Rax

Summary

Gene Symbol: Rax
Description: retina and anterior neural fold homeobox
Alias: 7530406A22Rik, E130303K03Rik, ey-1, ey1, retinal homeobox protein Rx, Rx/rax homeoprotein, eyeless 1, retina and anterior neural fold homeobox protein
Species: mouse

Top Publications

  1. ncbi Conditional alleles for activation and inactivation of the mouse Rx homeobox gene
    Vera A Voronina
    Laboratory of Cancer and Developmental Biology, NCI Frederick, National Institutes of Health, Frederick, Maryland 21707, USA
    Genesis 41:160-4. 2005
  2. pmc Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-β signaling system in the embryonic mouse retina
    Deepa Murali
    Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 52:2930-7. 2011
  3. pmc Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6
    Danielle Matsushima
    UNC Neuroscience Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Development 138:443-54. 2011
  4. pmc Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate
    Wei Liu
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Invest 120:3568-77. 2010
  5. doi Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium
    Naoko Fujimura
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Dev Biol 334:31-45. 2009
  6. ncbi Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression
    A Kimura
    Center for Ophthalmic Research, Brigham and Women s Hospital, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:1152-60. 2000
  7. ncbi Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity
    D Jonathan Horsford
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 132:177-87. 2005
  8. ncbi The Rx homeobox gene is essential for vertebrate eye development
    P H Mathers
    Laboratory of Developmental Biology, Food and Drug Administration, Rockville, Maryland 20852, USA
    Nature 387:603-7. 1997
  9. pmc rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
    T Furukawa
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:3088-93. 1997
  10. pmc Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system
    M Hallonet
    Department of Developmental Biochemistry, University of Gottingen, Institute for Biochemistry, 37073 Gottingen, Germany
    Genes Dev 13:3106-14. 1999

Scientific Experts

  • L K Laemle
  • Lin Ma
  • Whitney E Heavner
  • Milan Jamrich
  • Eric C Swindell
  • Gilles Bronchti
  • Nicole Chabot
  • Yuki Muranishi
  • Valérie Charbonneau
  • Takahisa Furukawa
  • Denis Boire
  • Chaomei Liu
  • Eriko Sakakura
  • Shoichi Irie
  • Sooyeon Yoo
  • Ana L Miranda-Angulo
  • Seth Blackshaw
  • Hong Wang
  • Juan Salvatierra
  • Hanako Ikeda
  • Thomas Pak
  • Fuqu Lu
  • Rikako Sanuki
  • Juxue Li
  • Lee Langer
  • Mototsugu Eiraku
  • Timothy F Plageman
  • Kapil Bharti
  • Deepa Murali
  • Danielle Matsushima
  • Anna Carin Hägglund
  • Marie Eve Laramée
  • Wei Liu
  • Richard A Lang
  • Michelle L Brinkmeier
  • Nicolas Tétreault
  • Peter H Mathers
  • Naoko Fujimura
  • Olga Medina-Martinez
  • Heinz Arnheiter
  • Rina Shah
  • Takafumi Wataya
  • Richard L Bennett
  • Felipe Amaya-Manzanares
  • Robin Tremblay
  • Gilbert Bernier
  • Kathleen A Mahon
  • Shinichi Aizawa
  • Kathleen Sulik
  • Yoshiki Sasai
  • Kiichi Watanabe
  • Guillermo Oliver
  • Donghui Zhang
  • Julie Lord-Grignon
  • Julian Morcillo
  • G Bernier
  • Stephane Robert
  • Dom Miceli
  • E Wagner
  • Roderick R McInnes
  • Yaping Wang
  • Hae Young Lee
  • Giovanna Alfano
  • Vera A Voronina
  • D Jonathan Horsford
  • P Gruss
  • Mathieu Piché
  • Yoko Tabata
  • N Gotoh
  • Jun Hatakeyama
  • Qing Liang Wang
  • Akihiro Nishida
  • Ryuichi Yamada
  • Nozomu Takata
  • Oleg V Lagutin
  • Taro Chaya
  • Kimiko Kato
  • Cristina Zibetti
  • Jose Manuel Garcia-Verdugo
  • Sara Gil-Perotin
  • David Cunningham
  • Jimmy de Melo
  • Ana M Miranda-Angulo
  • María Duran-Moreno
  • Elizabeth A Newman
  • Daniel A Lee
  • Joseph L Bedont
  • P H Mathers
  • Deborah M Kurrasch
  • Carol Schuurmans

Detail Information

Publications83

  1. ncbi Conditional alleles for activation and inactivation of the mouse Rx homeobox gene
    Vera A Voronina
    Laboratory of Cancer and Developmental Biology, NCI Frederick, National Institutes of Health, Frederick, Maryland 21707, USA
    Genesis 41:160-4. 2005
    ....
