Rara

Summary

Gene Symbol: Rara
Description: retinoic acid receptor, alpha
Alias: Nr1b1, RAR, RARalpha1, retinoic acid receptor alpha, RAR alpha 1, RAR-alpha, nuclear receptor subfamily 1 group B member 1
Species: mouse
Products:     Rara

Top Publications

  1. Ruberte E, Friederich V, Chambon P, Morriss Kay G. Retinoic acid receptors and cellular retinoid binding proteins. III. Their differential transcript distribution during mouse nervous system development. Development. 1993;118:267-82 pubmed
    ..Of the three retinoic acid receptors, only RAR-gamma was not expressed in developing neural structures...
  2. Leroy P, Krust A, Zelent A, Mendelsohn C, Garnier J, Kastner P, et al. Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid. EMBO J. 1991;10:59-69 pubmed
    Together with the previously described mouse retinoic acid receptor alpha-1 (mRAR-alpha 1, formerly mRAR-alpha 0), we have isolated and characterized here a total of seven mRAR-alpha cDNA isoforms (mRAR-alpha 1 to alpha 7)...
  3. Spencer S, Wilhelm C, Yang Q, Hall J, Bouladoux N, Boyd A, et al. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science. 2014;343:432-7 pubmed publisher
    ..Further, these data indicate that, during malnutrition, a switch to innate type 2 immunity may represent a powerful adaptation of the immune system to promote host survival in the face of ongoing barrier challenges. ..
  4. Gaub M, Rochette Egly C, Lutz Y, Ali S, Matthes H, Scheuer I, et al. Immunodetection of multiple species of retinoic acid receptor alpha: evidence for phosphorylation. Exp Cell Res. 1992;201:335-46 pubmed
    ..Western blotting analysis, or immunoprecipitation, they were found to be specific for human and mouse RAR-alpha 1 proteins produced by COS-1 cells transiently transfected with vectors expressing the RAR-alpha 1 cDNA...
  5. Chanda B, Ditadi A, Iscove N, Keller G. Retinoic acid signaling is essential for embryonic hematopoietic stem cell development. Cell. 2013;155:215-27 pubmed publisher
    ..Collectively, these findings position RA and Wnt signaling as key regulators of HSC development and in doing so provide molecular insights that will aid in developing strategies for their generation from pluripotent stem cells. ..
  6. Hill J, Hall J, Sun C, Cai Q, Ghyselinck N, Chambon P, et al. Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity. 2008;29:758-70 pubmed publisher
    ..Thus, cytokine-producing CD44(hi) cells actively restrain TGF-beta-mediated Foxp3 expression in naive T cells, and this balance can be shifted or fine-tuned by RA. ..
  7. Kupumbati T, Cattoretti G, Marzan C, Farias E, Taneja R, Mira y Lopez R. Dominant negative retinoic acid receptor initiates tumor formation in mice. Mol Cancer. 2006;5:12 pubmed
    Retinoic acid suppresses cell growth and promotes cell differentiation, and pharmacological retinoic acid receptor (RAR) activation is anti-tumorigenic...
  8. Taneja R, Bouillet P, Boylan J, Gaub M, Roy B, Gudas L, et al. Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types. Proc Natl Acad Sci U S A. 1995;92:7854-8 pubmed
    ..in F9 cell differentiation, "rescue" cell lines reexpressing RAR gamma 2 or overexpressing either RAR alpha 1 or RAR beta 2 were established in RAR gamma-null cells...
  9. Rego E, He L, Warrell R, Wang Z, Pandolfi P. Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins. Proc Natl Acad Sci U S A. 2000;97:10173-8 pubmed

More Information

Publications66

  1. Chen Y, Kerimo A, Khan S, Wei L. Real-time analysis of molecular interaction of retinoid receptors and receptor-interacting protein 140 (RIP140). Mol Endocrinol. 2002;16:2528-37 pubmed
    ..RIP140 interacts with retinoic acid receptor (RAR) and retinoid X receptor (RXR) with or without ligands...
