Rab6a

Summary

Gene Symbol: Rab6a
Description: RAB6A, member RAS oncogene family
Alias: 2610028L11Rik, AA419671, Rab6, ras-related protein Rab-6A, RAB6, member RAS oncogene family, rab-6
Species: mouse
Products:     Rab6a

Top Publications

  1. Echard A, Jollivet F, Martinez O, Lacapere J, Rousselet A, Janoueix Lerosey I, et al. Interaction of a Golgi-associated kinesin-like protein with Rab6. Science. 1998;279:580-5 pubmed
    ..Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified...
  2. Huang W, Wu G, Wang G. Cell type-specific and light-dependent expression of Rab1 and Rab6 GTPases in mammalian retinas. Vis Neurosci. 2009;26:443-52 pubmed publisher
    The Ras-like Rab1 and Rab6 GTPases modulate protein traffic along the early secretory pathway and are involved in the regulation of maturation of rhodopsin in the outer retina...
  3. Miserey Lenkei S, Bousquet H, Pylypenko O, Bardin S, Dimitrov A, Bressanelli G, et al. Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions. Nat Commun. 2017;8:1254 pubmed publisher
    ..In this study, we investigated whether RAB6 GTPase, a Golgi-associated RAB involved in the regulation of several transport steps at the Golgi level, and two of ..
  4. Shafaq Zadah M, Gomes Santos C, Bardin S, Maiuri P, Maurin M, Iranzo J, et al. Persistent cell migration and adhesion rely on retrograde transport of β(1) integrin. Nat Cell Biol. 2016;18:54-64 pubmed publisher
    ..These data more generally suggest that the retrograde route is used to relocalize plasma membrane machinery from previous sites of function to the leading edge of migratory cells. ..
  5. Matsuto M, Kano F, Murata M. Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport. Biochim Biophys Acta. 2015;1853:2592-609 pubmed publisher
    ..In this study, we reconstituted the Golgi targeting of Rab6A in streptolysin O (SLO)-permeabilized HeLa cells in a cytosol-dependent manner and investigated the biochemical ..
  6. Micaroni M, Stanley A, Khromykh T, Venturato J, Wong C, Lim J, et al. Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages. PLoS ONE. 2013;8:e57034 pubmed publisher
    ..b>Rab6a and Rab6a' (collectively Rab6) are trans-Golgi-localized GTPases known for roles in maintaining Golgi structure ..
  7. Kuroda T, Fukuda M, Ariga H, Mikoshiba K. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Biochem Biophys Res Commun. 2002;293:899-906 pubmed
    ..members, the SHD of Slp5 preferentially interacted with the GTP-bound form of Rab27A and marginally with Rab3A and Rab6A, both in vitro and in intact cells, but not with other Rabs tested (Rab1, Rab2, Rab4A, Rab5A, Rab7, Rab8, Rab9, ..
  8. Ahnert Hilger G, Kutay U, Chahoud I, Rapoport T, Wiedenmann B. Synaptobrevin is essential for secretion but not for the development of synaptic processes. Eur J Cell Biol. 1996;70:1-11 pubmed
    ..In mouse brains taken at different embryonic days, synaptobrevin, synaptotagmin, rab 6 and the membrane protein SNAP-25 were expressed earlier than synaptophysin and protein SV2...
  9. Landsman D, Wolffe A. Common sequence and structural features in the heat-shock factor and Ets families of DNA-binding domains. Trends Biochem Sci. 1995;20:225-6 pubmed

