Rbl1

Summary

Gene Symbol: Rbl1
Description: RB transcriptional corepressor like 1
Alias: AW547426, PRB1, p107, retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, retinoblastoma-like 1 (p107)
Species: mouse
Products:     Rbl1

Top Publications

  1. Spencer C, Pajovic S, Devlin H, Dinh Q, Corson T, Gallie B. Distinct patterns of expression of the RB gene family in mouse and human retina. Gene Expr Patterns. 2005;5:687-94 pubmed
    ..Murine retinoblastoma is initiated only when two of the RB family of genes, RB1 and p107 or p130, are inactivated...
  2. Viatour P, Ehmer U, Saddic L, Dorrell C, Andersen J, Lin C, et al. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med. 2011;208:1963-76 pubmed publisher
    ..the RB pathway in the liver of adult mice by deleting the three members of the Rb (Rb1) gene family: Rb, p107, and p130...
  3. Shin M, Pitot H, Lambert P. Pocket proteins suppress head and neck cancer. Cancer Res. 2012;72:1280-9 pubmed publisher
    ..susceptibility of mice deficient in the expression of pRb and either of two related "pocket" proteins, p107 and p130, that are also inactivated by E7...
  4. Robanus Maandag E, Dekker M, van der Valk M, Carrozza M, Jeanny J, Dannenberg J, et al. p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev. 1998;12:1599-609 pubmed
    ..To test whether concomitant inactivation of the Rb-related gene p107 is required to unleash the oncogenic potential of pRb deficiency in the mouse retina, we inactivated both Rb and ..
  5. Vanderluit J, Ferguson K, Nikoletopoulou V, Parker M, Ruzhynsky V, Alexson T, et al. p107 regulates neural precursor cells in the mammalian brain. J Cell Biol. 2004;166:853-63 pubmed
    Here we show a novel function for Retinoblastoma family member, p107 in controlling stem cell expansion in the mammalian brain. Adult p107-null mice had elevated numbers of proliferating progenitor cells in their lateral ventricles...
  6. Chen D, Livne Bar I, Vanderluit J, Slack R, Agochiya M, Bremner R. Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell. 2004;5:539-51 pubmed
    ..Rb or Rb/p107 loss causes retinoblastoma in humans or mice, respectively...
  7. Zhang J, Schweers B, Dyer M. The first knockout mouse model of retinoblastoma. Cell Cycle. 2004;3:952-9 pubmed
    ..These mice are being used as a preclinical model to test new therapies for retinoblastoma and to elucidate the downstream genetic events that occur after inactivation of Rb1 or its related family members. ..
  8. Dannenberg J, van Rossum A, Schuijff L, te Riele H. Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev. 2000;14:3051-64 pubmed
    The retinoblastoma suppressor pRB belongs to the family of so-called pocket proteins, which also includes p107 and p130. These proteins may functionally overlap in cell cycle control and tumor suppression...
  9. Haigis K, Sage J, Glickman J, Shafer S, Jacks T. The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. J Biol Chem. 2006;281:638-47 pubmed
    pRb, p107, and p130 are related proteins that play a central role in the regulation of cell cycle progression and terminal differentiation in mammalian cells...

More Information

Publications73

  1. Lara M, Santos M, Ruiz S, Segrelles C, Moral M, Martínez Cruz A, et al. p107 acts as a tumor suppressor in pRb-deficient epidermis. Mol Carcinog. 2008;47:105-13 pubmed
    ..Our previous data have demonstrated the existence of a functional compensation of Rb loss by Rbl1 (p107) in as the phenotypic differences with respect to controls are intensified...
  2. Schneider J, Gu W, Zhu L, Mahdavi V, Nadal Ginard B. Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science. 1994;264:1467-71 pubmed
    ..Development of the myogenic phenotype in Rb-/- cells correlated with increased expression of p107, which interacted with myogenic transcription factors...
