Rab3a

Summary

Gene Symbol: Rab3a
Description: RAB3A, member RAS oncogene family
Alias: ras-related protein Rab-3A
Species: mouse
Products:     Rab3a

Top Publications

  1. Schonn J, van Weering J, Mohrmann R, Schlüter O, Sudhof T, de Wit H, et al. Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells. Traffic. 2010;11:1415-28 pubmed publisher
    ..Here, we used a quadruple Rab3 knockout (KO) (rab3a, rab3b, rab3c, rab3d null, here denoted as ABCD(-/-) ) mouse line to investigate Rab3 function in embryonic mouse ..
  2. Leenders A, Lopes da Silva F, Ghijsen W, Verhage M. Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals. Mol Biol Cell. 2001;12:3095-102 pubmed
    ..The major rab protein in brain, rab3A, associates with synaptic vesicles...
  3. Liu R, Hannenhalli S, Bucan M. Motifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons. Genome Biol. 2009;10:R72 pubmed publisher
    ..Using unbiased in vivo and in vitro screens, we characterized the cis elements regulating the Rab3A gene, which is expressed abundantly in presynaptic neurons...
  4. Giovedi S, Darchen F, Valtorta F, Greengard P, Benfenati F. Synapsin is a novel Rab3 effector protein on small synaptic vesicles. II. Functional effects of the Rab3A-synapsin I interaction. J Biol Chem. 2004;279:43769-79 pubmed
    ..release, were recently demonstrated to interact with the synaptic vesicle-associated small G protein Rab3A within nerve terminals (Giovedi, S., Vaccaro, P., Valtorta, F., Darchen, F., Greengard, P., Cesareni, G...
  5. Schlüter O, Schmitz F, Jahn R, Rosenmund C, Sudhof T. A complete genetic analysis of neuronal Rab3 function. J Neurosci. 2004;24:6629-37 pubmed
    b>Rab3A, Rab3B, Rab3C, and Rab3D are closely related GTP-binding proteins of synaptic vesicles that may function in neurotransmitter release...
  6. Ozaki N, Shibasaki T, Kashima Y, Miki T, Takahashi K, Ueno H, et al. cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000;2:805-11 pubmed
    ..Accordingly, cAMP-GEFII is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, PKA-independent exocytosis. ..
  7. Lipovsek S, Janžekovič F, Leitinger G, Rupnik M. Rab3a ablation related changes in morphology of secretory vesicles in major endocrine pancreatic cells, pituitary melanotroph cells and adrenal gland chromaffin cells in mice. Gen Comp Endocrinol. 2013;185:67-79 pubmed publisher
    ..adrenal chromaffin cells in the normal mouse strain (wild type, WT) and mice with a known secretory deficit, the Rab3a knockout strain (Rab3a KO)...
  8. Star E, Newton A, Murthy V. Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function. J Physiol. 2005;569:103-17 pubmed
    We investigated the roles of two Rab-family proteins, Rab3a and Rab5a, in hippocampal synaptic transmission using real-time fluorescence imaging...
  9. Schlüter O, Basu J, Sudhof T, Rosenmund C. Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity. J Neurosci. 2006;26:1239-46 pubmed
    ..The four closely related small GTP-binding proteins Rab3A, Rab3B, Rab3C, and Rab3D are believed to be important for these steps...