More Information

Publications26

  1. Bell A, Ward M, Blackstock W, Freeman H, Choudhary J, Lewis A, et al. Proteomics characterization of abundant Golgi membrane proteins. J Biol Chem. 2001;276:5152-65 pubmed
  2. Coumailleau F, Das V, Alcover A, Raposo G, Vandormael Pournin S, Le Bras S, et al. Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol Biol Cell. 2004;15:4444-56 pubmed
    ..Rffl overexpression represents a novel means to inhibit recycling that will help to understand the mechanisms involved in recycling from the ERC to the plasma membrane. ..
  3. Bergo M, Leung G, Ambroziak P, Otto J, Casey P, Gomes A, et al. Isoprenylcysteine carboxyl methyltransferase deficiency in mice. J Biol Chem. 2001;276:5841-5 pubmed
    ..g. N-acetyl-S-geranylgeranyl-l-cysteine). In addition, Icmt-/- cells lacked the ability to methylate Rab proteins. Thus, Icmt appears to be the only enzyme participating in the carboxyl methylation of isoprenylated proteins. ..
  4. Bardin S, Miserey Lenkei S, Hurbain I, Garcia Castillo D, Raposo G, Goud B. Phenotypic characterisation of RAB6A knockout mouse embryonic fibroblasts. Biol Cell. 2015;107:427-39 pubmed publisher
    ..The two ubiquitous Rab isoforms, Rab6A and Rab6A', that are generated by alternative splicing of the RAB6A gene, regulate several transport steps at the ..
  5. Liu L, Watanabe N, Akatsu H, Nishimura M. Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease. Neuroscience. 2016;330:236-46 pubmed publisher
    ..Our results suggest that a decline of ILEI expression may cause accumulation of A? in the brain and the eventual development of AD. ..
  6. Ma R, Zhang J, Liu X, Li L, Liu H, Rui R, et al. Involvement of Rab6a in organelle rearrangement and cytoskeletal organization during mouse oocyte maturation. Sci Rep. 2016;6:23560 pubmed publisher
    ..Here we report severe disorganization of endoplasmic reticulum upon specific knockdown of Rab6a in mouse oocytes...
  7. Schlager M, Kapitein L, Grigoriev I, Burzynski G, Wulf P, Keijzer N, et al. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. EMBO J. 2010;29:1637-51 pubmed publisher
    ..Here, we identify Bicaudal-D-related protein 1 (BICDR-1) as an effector of the small GTPase Rab6 and key component of the molecular machinery that controls secretory vesicle transport in developing neurons...
  8. Chen Y, Jiang C, Jin M, Gong Y, Zhang X. The role of Rab6 GTPase in the maturation of phagosome against Staphylococcus aureus. Int J Biochem Cell Biol. 2015;61:35-44 pubmed publisher
    ..As reported, Rab6 GTPase was involved in the regulation of hemocytic phagocytosis in invertebrates...
  9. Janoueix Lerosey I, Jollivet F, Camonis J, Marche P, Goud B. Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6. J Biol Chem. 1995;270:14801-8 pubmed
    b>Rab6 is a small GTP-binding protein that belongs to the Ras superfamily and is involved in intra-Golgi transport...
  10. Thyrock A, Ossendorf E, Stehling M, Kail M, Kurtz T, Pohlentz G, et al. A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. PLoS ONE. 2013;8:e64149 pubmed publisher
    ..They have been shown to play a role in several human diseases. One prominent member, Rab6, is thought to be involved in the development of Alzheimer's Disease, the most prevalent mental disorder worldwide...
  11. Antony C, Huchet M, Changeux J, Cartaud J. Developmental regulation of membrane traffic organization during synaptogenesis in mouse diaphragm muscle. J Cell Biol. 1995;130:959-68 pubmed
  12. Yamada M, Kumamoto K, Mikuni S, Arai Y, Kinjo M, Nagai T, et al. Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement. Nat Commun. 2013;4:2033 pubmed publisher
    ..Here we report that the small GTPase Rab6a is essential for activation of idling dynein...
  13. Chavrier P, Simons K, Zerial M. The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992;112:261-4 pubmed
    ..These results confirm that the overall diversity of the Rab and Rho protein subfamilies account for more than thirty different members in mammalian cells. ..
  14. Miserey Lenkei S, Waharte F, Boulet A, Cuif M, Tenza D, El Marjou A, et al. Rab6-interacting protein 1 links Rab6 and Rab11 function. Traffic. 2007;8:1385-403 pubmed
    Rab11 and Rab6 guanosine triphosphatases are associated with membranes of the recycling endosomes (REs) and Golgi complex, respectively...
  15. Hume A, Collinson L, Rapak A, Gomes A, Hopkins C, Seabra M. Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J Cell Biol. 2001;152:795-808 pubmed
  16. Hou X, Zhang J, Li L, Ma R, Ge J, Han L, et al. Rab6a is a novel regulator of meiotic apparatus and maturational progression in mouse oocytes. Sci Rep. 2016;6:22209 pubmed publisher
    ..In this study, we report that when Rab6a is specifically knockdown, mouse oocytes are unable to progress normally through meiosis, arresting at metaphase I...
  17. Monier S, Jollivet F, Janoueix Lerosey I, Johannes L, Goud B. Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport. Traffic. 2002;3:289-97 pubmed
    ..we have isolated two clones that specifically interact with the three isoforms of Rab6 present in mammalian cells (Rab6A, A' and B)...