  3. Mulligan G, Wong J, Jacks T. p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB. Mol Cell Biol. 1998;18:206-20 pubmed
    The proteins encoded by the retinoblastoma gene family, pRB, p107, and p130, have been implicated in the regulation of cellular proliferation, differentiation, and transformation...
  4. Vooijs M, te Riele H, van der Valk M, Berns A. Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells. Oncogene. 2002;21:4635-45 pubmed
    ..not lead to retinoblastoma or any phenotypic changes, not even when photoreceptor cells are made deficient in Rb, p107 and Trp53...
  5. Donovan S, Schweers B, Martins R, Johnson D, Dyer M. Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biol. 2006;4:14 pubmed
    ..We found that the Rb family of proteins (Rb, p107 and p130) are expressed in a dynamic manner during mouse retinal development...
  6. MacPherson D, Sage J, Kim T, Ho D, McLaughlin M, Jacks T. Cell type-specific effects of Rb deletion in the murine retina. Genes Dev. 2004;18:1681-94 pubmed
    ..Conditional Rb mutation in the retina did not result in retinoblastoma formation even in a p53-mutant background. However, on a p107- or p130-deficient background, Rb mutation in the retina caused retinal dysplasia or retinoblastoma.
  7. Scime A, Soleimani V, Bentzinger C, Gillespie M, Le Grand F, Grenier G, et al. Oxidative status of muscle is determined by p107 regulation of PGC-1alpha. J Cell Biol. 2010;190:651-62 pubmed publisher
    Mice lacking p107 exhibit a white adipose deficiency yet do not manifest the metabolic changes typical for lipodystrophy, and instead exhibit low levels of serum triglycerides and a normal liver phenotype...
  8. Lipinski M, Jacks T. The retinoblastoma gene family in differentiation and development. Oncogene. 1999;18:7873-82 pubmed
    The retinoblastoma (Rb) tumor suppressor gene and its close relatives p107 and p130 are best known for their function in the control of cell cycle progression...
  9. Chen H, Gu X, Liu Y, Wang J, Wirt S, Bottino R, et al. PDGF signalling controls age-dependent proliferation in pancreatic ?-cells. Nature. 2011;478:349-55 pubmed publisher
    ..The discovery of a conserved pathway controlling age-dependent ?-cell proliferation indicates new strategies for ?-cell expansion. ..
  10. Laurie N, Mohan A, McEvoy J, Reed D, Zhang J, Schweers B, et al. Changes in retinoblastoma cell adhesion associated with optic nerve invasion. Mol Cell Biol. 2009;29:6268-82 pubmed publisher
    ..Most importantly, our studies are in agreement with genetic studies on human retinoblastomas, suggesting that changes in this pathway are involved in tumor progression. ..
  11. Brennan R, Federico S, Bradley C, Zhang J, Flores Otero J, Wilson M, et al. Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a. Cancer Res. 2011;71:4205-13 pubmed publisher
    ..Our studies provide a new standardized approach to evaluate and prioritize novel agents for incorporation into future clinical trials for retinoblastoma...
  12. Wirt S, Adler A, Gebala V, Weimann J, Schaffer B, Saddic L, et al. G1 arrest and differentiation can occur independently of Rb family function. J Cell Biol. 2010;191:809-25 pubmed publisher
    ..Here, we tested the requirement for the retinoblastoma (Rb) protein and its family members p107 and p130 in G0/G1 arrest and differentiation in mammalian cells...
  13. Cobrinik D, Lee M, Hannon G, Mulligan G, Bronson R, Dyson N, et al. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 1996;10:1633-44 pubmed
    ..normally associates with p130 in serum-starved mouse embryo fibroblasts associated instead with the highly related p107 protein...
  14. Shin M, Sage J, Lambert P. Inactivating all three rb family pocket proteins is insufficient to initiate cervical cancer. Cancer Res. 2012;72:5418-27 pubmed publisher
    ..cell cycle in part by binding and inducing the degradation of pRb and its related pocket protein family members, p107 and p130...
