Rbck1

Summary

Gene Symbol: Rbck1
Description: RanBP-type and C3HC4-type zinc finger containing 1
Alias: AL033326, HOIL-1, HOIL-1L, UIP28, Ubce7ip3, heme-oxidized IRP2 ubiquitin ligase 1 homolog, novel zinc finger, C3HC4 type (RING finger) protein, ranBP-type and C3HC4-type zinc finger-containing protein 1, ubcM4-interacting protein 28, ubiquitin conjugating enzyme 7 interacting protein 3, ubiquitin-conjugating enzyme 7-interacting protein 3
Species: mouse

Top Publications

  1. pmc Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex
    Yusuke Sato
    Structural Biology Laboratory, Life Science Division, Synchrotron Radiation Research Organization and Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 108:20520-5. 2011
  2. ncbi Identification of molecular determinants required for interaction of ubiquitin-conjugating enzymes and RING finger proteins
    G Martinez-Noel
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, Hamburg, Germany
    Eur J Biochem 268:5912-9. 2001
  3. pmc SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
    Fumiyo Ikeda
    Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Theodor Stern Kai 7, D 60590 Frankfurt, Main, Germany
    Nature 471:637-41. 2011
  4. doi SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Nature 471:633-6. 2011
  5. pmc Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction
    Kyung Soo Inn
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cell 41:354-65. 2011
  6. pmc Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development
    Kathrin Landgraf
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    Mol Cell Biol 30:5764-75. 2010
  7. pmc HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex
    Bruce S Hostager
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e11380. 2010
  8. doi Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    Tobias L Haas
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Mol Cell 36:831-44. 2009
  9. doi Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine and Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 11:123-32. 2009
  10. pmc Heme induces ubiquitination and degradation of the transcription factor Bach1
    Yukari Zenke-Kawasaki
    Department of Biochemistry, Tohoku University School of Medicine, Seiryo machi 2 1, Sendai, Japan
    Mol Cell Biol 27:6962-71. 2007

Research Grants

Scientific Experts

  • Bruce S Hostager
  • Charles R Farber
  • Fuminori Tokunaga
  • Kazuhiro Iwai
  • Tomoko Nakagawa
  • Shin ichi Sakata
  • Fumiyo Ikeda
  • Kyung Soo Inn
  • Yusuke Sato
  • Kathrin Landgraf
  • Yasushi Saeki
  • Keiji Tanaka
  • G Martinez-Noel
  • Tobias L Haas
  • Yukari Zenke-Kawasaki
  • Munehiro Nakamura
  • Lai Yee Wong
  • Atsushi Yamagata
  • Benjamin Stieglitz
  • Sigrid S Skånland
  • Ariadne Androulidaki
  • Manolis Pasparakis
  • Liliana Schaefer
  • Sjoerd J L van Wijk
  • Azusa Yoshikawa
  • Yonathan Lissanu Deribe
  • Michaela U Gack
  • Panchali Goswami
  • Masami Yamashita
  • Masaki Nakahara
  • Janos Terzic
  • Stephen E Kaiser
  • Boris Macek
  • John P Sundberg
  • Vanja Nagy
  • Caroline Grabbe
  • Hiroaki Fujita
  • Shuya Fukai
  • Hiroyasu Nakano
  • Katrin Rittinger
  • Mirita Franz-Wachtel
  • Ivan Dikic
  • Mude Shi
  • Masami Taniguchi
  • Jae U Jung
  • Christoph Englert
  • Frank Hänel
  • Mark Oliver Trowe
  • Frank Bollig
  • Christina Ebert
  • Dagmar Kruspe
  • Andreas Kispert
  • Birgit Besenbeck
  • K Harbers
  • Christoph H Emmerich
  • David Komander
  • Shigeo Murata
  • Michiko Kato
  • Toshifumi Takao
  • Kiyoko Kamei
  • Stefanie M Cordier
  • Till Wenger
  • Anna C Schmukle
  • Bjorn Gerlach
  • Yoshinori Satomi
  • Rebecca Feltham
  • Shoji Yamaoka
  • Eva Rieser
  • Henning Walczak
  • Ronald Koschny
  • John Silke
  • Uwe Warnken
  • Masahiro Yamamoto
  • Shizuo Akira
  • Takayoshi Kirisako
  • James Vince
  • Yasutake Katoh
  • Yoshihiro Dohi
  • Tsuyoshi Ikura
  • Masae Ikura
  • Kazuhiko Igarashi
  • Toshimasa Asahara
  • U Muller
  • T Tamura
  • R Niedenthal

