Rab3d

Summary

Gene Symbol: Rab3d
Description: RAB3D, member RAS oncogene family
Alias: C130057E11Rik, ras-related protein Rab-3D
Species: mouse
Products:     Rab3d

Top Publications

  1. Schlüter O, Khvotchev M, Jahn R, Sudhof T. Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion. J Biol Chem. 2002;277:40919-29 pubmed
    Rab3A, Rab3B, Rab3C, and Rab3D constitute a family of GTP-binding proteins that are implicated in regulated exocytosis...
  2. Tian X, Jin R, Bredemeyer A, Oates E, Błazewska K, McKenna C, et al. RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation. Mol Cell Biol. 2010;30:1269-84 pubmed publisher
    ..CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D. We next show that RAB26 and RAB3D expression is significantly downregulated in Mist1(-)(/)(-) ZCs, suggesting ..
  3. Meng Z, Edman M, Hsueh P, Chen C, Klinngam W, Tolmachova T, et al. Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome. Am J Physiol Cell Physiol. 2016;310:C942-54 pubmed publisher
    ..Here, we investigated the role of Rab3D, Rab27a, and Rab27b proteins in the enhanced release of CTSS from LGAC...
  4. Merino Gracia J, García Mayoral M, Rapali P, Valero R, Bruix M, Rodríguez Crespo I. DYNLT (Tctex-1) forms a tripartite complex with dynein intermediate chain and RagA, hence linking this small GTPase to the dynein motor. FEBS J. 2015;282:3945-58 pubmed publisher
    ..Recent data showed that DYNLT links the small GTPase Rab3D to microtubules and, for this to occur, the DYNLT homodimer needs to display a binding site for dynein ..
  5. Nabavi N, Pustylnik S, Harrison R. Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts. PLoS ONE. 2012;7:e46265 pubmed publisher
    ..analysis to identify the Rab GTPases that are up-regulated during a 5-day AA differentiation of OBs, namely Rab1, Rab3d, and Rab27b...
  6. Chen X, Edwards J, Logsdon C, Ernst S, Williams J. Dominant negative Rab3D inhibits amylase release from mouse pancreatic acini. J Biol Chem. 2002;277:18002-9 pubmed
    ..are believed to play an important role in regulated exocytosis and previous work has demonstrated the presence of Rab3D on pancreatic zymogen granules...
  7. Pavlos N, Cheng T, Qin A, Ng P, Feng H, Ang E, et al. Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption. Mol Cell Biol. 2011;31:1551-64 pubmed publisher
    ..However, the molecular mechanisms bridging these vesicle-microtubule interactions remain largely obscure. Rab3D, a member of the Rab3 subfamily (Rab3A/B/C/D) of small exocytotic GTPases, represents a core component of the ..
  8. Chen X, Ernst S, Williams J. Dominant negative Rab3D mutants reduce GTP-bound endogenous Rab3D in pancreatic acini. J Biol Chem. 2003;278:50053-60 pubmed
    Two dominant negative mutants of Rab3D, N135I and T36N were recently reported to inhibit the early phase of regulated amylase secretion from mouse pancreatic acini (Chen, X., Edwards, J. A., Logsdon, C. D., Ernst, S. A., and Williams, J...
  9. Schonn J, van Weering J, Mohrmann R, Schlüter O, Sudhof T, de Wit H, et al. Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells. Traffic. 2010;11:1415-28 pubmed publisher
    ..Here, we used a quadruple Rab3 knockout (KO) (rab3a, rab3b, rab3c, rab3d null, here denoted as ABCD(-/-) ) mouse line to investigate Rab3 function in embryonic mouse adrenal chromaffin ..

