Genomes and Genes
Gene Symbol: Rac1
Description: RAS-related C3 botulinum substrate 1
Alias: AL023026, D5Ertd559e, ras-related C3 botulinum toxin substrate 1, p21-Rac1
Publications175 found, 100 shown here
- Syndecan-4 regulates ATF-2 transcriptional activity in a Rac1-dependent mannerStefania Saoncella
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Biol Chem 279:47172-6. 2004..with wild type cells, fibronectin-adherent syndecan-4-null fibroblasts showed enhanced lamellipodia and increased Rac1 activity that could be down-regulated by re-expression of syndecan-4 in the mutant cells...
- Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particlesAkira Yamauchi
Inha University College of Medicine, Incheon, Korea
J Immunol 173:5971-9. 2004..production elicited by phorbol ester, fMLP, or IgG-coated particles, despite expression of the highly homologous Rac1 isoform...
- Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factorLuis Vidali
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Mol Biol Cell 17:2377-90. 2006Previous studies of Rac1 in fibroblasts have used dominant negative constructs, which may have nonspecific effects. We used a conditional Rac1 allele to critically examine Rac1 function in mouse fibroblasts...
- Requirement of Rac1 in the development of cardiac hypertrophyMinoru Satoh
Cardiovascular and Hematology Divisions, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:7432-7. 2006..However, it is not known which Rac isoform mediates this effect in the heart. Here we show that Rac1 is critical for generating oxidative stress and producing cardiac hypertrophy in the adult heart...
- Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system developmentYves Benninger
Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
J Cell Biol 177:1051-61. 2007..We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells...
- Rho GTPases and the actin cytoskeletonA Hall
Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
Science 279:509-14. 1998....
- Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidanceAnne Briançon-Marjollet
CRBM CNRS, UMR5237, 1919 Route de Mende, 34293 Montpellier Cedex 05, France
Mol Cell Biol 28:2314-23. 2008..cue netrin-1 promotes neurite outgrowth through its receptor Deleted in Colorectal Cancer (DCC) via activation of Rac1. The guanine nucleotide exchange factor (GEF) linking netrin-1/DCC to Rac1 activation has not yet been identified...
- Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formationPascale Dufourcq
INSERM U828, Av du haut lévèque, 33600 Pessac, France
Am J Pathol 172:37-49. 2008..This study illustrates a regulated pathway by sFRP-1 involving GSK-3beta and Rac-1 in endothelial cell cytoskeletal reorganization and in neovessel formation...
- Integrin beta 1 regulates phagosome maturation in macrophages through Rac expressionQing qing Wang
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 180:2419-28. 2008..We found that the expression of the Rho family GTPases Rac1, Rac2, and Cdc42 was reduced in integrin beta(1)-deficient macrophages...
- Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progressionAng Li
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
Dev Cell 21:722-34. 2011..Targeted deletion of Rac1 in melanoblasts during embryogenesis causes defects in migration, cell-cycle progression, and cytokinesis...
- A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylationErin M Griner
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
J Biol Chem 285:16931-41. 2010....
- Impact of Rac1 and Cdc42 signaling during early herpes simplex virus type 1 infection of keratinocytesPhilipp Petermann
Center for Biochemistry, University of Cologne, Cologne, Germany
J Virol 83:9759-72. 2009..contribute to the initial steps of HSV-1 infection of epithelial cells, and thus, we investigated the impact of Rac1 and Cdc42, which serve as key regulators of actin dynamics...
- Rac activity is polarized and regulates meiotic spindle stability and anchoring in mammalian oocytesGuillaume Halet
Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Dev Cell 12:309-17. 2007..These results demonstrate that Rac-GTP plays a major role in oocyte meiosis, via the regulation of spindle stability and anchoring to the cortex...
- Rac GTPases play critical roles in early T-cell developmentCeline Dumont
Division of Immune Cell Biology, Medical Research Council MRC National Institute for Medical Research, London, UK
Blood 113:3990-8. 2009The Rac1 and Rac2 GTPases play important roles in many processes including cytoskeletal reorganization, proliferation, and survival, and are required for B-cell development...
- Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetesJianmin Li
Critical Illness Research, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada
Diabetes 59:2033-42. 2010Our recent study demonstrated that Rac1 and NADPH oxidase activation contributes to cardiomyocyte apoptosis in short-term diabetes...
- Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesisDeqiang Li
Riley Heart Research Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Development 138:303-15. 2011..Biochemical analyses indicate that Daam1 does not regulate cytoskeletal organization through RhoA, Rac1 or Cdc42...
- Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activityJoan M Cook-Mills
Department of Pathology, University of Cincinnati, Cincinnati, OH 45267 0529, USA
Biochem J 378:539-47. 2004..Furthermore, VCAM-1 specifically activated the Rho-family GTPase Rac1, and VCAM-1 activation of NADPH oxidase was blocked by a dominant negative Rac1...
- Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activationTakeshi Tanaka
Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Japan
Biochem Biophys Res Commun 399:677-82. 2010..Here we explored that hypothesis that MCP-1 enhances efferocytosis through a Rac1/phosphatidylinositol 3-kinase (PI3-kinase)-dependent mechanism...
- Early requirement of Rac1 in a mouse model of pancreatic cancerIrina Heid
II Medizinische Klinik Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
Gastroenterology 141:719-30, 730.e1-7. 2011..RAS-related C3 botulinum substrate 1 (Rac1), which controls actin reorganization, can be activated by Ras, is up-regulated in several human cancers, and is ..
- The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and ErkE Arpaia
The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada
Oncogene 31:884-96. 2012..Cancer cells overexpressing CBD or lacking RhoC had reduced p130(Cas) phosphorylation and Rac1 activation, resulting in an inhibition of migration and invasion in vitro...
- Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migrationJulia Meller
Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
J Cell Sci 121:1981-9. 2008..Additionally, RhoG was not detectably activated by adhesion to fibronectin. Using Rac1(-/-) cells, we found that constitutively active RhoG induced membrane ruffling via both Rac-dependent and -..
- IRAK-1 contributes to lipopolysaccharide-induced reactive oxygen species generation in macrophages by inducing NOX-1 transcription and Rac1 activation and suppressing the expression of antioxidative enzymesUrmila Maitra
Departments of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
J Biol Chem 284:35403-11. 2009..On the other hand, we demonstrated that IRAK-1 associated with and activated small GTPase Rac1, a known activator of NOX-1 oxidase enzymatic activity...
- VASP is involved in cAMP-mediated Rac 1 activation in microvascular endothelial cellsNicolas Schlegel
Institute of Anatomy and Cell Biology, Julius Maximilians Univ, Koellikerstr 6, 97070 Wurzburg, Germany
Am J Physiol Cell Physiol 296:C453-62. 2009..Together, our data underline the significant role of cAMP-mediated Rac 1 activation for endothelial barrier stabilization and demonstrate that both AKAP-mediated PKA anchoring and VASP are required for this process...
- Activation of Rac-1 and Cdc42 stabilizes the microvascular endothelial barrierJens Waschke
Institute of Anatomy and Cell Biology, Julius Maximilians University, Koellikerstr 6, 97070, Wurzburg, Germany
Histochem Cell Biol 125:397-406. 2006..These experiments indicate that activation of Rac-1 and Cdc42 stabilizes microvascular endothelial barrier functions in vitro and in vivo, likely by increasing the junction-associated actin cytoskeleton...
- p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serumSusana Zuluaga
Departamento de Bioquimica y Biologia Molecular II, Facultad de Farmacia, UCM, Ciudad Universitaria, 28040 Madrid, Spain
FEBS Lett 581:3819-25. 2007..Our results indicate that p38alpha can differentially contribute to Rac-1 activation depending on the presence of serum...
- Mitogen-activated protein kinase phosphatase-1 inhibits myocardial TNF-α expression and improves cardiac function during endotoxemiaTing Zhang
Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1
Cardiovasc Res 93:471-9. 2012..The aim of this study was to investigate the role of mitogen-activated protein kinase phosphatase-1 (MKP1) pathway in myocardial TNF-α expression and cardiac function during endotoxemia...
