Rbck1

Summary

Gene Symbol: Rbck1
Description: RanBP-type and C3HC4-type zinc finger containing 1
Alias: AL033326, HOIL-1, HOIL-1L, UIP28, Ubce7ip3, heme-oxidized IRP2 ubiquitin ligase 1 homolog, novel zinc finger, C3HC4 type (RING finger) protein, ranBP-type and C3HC4-type zinc finger-containing protein 1, ubcM4-interacting protein 28, ubiquitin conjugating enzyme 7 interacting protein 3, ubiquitin-conjugating enzyme 7-interacting protein 3
Species: mouse

Top Publications

  1. ncbi A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4
    G Martinez-Noel
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, Germany
    FEBS Lett 454:257-61. 1999
  2. ncbi SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Nature 471:633-6. 2011
  3. ncbi Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction
    Kyung Soo Inn
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cell 41:354-65. 2011
  4. ncbi Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development
    Kathrin Landgraf
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    Mol Cell Biol 30:5764-75. 2010
  5. ncbi HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex
    Bruce S Hostager
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e11380. 2010
  6. ncbi Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    Tobias L Haas
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Mol Cell 36:831-44. 2009
  7. ncbi Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine and Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 11:123-32. 2009
  8. ncbi Heme induces ubiquitination and degradation of the transcription factor Bach1
    Yukari Zenke-Kawasaki
    Department of Biochemistry, Tohoku University School of Medicine, Seiryo machi 2 1, Sendai, Japan
    Mol Cell Biol 27:6962-71. 2007
  9. ncbi Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex
    Munehiro Nakamura
    Department of Molecular Cell Biology, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 351:340-7. 2006
  10. ncbi SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
    Fumiyo Ikeda
    Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Theodor Stern Kai 7, D 60590 Frankfurt, Main, Germany
    Nature 471:637-41. 2011

Research Grants

  1. Using gene targeting to address the role of LRRK2 in Parkinson's disease
    Bruce Hostager; Fiscal Year: 2007
  2. CHARACTERIZATION OF A MAJOR OBESITY LOCUS
    Charles Farber; Fiscal Year: 2007

Scientific Experts

  • Bruce S Hostager
  • Charles R Farber
  • Fuminori Tokunaga
  • Kazuhiro Iwai
  • Tomoko Nakagawa
  • Shin ichi Sakata
  • Fumiyo Ikeda
  • Kyung Soo Inn
  • Keiji Tanaka
  • Yasushi Saeki
  • Kathrin Landgraf
  • Tobias L Haas
  • Yukari Zenke-Kawasaki
  • Munehiro Nakamura
  • Sigrid S Skånland
  • Ariadne Androulidaki
  • Hiroyasu Nakano
  • Sjoerd J L van Wijk
  • Mude Shi
  • Manolis Pasparakis
  • Boris Macek
  • Ivan Dikic
  • Lai Yee Wong
  • John P Sundberg
  • Yonathan Lissanu Deribe
  • Masami Taniguchi
  • Jae U Jung
  • Liliana Schaefer
  • Michaela U Gack
  • Panchali Goswami
  • Janos Terzic
  • Vanja Nagy
  • Katrin Rittinger
  • Mirita Franz-Wachtel
  • Benjamin Stieglitz
  • Masaki Nakahara
  • Caroline Grabbe
  • Frank Hänel
  • Andreas Kispert
  • Christoph Englert
  • Dagmar Kruspe
  • Mark Oliver Trowe
  • Christina Ebert
  • Frank Bollig
  • Birgit Besenbeck
  • Michiko Kato
  • Bjorn Gerlach
  • Stefanie M Cordier
  • Yoshinori Satomi
  • John Silke
  • Takayoshi Kirisako
  • Eva Rieser
  • Toshifumi Takao
  • Shizuo Akira
  • David Komander
  • Shoji Yamaoka
  • James Vince
  • Christoph H Emmerich
  • Masahiro Yamamoto
  • Rebecca Feltham
  • Uwe Warnken
  • Shigeo Murata
  • Kiyoko Kamei
  • Till Wenger
  • Anna C Schmukle
  • Henning Walczak
  • Ronald Koschny
  • G Martinez-Noel
  • Tsuyoshi Ikura
  • Kazuhiko Igarashi
  • Toshimasa Asahara
  • Yasutake Katoh
  • Masae Ikura
  • Yoshihiro Dohi
  • Shin-ichi Sakata
  • T Tamura
  • R Niedenthal
  • K Harbers