  2. Dolle P, Ruberte E, Kastner P, Petkovich M, Stoner C, Gudas L, et al. Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse. Nature. 1989;342:702-5 pubmed
    ..CRABP transcripts, however, are excluded from regions expressing mRAR gamma and mRAR beta. These results indicate that all three RARs and CRABP have specific functions during morphogenesis and differentiation of the mouse limb. ..
  3. Manshouri T, Yang Y, Lin H, Stass S, Glassman A, Keating M, et al. Downregulation of RAR alpha in mice by antisense transgene leads to a compensatory increase in RAR beta and RAR gamma and development of lymphoma. Blood. 1997;89:2507-15 pubmed
    ..We generated transgenic mice that expressed an antisense construct of the RAR alpha. Homozygous transgenic mice demonstrated 30% to 80% reduction in RAR alpha protein expression in various tissues...
  4. He L, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, et al. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nat Genet. 1998;18:126-35 pubmed
    Acute promyelocytic leukaemia (APL), associated with chromosomal translocations involving the retinoic acid receptor alpha gene (RARA) and the PML gene, is sensitive to retinoic acid (RA) treatment, while APL patients harbouring ..
  5. Chapellier B, Mark M, Messaddeq N, Calléja C, Warot X, Brocard J, et al. Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled. EMBO J. 2002;21:3402-13 pubmed
    ..express RAR beta, conditional spatio-temporally controlled somatic mutagenesis was used to selectively ablate RAR alpha in keratinocytes of RAR gamma-null mice...
  6. Zimonjic D, Pollock J, Westervelt P, Popescu N, Ley T. Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice. Proc Natl Acad Sci U S A. 2000;97:13306-11 pubmed
    ..Deletion 2 appears to predispose APL cells to further chromosomal instability, which may lead to the acquisition of additional changes that provide an advantage to the transformed cells. ..
  7. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J. 1996;10:940-54 pubmed
    ..A major source of diversity originates from the existence of two families of retinoid acid (RA) receptors (R), the RAR isotypes (alpha, beta, and gamma) and the three RXR isotypes (alpha, beta, and gamma), and their numerous isoforms, ..
  8. Weston A, Rosen V, Chandraratna R, Underhill T. Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways. J Cell Biol. 2000;148:679-90 pubmed
    ..Moreover, an RAR antagonist accelerates chondroblast differentiation as demonstrated by the emergence of collagen type II-expressing ..
  9. Kastner P, Mark M, Ghyselinck N, Krezel W, Dupé V, Grondona J, et al. Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development. Development. 1997;124:313-26 pubmed
    ..congenital malformations in compound mutant fetuses bearing null alleles in one RXR (alpha, beta or gamma) and one RAR (alpha, beta or gamma) isotype gene...
  10. Chapellier B, Mark M, Garnier J, LeMeur M, Chambon P, Ghyselinck N. A conditional floxed (loxP-flanked) allele for the retinoic acid receptor alpha (RARalpha) gene. Genesis. 2002;32:87-90 pubmed
  11. Lee C, Wei L. Characterization of receptor-interacting protein 140 in retinoid receptor activities. J Biol Chem. 1999;274:31320-6 pubmed
    ..are organized into two clusters within this molecule, each differentially interacting with retinoic acid receptor (RAR) and retinoid X receptor (RXR). RAR interacts with the 5' cluster, whereas RXR interacts with both clusters...
  12. Wang Y, Shen K, Wang Y, Brooks S. Retinoic acid signaling is required for proper morphogenesis of mammary gland. Dev Dyn. 2005;234:892-9 pubmed
    ..Collectively, our data indicate for the first time that retinoic acid signaling is required to maintain the homeostasis of mammary gland morphogenesis. ..
  13. Roy B, Taneja R, Chambon P. Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific . Mol Cell Biol. 1995;15:6481-7 pubmed
    ..On their own, low concentrations of retinoids selective for either RAR alpha, RAR beta, or RAR gamma did not induce or very inefficiently induced the expression of several RA target genes ..