- Involvement of Beclin 1 in engulfment of apoptotic cellsAkimitsu Konishi
Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo 113 8510, Japan
J Biol Chem 287:13919-29. 2012..1 was recruited to the early phagocytic cup along with the generation of phosphatidylinositol 3-phosphate and Rac1, which regulates actin dynamics in lamellipodia...
- Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanismAng Li
The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
J Invest Dermatol 132:2610-21. 2012..The Ras oncogene also activates signaling via the related Rho GTPase Rac1, which can mediate growth, survival, and motility signaling...
- Integrin-linked kinase is a central mediator in angiotensin II type 1- and chemokine receptor CXCR4 signaling in myocardial hypertrophyStephanie I Bettink
Klinik fur Innere Medizin III, Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, 66421 Homburg Saar, Germany
Biochem Biophys Res Commun 397:208-13. 2010..in mouse models of cardiac hypertrophy (transaortic constriction, transgenic cardiac-specific overexpression of rac1) and in human CHF in association with increased cardiac ILK-expression...
- T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascadeVinod S Ramgolam
Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Departments of Medicine Cardiovascular Medicine and Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
PLoS ONE 5:e14450. 2010..However, little is known regarding integrin-induced signaling cascades that affect mRNA catabolism. This study examines the role of the GTPases, Rac 1 and Rac 2, and their downstream effectors, in the LFA-1-induced effects on mRNA...
- Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1Neil E Torbett
Protein Phosphorylation Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
J Biol Chem 278:32344-51. 2003..PKN1 translocation is dependent on Rac1 activation, although the GTPase binding HR1abc domain is not sufficient for this recruitment...
- EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signalingBalachandar Venkatesan
Research Service, Southeast Louisiana Veterans Health Care System, New Orleans, LA 70161, USA
J Mol Cell Cardiol 49:655-63. 2010..stimulates the activation of NF-kappaB, AP-1, CREB, and ATF-2 in cardiomyocytes, and induces IL-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-kappaB and MKK7/JNK/AP-1 signaling...
- Rac1 deletion in mouse neutrophils has selective effects on neutrophil functionsMichael Glogauer
Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 170:5652-7. 2003..However, the specific role of Rac1 in neutrophil function has been difficult to assess since deletion of Rac1 results in embryonic lethality in mice...
- Normal levels of Rac1 are important for dendritic but not axonal development in hippocampal neuronsSara Gualdoni
DIBIT, San Raffaele Scientific Institute, Milano, Italy
Biol Cell 99:455-64. 2007..Among these proteins, Rac1 is known to play a crucial role in the regulation of actin dynamics, and a number of studies indicate the ..
- Essential role of Rac1 and Rac3 GTPases in neuronal developmentSara Corbetta
Cell Adhesion Unit, San Raffaele Scientific Institute and University Vita Salute San Raffaele, Via Olgettina 58 20132 Milano, Italy
FASEB J 23:1347-57. 2009..Ubiquitous Rac1 and neuron-specific Rac3 GTPases are coexpressed in the developing mammalian brain...
- Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathwayFlorian Bassermann
Department of Internal Medicine III, Laboratory of Leukemogenesis, Technical University of Munich, 81675, Germany
J Biol Chem 277:12437-45. 2002....
- Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targetingMark A Baumeister
Department of Biochemistry and Biophysics and the Graduate Group in Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 278:11457-64. 2003..We then introduced the PH domain mutations into full-length Tiam-1 and found that its ability to activate Rac1 or serum response factor in vivo was abolished...
- Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation developmentDavid R Natale
Department of Physiology and Pharmacology University of Western Ontario, Ontario, London, Canada N6A 5C1
Gene Expr Patterns 2:17-22. 2002..proteins mediate E-cadherin-based cell-to-cell adhesion through interactions with beta-catenin and the Rho GTPases, rac1 and cdc42...
- Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation developmentDavid R Natale
Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
Mech Dev 119:S21-6. 2002..proteins mediate E-cadherin-based cell-to-cell adhesion through interactions with beta-catenin and the Rho GTPases, rac1 and cdc42...
- Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1Joseph L Kissil
Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Cell 12:841-9. 2003..This link provides a possible mechanism for the effect of loss of merlin expression in tumorigenesis...
- Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migrationClaire M Wells
Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, 91 Riding House Street, London WIW 7BS, UK
J Cell Sci 117:1259-68. 2004..Dominant-negative Rac1 has been used to implicate Rac GTPases in these responses, but which of the three mammalian Rac isoforms it ..
- cAMP protects endothelial barrier functions by preventing Rac-1 inhibitionJ Waschke
Dept of Physiology and Membrane Biology, School of Medicine, Univ of California, 1 Shields Ave, Davis, CA 95616, USA
Am J Physiol Heart Circ Physiol 287:H2427-33. 2004..Our study suggests that cAMP may provide its well-established protective effects at least in part by regulation of Rho proteins...
- Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compassChun Xiang Sun
Faculty of Dentistry, University of Toronto, Rm 241, 150 College St, Toronto, ON, Canada M5S 1A8
Blood 104:3758-65. 2004Although both of the small Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 have been demonstrated to play a role in chemotaxis, the precise and possible unique roles performed by each of these 2 Rac isoforms in neutrophil chemotaxis ..
- Stem cell depletion through epidermal deletion of Rac1Salvador Aznar Benitah
Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Science 309:933-5. 2005..Deletion of Rac1, a Rho guanosine triphosphatase, in adult mouse epidermis stimulated stem cells to divide and undergo terminal ..
- Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assemblyFukun Guo
Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
J Biol Chem 281:18652-9. 2006b>Rac1 is an intracellular signal transducer regulating a variety of cell functions...
- The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilizationJose A Cancelas
Division of Experimental Hematology, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45215, USA
Exp Hematol 34:976-85. 2006....
- Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivoTadanori Mammoto
Department of Medicine, Division of Interdisciplinary Medicine and Biotechnology and Center for Vascular Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Biol Chem 282:23910-8. 2007..This induces activation of one endogenous GTPase, Rac1, and inhibition of another, RhoA...
- Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelinationAlessandro Nodari
Department of Biological and Technological Research, San Raffaele Scientific Institute, 20132 Milan, Italy
J Cell Biol 177:1063-75. 2007..integrin migrate to and elongate on axons but cannot extend radial lamellae of cytoplasm, similar to cells with low Rac1 activation...
- The role of VASP in regulation of cAMP- and Rac 1-mediated endothelial barrier stabilizationN Schlegel
Institute of Anatomy and Cell Biology, University of Wurzburg, Wurzburg, Germany
Am J Physiol Cell Physiol 294:C178-88. 2008..All these data suggest that VASP is involved in the regulation of Rac 1 activity. Taking these findings together, our study indicates that VASP at least in part stabilizes endothelial barrier functions by control of Rho-family GTPases...
- Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migrationRebecca S Dise
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 0696, USA
Am J Physiol Gastrointest Liver Physiol 294:G276-85. 2008..Either Rac1 small interfering (si)RNA or a Rac1 inhibitor completely blocked EGF-stimulated wound closure...
- Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen speciesAnselm T Bäumer
Klinik III fur Innere Medizin, Universitat zu Koln, 50937 Koln, Germany
J Biol Chem 283:7864-76. 2008..ROS are required for PDGF-AA-dependent chemotaxis but not proliferation...
- cAMP induced Rac 1-mediated cytoskeletal reorganization in microvascular endotheliumY Baumer
Institute of Anatomy and Cell Biology, University of Wuerzburg, Koellikerstrabe 6, 97070, Wurzburg, Germany
Histochem Cell Biol 129:765-78. 2008..Taken together, these results indicate that Rac 1 activation likely contributes to the barrier-stabilizing effects of cAMP in microvascular endothelium and that these effects may in part be mediated by Epac/Rap 1...
- Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signalingXimei Wu
Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
Cell 133:340-53. 2008..Here we demonstrate that nuclear accumulation of beta-catenin in response to Wnt requires Rac1 activation...
- Role of Rac1 in a bleomycin-induced scleroderma model using fibroblast-specific Rac1-knockout miceShangxi Liu
University of Western Ontario, London, Ontario, Canada
Arthritis Rheum 58:2189-95. 2008..b>Rac1 plays a key role in adhesive signaling...
