Rack1

Summary

Gene Symbol: Rack1
Description: receptor for activated C kinase 1
Alias: AL033335, GB-like, Gnb2-rs1, Gnb2l1, p205, receptor of activated protein C kinase 1, 12-3, activated protein kinase C receptor, guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, guanine nucleotide binding protein related, guanine nucleotide binding protein, beta 2, related sequence 1, guanine nucleotide-binding protein subunit beta-2-like 1, receptor of activated protein kinase C 1
Species: mouse
Products:     Rack1

Top Publications

  1. Serrels B, Sandilands E, Serrels A, Baillie G, Houslay M, Brunton V, et al. A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity. Curr Biol. 2010;20:1086-92 pubmed publisher
    ..pathway that links the integrin effector focal adhesion kinase (FAK), the molecular scaffold protein RACK1, and activity of one of its client proteins, PDE4D5, a cAMP-degrading phosphodiesterase...
  2. Mor I, Sklan E, Podoly E, Pick M, Kirschner M, Yogev L, et al. Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility. J Cell Mol Med. 2008;12:479-95 pubmed publisher
    ..In meiotic spermatocytes from TgR mice, we detected AChE-R interaction with the scaffold protein RACK1 and elevated apoptosis...
  3. Chu L, Chen Y, Chuang N. Dimerize RACK1 upon transformation with oncogenic ras. Biochem Biophys Res Commun. 2005;330:474-82 pubmed
    ..And, RACK1 protein was reactive with syndecan-2 to keep Src inactivated, but not when Ras was overexpressed...
  4. Huang C, Liu C, Chuang N. An enhanced association of RACK1 with Abl in cells transfected with oncogenic ras. Int J Biochem Cell Biol. 2008;40:423-31 pubmed
    The cellular RACK1 was shown in association with Abl in BALB/3T3 cells transfected with S-ras(Q(61)K) by immunoprecipitation...
  5. Thorslund S, Edgren T, Pettersson J, Nordfelth R, Sellin M, Ivanova E, et al. The RACK1 signaling scaffold protein selectively interacts with Yersinia pseudotuberculosis virulence function. PLoS ONE. 2011;6:e16784 pubmed publisher
    ..can interact with the translocators, is exposed inside target cells and binds to the eukaryotic signaling protein RACK1. This protein is engaged upon Y...
  6. Dehghani H, Hahnel A. Expression profile of protein kinase C isozymes in preimplantation mouse development. Reproduction. 2005;130:441-51 pubmed
    ..delta, epsilon, eta, theta, zeta, iota/lambda) and a PKC-anchoring protein, receptor for activated C-kinase 1 (RACK1)...
  7. Ashique A, Kharazia V, Yaka R, Phamluong K, Peterson A, Ron D. Localization of the scaffolding protein RACK1 in the developing and adult mouse brain. Brain Res. 2006;1069:31-8 pubmed
    b>RACK1 is a multifunctional scaffolding protein known to be involved in the regulation of various signaling cascades in the central nervous system (CNS)...
  8. Kiely P, Leahy M, O Gorman D, O Connor R. RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251. J Biol Chem. 2005;280:7624-33 pubmed
    The scaffolding protein receptor for activated C kinase (RACK1) has been proposed to mediate the integration of insulin-like growth factor I receptor (IGF-IR) and adhesion signaling...
  9. Li G, Ji X, Gao H, Zhao J, Xu J, Sun Z, et al. EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex. Nat Commun. 2012;3:667 pubmed publisher

More Information

Publications64

  1. Li H, Jiao Y, Zhang L, Wang C, Zhang X, Guo H, et al. The interferon-inducible protein p205 acts as an activator in osteoblast differentiation of mouse BMSCs. Differentiation. 2016;92:318-325 pubmed publisher
    b>p205, an interferon-inducible protein, is induced in the course of osteogenesis in mouse bone marrow stromal cells (BMSCs)...