  14. Hörlein A, Näär A, Heinzel T, Torchia J, Gloss B, Kurokawa R, et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature. 1995;377:397-404 pubmed
  15. Maghsoodi B, Poon M, Nam C, Aoto J, Ting P, Chen L. Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity. Proc Natl Acad Sci U S A. 2008;105:16015-20 pubmed publisher
    ..Taken together, our results provide a direct link between dendritically localized RARalpha and local GluR1 synthesis in RNA granules during RA-mediated synaptic signaling in homeostatic synaptic plasticity. ..
  16. Mollard R, Viville S, Ward S, Decimo D, Chambon P, Dolle P. Tissue-specific expression of retinoic acid receptor isoform transcripts in the mouse embryo. Mech Dev. 2000;94:223-32 pubmed
    ..This study used in situ hybridization to describe the expression patterns of RARalpha1, RARalpha2, RARbeta1/3, RARbeta2/4, RARgamma1 and RARgamma2 isoform transcripts during mouse embryogenesis...
  17. Lee H, Park U, Kim E, Um S. MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. EMBO J. 2007;26:3545-57 pubmed
    We isolated MED25, which associates with retinoic acid (RA)-bound retinoic acid receptor (RAR) through the C-terminal nuclear hormone receptor (NR) box/LxxLL motif, and increases RAR/RXR-mediated transcription...
  18. Zelent A, Krust A, Petkovich M, Kastner P, Chambon P. Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin. Nature. 1989;339:714-7 pubmed
    ..the specific role that RARs might play during development and in adult tissues, we have cloned the mouse RAR alpha and RAR beta (mRAR alpha and mRAR beta)...
  19. Hall J, Cannons J, Grainger J, Dos Santos L, Hand T, Naik S, et al. Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity. 2011;34:435-47 pubmed publisher
    ..b>Retinoic acid receptor alpha (RARα) was the critical mediator of these effects...
  20. He L, Tribioli C, Rivi R, Peruzzi D, Pelicci P, Soares V, et al. Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice. Proc Natl Acad Sci U S A. 1997;94:5302-7 pubmed
    ..Acute promyelocytic leukemia (APL) is associated with reciprocal chromosomal translocations involving the retinoic acid receptor alpha (RARalpha) locus on chromosome 17...
  21. Jonk L, de Jonge M, Vervaart J, Wissink S, Kruijer W. Isolation and developmental expression of retinoic-acid-induced genes. Dev Biol. 1994;161:604-14 pubmed
    ..The results confirm the usefulness of the P19 system in the isolation and study of the regulation of developmentally expressed genes. ..
  22. Lu Y, Bertran S, Samuels T, Mira y Lopez R, Farias E. Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARalpha agonist AM580. Oncogene. 2010;29:3665-76 pubmed publisher
    ..The anticancer effect of RARalpha, together with the newly discovered pro-proliferative role of RARgamma, suggests that specific activation of RARalpha and inhibition of RARgamma might be effective in breast cancer therapy. ..
  23. Li E, Sucov H, Lee K, Evans R, Jaenisch R. Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene. Proc Natl Acad Sci U S A. 1993;90:1590-4 pubmed
    ..The two RAR alpha transcripts (RAR alpha 1 and -alpha 2) are differentially expressed and evolutionarily conserved, as are the RAR beta and -gamma ..
  24. Bowles J, Knight D, Smith C, Wilhelm D, Richman J, Mamiya S, et al. Retinoid signaling determines germ cell fate in mice. Science. 2006;312:596-600 pubmed
    ..Thus, precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate. ..
  25. Walkley C, Purton L, Snelling H, Yuan Y, Nakajima H, Chambon P, et al. Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiation. Blood. 2004;103:1286-95 pubmed
    ..the Myc antagonist Mad1, or both Mad1 and p27(Kip1), we observed that signals mediated through retinoic acid receptor alpha (RAR alpha), but not RAR beta or gamma, required both Mad1 and p27(Kip1) to induce cell cycle arrest ..
