Gene Symbol: Rbbp4
Description: retinoblastoma binding protein 4, chromatin remodeling factor
Alias: RBAP48, mRbAp48, histone-binding protein RBBP4, CAF-1 p48 subunit, CAF-1 subunit C, CAF-I 48 kDa subunit, CAF-I p48, RBBP-4, chromatin assembly factor 1 subunit C, chromatin assembly factor I p48 subunit, nucleosome-remodeling factor subunit RBAP48, retinoblastoma binding protein 4, retinoblastoma-binding protein p48
Species: mouse
Products:     Rbbp4

Top Publications

  1. Lee E, Hu N, Yuan S, Cox L, Bradley A, Lee W, et al. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 1994;8:2008-21 pubmed
    ..Taken together, these results suggest that the p110RB protein not only regulates progression through the cell cycle but is also important for cell survival and differentiation. ..
  2. Walker E, Chang W, Hunkapiller J, Cagney G, Garcha K, Torchia J, et al. Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2010;6:153-66 pubmed publisher
    ..We describe the role of PCL2 in both modulating transcription of ESC self-renewal genes in undifferentiated ESCs as well as developmental regulators during early commitment and differentiation. ..
  3. Ishimaru N, Arakaki R, Omotehara F, Yamada K, Mishima K, Saito I, et al. Novel role for RbAp48 in tissue-specific, estrogen deficiency-dependent apoptosis in the exocrine glands. Mol Cell Biol. 2006;26:2924-35 pubmed
    ..Here we show that RbAp48 overexpression induces p53-mediated apoptosis in the exocrine glands caused by estrogen deficiency...
  4. Shen X, Kim W, Fujiwara Y, Simon M, Liu Y, Mysliwiec M, et al. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell. 2009;139:1303-14 pubmed publisher
    ..Our results demonstrate that dynamic regulation of Polycomb complex activity orchestrated by JMJ balances self-renewal and differentiation, highlighting the involvement of chromatin dynamics in cell-fate transitions. ..
  5. Li G, Margueron R, Ku M, Chambon P, Bernstein B, Reinberg D. Jarid2 and PRC2, partners in regulating gene expression. Genes Dev. 2010;24:368-80 pubmed publisher
    ..In addition to the well-documented defects in embryonic viability upon down-regulation of Jarid2, ES cell differentiation is impaired, as is Oct4 silencing. ..
  6. Qian Y, Lee E. Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. J Biol Chem. 1995;270:25507-13 pubmed
    ..We have identified nine polypeptides that bind to the T-binding domains of Rb using an Rb affinity resin. RbAp48 and RbAp46 are quantitatively the major Rb-associated proteins purified by this approach...
  7. Balboula A, Stein P, Schultz R, Schindler K. RBBP4 regulates histone deacetylation and bipolar spindle assembly during oocyte maturation in the mouse. Biol Reprod. 2015;92:105 pubmed publisher
    ..b>RBBP4 is a component of several different histone deacetylase containing chromatin-remodeling complexes, but RBBP4's ..
  8. Whitcomb S, Fierz B, McGinty R, Holt M, Ito T, Muir T, et al. Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2. J Biol Chem. 2012;287:23718-25 pubmed publisher
    ..Taken together, these results highlight how the position of nucleosome monoubiquitylation affects the specificity and direction of cross-talk with enzymatic activities on chromatin. ..
  9. Lagger G, O Carroll D, Rembold M, Khier H, Tischler J, Weitzer G, et al. Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J. 2002;21:2672-81 pubmed
    ..Our study provides the first evidence that a histone deacetylase is essential for unrestricted cell proliferation by repressing the expression of selective cell cycle inhibitors. ..