  2. pmc Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-β signaling system in the embryonic mouse retina
    Deepa Murali
    Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 52:2930-7. 2011
    ..The present study was aimed at defining developmental roles of Smad4, a key mediator of the TGF-β superfamily signaling system, in the embryonic mouse retina...
  3. pmc Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6
    Danielle Matsushima
    UNC Neuroscience Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Development 138:443-54. 2011
    ..Collectively, these results demonstrate that precise regulation of the ratio of SOX2 to PAX6 is necessary to ensure accurate progenitor cell specification, and place SOX2 as a decisive factor of neural competence in the retina...
  4. pmc Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate
    Wei Liu
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Invest 120:3568-77. 2010
    ....
  5. doi Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium
    Naoko Fujimura
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Dev Biol 334:31-45. 2009
    ..Combined, our data suggest that Wnt/beta-catenin signaling plays an essential role in development of RPE by maintaining or inducing expression of Mitf and Otx2...
  6. ncbi Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression
    A Kimura
    Center for Ophthalmic Research, Brigham and Women s Hospital, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:1152-60. 2000
    ..Thus, photoreceptor specificity can be achieved by multiple promoter elements interacting with a combination of both photoreceptor-specific regulatory factors and factors present in closely related cell lineages...
  7. ncbi Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity
    D Jonathan Horsford
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 132:177-87. 2005
    ..We demonstrate that the repression of Mitf by FGF is Chx10 dependent, indicating that FGF, Chx10 and Mitf are components of a pathway that determines and maintains the identity of the NR...
  8. ncbi The Rx homeobox gene is essential for vertebrate eye development
    P H Mathers
    Laboratory of Developmental Biology, Food and Drug Administration, Rockville, Maryland 20852, USA
    Nature 387:603-7. 1997
    ..Mouse embryos carrying a null allele of this gene do not form optic cups and so do not develop eyes. The Rx gene family plays an important role in the establishment and/or proliferation of retinal progenitor cells...
  9. pmc rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina
    T Furukawa
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:3088-93. 1997
    ..In this paper, we report the identification of a novel homeobox gene, rax (retina and anterior neural fold homeobox), whose expression pattern suggests an important role in eye development...
  10. pmc Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system
    M Hallonet
    Department of Developmental Biochemistry, University of Gottingen, Institute for Biochemistry, 37073 Gottingen, Germany
    Genes Dev 13:3106-14. 1999
    ..On the basis of these results, we propose a model for a molecular cascade involved in the establishment of structures of the visual system...
  11. doi The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation
    Nicolas Tétreault
    Developmental Biology Laboratory, Maisonneuve Rosemont Hospital, 5415 Boulevard l Assomption, Montreal, Canada, H1T 2M4
    Dev Biol 327:541-50. 2009
    ..Our work reveals how two master regulators of eye development coordinate their action to sequentially promote tissue-specific transcriptional initiation and full activation of a retinal determinant gene...