  2. Kong Q, Gao L, Niu Y, Gongpan P, Xu Y, Li Y, et al. RACK1 is required for adipogenesis. Am J Physiol Cell Physiol. 2016;311:C831-C836 pubmed publisher
    Adipose tissue plays a critical role in metabolic diseases and the maintenance of energy homeostasis. RACK1 has been identified as an adaptor protein involved in multiple intracellular signal transduction pathways and diseases...
  3. Palis J, Kingsley P. Differential gene expression during early murine yolk sac development. Mol Reprod Dev. 1995;42:19-27 pubmed
    ..These results are consistent with the hypothesis that at E7.5, the yolk sac endoderm provides differentiated liver-like functions, while the newly developing extraembryonic mesoderm is still a largely undifferentiated tissue. ..
  4. Kershner L, Welshhans K. RACK1 is necessary for the formation of point contacts and regulates axon growth. Dev Neurobiol. 2017;77:1038-1056 pubmed publisher
    Receptor for activated C kinase 1 (RACK1) is a multifunctional ribosomal scaffolding protein that can interact with multiple signaling molecules concurrently through its seven WD40 repeats...
  5. Zhang J, Zhu F, Li X, Xu Y, Peng C, Li S, et al. Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation. Oncogene. 2012;31:1835-44 pubmed publisher
    ..Here, we show that receptor for activated C-kinase 1 (Rack1) can bind with c-Jun and ubiquitin ligase Fbw7 to form a complex...
  6. Imai Y, Suzuki Y, Tohyama M, Wanaka A, Takagi T. Cloning and expression of a neural differentiation-associated gene, p205, in the embryonal carcinoma cell line P19 and in the developing mouse. Brain Res Mol Brain Res. 1994;24:313-9 pubmed
    ..One clone was positive in the secondary screening and was designated as p205. This clone (1.1 kb) has an open reading frame of 317 amino acids with homology to G-protein beta subunit...
  7. BoseDasgupta S, Moes S, Jenoe P, Pieters J. Cytokine-induced macropinocytosis in macrophages is regulated by 14-3-3ζ through its interaction with serine-phosphorylated coronin 1. FEBS J. 2015;282:1167-81 pubmed publisher
    ..stimulation, phosphorylated coronin 1 transiently associated with 14-3-3ζ and receptor of activated C kinase 1 (RACK1)...
  8. Wan L, Su L, Xie Y, Liu Y, Wang Y, Wang Z. Protein receptor for activated C kinase 1 is involved in morphine reward in mice. Neuroscience. 2009;161:734-42 pubmed publisher
    ..b>RACK1, the protein receptor for activated C kinase 1, is a multifunctional scaffolding protein known to be a key ..
  9. Zhu J, Chen X, Song Y, Zhang Y, Zhou L, Wan L. Deficit of RACK1 contributes to the spatial memory impairment via upregulating BECLIN1 to induce autophagy. Life Sci. 2016;151:115-121 pubmed publisher
    Deficiency of activated C kinase1 (RACK1) in the brain of aging animal and Alzheimer's disease was characterized by cognitive dementia and spatial memory impairment...
  10. Liu X, Zhu M, Yang X, Wang Y, Qin B, Cui C, et al. Inhibition of RACK1 ameliorates choroidal neovascularization formation in vitro and in vivo. Exp Mol Pathol. 2016;100:451-9 pubmed publisher
    ..The receptor for activated C-kinase 1 (RACK1) serves as a scaffold protein which is recently found to promote angiogenesis...
  11. Bjørndal B, Myklebust L, Rosendal K, Myromslien F, Lorens J, Nolan G, et al. RACK1 regulates Ki-Ras-mediated signaling and morphological transformation of NIH 3T3 cells. Int J Cancer. 2007;120:961-9 pubmed
    ..Ras-mediated morphological transformation encoded by a truncated version of the receptor for activated C-kinase (RACK1)...
  12. Guillemot F, Billault A, Auffray C. Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex. Proc Natl Acad Sci U S A. 1989;86:4594-8 pubmed
    ..A possible involvement of the C12.3 gene product in major histocompatibility complex-linked control of lymphocyte proliferation in chickens is discussed. ..
