Genomes and Genes
Gene Symbol: Rab5b
Description: RAB5B, member RAS oncogene family
Alias: C030027M18Rik, ras-related protein Rab-5B
- Shin N, Jeong H, Kwon J, Heo H, Kwon J, Yun H, et al. LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res. 2008;314:2055-65 pubmed publisher..In this study, using yeast two-hybrid screening, we report the identification of Rab5b as an LRRK2-interacting protein...
- Hryciw T, MacDonald J, Phillips R, Seah C, Pasternak S, Meakin S. The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons. J Neurochem. 2010;112:924-39 pubmed publisher..Collectively, these data suggest that neuronal Frs3 functions as a novel microtubule binding protein and they provide the first biochemical evidence that neuronal Frs3 is functionally distinct from Frs2/Frs2alpha. ..
- Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, et al. DJ-1 associates with synaptic membranes. Neurobiol Dis. 2011;43:651-62 pubmed publisher..These results indicate that DJ-1 associates with membranous organelles including synaptic membranes to exhibit its normal function. ..
- Zeigerer A, Gilleron J, Bogorad R, Marsico G, Nonaka H, Seifert S, et al. Rab5 is necessary for the biogenesis of the endolysosomal system in vivo. Nature. 2012;485:465-70 pubmed publisher..Our results demonstrate for the first time, to our knowledge, the role of Rab5 as an endosome organizer in vivo and reveal the resilience mechanisms of the endocytic system...
- Ali N, Jurczyluk J, Shay G, Tnimov Z, Alexandrov K, Munoz M, et al. A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton. Small Gtpases. 2015;6:202-11 pubmed publisher..Finally, we also detected a clear effect of subcutaneous ZOL administration in vivo on the prenylation of Rab1A, Rab5B, Rab7A and Rab14 in mouse peritoneal macrophages, confirming that systemic treatment with bisphosphonate drug can ..