  12. pmc Eye formation in the absence of retina
    Eric C Swindell
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Biol 322:56-64. 2008
    ..One involved in the formation of the eyeball and the second involved in the formation of the auxiliary eye structures...
  13. ncbi The eyeless mouse mutation (ey1) removes an alternative start codon from the Rx/rax homeobox gene
    P Tucker
    Museum of Zoology and Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, USA
    Genesis 31:43-53. 2001
    ..We mapped ey1 to chromosome 18 using an F2 genome scan and there found a Met10-->Leu mutation in Rx/rax, a homeobox gene that is expressed in the anterior headfold, developing retina, pineal, and hypothalamus and is ..
  14. ncbi Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH
    Julian Morcillo
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 133:3179-90. 2006
    ..Collectively, these data indicate that BMP7 is required for retinal fissure formation and that its activity is needed, before SHH signalling, for the generation of PAX2-positive cells at the optic disc...
  15. pmc Generation of an Rx-tTA: TetOp-Cre knock-in mouse line for doxycycline regulated Cre activity in the Rx expression domain
    Timothy F Plageman
    Visual Systems Group, Children s Hospital Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e50426. 2012
    ..This line has the potential to facilitate conditional knock-out experimentation to study early retina and/or posterior pituitary development...
  16. pmc Rax is a selector gene for mediobasal hypothalamic cell types
    Fuqu Lu
    Department of Medical Genetics, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 33:259-72. 2013
    ..Here, we demonstrate that the Retina and anterior neural fold homeobox (Rax) gene plays a key role in establishing ARC and VMH nuclei in mice...
  17. pmc Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development
    Oleg V Lagutin
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Genes Dev 17:368-79. 2003
    ..Furthermore, these results support the hypothesis that a Wnt signal gradient specifies posterior fates in the anterior neural plate...
  18. ncbi Rx-Cre, a tool for inactivation of gene expression in the developing retina
    Eric C Swindell
    Genesis 44:361-3. 2006
    ..Using these sequences, we made a Cre line that can be used for inactivation of gene expression in the developing retina...
  19. ncbi Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina
    Yaping Wang
    Molecular Medicine Program, Ottawa Health Research Institute and University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Development 132:5103-13. 2005
    ....
  20. ncbi Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development
    Akihiro Nishida
    Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Nat Neurosci 6:1255-63. 2003
    ..Thus, Otx2 is a key regulatory gene for the cell fate determination of retinal photoreceptor cells. Our results reveal the key molecular steps required for photoreceptor cell-fate determination and pinealocyte development...
  21. ncbi Function of Rx, but not Pax6, is essential for the formation of retinal progenitor cells in mice
    L Zhang
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 28:135-42. 2000
    ....
  22. doi Specification of embryonic stem cell-derived tissues into eye fields by Wnt signaling using rostral diencephalic tissue-inducing culture
    Eriko Sakakura
    Laboratory for in vitro Histogenesis, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Mech Dev 141:90-9. 2016
    ..Taking advantage of embryonic stem cell (ESC) culture using a Rax reporter line to monitor rostral diencephalon formation, we found that ESC-derived tissues at day 7 grown in ..
  23. doi An essential role for RAX homeoprotein and NOTCH-HES signaling in Otx2 expression in embryonic retinal photoreceptor cell fate determination
    Yuki Muranishi
    Department of Developmental Biology, Osaka Bioscience Institute, Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Osaka 565 0874, Japan
    J Neurosci 31:16792-807. 2011
    ..We found that the RAX homeoprotein interacts with EELPOT to transactivate Otx2, mainly in the final cell cycle of retinal progenitors...
  24. pmc SOX2 hypomorphism disrupts development of the prechordal floor and optic cup
    Lee Langer
    Department of Genetics, University of North Carolina at Chapel Hill, 115 Mason Farm Rd, CB 7250, Chapel Hill, NC 27599, USA
    Mech Dev 129:1-12. 2012
    ....