  26. Batourina E, Gim S, Bello N, Shy M, Clagett Dame M, Srinivas S, et al. Vitamin A controls epithelial/mesenchymal interactions through Ret expression. Nat Genet. 2001;27:74-8 pubmed
    ..We previously showed that two RAR genes, Rara and Rarb2, were colocalized in stromal mesenchyme, a third renal cell type, where their deletion led to altered ..
  27. Dupé V, Pellerin I. Retinoic acid receptors exhibit cell-autonomous functions in cranial neural crest cells. Dev Dyn. 2009;238:2701-11 pubmed publisher
    ..However, ablation of Rara and Rarg genes in NCC yields an agenesis of the median portion of the face, demonstrating that RARalpha and ..
  28. Lohnes D, Mark M, Mendelsohn C, Dolle P, Dierich A, Gorry P, et al. Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants. Development. 1994;120:2723-48 pubmed
    ..G., Roth, C. B., Warkany, J., (1953), Am. J. Anat. 92, 189-217]. Previous studies of retinoic acid receptor (RAR) mutant mice have not revealed any of these malformations [Li, E., Sucov, H. M., Lee, K.-F., Evans, R. M...
  29. Chen C, Lohnes D. Dominant-negative retinoic acid receptors elicit epidermal defects through a non-canonical pathway. J Biol Chem. 2005;280:3012-21 pubmed
    Previous work has shown that a dominant-negative retinoic acid receptor alpha (dnRARalpha), expressed under the K14 promoter, causes severe epidermal defects...
  30. Kastner P, Chan S. Function of RARalpha during the maturation of neutrophils. Oncogene. 2001;20:7178-85 pubmed
    The retinoic acid receptor alpha gene is the target of chromosomal rearrangements in all cases of acute promyelocytic leukemia (APL)...
  31. Ratnam K, Feng X, Chuang P, Verma V, Lu T, Wang J, et al. Role of the retinoic acid receptor-? in HIV-associated nephropathy. Kidney Int. 2011;79:624-634 pubmed publisher
    ..HIV-induced podocyte proliferation and restores podocyte differentiation markers by activating its receptor-? (RAR?)...
  32. Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P. Function of retinoic acid receptor gamma in the mouse. Cell. 1993;73:643-58 pubmed
    Null mutant mice for retinoic acid receptor gamma 2 (RAR gamma 2) or all RAR gamma isoforms were generated...
  33. Segalla S, Rinaldi L, Kilstrup Nielsen C, Badaracco G, Minucci S, Pelicci P, et al. Retinoic acid receptor alpha fusion to PML affects its transcriptional and chromatin-remodeling properties. Mol Cell Biol. 2003;23:8795-808 pubmed
    PML-RAR is an oncogenic transcription factor forming in acute promyelocytic leukemias (APL) because of a chromosomal translocation...
  34. Mendelsohn C, Lohnes D, Decimo D, Lufkin T, LeMeur M, Chambon P, et al. Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development. 1994;120:2749-71 pubmed
    Compound null mutations of retinoic acid receptor (RAR) genes lead to lethality in utero or shortly after birth and to numerous developmental abnormalities. In the accompanying paper (Lohnes, D., Mark., M., Mendelsohn, C., Dollé, P...
  35. Ghyselinck N, Dupé V, Dierich A, Messaddeq N, Garnier J, Rochette Egly C, et al. Role of the retinoic acid receptor beta (RARbeta) during mouse development. Int J Dev Biol. 1997;41:425-47 pubmed
    ..b>RAR alpha/RAR beta double mutants display numerous visceral abnormalities, most of which are incompatible with post-natal ..