- Regulation of endothelial nitric oxide synthase and postnatal angiogenesis by Rac1Naoki Sawada
Vascular Medicine Research, Department of Medicine, Brigham and Women s Hospital, Cambridge, MA 02139, USA
Circ Res 103:360-8. 2008..Because Rac1, a Rho family member, mediates cellular motility and generation of reactive oxygen species, it could be involved in ..
- Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1Sebastian Fuchs
Institute of Anatomy, University of Zurich, CH 8057 Zurich, Switzerland
Cell Stem Cell 4:236-47. 2009..Deletion of either Cdc42 or Rac1 in the NC results in size reduction of multiple NC target structures because of increased cell-cycle exit, while NC ..
- Rac1 is required for cardiomyocyte apoptosis during hyperglycemiaE Shen
Critical Illness Research, Lawson Health Research Institute, University of Western Ontario, Ontario, Canada
Diabetes 58:2386-95. 2009..The present study was to investigate the role of Rac1 in ROS production and cardiomyocyte apoptosis during hyperglycemia.
- The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilamentsJ Moll
Department of Biotechnology, Ciba Geigy Ltd, Basel, Switzerland
Oncogene 6:863-6. 1991A 886 bp cDNA encoding the murine rac1 protein has been isolated. The abundance of rac1 mRNA was determined in fourteen tissues from both mouse and pig...
- Small GTP-binding proteins and the regulation of the actin cytoskeletonA Hall
MRC Laboratory for Molecular Cell Biology, University College London, England
Annu Rev Cell Biol 10:31-54. 1994
- Rac1 is required for the formation of three germ layers during gastrulationK Sugihara
Division of DNA Biology and Embryo Engineering, Center for Experimental Medicine, The Institute of Medical Science, University of Tokyo, Japan
Oncogene 17:3427-33. 1998The Rac1, a member of the Rho family proteins, regulates actin organization of cytoskeleton and cell adhesion. We used genetic analysis to elucidate the role of Rac1 in mouse embryonic development...
- IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane rufflingH Miki
Department of Biochemistry, Institute of Medical Science, University of Tokyo, and CREST, Japan Science and Technology Corporation
Nature 408:732-5. 2000..From studies of ectopic expression, we found that IRSp53 is essential for Rac to induce membrane ruffling, probably because it recruits WAVE, which stimulates actin polymerization mediated by the Arp2/3 complex...
- The GTPase Rac-1 controls cell fate in the thymus by diverting thymocytes from positive to negative selectionM Gomez
Imperial Cancer Research Fund, Lymphocyte Activation Laboratory, 44 Lincoln s Inn Fields, London, WC2A 3PX, United Kingdom
Immunity 15:703-13. 2001..The ability of Rac-1 to switch thymocytes from a destiny of positive to negative selection identifies this molecule as a critical regulator of the developmental processes in T cells that are essential for immune homeostasis...
- Selective expression of the small GTPase RhoB in the early developing mouse lensR Maddala
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
Dev Dyn 222:534-7. 2001....
- Oncogenic H-Ras enhances DNA repair through the Ras/phosphatidylinositol 3-kinase/Rac1 pathway in NIH3T3 cells. Evidence for association with reactive oxygen speciesHyun Ju Cho
Department of Pharmacology, School of Medicine, the Research Center for Proteineous Materials, Chosun University, 375 Seosuk dong, Kwangju 501 759, Korea
J Biol Chem 277:19358-66. 2002..of DNA repair capacity was inhibited by transient transfection with dominant-negative H-Ras (N17-H-Ras) or Rac1 (N17-Rac1) plasmids...
- Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functionsShijun Li
Herman B Wells Center for Pediatric Research and Department of Pediatrics Hematology Oncology, Indiana University Medical School, Indianapolis 46202, USA
J Immunol 169:5043-51. 2002The hemopoietic-specific Rho family GTPase Rac2 shares 92% amino acid identity with ubiquitously expressed Rac1. Neutrophils from rac2(-/-) mice have multiple defects, including chemoattractant-stimulated NADPH oxidase activity and ..
- Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPasesFeng Shao
Department of Biological Chemistry and Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 100:904-9. 2003..YopT also cleaves both farnesylated and geranylgeranylated forms of RhoA. The polybasic sequence in the C terminus of RhoA is essential for YopT substrate recognition and cleavage...
- Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by SrcJoan Marc Servitja
Oral and Pharyngeal Cancer Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Biol Chem 278:34339-46. 2003..Here we show that Rac1 activity is strongly elevated in Src-transformed cells and that this small G protein is a critical component of the ..
- Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signalingPaulo Matos
Centro de Genética Humana, Instituto Nacional de Saude Dr Ricardo Jorge, Avenida Padre Cruz, 1649 016 Lisboa, Portugal
J Biol Chem 278:50442-8. 2003b>Rac1 is a member of the Rho family of small GTPases, which control signaling pathways that regulate actin cytoskeletal dynamics and gene transcription...
- Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatasesYi Gu
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Science 302:445-9. 2003The Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 are critical signaling regulators in mammalian cells...
- Critical roles for Rac1 and Rac2 GTPases in B cell development and signalingMarita J Walmsley
Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
Science 302:459-62. 2003The Rac1 guanosine triphosphatase (GTPase) has been implicated in multiple cellular functions, including actin dynamics, proliferation, apoptosis, adhesion, and migration resulting from signaling by multiple receptors, including the B ..
- Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiationAnnalisa Bolis
Cell Adhesion Unit, Department of Molecular Biology and Functional Genomics, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Eur J Neurosci 18:2417-24. 2003Rac3 is one of the three known Rac GTPases in vertebrates. Rac3 shows high sequence homology to Rac1, and its transcript is specifically expressed in the developing nervous system, where its localization and function are unknown...
- Integrins regulate Rac targeting by internalization of membrane domainsMiguel A Del Pozo
Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 303:839-42. 2004Translocation of the small GTP-binding protein Rac1 to the cell plasma membrane is essential for activating downstream effectors and requires integrin-mediated adhesion of cells to extracellular matrix...
- Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1betaPeter Schotte
Unit of Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology VIB, Ghent Unniversity, Ghent, Belgium
J Biol Chem 279:25134-42. 2004..Rho GTPase mutants or treatment with Rho GTPase inhibitors confirmed the role of Rho GTPases and, in particular, Rac1 in the autoactivation of caspase-1...
- Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1Frédéric Causeret
Institut Cochin, GDPM, INSERM U567, CNRS 8104, Universite Paris V, CHU Cochin, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
Development 131:2841-52. 2004....
- Regulation of dendritic spine motility and stability by Rac1 and Rho kinase: evidence for two forms of spine motilityAyumu Tashiro
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Mol Cell Neurosci 26:429-40. 2004..Spine morphology was previously shown to be regulated by the Rho GTPases Rac1 and RhoA...
- Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migrationCornelia Weiss-Haljiti
Serono Pharmaceutical Research Institute, Serono International S A, 14 Chemin des Aulx, CH 1228 Plan les Ouates, Geneva, Switzerland
J Biol Chem 279:43273-84. 2004..Retroviral transduction of tagged Rac1 and -2 indicates that RANTES/CCL5-mediated activation of PI3Kgamma triggers Rac1 but not Rac2...
- Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cellsKazuhiro Aoki
Department of Tumor Virology, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
Mol Biol Cell 16:2207-17. 2005Neurite outgrowth is an important process in the formation of neuronal networks. Rac1 and Cdc42, members of the Rho-family GTPases, positively regulate neurite extension through reorganization of the actin cytoskeleton...
- Generation and characterization of Rac3 knockout miceSara Corbetta
Department of Molecular Biology and Functional Genomics, San Raffaele Scientific Institute, 20132 Milan, Italy
Mol Cell Biol 25:5763-76. 2005..The three highly homologous Rac proteins in mammals are the ubiquitous Rac1, the hematopoiesis-specific Rac2, and the least-characterized Rac3...
- Rac GTPases differentially integrate signals regulating hematopoietic stem cell localizationJose A Cancelas
Hoxworth Blood Center, University of Cincinnati Medical Center, 3130 Highland Avenue, Cincinnati, Ohio, 45267, USA
Nat Med 11:886-91. 2005..We have examined the role of the Rho GTPases Rac1 and Rac2 in HSC engraftment and mobilization...
- Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS)D Ferraro
Institute of General Pathology, Catholic University Medical School, Rome, Italy
Oncogene 25:3689-98. 2006..Thus, we have outlined a novel cascade triggered by c-Met and mediated by ROS, linked to metastasis and potentially targetable by new antimetastatic, redox-based therapies...
- Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxisKersi N Pestonjamasp
Departments of Immunology and Cell Biology IMM14, The Scripps Research Institute, La Jolla, CA, USA
Blood 108:2814-20. 2006..plays a critical role in cell migration, and recent work has focused on elucidating the specific roles played by Rac1, Rac2, Cdc42, and Rho during cellular chemotaxis...
- Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermisAnna Chrostek
Heisenberg Group Regulation of Cytoskeletal Organization, Max Planck Institute of Biochemistry, Martinsried, Germany
Mol Cell Biol 26:6957-70. 2006b>Rac1 is a small GTPase that regulates the actin cytoskeleton but also other cellular processes. To investigate the function of Rac1 in skin, we generated mice with a keratinocyte-restricted deletion of the rac1 gene...
- Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNSTina Thurnherr
Institute for Cell Biology, Department of Biology, Federal Institute of Technology ETH Zurich, CH 8093 Zurich, Switzerland
J Neurosci 26:10110-9. 2006..Ablation of Rac1 also resulted in the abnormal accumulation of cytoplasm in the inner tongue of the oligodendrocyte process, and we ..
- Epidermal deletion of Rac1 causes stem cell depletion, irrespective of whether deletion occurs during embryogenesis or adulthoodSalvador A Benitah
J Invest Dermatol 127:1555-7. 2007
- Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1Michael Tscharntke
Department of Dermatology, University of Cologne, Center for Molecular Medicine, CMMC, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
J Cell Sci 120:1480-90. 2007To address the functions of Rac1 in keratinocytes of the basal epidermal layer and in the outer root sheath of hair follicles, we generated transgenic mice expressing a dominant inhibitory mutant of Rac, N17Rac1, under the control of the ..
- Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neuronsLei Chen
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Neurosci 27:3884-93. 2007Previous studies using dominant-mutant constructs have implicated Rac1 GTPase in neuritogenesis and neuronal migration...
- Genetic ablation of Rac1 in cartilage results in chondrodysplasiaGuoyan Wang
CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
Dev Biol 306:612-23. 2007..Here we describe the effects of cartilage-specific inactivation of the Rac1 gene in mice...
- Requirement for Rac1 in a K-ras induced lung cancer in the mouseJoseph L Kissil
Program in Molecular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA
Cancer Res 67:8089-94. 2007..To directly assess the requirement for Rac1 in K-ras-induced tumorigenesis, we employed a model of lung cancer in which an oncogenic allele of K-ras could be ..
- Trio controls the mature organization of neuronal clusters in the hindbrainStéphanie Backer
Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104, 75014 Paris, France
J Neurosci 27:10323-32. 2007..We report that the absence of the Rho-guanine exchange factor Trio, which can activate both RhoG and Rac1 in vivo, prevents the proper formation of ION and fMN subnuclei...
- Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axisKirstine Roepstorff
Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, 2200N Copenhagen, Denmark
J Biol Chem 283:7983-93. 2008..Both Rac1 and the GTP exchange factor VAV1 were required as upstream signaling proteins in the formyl-methionyl-leucyl-..
- Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formationEloisa Arana
Lymphocyte Interaction Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Immunity 28:88-99. 2008..Here, we show that both isoforms of the small GTPase Rac expressed by primary B cells, Rac1 and Rac2, were activated rapidly downstream of Src-family kinases, guanine-nucleotide exchange factors Vav1 and ..
- An essential role for Rac1 in endothelial cell function and vascular developmentWenfu Tan
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Dr, Bethesda, MD 20892, USA
FASEB J 22:1829-38. 2008..Here, we have used a conditional Cre/Flox approach, enabling the deletion of the Rac1 gene in endothelial cells, to examine the role of the Rho-related GTPase Rac1 in endothelial cell function and ..