  25. pmc Rax Homeoprotein Regulates Photoreceptor Cell Maturation and Survival in Association with Crx in the Postnatal Mouse Retina
    Shoichi Irie
    Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Suita, Osaka, Japan Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Suita, Osaka, Japan Kyoto University Graduate School of Medicine, Kyoto, Japan
    Mol Cell Biol 35:2583-96. 2015
    The Rax homeobox gene plays essential roles in multiple processes of vertebrate retina development. Many vertebrate species possess Rax and Rax2 genes, and different functions have been suggested...
  26. doi Cortical and subcortical projections to primary visual cortex in anophthalmic, enucleated and sighted mice
    Valérie Charbonneau
    Groupe de Recherche en Neurosciences, Departement de Chimie Biologie, Universite du Quebec a Trois Rivieres, Trois Rivieres, QC, Canada
    Eur J Neurosci 36:2949-63. 2012
    ....
  27. pmc The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation
    Juan Salvatierra
    Department of Neuroscience
    J Neurosci 34:16809-20. 2014
    ..Lhx2-deficient tanycytes lost expression of tanycyte-specific genes, such as Rax, while also displaying ectopic expression of genes specific to cuboid ependymal cells, such as Rarres2...
  28. pmc Rax-CreERT2 knock-in mice: a tool for selective and conditional gene deletion in progenitor cells and radial glia of the retina and hypothalamus
    Thomas Pak
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 9:e90381. 2014
    To study gene function in neural progenitors and radial glia of the retina and hypothalamus, we developed a Rax-CreERT2 mouse line in which a tamoxifen-inducible Cre recombinase is inserted into the endogenous Rax locus...
  29. pmc Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling
    Whitney E Heavner
    UNC Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Neural Dev 9:27. 2014
    ..We addressed whether SOX2 co-ordinates the neurogenic boundary of the retina through modulating the WNT/β-Catenin pathway by using a genetic approach in the mouse...
  30. pmc Multiple requirements for Hes 1 during early eye formation
    Hae Young Lee
    Department of Pediatrics, Northwestern University Medical School at Children s Memorial Institute for Education and Research, Chicago, IL 60614, USA
    Dev Biol 284:464-78. 2005
    ..Together, these studies demonstrate that Hes1, like Pax6, simultaneously regulates multiple developmental processes during optic development...
  31. pmc A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development
    Kapil Bharti
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002757. 2012
    ..The results suggest that careful manipulation of the Pax6 regulatory circuit may facilitate the generation of retinal and pigment epithelium cells from embryonic or induced pluripotent stem cells...
  32. pmc IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes
    Juxue Li
    Department of Molecular Pharmacology, Bronx, New York 10461, USA
    Nat Cell Biol 14:999-1012. 2012
    ..In conclusion, adult htNSCs are important for the central regulation of metabolic physiology, and IKKβ/NF-κB-mediated impairment of adult htNSCs is a critical neurodegenerative mechanism for obesity and related diabetes...
  33. ncbi QRX, a novel homeobox gene, modulates photoreceptor gene expression
    Qing Liang Wang
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Mol Genet 13:1025-40. 2004
    ..Its homeodomain is nearly identical to that of Rx/Rax, a transcription factor that is essential for eye development, but it shares only limited homology elsewhere...
  34. ncbi Environmental enrichment enhances auditory takeover of the occipital cortex in anophthalmic mice
    Mathieu Piché
    Department of Chemistry and Biology, Universite du Quebec a Trois Rivieres, 3351 Des Forges, C P 500, Trois Rivieres, Quebec, G9A 5H7 Canada
    Eur J Neurosci 20:3463-72. 2004
    ..This animal model will be useful for understanding neuronal mechanisms underlying some cross-modal sensory phenomena observed in blind or deaf humans...