Detail Information

Publications13

  1. pmc Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex
    Yusuke Sato
    Structural Biology Laboratory, Life Science Division, Synchrotron Radiation Research Organization and Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 108:20520-5. 2011
    ..The NZF tail binds the proximal ubiquitin to enhance the binding affinity. These recognition mechanisms were supported by the accompanying in vitro and in vivo structure-based mutagenesis experiments...
  2. ncbi Identification of molecular determinants required for interaction of ubiquitin-conjugating enzymes and RING finger proteins
    G Martinez-Noel
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, Hamburg, Germany
    Eur J Biochem 268:5912-9. 2001
    ..The result that single amino-acid changes can regulate binding of E2 enzymes to different RING finger proteins suggests a novel approach to experimentally manipulate proteolytic pathways mediated by RING finger proteins...
  3. pmc SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
    Fumiyo Ikeda
    Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Theodor Stern Kai 7, D 60590 Frankfurt, Main, Germany
    Nature 471:637-41. 2011
    ..This effect is further enhanced upon concurrent downregulation of HOIL-1L (also known as RBCK1), another HOIP-binding component of LUBAC...
  4. doi SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Nature 471:633-6. 2011
    ..SHARPIN shows significant similarity to HOIL-1L (also known as RBCK1), a component of linear ubiquitin chain assembly complex (LUBAC), which induces NF-κB activation through ..
  5. pmc Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction
    Kyung Soo Inn
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cell 41:354-65. 2011
    ....
  6. pmc Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development
    Kathrin Landgraf
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    Mol Cell Biol 30:5764-75. 2010
    ..Here we report the identification of the related proteins Sipl1 (Shank-interacting protein-like 1) and Rbck1 (RBCC protein interacting with PKC1) as novel interaction partners of Eya1...
  7. pmc HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex
    Bruce S Hostager
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e11380. 2010
    ....
  8. doi Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    Tobias L Haas
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Mol Cell 36:831-44. 2009
    ..Finally, we demonstrate that sustained stability of the TNF-RSC requires LUBAC's enzymatic activity, thereby adding a third form of ubiquitin linkage to the triggering of TNF signaling by the TNF-RSC...
  9. doi Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine and Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 11:123-32. 2009
    ..These results indicate that LUBAC is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of NEMO...
  10. pmc Heme induces ubiquitination and degradation of the transcription factor Bach1
    Yukari Zenke-Kawasaki
    Department of Biochemistry, Tohoku University School of Medicine, Seiryo machi 2 1, Sendai, Japan
    Mol Cell Biol 27:6962-71. 2007
    ..These results suggest that heme within a cell regulates the polyubiquitination and degradation of Bach1...
  11. ncbi Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex
    Munehiro Nakamura
    Department of Molecular Cell Biology, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 351:340-7. 2006
    ..These results indicate that LUBAC is an E3 for activated conventional PKC, and that PKC and LUBAC regulate each other for proper PKC signaling...
  12. ncbi A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4
    G Martinez-Noel
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, Germany
    FEBS Lett 454:257-61. 1999
    ....
  13. pmc Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains
    Charles R Farber
    Department of Animal Science, University of California Davis, One Shields Ave, Davis, CA 95016 8521, USA
    BMC Genomics 7:102. 2006
    ..To confirm and further characterize each QTL, two panels of speed congenic strains were developed by introgressing CAST/EiJ (CAST) QTL alleles onto either mutant C57Bl/6J-hg/hg (HG) or wild type C57Bl/6J (B6) genetic backgrounds...

Research Grants3

  1. Using gene targeting to address the role of LRRK2 in Parkinson's disease
    Bruce Hostager; Fiscal Year: 2007
    ..This knowledge will aid in the identification of the environmental triggers and additional genetic factors that participate in the development of Parkinson's disease. ..
  2. CHARACTERIZATION OF A MAJOR OBESITY LOCUS
    Charles Farber; Fiscal Year: 2007
    ..Lastly, aim 3 uses a genetical genomics approach to map eQTL for genes within the congenic interval. Data from these aims will enhance our understanding of the genetics and physiology of obesity. ..