Gene Symbol: RanBPM
Description: RAN binding protein 9
Alias: IBAP-1, Ibap1, RanBPM, ran-binding protein 9, B cell antigen receptor Ig beta associated protein 1, ran-binding protein M
Species: mouse
Products:     RanBPM

Top Publications

  1. Cheng L, Lemmon S, Lemmon V. RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation. J Neurochem. 2005;94:1102-10 pubmed
    ..screen using the last 28 amino acids of the cytoplasmic domain of the neural cell adhesion molecule L1 identified RanBPM as an L1-interacting protein...
  2. Liu T, Roh S, Woo J, Ryu H, Kang D. Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis. Cell Death Dis. 2013;4:e476 pubmed publisher
    ..Taken together, these finding implicate the RanBP9/p73 complex in mitochondria-mediated apoptosis in addition to its role in enhancing A? generation. ..
  3. Lakshmana M, Hayes C, Bennett S, Bianchi E, Reddy K, Koo E, et al. Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. FASEB J. 2012;26:2072-83 pubmed publisher
    ..If so, RanBP9 provides a great opportunity to develop novel therapy for AD. ..
  4. Puverel S, Barrick C, Dolci S, Coppola V, Tessarollo L. RanBPM is essential for mouse spermatogenesis and oogenesis. Development. 2011;138:2511-21 pubmed publisher
    b>RanBPM is a recently identified scaffold protein that links and modulates interactions between cell surface receptors and their intracellular signaling pathways...
  5. Costa Y, Speed R, Gautier P, Semple C, Maratou K, Turner J, et al. Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006;15:2324-34 pubmed
    ..The presence of MAEL in these critical compartments of male germ cells and its interactions provide a link suggesting the involvement of the miRNA pathway in MSUC...
  6. Bowman A, Catino D, Strong J, Randall W, Kontrogianni Konstantopoulos A, Bloch R. The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9. Mol Biol Cell. 2008;19:3782-92 pubmed publisher
    ..The organization of other sarcomeric markers, including alpha-actinin, was not affected. We identified Ran binding protein 9 (RanBP9) as a novel ligand of the Rho-GEF domain and showed that binding is specific, with an apparent ..
  7. Palavicini J, Lloyd B, Hayes C, Bianchi E, Kang D, Dawson Scully K, et al. RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice. PLoS ONE. 2013;8:e66908 pubmed publisher
    ..Both ERK1 and L1CAM interact with RanBP9. Thus, RanBP9 appears to control brain growth and development through signaling mechanisms involving ERK1 and L1CAM receptor. ..
  8. Wang D, Li Z, Messing E, Wu G. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. J Biol Chem. 2002;277:36216-22 pubmed
    ..In this study, RanBPM, also known as RanBP9, is identified as a novel interacting protein of MET through yeast two-hybrid screen...
  9. Shibata N, Tsunekawa N, Okamoto Ito S, Akasu R, Tokumasu A, Noce T. Mouse RanBPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein. Mol Reprod Dev. 2004;67:1-7 pubmed
    ..Using the yeast two-hybrid system, we found that MVH interacts with mouse RanBPM, a Ran-GTP binding protein involved in microtubule nucleation...

More Information


  1. Denti S, Sirri A, Cheli A, Rogge L, Innamorati G, Putignano S, et al. RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1. J Biol Chem. 2004;279:13027-34 pubmed
    ..We have identified RanBPM as a novel interactor of the beta(2) integrin LFA-1 in a yeast-two-hybrid screen...
  2. Menon R, Gibson T, Pastore A. The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre. J Mol Biol. 2004;343:43-53 pubmed
    ..FMRP fishes out a protein that spans the sequence of the Ran-binding protein in the microtubule-organising centre (RanBPM/RanBP9). Specific interaction of RanBPM with FMRP was confirmed by in vivo and in vitro assays...
  3. Ma L, Buchold G, Greenbaum M, Roy A, Burns K, Zhu H, et al. GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet. 2009;5:e1000635 pubmed publisher
    ..These studies provide the first evidence for an essential structural role for GASZ in male fertility and epigenetic and post-transcriptional silencing of retrotransposons by stabilizing MILI in nuage. ..