  35. pmc Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells
    Hanako Ikeda
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 102:11331-6. 2005
    ..Taken together, ES cells treated with SFEB/Dkk1/LeftyA/serum/activin generate neural retinal precursors, which have the competence of photoreceptor differentiation...
  36. ncbi Identification of genes expressed in retinal progenitor/stem cell colonies isolated from the ocular ciliary body of adult mice
    Julie Lord-Grignon
    Developmental Biology Laboratory, Maisonneuve Rosemont Hospital, 5415 Boul l Assomption, Montreal, Canada H1T 2M4
    Gene Expr Patterns 6:992-9. 2006
    ..Taken together, our study reveals that PSC isolated from the ocular CB express genes involved in the control of embryonic development, retinal identity, redox metabolism, and cellular proliferation...
  37. pmc Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina
    Lin Ma
    IMCH, HBI, University of Calgary, T2N 4N1, Canada
    Neural Dev 2:11. 2007
    ..Here we report a similar role for two tumor suppressor genes, the Zac1 zinc finger transcription factor and that encoding the cytokine TGFbetaII, in the developing retina...
  38. ncbi Audition differently activates the visual system in neonatally enucleated mice compared with anophthalmic mutants
    Nicole Chabot
    Departement de Psychologie, and Groupe de Recherche en Neurosciences, Université de Québec à Trois Rivières, Trois Rivieres, Quebec, G9A 5H7, Canada
    Eur J Neurosci 26:2334-48. 2007
    ..None was found in controls with intact eyes. We suggest that the prenatal period of spontaneous retinal activity shapes the differences of the sensory reorganization in mice...
  39. doi Subcortical auditory input to the primary visual cortex in anophthalmic mice
    Nicole Chabot
    Universite du Quebec a Trois Rivieres, Groupe de Recherche en Neurosciences, Canada
    Neurosci Lett 433:129-34. 2008
    ..In particular, we find no evidence of a direct projection from the auditory mesencephalon to the cortex in this animal model of blindness...
  40. pmc RAX is required for fly neuronal development and mouse embryogenesis
    Richard L Bennett
    University of Florida, Shands Cancer Center, Kevin Cameron Laboratory, 1376 Mowry Road, P O Box 103633, Gainesville, FL 32610 3633, USA
    Mech Dev 125:777-85. 2008
    b>RAX was originally discovered as the unique cellular activator for the dsRNA-dependent, interferon-inducible protein kinase PKR...
  41. pmc Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation
    Takafumi Wataya
    Organogenesis and Neurogenesis Group and Division of Human Stem Cell Technology, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 105:11796-801. 2008
    ..factors during early differentiation steps induces efficient generation of rostral hypothalamic-like progenitors (Rax(+)/Six3(+)/Vax1(+)) in mouse ES cell-derived neuroectodermal cells...
  42. pmc Cell-autonomous requirement for rx function in the mammalian retina and posterior pituitary
    Olga Medina-Martinez
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 4:e4513. 2009
    ..Our observations suggest that Rx function is not only required for the morphogenesis of the retina and posterior pituitary, but also prior to morphogenesis, for the sorting out of cells to form distinct fields of retinal/pituitary cells...
  43. pmc Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development
    Anna Carin Hägglund
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    PLoS ONE 6:e23387. 2011
    ..Thus, we have defined a distinct progenitor cell population in the forebrain committed to eye development and identified genes linked to Lhx2's function in the expansion and patterning of these progenitor cells...
  44. ncbi The relationship between circadian rhythmicity and vasoactive intestinal polypeptide in the suprachiasmatic nucleus of congenitally anophthalmic mice
    L K Laemle
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Brain Res 917:105-11. 2001
    ..Our data provide the first definitive evidence that the presence of VIP neurons in the SCN is not sufficient for generation of circadian locomotor rhythms...
  45. ncbi Callosal connections of the posterior neocortex in normal-eyed, congenitally anophthalmic, and neonatally enucleated mice
    J Olavarria
    J Comp Neurol 230:249-68. 1984
    ..Finally, examination of coronal sections indicates that the laminar distribution of callosal connections develops normally in both groups of eyeless mice...