More Information


  1. Bai X, Wang D, Ji H, Zheng L, Lu Y, Tang W, et al. RbAp48 Is Critical for the Proliferation of Hypopharyngeal Carcinoma. ORL J Otorhinolaryngol Relat Spec. 2015;77:310-9 pubmed publisher
    Emerging evidence has indicated the significance of RbAp48 in tumorigenesis...
  2. Yuan S, Cox L, Dasika G, Lee E. Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. Dev Biol. 1999;207:62-75 pubmed
    ..Thus Rig-1, a possible distant relative of roundabout, may mediate some of the pleiotropic roles of RB in the developing neurons. ..
  3. Zhang Q, Vo N, Goodman R. Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB. Mol Cell Biol. 2000;20:4970-8 pubmed
    ..One of the strongest interactions identified the histone binding protein RbAp48. RbAp48 also interacted weakly with CBP alone but did not interact with phosphorylated or nonphosphorylated CREB...
  4. Davidovich C, Wang X, Cifuentes Rojas C, Goodrich K, Gooding A, Lee J, et al. Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA. Mol Cell. 2015;57:552-8 pubmed publisher
    ..We conclude that promiscuous and specific RNA-binding activities of PRC2 in vitro are not mutually exclusive, and that binding specificity in vivo remains to be demonstrated. ..
  5. Ma P, Lin S, Bartolomei M, Schultz R. Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. Biol Reprod. 2010;83:1027-35 pubmed publisher
    ..Taken together, our results support a role for MTA2 within the NuRD complex in genomic imprinting. ..
  6. Ishimaru N, Arakaki R, Yoshida S, Yamada A, Noji S, Hayashi Y. Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy. J Exp Med. 2008;205:2915-27 pubmed publisher
    ..Recently, we found that retinoblastoma-associated protein 48 (RbAp48) induces tissue-specific apoptosis in the exocrine glands depending on the level of estrogen deficiency...
  7. Arakaki R, Ishimaru N, Hayashi Y. Immunotherapeutic targets in estrogen deficiency-dependent Sjögren's syndrome-related manifestations. Immunotherapy. 2010;2:339-46 pubmed publisher
    ..We found that RbAp48 overexpression induces p53-mediated apoptosis in the exocrine glands depending on estrogen deficiency...
  8. Rodriguez P, Bonte E, Krijgsveld J, Kolodziej K, Guyot B, Heck A, et al. GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO J. 2005;24:2354-66 pubmed
    ..Based on these findings, we suggest a model for the different roles of GATA-1 in erythroid differentiation. ..
  9. Yang J, Kiefer S, Rauchman M. Characterization of the gene encoding mouse retinoblastoma binding protein-7, a component of chromatin-remodeling complexes. Genomics. 2002;80:407-15 pubmed
  10. Vaute O, Nicolas E, Vandel L, Trouche D. Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases. Nucleic Acids Res. 2002;30:475-81 pubmed
    ..bound the so-called 'core histone deacetylase complex', composed of HDAC1, HDAC2 and the Rb-associated proteins RbAp48 and RbAp46...
  11. Taplick J, Kurtev V, Kroboth K, Posch M, Lechner T, Seiser C. Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1. J Mol Biol. 2001;308:27-38 pubmed
    ..Furthermore, the same HDAC1 domain is also necessary for in vitro binding of HDAC2 and HDAC3, association with RbAp48 and for catalytic activity of the enzyme...
  12. Downes M, Ordentlich P, Kao H, Alvarez J, Evans R. Identification of a nuclear domain with deacetylase activity. Proc Natl Acad Sci U S A. 2000;97:10330-5 pubmed
    ..We demonstrate that HDAC5 and 7 can associate with at least 12 distinct proteins, including several members of the NuRD and Sin3A repression complexes, and appear to define a new but related complex. ..
  13. Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho Santos M, et al. Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet. 2012;8:e1002576 pubmed publisher
    ..Thus, Pcl3 is a component of PRC2 critical for ESC self-renewal, histone methylation, and recruitment of PRC2 to a subset of its genomic sites. ..
  14. Pavlopoulos E, Jones S, Kosmidis S, Close M, Kim C, Kovalerchik O, et al. Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48. Sci Transl Med. 2013;5:200ra115 pubmed publisher
    ..The most significant change was an age-related decline in RbAp48, a histone-binding protein that modifies histone acetylation...
  15. Laherty C, Billin A, Lavinsky R, Yochum G, Bush A, Sun J, et al. SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol Cell. 1998;2:33-42 pubmed