  36. Haidar M, Manshouri T, Keating M, Kantarjian H, Freireich E, Mehta K, et al. Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic acid receptor alpha-deficient transgenic mice. Int J Oncol. 2000;16:561-5 pubmed
    We recently demonstrated lymphoma development in transgenic mice deficient in retinoic acid receptor alpha (RARalpha)...
  37. Kastner P, Messaddeq N, Mark M, Wendling O, Grondona J, Ward S, et al. Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes. Development. 1997;124:4749-58 pubmed
  38. Purton L, Dworkin S, Olsen G, Walkley C, Fabb S, Collins S, et al. RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation. J Exp Med. 2006;203:1283-93 pubmed
    ..We observe that the retinoic acid receptor (RAR)gamma is selectively expressed in primitive hematopoietic precursors and that the bone marrow of RARgamma knockout ..
  39. Zhu J, Nasr R, Peres L, Riaucoux Lormière F, Honoré N, Berthier C, et al. RXR is an essential component of the oncogenic PML/RARA complex in vivo. Cancer Cell. 2007;12:23-35 pubmed
    Although PML-enforced RARA homodimerization allows PML/RARA to bind DNA independently of its coreceptor RXR, the latter was identified within the PML/RARA complex...
  40. Kamashev D, Vitoux D, De The H. PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation. J Exp Med. 2004;199:1163-74 pubmed
    PML-RARA was proposed to initiate acute promyelocytic leukemia (APL) through PML-RARA homodimer-triggered repression. Here, we examined the nature of the PML-RARA protein complex and of its DNA targets in APL cells...
  41. Mascrez B, Mark M, Dierich A, Ghyselinck N, Kastner P, Chambon P. The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development. Development. 1998;125:4691-707 pubmed
    ..of the defects that characterize the fetal vitamin A-deficiency (VAD) syndrome and were previously found in RAR single and compound mutants, as well as in RXRalpha/RAR(alpha, beta or gamma) compound mutants...
  42. Hörnberg M, Gussing F, Berghard A, Bohm S. Retinoic acid selectively inhibits death of basal vomeronasal neurons during late stage of neural circuit formation. J Neurochem. 2009;110:1263-75 pubmed publisher
    ..Collectively, the results indicate a novel connection between pre-synaptic RA receptor signaling and neural activity-dependent events that together regulate neuronal survival and maintenance of synaptic contacts. ..
  43. Rochette Egly C, Lutz Y, Saunders M, Scheuer I, Gaub M, Chambon P. Retinoic acid receptor gamma: specific immunodetection and phosphorylation. J Cell Biol. 1991;115:535-45 pubmed
    ..and mouse retinoic acid receptor gamma 1 (hRAR-gamma 1 and mRAR-gamma 1, respectively) were used to generate anti-RAR-gamma 1 antibodies...
  44. Kastner P, Lawrence H, Waltzinger C, Ghyselinck N, Chambon P, Chan S. Positive and negative regulation of granulopoiesis by endogenous RARalpha. Blood. 2001;97:1314-20 pubmed
    Acute promyelocytic leukemia (APL) is always associated with chromosomal translocations that disrupt the retinoic acid receptor alpha (RARalpha) gene...
  45. Toresson H, Mata De Urquiza A, Fagerstrom C, Perlmann T, Campbell K. Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation. Development. 1999;126:1317-26 pubmed
    ..These findings, therefore, strongly support the notion that local retinoid signalling within the lateral ganglionic eminence regulates striatal neuron differentiation. ..
  46. Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub M, et al. High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A. 1993;90:7225-9 pubmed
    ..investigate the function of the RAR alpha gene, we have disrupted, in the mouse, the whole gene or the isoform RAR alpha 1. Although RAR alpha 1 is the predominant isoform and is highly conserved among vertebrates, RAR alpha 1-null ..
  47. Nasr R, Guillemin M, Ferhi O, Soilihi H, Peres L, Berthier C, et al. Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation. Nat Med. 2008;14:1333-42 pubmed publisher
    ..arsenic trioxide target the protein stability and transcriptional repression activity of the fusion oncoprotein PML-RARA, resulting in regression of acute promyelocytic leukemia (APL)...