  46. ncbi Development and aging of the eye in mice with inherited optic nerve aplasia: histopathological studies
    J Silver
    Exp Eye Res 38:257-66. 1984
    ..Retinal rosettes were also commonly present...
  47. ncbi Intrauterine enucleation of normal mice mimics a structural compensatory response in the geniculate of eyeless mutant mice
    I R Kaiserman-Abramof
    Brain Res 270:149-53. 1983
    ..This evidence demonstrates that the anophthalmic mutant mouse is a valid model system for analysis of thalamic reorganization that occurs in normal mice after perinatal enucleation...
  48. ncbi The thalamic projection to cortical area 17 in a congenitally anophthalmic mouse strain
    I R Kaiserman-Abramof
    Neuroscience 5:41-52. 1980
  49. ncbi The geniculohypothalamic pathway in a congenitally anophthalmic mouse
    L K Laemle
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, Newark 07103
    Brain Res 618:352-7. 1993
    ..Although the cytoarchitectural organization of the anophthalmic IGL differs from that of the control mouse, the distribution of NPY plexuses in the suprachiasmatic nucleus is remarkably similar...
  50. ncbi Diurnal variations in vasoactive intestinal polypeptide-like immunoreactivity in the suprachiasmatic nucleus of congenitally anophthalmic mice
    L K Laemle
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, Newark 07103, USA
    Brain Res 688:203-8. 1995
    ..These observations support the hypothesis that expression of VIP is related to regulation of circadian rhythms by the SCN...
  51. ncbi Daily patterns of running wheel activity in male anophthalmic mice
    L K Laemle
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, Newark 07103, USA
    Physiol Behav 64:165-71. 1998
    ....
  52. ncbi Apoptosis in early ocular morphogenesis in the mouse
    L K Laemle
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ, New Jersey Medical School, Newark 07103, USA
    Brain Res Dev Brain Res 112:129-33. 1999
    ..Our data indicate that apoptosis plays a role in normal ocular morphogenesis and provides the groundwork for studies of abnormal ocular development...
  53. ncbi Nonphotic entrainment of activity and temperature rhythms in anophthalmic mice
    L K Laemle
    Department of Anatomy, Cell Biology, and Injury Sciences, UMDNJ New Jersey Medical School, Newark 07103, USA
    Physiol Behav 66:461-71. 1999
    ..Both sighted and anophthalmic mice were able to entrain to restricted wheel access, although not all animals responded. Mice that did not entrain showed either no effect of wheel locking or exhibited masking...
  54. ncbi Retinoic acid in the formation of the dorsoventral retina and its central projections
    E Wagner
    Eunice Kennedy Shriver Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Biol 222:460-70. 2000
    ..These observations indicate that the dorsoventral axis of the embryonic eye anlage determines the functional coordinates of both vision and eye movements in the adult...
  55. ncbi The homeobox gene Hesx1 is required in the anterior neural ectoderm for normal forebrain formation
    J P Martinez-Barbera
    Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, London, NW7 1AA, United Kingdom
    Dev Biol 223:422-30. 2000
    ..5- and 7.5-dpc Hesx1(-/-) mutants. Expression of the ANE markers Six3 and Rax/Rx was also unperturbed in the Hesx1(-/-) mutants from late gastrula to late headfold stages...
  56. ncbi A comparison of visual callosal organization in normal, bilaterally enucleated and congenitally anophthalmic mice
    R W Rhoades
    Exp Brain Res 56:92-105. 1984
    ..One of these was always located at the 17-18a border, and here the laminar distribution of labelled cells and anterograde labelling was the same as in the normals.(ABSTRACT TRUNCATED AT 400 WORDS)..