  15. Dannenberg J, Schuijff L, Dekker M, van der Valk M, te Riele H. Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev. 2004;18:2952-62 pubmed
    The retinoblastoma gene family consists of three genes: RB, p107, and p130. While loss of pRB causes retinoblastoma in humans and pituitary gland tumors in mice, tumorigenesis in other tissues may be suppressed by p107 and p130...
  16. Lee M, Williams B, Mulligan G, Mukai S, Bronson R, Dyson N, et al. Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 1996;10:1621-32 pubmed
    To explore the physiological role of p107, a member of retinoblastoma gene (Rb) family, we disrupted the mouse gene by homologous recombination in embryonic stem cells...
  17. Jiang Z, Deng T, Jones R, Li H, Herschkowitz J, Liu J, et al. Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status. J Clin Invest. 2010;120:3296-309 pubmed publisher
    ..Here we report that deletion of Rb alone or together with its relative p107 in mouse mammary stem/bipotent progenitor cells induced focal acinar hyperplasia with squamous metaplasia...
  18. Hurford R, Cobrinik D, Lee M, Dyson N. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 1997;11:1447-63 pubmed
    ..factor is controlled by physical association with the retinoblastoma protein (pRB) and two related proteins, p107 and p130...
  19. Vanderluit J, Wylie C, McClellan K, Ghanem N, Fortin A, Callaghan S, et al. The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate. J Cell Biol. 2007;178:129-39 pubmed
    The Retinoblastoma protein p107 regulates the neural precursor pool in both the developing and adult brain...
  20. Ruiz S, Santos M, Segrelles C, Leis H, Jorcano J, Berns A, et al. Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis. Development. 2004;131:2737-48 pubmed
    ..pRb and its closely related family members p107 and p130 perform exclusive and overlapping functions during mouse development...
  21. Berman S, West J, Danielian P, Caron A, Stone J, Lees J. Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proc Natl Acad Sci U S A. 2009;106:14932-6 pubmed publisher
    The retinoblastoma tumor-suppressor protein, pRb, is a member of the pocket protein family that includes p107 and p130...
  22. Sage J, Miller A, Perez Mancera P, Wysocki J, Jacks T. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature. 2003;424:223-8 pubmed
    ..This difference is explained in part by functional compensation by the Rb-related gene p107. We also show that acute loss of Rb in senescent cells leads to reversal of the cellular senescence programme...
  23. Viatour P, Somervaille T, Venkatasubrahmanyam S, Kogan S, McLaughlin M, Weissman I, et al. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell. 2008;3:416-28 pubmed publisher
    ..Here we employed a conditional knockout strategy to simultaneously inactivate all three members, Rb, p107, and p130, in adult hematopoietic stem cells (HSCs)...
  24. Rossi F, MacLean H, Yuan W, Francis R, Semenova E, Lin C, et al. p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development. Dev Biol. 2002;247:271-85 pubmed
    ..Through analysis of mice lacking the pRB-related p107 and p130 proteins, we found that p107 was required in prechondrogenic condensations for cell cycle withdrawal and ..
  25. Simpson D, Mason Richie N, Gettler C, Wikenheiser Brokamp K. Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis. Cancer Res. 2009;69:8733-41 pubmed publisher
    ..frequently than Rb loss, suggesting that p16 suppresses cancer by regulating Rb as well as the related proteins p107 and p130...
  26. LeCouter J, Kablar B, Hardy W, Ying C, Megeney L, May L, et al. Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene. Mol Cell Biol. 1998;18:7455-65 pubmed
    To investigate the function of the Rb-related p107 gene, a null mutation in p107 was introduced into the germ line of mice and bred into a BALB/cJ genetic background...
  27. Scime A, Grenier G, Huh M, Gillespie M, Bevilacqua L, Harper M, et al. Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Cell Metab. 2005;2:283-95 pubmed
    The Rb family, Rb, p107, and p130, play important roles in cell cycle control and cellular differentiation, and Rb has been suggested to regulate adipocyte differentiation...
  28. Burkhart D, Wirt S, Zmoos A, Kareta M, Sage J. Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. PLoS Genet. 2010;6:e1001003 pubmed publisher
    ..In particular, p107, a protein related to Rb, has been shown to functionally overlap for loss of Rb in several cellular contexts...