  48. Horn V, Minucci S, Ogryzko V, Adamson E, Howard B, Levin A, et al. RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells. FASEB J. 1996;10:1071-7 pubmed
    ..Synthetic retinoids that are selective for RA receptors (RAR) were also effective in inducing apoptosis, whereas RXR selective ligands were without effect...
  49. Luo J, Pasceri P, Conlon R, Rossant J, Giguere V. Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid. Mech Dev. 1995;53:61-71 pubmed
    ..The RAR family is composed of three genes: RAR alpha, beta, and gamma...
  50. Khetchoumian K, Teletin M, Mark M, Lerouge T, Cerviño M, Oulad Abdelghani M, et al. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem. 2004;279:48329-41 pubmed
    ..Collectively, these data are consistent with specific, nonredundant functions for the TIF1 family members in vivo and suggest a role for TIF1delta in heterochromatin-mediated gene silencing during postmeiotic phases of spermatogenesis. ..
  51. Cammas L, Trensz F, Jellali A, Ghyselinck N, Roux M, Dolle P. Retinoic acid receptor (RAR)-alpha is not critically required for mediating retinoic acid effects in the developing mouse retina. Invest Ophthalmol Vis Sci. 2010;51:3281-90 pubmed publisher
    ..RARalpha mutant (Rara(-/-)) mice were compared with wild-type littermates at several stages of pre- and postnatal development...
  52. Muenzner M, Tuvia N, Deutschmann C, Witte N, Tolkachov A, Valai A, et al. Retinol-binding protein 4 and its membrane receptor STRA6 control adipogenesis by regulating cellular retinoid homeostasis and retinoic acid receptor ? activity. Mol Cell Biol. 2013;33:4068-82 pubmed publisher
    ..complex regulators of adipogenesis by activating specific nuclear receptors, including the retinoic acid receptor (RAR) and retinoid X receptor (RXR)...
  53. Ma M, Li P, Shen H, Estrada K, Xu J, Kumar S, et al. Dysregulated endocardial TGFβ signaling and mesenchymal transformation result in heart outflow tract septation failure. Dev Biol. 2016;409:272-276 pubmed publisher
    ..By combining RAR gene mutation with tissue-specific Cre drivers and a conditional type II TGFβ receptor (Tgfbr2) allele, we ..
  54. Yao T, Ku G, Zhou N, Scully R, Livingston D. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc Natl Acad Sci U S A. 1996;93:10626-31 pubmed
    ..Together, these results implicate p300 as a component of the retinoic acid signaling pathway, operating, in part, through specific interaction with a nuclear hormone receptor coactivator, SRC-1. ..
  55. Heiermann R, Rentrop M, Lang E, Maelicke A. Cloning of several genes coding for retinoic acid nuclear receptors in the mouse embryonal carcinoma cell line PCC7-MZ1. J Recept Res. 1993;13:693-709 pubmed
    ..and partial length cDNAs coding for the alpha 2, beta 1 and beta 3 isoforms of the retinoic acid nuclear receptor (RAR). The cloned cDNAs did not differ in sequence from those of normal mouse cells...
  56. Khetchoumian K, Teletin M, Tisserand J, Mark M, Herquel B, Ignat M, et al. Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet. 2007;39:1500-6 pubmed
    ..We further show that deletion of a single retinoic acid receptor alpha (Rara) allele in a Trim24-null background suppresses HCC development and restores wild-type expression ..
  57. Yang L, Naltner A, Yan C. Overexpression of dominant negative retinoic acid receptor alpha causes alveolar abnormality in transgenic neonatal lungs. Endocrinology. 2003;144:3004-11 pubmed
    To assess retinoic acid receptor (RAR) function in alveolarization and respiratory epithelial cell differentiation/proliferation, doxycycline (Dox)-regulatable double-transgenic mouse lines were established, in which the dominant ..