pubmed
  67. García Cao M, Gonzalo S, Dean D, Blasco M. A role for the Rb family of proteins in controlling telomere length. Nat Genet. 2002;32:415-9 pubmed
    ..the members of the retinoblastoma family of proteins, Rb1 (retinoblastoma 1), Rbl1 (retinoblastoma-like 1) and Rbl2 (retinoblastoma-like 2), and the mechanisms that regulate telomere length...
  68. Kobayashi T, Owczarek T, McKiernan J, Abate Shen C. Modelling bladder cancer in mice: opportunities and challenges. Nat Rev Cancer. 2015;15:42-54 pubmed publisher
    ..This Review focuses on opportunities for improving the landscape of mouse models of bladder cancer. ..
  69. Ruiz S, Segrelles C, Bravo A, Santos M, Perez P, Leis H, et al. Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130. Development. 2003;130:2341-53 pubmed
    The functions of p107 and p130, members of the retinoblastoma family, include the control of cell cycle progression and differentiation in several tissues...
  70. McEvoy J, Flores Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, et al. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell. 2011;20:260-75 pubmed publisher
    ..Furthermore, neurotransmitter receptors, transporters, and biosynthetic enzymes are expressed in human retinoblastoma, and targeted disruption of these pathways reduces retinoblastoma growth in vivo and in vitro. ..
  71. LeCouter J, Whyte P, Rudnicki M. Cloning and expression of the Rb-related mouse p130 mRNA. Oncogene. 1996;12:1433-40 pubmed
    The mouse p130 cDNA was cloned from a thymus-derived library using the human p130 cDNA as a probe. The 4515-bp mouse cDNA encodes a putative 1092 aa protein with predicted molecular mass of 123 kD...
  72. De Leonardis F, Monti L, Gualeni B, Tenni R, Forlino A, Rossi A. Altered signaling in the G1 phase deregulates chondrocyte growth in a mouse model with proteoglycan undersulfation. J Cell Biochem. 2014;115:1779-86 pubmed publisher
    ..cell cycle progression is compromised in the G1 phase due to reduced phosphorylation of the pocket protein p130 leading to inhibition of transcription factors of the E2F family which are crucial for cell cycle progression and ..
  73. Spiller C, Wilhelm D, Koopman P. Retinoblastoma 1 protein modulates XY germ cell entry into G1/G0 arrest during fetal development in mice. Biol Reprod. 2010;82:433-43 pubmed publisher
    ..At each stage analyzed, we saw no increase in expression of RB1 family members Rbl1 and Rbl2 in the Rb1(-/-) testes, but we saw a significant increase of cyclin-dependent kinase (CDK) inhibitor Cdkn1b and ..