  29. Beijersbergen R, Carlee L, Kerkhoven R, Bernards R. Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev. 1995;9:1340-53 pubmed
    ..We show here that phosphorylation of the pRb-related p107 is also cell cycle regulated...
  30. Wikenheiser Brokamp K. Retinoblastoma family proteins: insights gained through genetic manipulation of mice. Cell Mol Life Sci. 2006;63:767-80 pubmed
    ..Animals lacking Rb and/or its family members p107 and p130 have led scientists to uncover new and exciting roles for this protein family in development as well as ..
  31. Rodier G, Makris C, Coulombe P, Scime A, Nakayama K, Nakayama K, et al. p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2. J Cell Biol. 2005;168:55-66 pubmed
    Cell cycle progression is negatively regulated by the pocket proteins pRb, p107, and p130. However, the mechanisms responsible for this inhibition are not fully understood...
  32. Sage J, Mulligan G, Attardi L, Miller A, Chen S, Williams B, et al. Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev. 2000;14:3037-50 pubmed
    The retinoblastoma protein, pRB, and the closely related proteins p107 and p130 are important regulators of the mammalian cell cycle...
  33. Slack R, el Bizri H, Wong J, Belliveau D, Miller F. A critical temporal requirement for the retinoblastoma protein family during neuronal determination. J Cell Biol. 1998;140:1497-509 pubmed
  34. McEvoy J, Flores Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, et al. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell. 2011;20:260-75 pubmed publisher
    ..Furthermore, neurotransmitter receptors, transporters, and biosynthetic enzymes are expressed in human retinoblastoma, and targeted disruption of these pathways reduces retinoblastoma growth in vivo and in vitro. ..
  35. Chen D, Opavsky R, Pacal M, Tanimoto N, Wenzel P, Seeliger M, et al. Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol. 2007;5:e179 pubmed
    ..These data reveal a mechanism through which Rb regulates neural differentiation directly, and, unexpectedly, it involves inhibition of E2f3a, not potentiation of tissue-specific factors. ..
  36. Jiang Z, Zacksenhaus E, Gallie B, Phillips R. The retinoblastoma gene family is differentially expressed during embryogenesis. Oncogene. 1997;14:1789-97 pubmed
    We report differential expression of the RB1 tumor suppressor gene and the homologous genes p107 and p130 during embryogenesis...
  37. Burkhart D, Ngai L, Roake C, Viatour P, Thangavel C, Ho V, et al. Regulation of RB transcription in vivo by RB family members. Mol Cell Biol. 2010;30:1729-45 pubmed publisher
    ..Using these reporter mice and mutant alleles for Rb, p107, and p130, we found that RB family members modulate Rb transcription in specific cell populations in vivo and in ..
  38. Laurie N, Donovan S, Shih C, Zhang J, Mills N, Fuller C, et al. Inactivation of the p53 pathway in retinoblastoma. Nature. 2006;444:61-6 pubmed
    ..In addition, they support the idea that MDMX is a specific chemotherapeutic target for treating retinoblastoma. ..
  39. Sangwan M, McCurdy S, Livne Bar I, Ahmad M, Wrana J, Chen D, et al. Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation. Oncogene. 2012;31:5019-28 pubmed publisher
    RB(+/-) individuals develop retinoblastoma and, subsequently, many other tumors. The Rb relatives p107 and p130 protect the tumor-resistant Rb(-/-) mouse retina...
  40. Harrington E, Bruce J, Harlow E, Dyson N. pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc Natl Acad Sci U S A. 1998;95:11945-50 pubmed
    ..In contrast, the pRB related proteins p107 and p130 do not play an essential part in the DNA damage response...
  41. Filtz E, Emery A, Lu H, Forster C, Karasch C, Hallstrom T. Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice. PLoS ONE. 2015;10:e0136729 pubmed publisher
    ..Rb1 hetero- or homo-zygous co-deletion greatly increases the incidence and the rapidity of onset of adipogenic tumors, again, with only rare osteosarcoma tumors. ..