Detail Information

Publications11

  1. ncbi A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4
    G Martinez-Noel
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, Germany
    FEBS Lett 454:257-61. 1999
    ....
  2. ncbi SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Nature 471:633-6. 2011
    ..SHARPIN shows significant similarity to HOIL-1L (also known as RBCK1), a component of linear ubiquitin chain assembly complex (LUBAC), which induces NF-κB activation through ..
  3. ncbi Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction
    Kyung Soo Inn
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cell 41:354-65. 2011
    ....
  4. ncbi Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development
    Kathrin Landgraf
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    Mol Cell Biol 30:5764-75. 2010
    ..Here we report the identification of the related proteins Sipl1 (Shank-interacting protein-like 1) and Rbck1 (RBCC protein interacting with PKC1) as novel interaction partners of Eya1...
  5. ncbi HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex
    Bruce S Hostager
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e11380. 2010
    ....
  6. ncbi Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    Tobias L Haas
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Mol Cell 36:831-44. 2009
    ..Finally, we demonstrate that sustained stability of the TNF-RSC requires LUBAC's enzymatic activity, thereby adding a third form of ubiquitin linkage to the triggering of TNF signaling by the TNF-RSC...
  7. ncbi Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine and Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 11:123-32. 2009
    ..These results indicate that LUBAC is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of NEMO...
  8. ncbi Heme induces ubiquitination and degradation of the transcription factor Bach1
    Yukari Zenke-Kawasaki
    Department of Biochemistry, Tohoku University School of Medicine, Seiryo machi 2 1, Sendai, Japan
    Mol Cell Biol 27:6962-71. 2007
    ..These results suggest that heme within a cell regulates the polyubiquitination and degradation of Bach1...
  9. ncbi Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex
    Munehiro Nakamura
    Department of Molecular Cell Biology, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 351:340-7. 2006
    ..These results indicate that LUBAC is an E3 for activated conventional PKC, and that PKC and LUBAC regulate each other for proper PKC signaling...
  10. ncbi SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
    Fumiyo Ikeda
    Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Theodor Stern Kai 7, D 60590 Frankfurt, Main, Germany
    Nature 471:637-41. 2011
    ..This effect is further enhanced upon concurrent downregulation of HOIL-1L (also known as RBCK1), another HOIP-binding component of LUBAC...
  11. ncbi Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains
    Charles R Farber
    Department of Animal Science, University of California Davis, One Shields Ave, Davis, CA 95016 8521, USA
    BMC Genomics 7:102. 2006
    ..To confirm and further characterize each QTL, two panels of speed congenic strains were developed by introgressing CAST/EiJ (CAST) QTL alleles onto either mutant C57Bl/6J-hg/hg (HG) or wild type C57Bl/6J (B6) genetic backgrounds...

Research Grants3

  1. Using gene targeting to address the role of LRRK2 in Parkinson's disease
    Bruce Hostager; Fiscal Year: 2007
    ..This knowledge will aid in the identification of the environmental triggers and additional genetic factors that participate in the development of Parkinson's disease. ..
  2. CHARACTERIZATION OF A MAJOR OBESITY LOCUS
    Charles Farber; Fiscal Year: 2007
    ..Lastly, aim 3 uses a genetical genomics approach to map eQTL for genes within the congenic interval. Data from these aims will enhance our understanding of the genetics and physiology of obesity. ..