  4. Nishitani H, Hirose E, Uchimura Y, Nakamura M, Umeda M, Nishii K, et al. Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex. Gene. 2001;272:25-33 pubmed
    Previously isolated RanBPM, a Ran-binding protein in the microtubule-organizing center, which had been thought to play a role in Ran-stimulated microtubule assembly, turned out to be a truncated protein...
  5. Woo J, Jung A, Lakshmana M, Bedrossian A, Lim Y, Bu J, et al. Pivotal role of the RanBP9-cofilin pathway in A?-induced apoptosis and neurodegeneration. Cell Death Differ. 2012;19:1413-23 pubmed publisher
    ..These findings implicate the RanBP9-cofilin pathway as critical therapeutic targets not only for stemming A? generation but also antagonizing A?-induced neurotoxicity. ..
  6. Suresh B, Ramakrishna S, Kim Y, Kim S, Kim M, Baek K. Stability and function of mammalian lethal giant larvae-1 oncoprotein are regulated by the scaffolding protein RanBPM. J Biol Chem. 2010;285:35340-9 pubmed publisher
    ..In the current study, we have identified Ran-binding protein M (RanBPM) as a novel binding partner of Mgl-1, a mammalian homolog of Drosophila tumor suppressor protein lethal (2) giant ..
  7. Seebahn A, Rose M, Enz R. RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors. FEBS Lett. 2008;582:2453-7 pubmed publisher
    ..proteins interacting with two metabotropic glutamate receptor type 8 isoforms (mGlu8a and mGlu8b) and identified RanBPM. RanBPM is expressed in several brain regions, including the retina...
  8. Bai D, Chen H, Huang B. RanBPM is a novel binding protein for p75NTR. Biochem Biophys Res Commun. 2003;309:552-7 pubmed
    ..Using yeast two-hybrid system, we identified the Ran-binding protein (RanBPM) as an interactor with the intracytoplasmic domain of p75NTR (p75ICD)...
  9. Lakshmana M, Yoon I, Chen E, Bianchi E, Koo E, Kang D. Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation. J Biol Chem. 2009;284:11863-72 pubmed publisher
    ..These findings not only implicate RanBP9 as a novel and potent regulator of APP processing but also as a potential therapeutic target for Alzheimer disease. ..
  10. Bao J, Tang C, Li J, Zhang Y, Bhetwal B, Zheng H, et al. RAN-binding protein 9 is involved in alternative splicing and is critical for male germ cell development and male fertility. PLoS Genet. 2014;10:e1004825 pubmed publisher
    ..Our data uncovered a novel role of Ranbp9 in regulating alternative splicing in spermatogenic cells, which is critical for normal spermatogenesis and male fertility. ..
  11. Tsioras K, Papastefanaki F, Politis P, Matsas R, Gaitanou M. Functional Interactions between BM88/Cend1, Ran-binding protein M and Dyrk1B kinase affect cyclin D1 levels and cell cycle progression/exit in mouse neuroblastoma cells. PLoS ONE. 2013;8:e82172 pubmed publisher
    ..In the current study we identified the signal transduction scaffolding protein Ran-binding protein M (RanBPM) as a BM88/Cend1 binding partner and showed that BM88/Cend1, RanBPM and the dual specificity tyrosine-..
  12. Wang R, Palavicini J, Wang H, Maiti P, Bianchi E, Xu S, et al. RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer's disease. Neurobiol Dis. 2014;69:169-79 pubmed publisher
    ..Since RanBP9 protein levels are increased in AD brains, RanBP9 might play a crucial role in the loss of spines and synapses in AD. ..
  13. Otipoby K, Waisman A, Derudder E, Srinivasan L, Franklin A, Rajewsky K. The B-cell antigen receptor integrates adaptive and innate immune signals. Proc Natl Acad Sci U S A. 2015;112:12145-50 pubmed publisher
    ..These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response. ..