  42. Spiller C, Wilhelm D, Jans D, Bowles J, Koopman P. Mice Lacking Hbp1 Function Are Viable and Fertile. PLoS ONE. 2017;12:e0170576 pubmed publisher
    ..Lastly, in a model of defective germ cell G1/G0 arrest, the Rb1-knockout model, we found no evidence for Hbp1 mis-regulation, suggesting that the reported RB1-HBP1 interaction is not critical in the germline, despite co-expression. ..
  43. Kim K, Soonpaa M, Daud A, Koh G, Kim J, Field L. Tumor suppressor gene expression during normal and pathologic myocardial growth. J Biol Chem. 1994;269:22607-13 pubmed
    Previous studies have identified several host proteins (p53, p107, and p193), which form prominent complexes with SV40 T antigen in transformed cardiomyocytes...
  44. Santos M, Ruiz S, Lara M, Segrelles C, Moral M, Martínez Cruz A, et al. Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage. Mol Carcinog. 2008;47:815-21 pubmed publisher
    ..at least partially, to the possible overlapping functions carried out by the related retinoblastoma family members p107 and p130...
  45. Soonpaa M, Kim K, Pajak L, Franklin M, Field L. Cardiomyocyte DNA synthesis and binucleation during murine development. Am J Physiol. 1996;271:H2183-9 pubmed
    ..Northern and Western blot analyses identified several candidate genes that were differentially expressed during the reduplicative and binucleation phases of cardiomyocyte growth. ..
  46. Tarangelo A, Lo N, Teng R, Kim E, Le L, Watson D, et al. Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. Nat Commun. 2015;6:10028 pubmed publisher
    ..These data indicate that both the physiological and the oncogenic activities of E2f result in distinct transcriptional responses, which could be exploited to target E2f oncogenic activity for therapy. ..
  47. Batsche E, Moschopoulos P, Desroches J, Bilodeau S, Drouin J. Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription. J Biol Chem. 2005;280:16088-95 pubmed
    ..of limiting Rb expression in these cells, we investigated the action of Rb and its related pocket proteins, p107 and p130, on POMC gene transcription...
  48. Flowers S, Patel P, Gleicher S, Amer K, Himelman E, Goel S, et al. p107-Dependent recruitment of SWI/SNF to the alkaline phosphatase promoter during osteoblast differentiation. Bone. 2014;69:47-54 pubmed publisher
    ..The role of the following proteins, pRB, p107 and p130, is particularly significant in differentiation to the osteoblast lineage, as human germ-line mutations of ..
  49. Landman A, Danielian P, Lees J. Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation. Oncogene. 2013;32:4798-805 pubmed publisher
    The pocket proteins pRB, p107 and p130 have established roles in regulating the cell cycle through the control of E2F activity...
  50. Laplantine E, Rossi F, Sahni M, Basilico C, Cobrinik D. FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest. J Cell Biol. 2002;158:741-50 pubmed
    ..Because mice with targeted mutations of the retinoblastoma (Rb)-related proteins p107 and p130 present severe endochondral bone defects with excessive chondrocyte proliferation, we have investigated ..
  51. Dealy M, Nguyen K, Lo J, Gstaiger M, Krek W, Elson D, et al. Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E. Nat Genet. 1999;23:245-8 pubmed
    ..We show that Cul1 is required for early mouse development and that Cul1 mutants fail to regulate the abundance of the G1 cyclin, cyclin E (encoded by Ccne), during embryogenesis. ..
  52. Huppi K, Siwarski D, Mock B, Dosik J, Hamel P. Molecular cloning, chromosomal mapping, and expression of the mouse p107 gene. Mamm Genome. 1996;7:353-5 pubmed
    Progression through the G1 phase of the cell cycle is regulated, in part, by the pRB-family proteins, pRB and p107. The basis for this regulation is due to a network of interactions between the pRB-family proteins, pRB, p107, and p130; ..
