Rabep1

Summary

Gene Symbol: Rabep1
Description: rabaptin, RAB GTPase binding effector protein 1
Alias: Rab5ep, rabaptin-5, rabaptin-5alpha, rab GTPase-binding effector protein 1, RAB5 effector protein, neurocrescin, rabaptin 5
Species: mouse
Products:     Rabep1

Top Publications

  1. Stewart G, Savioz A, Davies R. Sequence analysis of 497 mouse brain ESTs expressed in the substantia nigra. Genomics. 1997;39:147-53 pubmed
    ..The total number of ESTs reported that are new for the mouse is 407, which, together with the 90 ESTs corresponding to known mouse genes or cDNAs, contributes to the molecular description of the substantia nigra. ..
  2. Kalesnikoff J, Rios E, Chen C, Alejandro Barbieri M, Tsai M, Tam S, et al. Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells. Blood. 2007;109:5308-17 pubmed
    ..By contrast, correction of these -/- phenotypes required a functional Vps9 domain. Thus, Fc epsilon RI-mediated mast cell functional activation is dependent on RabGEF1's GEF activity. ..
  3. Ninkovic M, Mitkovski M, Kohl T, Stuhmer W, Pardo L. Physical and functional interaction of KV10.1 with Rabaptin-5 impacts ion channel trafficking. FEBS Lett. 2012;586:3077-84 pubmed publisher
    ..1, indicating a role of Rabaptin-5 in channel trafficking. K(V)10.1 co-localizes, but does not physically interact, with Rab7 and Rab11. Our data highlights the complex control of the amount of K(V)10.1 channels on the cell surface. ..
  4. Gournier H, Stenmark H, Rybin V, Lippe R, Zerial M. Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion. EMBO J. 1998;17:1930-40 pubmed
    ..Our results suggest that Rab5 binds to at least two distinct effectors which cooperate for optimal endocytic membrane docking and fusion. ..
  5. Watters J, Dietrich W. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11. Genomics. 2001;73:223-31 pubmed
    ..Additionally, a region of 100 kb or more is deleted in the Ltxs1 interval of some strains. Our genetic, physical, and transcript map provides an important resource for the molecular cloning of Ltxs1. ..
  6. Rios E, Piliponsky A, Ra C, Kalesnikoff J, Galli S. Rabaptin-5 regulates receptor expression and functional activation in mast cells. Blood. 2008;112:4148-57 pubmed publisher
    ..These findings show that, although dispensable for canonical Rab5 processes in mast cells, Rabaptin-5 importantly contributes to mast cell IgE-dependent immunologic function by enhancing mast cell receptor surface stability. ..
  7. Cataldo A, Petanceska S, Peterhoff C, Terio N, Epstein C, Villar A, et al. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci. 2003;23:6788-92 pubmed
    ..These results identify an essential role for App gene triplication in causing AD-related endosomal abnormalities and further establish the pathogenic significance of endosomal dysfunction in AD. ..
  8. Frederikse P, Yun E, Kao H, Zigler J, Sun Q, Qazi A. Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation. Mol Vis. 2004;10:794-804 pubmed
  9. Surendran S, Tyring S, Matalon R. Expression of calpastatin, minopontin, NIPSNAP1, rabaptin-5 and neuronatin in the phenylketonuria (PKU) mouse brain: possible role on cognitive defect seen in PKU. Neurochem Int. 2005;46:595-9 pubmed
    ..These changes in the PKU mouse brain are likely to contribute cognitive impairment seen in the PKU mouse, if documented also in patients with PKU. ..

More Information

Publications19

  1. Lucitti J, Sealock R, Buckley B, Zhang H, Xiao L, Dudley A, et al. Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke. Stroke. 2016;47:3022-3031 pubmed
    ..Naturally occurring variants of Rabep2 are major determinants of variation in collateral extent and stroke severity in mice. ..
  2. Zhu H, Qian H, Li G. Delayed onset of positive feedback activation of Rab5 by Rabex-5 and Rabaptin-5 in endocytosis. PLoS ONE. 2010;5:e9226 pubmed publisher
    ..Thus the direct and indirect pathways cooperate in the regulation of early endosome fusion. ..
  3. Korobko E, Smirnova E, Kiselev S, Georgiev G, Korobko I. Identification of a new alternative-splicing transcript of Rabaptin-5 interacting with protein kinase MAK-V. Dokl Biochem. 2000;370:1-3 pubmed
  4. Azouz N, Zur N, Efergan A, Ohbayashi N, Fukuda M, Amihai D, et al. Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis. J Immunol. 2014;192:4043-53 pubmed publisher
    ..Collectively, our results assign Rab5 a key role in mediating mast cell SG fusion during biogenesis, thereby controlling the amount and composition of the SGs content and maintaining the communication between new and pre-existing SGs. ..
  5. Nishimune H, Uyeda A, Nogawa M, Fujimori K, Taguchi T. Neurocrescin: a novel neurite-outgrowth factor secreted by muscle after denervation. Neuroreport. 1997;8:3649-54 pubmed
    ..We report here the cloning of a novel neurite outgrowth factor, designated neurocrescin, from chick denervated skeletal muscle...
  6. Christoforides C, Rainero E, Brown K, Norman J, Toker A. PKD controls ?v?3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5. Dev Cell. 2012;23:560-72 pubmed publisher
    ..These findings demonstrate that the PKD pathway couples receptor tyrosine kinase signaling to an integrin switch via Rabaptin-5 phosphorylation. ..
  7. Korobko E, Kiselev S, Korobko I. Characterization of Rabaptin-5 γ isoform. Biochemistry (Mosc). 2014;79:856-64 pubmed publisher
    ..Our study signifies the role of alternative splicing in determination of functional activities of Rab effector molecules. ..
  8. Korobko E, Kiselev S, Korobko I. Multiple Rabaptin-5-like transcripts. Gene. 2002;292:191-7 pubmed
    ..strongly suggest that these transcripts along with Rabaptin-5 and Rabaptin-4 are encoded by a single gene, RAB5EP, and differ due to alternative pre-mRNA splicing...
  9. Mori Y, Matsui T, Fukuda M. Rabex-5 protein regulates dendritic localization of small GTPase Rab17 and neurite morphogenesis in hippocampal neurons. J Biol Chem. 2013;288:9835-47 pubmed publisher
  10. Kim H, Xu H, Yao Q, Li W, Huang Q, Outeda P, et al. Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism. Nat Commun. 2014;5:5482 pubmed publisher
    ..Using yeast two-hybrid screening coupled with a candidate approach, we identify a Rabep1/GGA1/Arl3-dependent ciliary targeting mechanism, whereby Rabep1 couples the polycystin complex to a GGA1/Arl3-..