  13. Liu Z, Chen Y, Mo R, Hui C, Cheng J, Mohandas N, et al. Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis. J Biol Chem. 2000;275:25641-51 pubmed
    ..These results pinpoint RhCG and Rhcg as novel polytopic membrane glycoproteins that may function as epithelial transporters maintaining normal homeostatic conditions in kidney and testis. ..
  14. Kwon H, Bae S, Son Y, Chung H. Expression of the Xenopus homologue of the receptor for activated C-kinase 1 (RACK1) in the Xenopus embryo. Dev Genes Evol. 2001;211:195-7 pubmed
    We have isolated the Xenopus homologue of the receptor for activated C-kinase 1 (RACK1), whose amino acid sequence shows significant similarity with other vertebrate RACK1s...
  15. Wang W, Yeh S, Chang Y, Hsiao S, Lian W, Lin C, et al. PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells. J Biol Chem. 2003;278:37705-12 pubmed
    ..These findings indicate a previously unidentified role for PICK1 in anchoring PKCalpha to mitochondria in a ligand-specific manner. ..
  16. Hermanto U, Zong C, Li W, Wang L. RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix. Mol Cell Biol. 2002;22:2345-65 pubmed
    ..We identified RACK1, a WD repeat family member and a Gbeta homologue, and demonstrated that RACK1 interacts with the IGF-IR but not ..
  17. Inayat Hussain S, Wong L, Chan K, Rajab N, Din L, Harun R, et al. RACK-1 overexpression protects against goniothalamin-induced cell death. Toxicol Lett. 2009;191:118-22 pubmed publisher
    ..2 cells. This data demonstrate that RACK-1 plays a crucial role in regulating cell death signalling pathways induced by goniothalamin. ..
  18. Besson A, Wilson T, Yong V. The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility. J Biol Chem. 2002;277:22073-84 pubmed
    ..We provide novel evidence that the scaffolding protein RACK1 mediates the interaction between integrin beta chain and activated PKCepsilon...
  19. Ma J, Wu R, Zhang Q, Wu J, Lou J, Zheng Z, et al. DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. Biochem J. 2014;462:489-97 pubmed publisher
    ..However, the molecular mechanism is still unclear. In the present study we show that DJ-1 interacts with RACK1 (receptor of activated C kinase 1) and increases its dimerization and protein stability...
  20. Lin J, Lee D, Choi Y, Lee S. The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors. Sci Signal. 2015;8:ra54 pubmed publisher
    ..We found that the scaffold protein RACK1 (receptor for activated C kinase 1) selectively mediated the RANKL-dependent activation of p38 MAPK through the ..
  21. Li S, Esterberg R, Lachance V, Ren D, Radde Gallwitz K, Chi F, et al. Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity. Proc Natl Acad Sci U S A. 2011;108:2264-9 pubmed publisher
    ..Here, we report the identification of Rack1 as an interacting protein of a vertebrate Vang protein, Vangl2...
  22. Dell E, Connor J, Chen S, Stebbins E, Skiba N, Mochly Rosen D, et al. The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. J Biol Chem. 2002;277:49888-95 pubmed
    ..Two of these proteins, the receptor for activated C kinase 1 (RACK1) and the dynein intermediate chain, co-immunoprecipitate with Gbetagamma using an anti-Gbeta antibody...
  23. Huang C, Fan J, Chuang N. Farnesyl pyrophosphate promotes and is essential for the binding of RACK1 with beta-tubulin. J Exp Zool A Comp Exp Biol. 2003;298:119-27 pubmed
    ..b>RACK1 isolated from BALB/3T3 cells transformed with S-ras(Q61K) exhibits receptor activity for PKCgamma as competent as ..
  24. Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, et al. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal. 2010;3:ra7 pubmed publisher
    ..We found that the scaffold protein receptor for activated C-kinase 1 (RACK1) interacted with IRE1alpha in a glucose-stimulated or endoplasmic reticulum (ER) stress-responsive manner in ..