- Rac1 in cortical projection neurons is selectively required for midline crossing of commissural axonal formationHidetoshi Kassai
Division of Molecular Genetics, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Eur J Neurosci 28:257-67. 2008b>Rac1 is a member of Rho family GTPases and regulates multiple cellular functions through actin cytoskeleton reorganization...
- Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephalyLei Chen
Divisios of Experimental Hematology, University of Cincinnati, Cincinnati, OH 45229, USA
Dev Biol 325:162-70. 2009..Here, we examine the role of Rac1 in mammalian neural progenitors and forebrain development by a conditional gene-targeting strategy using the Foxg1-..
- Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDIHanan Abramovici
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
Mol Biol Cell 20:2049-59. 2009Activation of Rac1 GTPase signaling is stimulated by phosphorylation and release of RhoGDI by the effector p21-activated kinase 1 (PAK1), but it is unclear what initiates this potential feed-forward mechanism for regulation of Rac ..
- Rac1 expression by fibroblasts is required for tissue repair in vivoShangxi Liu
Department of Physiology and Pharmacology, Division of Oral Biology, Schulich School of Medicine and Dentistry, Canadian Institute of Health Research Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario, Canada
Am J Pathol 174:1847-56. 2009..specific components of adhesive signaling in fibrogenic responses is unclear, but may involve small GTPases such as Rac1. To address the functions of Rac1 in fibroblasts, we generated mice containing a fibroblast-specific deletion of ..
- The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouseElena Vasyutina
Max Delbruck Center for Molecular Medicine, Department of Neuroscience, Robert Rossle Strasse 10, 13125 Berlin, Germany
Proc Natl Acad Sci U S A 106:8935-40. 2009b>Rac1 and Cdc42 are small G-proteins that regulate actin dynamics and affect plasma membrane protrusion and vesicle traffic...
- Rac1 mediates sex difference in cardiac tumor necrosis factor-alpha expression via NADPH oxidase-ERK1/2/p38 MAPK pathway in endotoxemiaHuaqing Zhu
Critical Illness Research, Lawson Health Research Institute, London Health Sciences Center, London, Ontario, Canada
J Mol Cell Cardiol 47:264-74. 2009The purpose of this study was to investigate the role of Rac1 and estrogen in sex difference of cardiac tumor necrosis factor-alpha (TNF-alpha) expression during endotoxemia...
- Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathwayArye Elfenbein
Laboratory of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto, Japan
J Cell Biol 186:75-83. 2009..Angiogenesis requires polarized activation of the small guanosine triphosphatase Rac1, which involves localized dissociation from RhoGDI1 and association with the plasma membrane...
- The absence of caveolin-1 increases proliferation and anchorage- independent growth by a Rac-dependent, Erk-independent mechanismAna Cerezo
Integrin Signaling Laboratory, Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernandez Almagro 3, Madrid, Spain
Mol Cell Biol 29:5046-59. 2009..AIG was induced in Cav1-expressing cells by forced membrane targeting of Rac1 or by inhibiting Cav1-mediated internalization of plasma membrane ordered domains at which Rac1 accumulates...
- Sequential signaling in plasma-membrane domains during macropinosome formation in macrophagesSei Yoshida
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Cell Sci 122:3250-61. 2009..Ratiometric and fluorescence resonance energy transfer (FRET) microscopy determined that Rac1 activity and phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P(3)] levels increased transiently, peaking ..
- STRUCTURE/FUNCTION ANALYSIS OF PHAGOCYTE PROTEINSMary Dinauer; Fiscal Year: 2009..These studies will provide further insight into the superoxide- generating system of the phagocyte, which may lead to new approaches in modulating superoxide formation in the inflammatory response and host defense. ..
- The NF2 gene: elucidation of tumor suppressor functionJOSEPH KISSIL; Fiscal Year: 2004..This should lead to a better understanding of merlin function in normal cells and the consequences of its loss in tumor development. Such information will directly assist in the search for effective therapies. ..
- 2005 Phagocytes Gordon ConferenceMary Dinauer; Fiscal Year: 2005..The program will provide opportunities for participation of scientists at all levels and we will particularly promote the participation of junior investigators, postdoctoral trainees and "new investigators to the field". ..