  57. ncbi Crystallin synthesis in the lens rudiment of a strain of mice with congenital anophthalmia
    J Zwaan
    Exp Eye Res 36:551-7. 1983
    ..This indicates that the optic vesicle in this mutant is capable of inducing a lens, while the surface ectoderm can respond to the stimulus in a normal fashion...
  58. ncbi Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6
    M Schwarz
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Development 127:4325-34. 2000
    ..Based on our findings, we propose a model for Pax gene regulation that establishes the proper spatial regionalization of the mammalian visual system...
  59. ncbi Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins
    I Mikkola
    Department of Biochemistry, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 276:4109-18. 2001
    ..The paired-like homeodomain protein Rax behaved similarly to Pax6DeltaPD...
  60. ncbi Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium
    G Bernier
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, 37077 Gottingen, Germany
    Development 128:3987-94. 2001
    ..Taken together, our results provide evidence that Necab is genetically downstream of Pax6 and that it is a part of a signal transduction pathway in retina development...
  61. ncbi The extracellular matrix between the optic vesicle and presumptive lens during lens morphogenesis in an anophthalmic strain of mice
    E H Webster
    Dev Biol 103:142-50. 1984
    ..B. Chase (1941, J. Morphol. 68, 279-301) that there may be abnormal contact between the optic vesicle and presumptive lens ectoderm in the mutant strain, although there is a differing view on the cause of the abnormal contact...
  62. ncbi Subcortical projections of area 17 in the anophthalmic mouse
    R W Rhoades
    Brain Res 349:171-81. 1985
    ..These data demonstrate that a signal from the retina is not required for either the restriction of 'visual' cortical axons to their normal subcortical targets or the achievement of normal topography within those target nuclei...
  63. ncbi Circadian rest-activity rhythms in the anophthalmic, monocular and binocular ZRDCT/An mice. Retinal and serotoninergic (raphe) influences
    H Faradji-Prevautel
    Department of Experimental Medicine, University Claude Bernard Lyon I, France
    Brain Res 526:207-16. 1990
    ..Further, a circadian variation of this signal is superimposed to that of the waking state amount. Such circadian variations are synchronized to the L/D cycle in C57 Black/6 animals and free running in the AN mice...
  64. ncbi Physiological and anatomical properties of the suprachiasmatic nucleus of an anophthalmic mouse
    L K Laemle
    Department of Ophthalmology, UMDNJ New Jersey Medical School, 90 Bergen Street, Newark, NJ 10703, USA
    Brain Res 953:73-81. 2002
    ..These data suggest that the characteristic irregular firing pattern of anophthalmics, and of controls at night, results from extrinsic, at least in part, GABAergic input...
  65. ncbi Cell-autonomous involvement of Mab21l1 is essential for lens placode development
    Ryuichi Yamada
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    Development 130:1759-70. 2003
    ..We conclude that Mab21l1 expression dependent on PAX6 is essential for lens placode growth and for formation of the lens vesicle; lack of Mab21l1 expression causes reduced expression of Foxe3 in a cell-autonomous manner...
  66. ncbi The anophthalmic mutant of the mouse. I. Genetic contribution to the anophthalmic phenotype
    S L Beck
    J Hered 54:39-44. 1963
  67. ncbi The anophthalmic mutant of the mouse. II. An association of anophthalmia and polydactyly
    S L Beck
    J Hered 54:79-83. 1963
  68. ncbi FREQUENCIES OF TERATOLOGIES AMONG HOMOZYGOUS NORMAL MICE COMPARED WITH THOSE HETEROZYGOUS FOR ANOPHTHALMIA
    S L Beck
    Nature 200:810-1. 1963
  69. ncbi VIP-like immunoreactivity in the suprachiasmatic nuclei of a mutant anophthalmic mouse
    L K Laemle
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, Newark 07103
    Brain Res 589:124-8. 1992
    ..Within the SCN, the distribution of VIP-immunoreactive cells was more diffuse in anophthalmic mice than in the controls; immunoreactive neurons were frequently observed in ectopic locations in the mutant animals...