  53. Spiller C, Wilhelm D, Koopman P. Retinoblastoma 1 protein modulates XY germ cell entry into G1/G0 arrest during fetal development in mice. Biol Reprod. 2010;82:433-43 pubmed publisher
    ..At each stage analyzed, we saw no increase in expression of RB1 family members Rbl1 and Rbl2 in the Rb1(-/-) testes, but we saw a significant increase of cyclin-dependent kinase (CDK) inhibitor ..
  54. Petrenko O, Moll U. Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway. Mol Cell. 2005;17:225-36 pubmed
    ..A proinflammatory molecule interfering with tumor suppression and DNA replication provides a compelling molecular link for the association of chronic inflammation and tumorigenesis. ..
  55. Pilkinton M, Sandoval R, Colamonici O. Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex. Oncogene. 2007;26:7535-43 pubmed
    ..In G(0)/early G(1), Mip/LIN-9 forms a complex with E2F4 and p107 or p130, while in late G(1)/S phase, it associates with B-Myb...
  56. Dirlam A, Spike B, Macleod K. Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol Cell Biol. 2007;27:8713-28 pubmed
    ..The identification of a tissue-restricted role for E2f-2 in erythropoiesis highlights the nonredundant nature of E2f transcription factor activities in cell growth and differentiation...
  57. García Cao M, Gonzalo S, Dean D, Blasco M. A role for the Rb family of proteins in controlling telomere length. Nat Genet. 2002;32:415-9 pubmed
    ..Here, we report a connection between the members of the retinoblastoma family of proteins, Rb1 (retinoblastoma 1), Rbl1 (retinoblastoma-like 1) and Rbl2 (retinoblastoma-like 2), and the mechanisms that regulate telomere length...
  58. Svoboda D, Paquin A, Park D, Slack R. Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis. Dev Biol. 2013;384:101-13 pubmed publisher
    Pocket proteins (pRb, p107 and p130) are well studied in their role of regulating cell cycle progression...
  59. Cai E, Luk C, Wu X, Schroer S, Shi S, Sivasubramaniyam T, et al. Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action. Diabetologia. 2014;57:2555-65 pubmed publisher
    ..these processes; thus, we hypothesised that the related cell cycle regulators retinoblastoma protein (Rb) and p107 were involved in GLP-1 action...
  60. Kobayashi T, Owczarek T, McKiernan J, Abate Shen C. Modelling bladder cancer in mice: opportunities and challenges. Nat Rev Cancer. 2015;15:42-54 pubmed publisher
    ..This Review focuses on opportunities for improving the landscape of mouse models of bladder cancer. ..
  61. Kim E, Cheng Y, Bolton Gillespie E, Cai X, Ma C, Tarangelo A, et al. Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression. J Exp Med. 2017;214:1901-1912 pubmed publisher
    ..Therefore, Rb proteins act as a central hub of quiescence and homeostasis by coordinating the regulation of both cell cycle and Jak2 signaling in HSCs. ..
  62. Ruiz S, Segrelles C, Bravo A, Santos M, Perez P, Leis H, et al. Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130. Development. 2003;130:2341-53 pubmed
    The functions of p107 and p130, members of the retinoblastoma family, include the control of cell cycle progression and differentiation in several tissues...
  63. Chen D, Chen Y, Forrest D, Bremner R. E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3. Cell Death Differ. 2013;20:931-40 pubmed publisher
    ..These neurons survive Rb loss, but undergo apoptosis in the cancer-prone retina lacking both Rb and its relative p107. We show that while E2f1 killed Rb/p107 null rod, bipolar and ganglion neurons, E2f2 was required and sufficient ..
  64. Chibazakura T, McGrew S, Cooper J, Yoshikawa H, Roberts J. Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome stability by p21, p27, and p107. Proc Natl Acad Sci U S A. 2004;101:4465-70 pubmed
    ..The protein responsible for CDK inactivation during mitotic exit in p21/p27 null cells was the Rb family member, p107. p107 bound to cyclin A47 when p21 and p27 were absent, and cyclin A47-CDK activity was not inactivated during the ..