Gene Symbol: Rae1
Description: ribonucleic acid export 1
Alias: 3230401I12Rik, D2Ertd342e, MNRP, MNRP41, mRNA export factor, RAE1 RNA export 1 homolog, mRNA-associated protein mrnp 41, rae1 protein homolog
Species: mouse
Products:     Rae1

Top Publications

  1. Wang X, Babu J, Harden J, Jablonski S, Gazi M, Lingle W, et al. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. J Biol Chem. 2001;276:26559-67 pubmed
    The mRNA export factor RAE1 (also called GLE2) and the mitotic checkpoint protein BUB3 share extensive sequence homology in yeast as well as higher eukaryotes, although the biological relevance of their similarity is unclear...
  2. Baker D, Jeganathan K, Malureanu L, Perez Terzic C, Terzic A, van Deursen J. Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol. 2006;172:529-40 pubmed
    ..phenotypes appear early in mice that are double haploinsufficient for the mitotic checkpoint genes Bub3 and Rae1 but not in mice that are single haploinsufficient for these genes...
  3. Babu J, Jeganathan K, Baker D, Wu X, Kang Decker N, van Deursen J. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol. 2003;160:341-53 pubmed
    The WD-repeat proteins Rae1 and Bub3 show extensive sequence homology, indicative of functional similarity. However, previous studies have suggested that Rae1 is involved in the mRNA export pathway and Bub3 in the mitotic checkpoint...
  4. Jeganathan K, Malureanu L, van Deursen J. The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. Nature. 2005;438:1036-9 pubmed
    ..show that in mitosis timely destruction of securin by APC is regulated by the nucleocytoplasmic transport factors Rae1 and Nup98...
  5. Qian L, Liu Y, Wang S, Gong W, Jia X, Liu L, et al. NKG2D ligand RAE1? induces generation and enhances the inhibitor function of myeloid-derived suppressor cells in mice. J Cell Mol Med. 2017;21:2046-2054 pubmed publisher
    ..Here, we report that surface NKG2D ligand RAE1? on tumour cells induces CD11b+ Gr-1+ myeloid-derived suppressor cell (MDSC) via NKG2D in ..
  6. Sauer M, Schuldner M, Hoffmann N, Cetintas A, Reiners K, Shatnyeva O, et al. CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells. Oncogene. 2017;36:933-941 pubmed publisher
    ..These findings might help to develop novel immunotherapeutic approaches against cancer. ..
  7. Coursey T, Bohat R, Barbosa F, Pflugfelder S, de Paiva C. Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-γ in experimental dry eye. J Immunol. 2014;193:5264-72 pubmed publisher
    ..This study provides insight into the events that trigger the initial immune response in dry eye pathology. ..
  8. Weinger J, Plaisted W, Maciejewski S, Lanier L, Walsh C, Lane T. Activating receptor NKG2D targets RAE-1-expressing allogeneic neural precursor cells in a viral model of multiple sclerosis. Stem Cells. 2014;32:2690-701 pubmed publisher
    ..Collectively, these results show that in a viral-induced demyelination model, NK cells contribute to rejection of allogeneic NPCs through an NKG2D signaling pathway. ..
  9. Cheng M, Zhi K, Gao X, He B, Li Y, Han J, et al. Activation of cellular immunity and marked inhibition of liver cancer in a mouse model following gene therapy and tumor expression of GM-SCF, IL-21, and Rae-1. Mol Cancer. 2013;12:166 pubmed publisher
    ..Rae-1 receptor expressing CTL and NK cells removed liver cancer. The recombinant expression plasmid inhibited liver cancer by a mechanism that involved activation of cell-mediated immunity and Rae-1 in liver cancer. ..