  25. Du Y, Meng J, Huang Y, Wu J, Wang B, Ibrahim M, et al. Guanine nucleotide-binding protein subunit beta-2-like 1, a new Annexin A7 interacting protein. Biochem Biophys Res Commun. 2014;445:58-63 pubmed publisher
    We report for the first time that Guanine nucleotide-binding protein subunit beta-2-like 1 (RACK1) formed a complex with Annexin A7...
  26. Dermott J, Gooya J, Asefa B, Weiler S, Smith M, Keller J. Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation. Stem Cells. 2004;22:832-48 pubmed
    b>p205 belongs to a family of interferon-inducible proteins called the IFI-200 family, which have been implicated in the regulation of cell growth and differentiation...
  27. Zhao Y, Wang Q, Qiu G, Zhou S, Jing Z, Wang J, et al. RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK. Cell Rep. 2015;13:1407-1417 pubmed publisher
    ..However, the role of WD40-repeat-only proteins, such as RACK1, in postnatal mammalian physiology remains unknown...
  28. Berns H, Humar R, Hengerer B, Kiefer F, Battegay E. RACK1 is up-regulated in angiogenesis and human carcinomas. FASEB J. 2000;14:2549-58 pubmed
    ..We detected the receptor for activated C kinase 1 (RACK1), the specific receptor for activated protein kinase C beta (PKC beta), to be up-regulated in bovine cord-forming ..
  29. Mamidipudi V, Miller L, Mochly Rosen D, Cartwright C. Peptide modulators of Src activity in G1 regulate entry into S phase and proliferation of NIH 3T3 cells. Biochem Biophys Res Commun. 2007;352:423-30 pubmed
    ..Previously, we identified RACK1 as an endogenous substrate, binding partner and inhibitor of Src tyrosine kinases...
  30. Zheng Y, Zhang L, Jia X, Wang H, Hu Y. Interaction of protein inhibitor of activated STAT 2 (PIAS2) with receptor of activated C kinase 1, RACK1. FEBS Lett. 2012;586:122-6 pubmed publisher
    In this study, the evolutionarily conserved intracellular adaptor protein, receptor of activated C kinase 1 (RACK1) was identified as a novel interaction partner of protein inhibitor of activated STAT 2 (PIAS2) using a yeast two-hybrid ..
  31. Wan L, Xie Y, Su L, Liu Y, Wang Y, Wang Z. RACK1 affects morphine reward via BDNF. Brain Res. 2011;1416:26-34 pubmed publisher
    ..Our previous studies have shown that RACK1 is involved in morphine reward in mice...
  32. Meyer S, Jirtle R. Old dance with a new partner: EGF receptor as the phenobarbital receptor mediating Cyp2B expression. Sci Signal. 2013;6:pe16 pubmed publisher
    ..pathway affected by the PhB-EGFR interaction is the loss of tyrosine phosphorylation of the scaffold protein RACK1. Dephosphorylated RACK1 provides the mechanistic link between the binding of PhB to EGFR and its effects on CAR by ..
  33. Campagne C, Reyes Gomez E, Picco M, Loiodice S, Salaun P, Ezagal J, et al. RACK1 cooperates with NRASQ61K to promote melanoma in vivo. Cell Signal. 2017;36:255-266 pubmed publisher
    Melanoma is the deadliest skin cancer. RACK1 (Receptor for activated protein kinase C) protein was proposed as a biological marker of melanoma in human and domestic animal species harboring spontaneous melanomas...
  34. Liu L, Zhang H, Zhang Q, Guo X. Effects of insulin-like growth factor binding protein-related protein 1 in mice with hepatic fibrosis induced by thioacetamide. Chin Med J (Engl). 2010;123:2521-6 pubmed
    ..The mechanism for this suppression of fibrosis is associated with the TGF-?1/Smad3 signaling pathways. ..
  35. Huang J, Chen C, Chuang N. P120-GAP associated with syndecan-2 to function as an active switch signal for Src upon transformation with oncogenic ras. Biochem Biophys Res Commun. 2005;329:855-62 pubmed
    ..and p120-GAP, we further purified p120-GAP protein from mouse brains by using an affinity column of HiTrap-RACK1 and expressed mouse RACK1-encoded fusion protein and mouse syndecan-2-encoded fusion protein in bacteria...