More Information

Publications21

  1. Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, et al. Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. Proc Natl Acad Sci U S A. 2004;101:8313-8 pubmed
    ..Thus, Noc2, a critical effector of Rab3, is essential in normal regulation of exocytosis in both endocrine and exocrine cells. ..
  2. Da Costa S, Wu K, Veigh M, Pidgeon M, Ding C, Schechter J, et al. Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development. Exp Eye Res. 2006;82:33-45 pubmed
    ..b>Rab3D immunofluorescence associated with mature secretory vesicles was distributed abundantly in a continuous vesicular ..
  3. Schlüter O, Schmitz F, Jahn R, Rosenmund C, Sudhof T. A complete genetic analysis of neuronal Rab3 function. J Neurosci. 2004;24:6629-37 pubmed
    Rab3A, Rab3B, Rab3C, and Rab3D are closely related GTP-binding proteins of synaptic vesicles that may function in neurotransmitter release...
  4. Evans E, Zhang W, Jerdeva G, Chen C, Chen X, Hamm Alvarez S, et al. Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells. Am J Physiol Cell Physiol. 2008;294:C662-74 pubmed publisher
    ..Immunofluorescent labeling of rabbit lacrimal gland acinar cells (LGACs) revealed that the small GTPase Rab3D, a regulated secretory vesicle marker, and the pIgR are colocalized in subapical membrane vesicles...
  5. Schlüter O, Basu J, Sudhof T, Rosenmund C. Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity. J Neurosci. 2006;26:1239-46 pubmed
    ..The four closely related small GTP-binding proteins Rab3A, Rab3B, Rab3C, and Rab3D are believed to be important for these steps...
  6. Pavlos N, Xu J, Riedel D, Yeoh J, Teitelbaum S, Papadimitriou J, et al. Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption. Mol Cell Biol. 2005;25:5253-69 pubmed
    ..Our data indicate that Rab3D is the major Rab3 species expressed in osteoclasts...
  7. Baldini G, Hohl T, Lin H, Lodish H. Cloning of a Rab3 isotype predominantly expressed in adipocytes. Proc Natl Acad Sci U S A. 1992;89:5049-52 pubmed
    We have isolated the cDNA for Rab3D, an additional member of the small molecular weight GTP-binding protein family. Rab3D message is abundant in mouse adipocytes...
  8. Johnson C, Kowalik A, Rajakumar N, Pin C. Mist1 is necessary for the establishment of granule organization in serous exocrine cells of the gastrointestinal tract. Mech Dev. 2004;121:261-72 pubmed
    ..link between granule targeting and the loss of Mist1 function, intercellular junctions and the expression of Rab3D were assessed...
  9. Riedel D, Antonin W, Fernandez Chacon R, Alvarez de Toledo G, Jo T, Geppert M, et al. Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Mol Cell Biol. 2002;22:6487-97 pubmed
    b>Rab3D, a member of the Rab3 subfamily of the Rab/ypt GTPases, is expressed on zymogen granules in the pancreas as well as on secretory vesicles in mast cells and in the parotid gland...
  10. Bergo M, Leung G, Ambroziak P, Otto J, Casey P, Gomes A, et al. Isoprenylcysteine carboxyl methyltransferase deficiency in mice. J Biol Chem. 2001;276:5841-5 pubmed
    ..g. N-acetyl-S-geranylgeranyl-l-cysteine). In addition, Icmt-/- cells lacked the ability to methylate Rab proteins. Thus, Icmt appears to be the only enzyme participating in the carboxyl methylation of isoprenylated proteins. ..
  11. Wang X, Hu B, Zimmermann B, Kilimann M. Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha -helix motifs. J Biol Chem. 2001;276:32480-8 pubmed
    ..The latter, however, was inhibited rather than stimulated by GTP. ..
  12. Adachi R, Nigam R, Tuvim M, DeMayo F, Dickey B. Genomic organization, chromosomal localization, and expression of the murine RAB3D gene. Biochem Biophys Res Commun. 2000;273:877-83 pubmed
    ..We report our studies on the murine rab3D gene, one of the four mammalian Rab3 isoforms. We located this gene on chromosome 13, region A(2-3)...