More Information


  1. Girardi M, Oppenheim D, Steele C, Lewis J, Glusac E, Filler R, et al. Regulation of cutaneous malignancy by gammadelta T cells. Science. 2001;294:605-9 pubmed
    ..Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy. ..
  2. Mitra A, Satelli A, Yan J, Xueqing X, Gagea M, Hunter C, et al. IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice. Hepatology. 2014;60:2027-39 pubmed publisher
    ..natural killer group 2, member D (NKG2D) ligand and bind with the NKG2D ligand, retinoic acid early inducible 1 (Rae1), and positively activated HSCs to ameliorate liver fibrosis...
  3. Lam A, Bert N, Ho S, Shen Y, Tang L, Xiong G, et al. RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma. Cancer Res. 2014;74:2193-2203 pubmed publisher
    ..Here, we report that the induction of retinoic acid early transcript 1 (RAE1) ligands for NKG2D by the DDR relies on a STING-dependent DNA sensor pathway involving the effector molecules TBK1 ..
  4. Baker D, Dawlaty M, Wijshake T, Jeganathan K, Malureanu L, van Ree J, et al. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol. 2013;15:96-102 pubmed publisher
    ..Collectively, these data uncover a generalized function for BubR1 in counteracting defects that cause whole-chromosome instability and suggest that modulating BubR1 provides a unique opportunity to extend healthy lifespan...
  5. Radaeva S, Wang L, Radaev S, Jeong W, Park O, Gao B. Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1. Am J Physiol Gastrointest Liver Physiol. 2007;293:G809-16 pubmed
    ..In contrast, fully activated HSCs become resistant to NK cell killing because of lack of RAE1 expression, leading to chronic liver fibrosis and disease.
  6. Faria P, Chakraborty P, Levay A, Barber G, Ezelle H, Enninga J, et al. VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway. Mol Cell. 2005;17:93-102 pubmed
    ..Here we show that VSV M protein binds the mRNA export factor Rae1/mrnp41. A mutant of M protein defective in Rae1 binding is unable to inhibit mRNA nuclear export...
  7. Hou X, Zhou R, Wei H, Sun R, Tian Z. NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis. Hepatology. 2009;49:940-9 pubmed publisher
    ..into mice could promote tumor necrosis factor-alpha production and surface retinoic acid early inducible-1 (Rae1) protein expression by Kupffer cells, which then activated NK cells to produce interferon-gamma via NKG2D-Rae1 ..
  8. Cheng F, Feng L, Li S, Tan J, Cao L, He Y, et al. Yisheng injection decreases the expression of H60 and RAE-1 genes in ischemic mice liver. Transplant Proc. 2006;38:2210-3 pubmed
    ..YS treatment effectively reduced this increase, seeming to attenuate NKG2D-ligand-mediated immune responses caused by IRI. This may suggest a new concept to prevent IRI and graft rejection. ..
  9. Spada R, Rojas J, Pérez Yagüe S, Mulens V, Cannata Ortiz P, Bragado R, et al. NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery. J Leukoc Biol. 2015;97:583-98 pubmed publisher
    ..These findings and the presence of glomerulus-specific NKG2D ligands in lupus-prone mice identify a role for NK cells and NKG2D ligands in the lupus nephritic process, which could aid in understanding their role in human SLE. ..
  10. Feng L, Cheng F, Ye Z, Li S, He Y, Yao X, et al. The effect of renal ischemia-reperfusion injury on expression of RAE-1 and H60 in mice kidney. Transplant Proc. 2006;38:2195-8 pubmed
    ..The IRI-induced expression of the NKG2D ligand, Rae-1, might activate NK and CD8+ T cells. Our results suggested that MIC may be an important link between innate and adaptive immunity in kidney IRI. ..
  11. Greene T, Tokuyama M, Knudsen G, Kunz M, Lin J, Greninger A, et al. A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression. elife. 2016;5: pubmed publisher
    ..Thus our findings indicate that virally mediated HDAC inhibition can act as a signal for the host to activate NK-cell recognition. ..
  12. Wang R, Natarajan K, Revilleza M, Boyd L, Zhi L, Zhao H, et al. Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1? reveals a paradigm for MHC/MHC interaction in immune evasion. Proc Natl Acad Sci U S A. 2012;109:E3578-87 pubmed publisher
    ..The mouse CMV MHC class I (MHC-I)-like m152/gp40 glycoprotein down-regulates retinoic acid early inducible-1 (RAE1) NKG2D ligands as well as host MHC-I...
  13. Ogawa T, Tsuji Kawahara S, Yuasa T, Kinoshita S, Chikaishi T, Takamura S, et al. Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions In Vivo. J Virol. 2011;85:5423-35 pubmed publisher
    ..Enhanced retroviral replication due to host gene-targeting resulted in markedly increased RAE-1 expression in the absence of massive erythroid cell proliferation, indicating a direct role of retroviral replication in RAE-1 upregulation...