  14. Puverel S, Kiris E, Singh S, Klarmann K, Coppola V, Keller J, et al. RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells. Oncotarget. 2016;7:85109-85123 pubmed publisher
    ..Yet, very little is known about the mechanisms that control c-Kit protein levels. Here we show that the RanBPM/RanBP9 scaffold protein binds to c-Kit and is necessary for normal c-Kit protein expression in the mouse testis ..
  15. Gao X, Sadana R, Dessauer C, Patel T. Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits. J Biol Chem. 2007;282:294-302 pubmed
    ..Moreover, Gbetagamma subunits derived from a source(s) other than G(i) are necessary for the full activation of hACVI by isoproterenol in intact cells. ..
  16. Woo J, Boggess T, Uhlar C, Wang X, Khan H, Cappos G, et al. RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction. Cell Death Dis. 2015;6:1676 pubmed publisher
  17. Tarabay Y, Achour M, Teletin M, Ye T, Teissandier A, Mark M, et al. Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression. J Cell Sci. 2017;130:1463-1474 pubmed publisher
    ..We therefore identified two new members of the postnatal piRNA pathway. ..
  18. Ideguchi H, Ueda A, Tanaka M, Yang J, Tsuji T, Ohno S, et al. Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. Biochem J. 2002;367:87-95 pubmed
    b>RanBPM is a RanGTP-binding protein required for correct nucleation of microtubules...
  19. Wang H, Dey D, Carrera I, Minond D, Bianchi E, Xu S, et al. COPS5 (Jab1) protein increases ? site processing of amyloid precursor protein and amyloid ? peptide generation by stabilizing RanBP9 protein levels. J Biol Chem. 2013;288:26668-77 pubmed publisher
    ..Taken together, these results suggest that COPS5 increases A? generation by increasing RanBP9 levels. Thus, COPS5 is a novel RanBP9-binding protein that increases APP processing and A? generation by stabilizing RanBP9 protein levels. ..
  20. Greenbaum L, Katcoff D, Dou H, Gozlan Y, Malik Z. A porphobilinogen deaminase (PBGD) Ran-binding protein interaction is implicated in nuclear trafficking of PBGD in differentiating glioma cells. Oncogene. 2003;22:5221-8 pubmed
    ..Using the yeast two-hybrid system, we identified RanBPM, the nuclear Ran-binding protein, as an interacting partner of PBGD...
  21. Subramanian M, Hayes C, Thome J, Thorp E, Matsushima G, Herz J, et al. An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. J Clin Invest. 2014;124:1296-308 pubmed publisher
    ..The discovery of this multiprotein complex that mediates functionally important DC efferocytosis in vivo may have implications for future studies related to host defense and DC-based vaccines. ..
  22. Palavicini J, Wang H, Bianchi E, Xu S, Rao J, Kang D, et al. RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes. Cell Death Dis. 2013;4:e667 pubmed publisher
    ..More importantly, both AP?E9 and AP?E9/RanBP9 mice showed impaired learning and memory skills compared to WT controls. These data suggest that RanBP9 might play a crucial role in the loss of spines and synapses in AD. ..
  23. Scapoli L, Martinelli M, Pezzetti F, Palmieri A, Girardi A, Savoia A, et al. Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palate. Hum Mutat. 2010;31:794-800 pubmed publisher
    ..Understanding the molecular role of JARID2 within facial development may offer additional information to further unravel the complex genetics of CL/P...
  24. Shiroshima T, Oka C, Kawaichi M. Identification of LRP1B-interacting proteins and inhibition of protein kinase Calpha-phosphorylation of LRP1B by association with PICK1. FEBS Lett. 2009;583:43-8 pubmed publisher
    ..This study presents the possibility that LRP1B participates in signal transduction which PICK1 may regulate by inhibiting PKCalpha phosphorylation of LRP1B. ..
  25. Yang J, Zhang Z, Zhang Y, Zheng X, Lu Y, Tao D, et al. CLOCK interacts with RANBP9 and is involved in alternative splicing in spermatogenesis. Gene. 2018;642:199-204 pubmed publisher
    ..These results reveal a novel mechanism for CLOCK in spermatogenesis. ..