  36. Zakrzewicz A, Hecker M, Marsh L, Kwapiszewska G, Nejman B, Long L, et al. Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension. Circulation. 2007;115:2957-68 pubmed
    ..We identified the receptor for activated C-kinase (RACK1) as a novel interaction partner of BMPRII by yeast 2-hybrid analyses using the kinase domain of BMPRII as a bait...
  37. Birikh K, Sklan E, Shoham S, Soreq H. Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior. Proc Natl Acad Sci U S A. 2003;100:283-8 pubmed
    ..stress-induced splice variant of acetylcholinesterase, AChE-R, interacts intraneuronally with the scaffold protein RACK1 and through it, with its target, protein kinase CbetaII (PKCbetaII), which is known to be involved in fear ..
  38. Huang J, Chen C, Chuang N. Trap RACK1 with Ras to mobilize Src signaling at syndecan-2/p120-GAP upon transformation with oncogenic ras. Biochem Biophys Res Commun. 2005;330:1087-94 pubmed
    HiTrap-syndecan-2/p120-GAP and HiTrap-syndecan-2/RACK1 affinity columns were applied to reveal that Src tyrosine kinase was highly expressed in BALB/3T3 cells transfected with plasmids pcDNA3.1-[S-ras(Q(61)K)] of shrimp Penaeus japonicus...
  39. Marubashi S, Ohbayashi N, Fukuda M. A Varp-Binding Protein, RACK1, Regulates Dendrite Outgrowth through Stabilization of Varp Protein in Mouse Melanocytes. J Invest Dermatol. 2016;136:1672-1680 pubmed publisher
    ..Here, we identified RACK1 (receptor of activated protein kinase C 1) as a Varp-ANKR2 binding partner and investigated its involvement in Varp stabilization in mouse ..
  40. Nilsson J, Sengupta J, Frank J, Nissen P. Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome. EMBO Rep. 2004;5:1137-41 pubmed
    The receptor for activated C-kinase (RACK1) is a scaffold protein that is able to interact simultaneously with several signalling molecules. It binds to protein kinases and membrane-bound receptors in a regulated fashion...
  41. Vomastek T, Iwanicki M, Schaeffer H, Tarcsafalvi A, Parsons J, Weber M. RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. Mol Cell Biol. 2007;27:8296-305 pubmed
    ..Here we show that the RACK1 scaffold protein functions specifically in integrin-mediated activation of the mitogen-activated protein kinase/..
  42. Cao G, Thebault S, van der Wijst J, van der Kemp A, Lasonder E, Bindels R, et al. RACK1 inhibits TRPM6 activity via phosphorylation of the fused alpha-kinase domain. Curr Biol. 2008;18:168-76 pubmed publisher
    ..Here, we identify the receptor for activated C-kinase 1 (RACK1) as the first regulatory protein of TRPM6 that associates with the alpha-kinase domain...
  43. Zhang W, Cheng G, Gong J, Hermanto U, Zong C, Chan J, et al. RACK1 and CIS mediate the degradation of BimEL in cancer cells. J Biol Chem. 2008;283:16416-26 pubmed publisher
    b>RACK1 is a 7-WD motif-containing protein with numerous downstream effectors regulating various cellular functions. Using a yeast two-hybrid screen, we identified dynein light chain 1 as a novel interacting partner of RACK1...
  44. Pawlowski T, Heringer Walther S, Cheng C, Archie J, Chen C, Walther T, et al. Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice. Genomics. 2009;94:188-95 pubmed publisher
    ..This study provides insight into Agtr2 influenced candidate genes and suggests that expression dysregulation of these genes may modulate Agtr2 actions in the brain that influences learning and memory. ..
  45. Wu J, Meng J, Du Y, Huang Y, Jin Y, Zhang J, et al. RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway. Biomed Pharmacother. 2013;67:313-9 pubmed publisher
    ..Receptor of activated C-kinase 1 (Rack1), together with Jnk1 and gelsolin (Gsn) were previously identified as differentially expressed proteins for ..