  70. ncbi Cytological organization of the dorsal lateral geniculate nuclei in mutant anophthalmic and postnatally enucleated mice
    M J Cullen
    J Neurocytol 5:407-24. 1976
    ..The possibility that some of these large replacement terminals originate from cortical or recurrent collateral axons is considered...
  71. pmc Specification of the retinal fate of mouse embryonic stem cells by ectopic expression of Rx/rax, a homeobox gene
    Yoko Tabata
    Division of Molecular and Developmental Biology, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Mol Cell Biol 24:4513-21. 2004
    ..of generating retinal cells from mouse embryonic stem (ES) cells by exogenous gene transfer, we introduced the Rx/rax transcription factor, which is expressed in immature retinal cells, into feeder-free mouse ES cells (CCE)...
  72. ncbi Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation
    Jun Hatakeyama
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Development 131:5539-50. 2004
    ..Our data also indicate that embryonic neural stem cells change their characters over time in the following order: Hes-independent neuroepithelial cells, transitory Hes-dependent neuroepithelial cells and Hes-dependent radial glial cells...
  73. pmc Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches
    Michelle L Brinkmeier
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109 5618, USA
    Genomics 93:449-60. 2009
    ..These genes are exciting candidates for regulators of pituitary development and function...
  74. pmc Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina
    N Gotoh
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:17144-9. 2004
    ..These experiments demonstrate that intracellular signals that depend on specific tyrosine residues in FRS2alpha lie upstream of gene products critical for induction of lens and retina...
  75. ncbi A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse
    H Li
    E Kennedy Shriver Center, Waltham, MA 02452, USA
    Mech Dev 95:283-9. 2000
    ..From here it extends via the piriform cortex into the lower part of the septum. Of the three RALDHs, RALDH3 shows the strongest predilection for epithelia...
  76. ncbi Patterning the optic neuroepithelium by FGF signaling and Ras activation
    S Zhao
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 128:5051-60. 2001
    ..In mouse embryos lacking FGF9, the retinal pigment epithelium extends into the presumptive neural retina, indicating a role of FGF9 in defining the boundary of the neural retina...
  77. ncbi Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development
    Donghui Zhang
    Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health Research Triangle Park, North Carolina 27709, USA
    J Neurochem 98:860-75. 2006
    ..These data suggest that RFX4_v3 may act upstream of critical signaling pathways in the process of brain development...
  78. ncbi Studies on an anophthalmic strain of mice. VI. Lens and cup interaction
    C Hårch
    Dev Biol 63:352-7. 1978
  79. ncbi exma: an X-linked insertional mutation that disrupts forebrain and eye development
    David Cunningham
    Division of Human and Molecular Genetics, Dept of Pediatrics and Children s Research Institute, The Ohio State University, Children s Research Institute, 700 Children s Drive, Rm 403, Columbus, Ohio 43205, USA
    Mamm Genome 13:179-85. 2002
    ..From the physical mapping results, we propose a model of the gross rearrangements that accompanied transgene integration and discuss its implications for evaluating candidate genes for exma...
  80. ncbi Natural antisense transcripts associated with genes involved in eye development
    Giovanna Alfano
    Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy
    Hum Mol Genet 14:913-23. 2005
    ..identification of eight novel mouse NATs associated with transcription factors (Pax6, Pax2, Six3, Six6, Otx2, Crx, Rax and Vax2) that play an important role in eye development and function...
  81. ncbi Abnormal development of the suprachiasmatic nuclei of the hypothalamus in a strain of genetically anophthalmic mice
    J Silver
    J Comp Neurol 176:589-606. 1977
    ..These observations suggest that regular formation of the suprachiasmatic region of the hypothalamus and especially the suprachiasmatic nuclei, may depend during development upon the presence of the eye or the subjacent optic axons...