  46. Volta V, Beugnet A, Gallo S, Magri L, Brina D, Pesce E, et al. RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency. Cell Mol Life Sci. 2013;70:1439-50 pubmed publisher
    The receptor for activated C-kinase 1 (RACK1) is a conserved structural protein of 40S ribosomes. Strikingly, deletion of RACK1 in yeast homolog Asc1 is not lethal...
  47. Liu M, Peng P, Wang J, Wang L, Duan F, Jia D, et al. RACK1-mediated translation control promotes liver fibrogenesis. Biochem Biophys Res Commun. 2015;463:255-61 pubmed publisher
    ..Our previous report suggests that up-regulation of receptor for activated C-kinase 1(RACK1) in HSCs is critical for liver fibrogenesis...
  48. Mamidipudi V, Zhang J, Lee K, Cartwright C. RACK1 regulates G1/S progression by suppressing Src kinase activity. Mol Cell Biol. 2004;24:6788-98 pubmed
    ..Cancer cells subvert controls at work at this restriction point and remain in cycle. Previously, we showed that RACK1 inhibits the oncogenic Src tyrosine kinase and NIH 3T3 cell growth...
  49. Liu L, Zhu J, Zhou L, Wan L. RACK1 promotes maintenance of morphine-associated memory via activation of an ERK-CREB dependent pathway in hippocampus. Sci Rep. 2016;6:20183 pubmed publisher
    Existence of long-term drug-associated memories may be a crucial factor in drug cravings and relapse. RACK1 plays a critical role in morphine-induced reward...
  50. Robles M, Boyault C, Knutti D, Padmanabhan K, Weitz C. Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock. Science. 2010;327:463-6 pubmed publisher
    ..Receptor for activated C kinase-1 (RACK1) and protein kinase C-alpha (PKCalpha) were recruited in a circadian manner into a nuclear BMAL1 complex during ..
  51. Jia D, Duan F, Peng P, Sun L, Liu X, Wang L, et al. Up-regulation of RACK1 by TGF-?1 promotes hepatic fibrosis in mice. PLoS ONE. 2013;8:e60115 pubmed publisher
    ..b>RACK1, the receptor for activated C-kinase 1, is a classical scaffold protein implicated in numerous signaling pathways ..
  52. Villafuerte B, Barati M, Rane M, Isaacs S, Li M, Wilkey D, et al. Over-expression of insulin-response element binding protein-1 (IRE-BP1) in mouse pancreatic islets increases expression of RACK1 and TCTP: Beta cell markers of high glucose sensitivity. Biochim Biophys Acta Proteins Proteom. 2017;1865:186-194 pubmed publisher
    ..a novel interaction between two differentially regulated proteins receptor for activated protein kinase C (RACK1) and translationally controlled tumor protein (TCTP)...
  53. MacDonald D, Weerapura M, Beazely M, Martin L, Czerwinski W, Roder J, et al. Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src. J Neurosci. 2005;25:11374-84 pubmed
    ..Peptides that mimic the binding sites for either Fyn or Src on receptor for activated C kinase-1 (RACK1) also enhanced NMDAR in CA1 neurons, but their effects were blocked by Src(40-58), implying that Src is the ..
  54. Asefa B, Dermott J, Kaldis P, Stefanisko K, Garfinkel D, Keller J. p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation. FEBS Lett. 2006;580:1205-14 pubmed
    b>p205 is a member of the interferon-inducible p200 family of proteins that regulate cell proliferation. Over-expression of p205 inhibits cell growth, although its mechanism of action is currently unknown...
  55. Chen S, Lin F, Hamm H. RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation. J Biol Chem. 2005;280:33445-52 pubmed
    Receptor for Activated C Kinase 1 (RACK1), a novel G betagamma-interacting protein, selectively inhibits the activation of a subclass of G betagamma effectors such as phospholipase C beta2 (PLCbeta2) and adenylyl cyclase II by direct ..