More Information

Publications79

  1. Geppert M, Bolshakov V, Siegelbaum S, Takei K, De Camilli P, Hammer R, et al. The role of Rab3A in neurotransmitter release. Nature. 1994;369:493-7 pubmed
    The small GTP-binding protein Rab3A is a Rab family member that is abundant in brain synaptic vesicles...
  2. Schlüter O, Khvotchev M, Jahn R, Sudhof T. Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion. J Biol Chem. 2002;277:40919-29 pubmed
    b>Rab3A, Rab3B, Rab3C, and Rab3D constitute a family of GTP-binding proteins that are implicated in regulated exocytosis...
  3. Schlüter O, Schnell E, Verhage M, Tzonopoulos T, Nicoll R, Janz R, et al. Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release. J Neurosci. 1999;19:5834-46 pubmed
    b>Rab3A and rab3C are GTP-binding proteins of synaptic vesicles that regulate vesicle exocytosis...
  4. Tanaka M, Miyoshi J, Ishizaki H, Togawa A, Ohnishi K, Endo K, et al. Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction. Mol Biol Cell. 2001;12:1421-30 pubmed
    The Rab3 small G protein family consists of four members, Rab3A, -3B, -3C, and -3D. Of these members, Rab3A regulates Ca(2+)-dependent neurotransmitter release...
  5. Nakanishi H, Takai Y. [Regulatory mechanism of neurotransmitter release by low-molecular-weight G protein, Rab3A and the regulatory proteins]. Masui. 2001;50 Suppl:S51-5 pubmed
  6. Frederikse P, Yun E, Kao H, Zigler J, Sun Q, Qazi A. Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation. Mol Vis. 2004;10:794-804 pubmed
  7. Hensbroek R, Kamal A, Baars A, Verhage M, Spruijt B. Spatial, contextual and working memory are not affected by the absence of mossy fiber long-term potentiation and depression. Behav Brain Res. 2003;138:215-23 pubmed
    ..Here, we have exploited a genetic model, the rab3A null-mutant, which is characterized by the absence of both mossy fiber long-term potentiation and long-term ..
  8. Medrihan L, Rohlmann A, Fairless R, Andrae J, Döring M, Missler M, et al. Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses. J Physiol. 2009;587:5095-106 pubmed publisher
  9. Powell C, Schoch S, Monteggia L, Barrot M, Matos M, Feldmann N, et al. The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron. 2004;42:143-53 pubmed
    ..Mice with a synaptotagmin 1 mutation, which selectively lowers release probability, and mice with Rab3A deletion, which selectively abolishes presynaptic long-term potentiation, do not exhibit this abnormality...
  10. Fukuda M, Kanno E, Yamamoto A. Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells. J Biol Chem. 2004;279:13065-75 pubmed
    Rabphilin and Noc2 were originally described as Rab3A effector proteins involved in the regulation of secretory vesicle exocytosis, however, recently both proteins have been shown to bind Rab27A in vitro in preference to Rab3A (Fukuda, M...
  11. Sons M, Plomp J. Rab3A deletion selectively reduces spontaneous neurotransmitter release at the mouse neuromuscular synapse. Brain Res. 2006;1089:126-34 pubmed
    b>Rab3A is a synaptic vesicle-associated GTP-binding protein thought to be involved in modulation of presynaptic transmitter release through regulation of vesicle trafficking and membrane fusion...
  12. Feliciano P, Andrade R, Bykhovskaia M. Synapsin II and Rab3a cooperate in the regulation of epileptic and synaptic activity in the CA1 region of the hippocampus. J Neurosci. 2013;33:18319-30 pubmed publisher
    ..epileptic phenotype seen in synapsin II knock-out mice (SynII(-)) can be rescued by the genetic deletion of the Rab3a protein...
  13. Ward C, Faundes D, Foster J. The monomeric GTP binding protein, rab3a, is associated with the acrosome in mouse sperm. Mol Reprod Dev. 1999;53:413-21 pubmed
    ..Monomeric G proteins of the rab3 subfamily, specifically rab3a, have been shown to be important regulators of exocytosis in secretory cells, and we hypothesized that these ..
  14. Geppert M, Goda Y, Stevens C, Sudhof T. The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion. Nature. 1997;387:810-4 pubmed
    ..In brain, the Rab protein Rab3A is specific to synaptic vesicles, whose exocytosis can be monitored with submillisecond resolution by following ..
  15. Marsh B, Soden C, Alarcon C, Wicksteed B, Yaekura K, Costin A, et al. Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells. Mol Endocrinol. 2007;21:2255-69 pubmed
    ..despite an abnormal imbalance of glucose/glucagon-like peptide 1 regulated insulin production over secretion in Rab3A(-/-) mice compared with control animals, insulin storage levels were maintained due to increased intracellular ..
  16. Wang X, Wang Q, Yang S, Bucan M, Rich M, Engisch K. Impaired activity-dependent plasticity of quantal amplitude at the neuromuscular junction of Rab3A deletion and Rab3A earlybird mutant mice. J Neurosci. 2011;31:3580-8 pubmed publisher
    b>Rab3A is a small GTPase associated with synaptic vesicles that is required for some forms of activity-dependent plasticity...
  17. Rastaldi M, Armelloni S, Berra S, Calvaresi N, Corbelli A, Giardino L, et al. Glomerular podocytes contain neuron-like functional synaptic vesicles. FASEB J. 2006;20:976-8 pubmed
    ..We previously described that podocytes express Rab3A, a GTPase restricted to cell types that are capable of highly regulated exocytosis, such as neuronal cells...
  18. Blundell J, Kaeser P, Sudhof T, Powell C. RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia. J Neurosci. 2010;30:5326-33 pubmed publisher
    ..are relatively selective to RIM1alpha-deficient mice, as mice bearing mutations in the RIM1alpha binding partners Rab3A or synaptotagmin 1 only show decreased prepulse inhibition...
  19. Huang Y, Zakharenko S, Schoch S, Kaeser P, Janz R, Sudhof T, et al. Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. Proc Natl Acad Sci U S A. 2005;102:9365-70 pubmed
    The synaptic vesicle protein Rab3A is a small GTP-binding protein that interacts with rabphilin and RIM1alpha, two presynaptic substrates of protein kinase A (PKA)...
  20. Kim J, Lee S, Park C, Park S, Yin J, Kim J, et al. Rab3a promotes brain tumor initiation and progression. Mol Biol Rep. 2014;41:5903-11 pubmed publisher
    ..In particular, Rab3a which is one of four Rab3 proteins (a, b, c, and d isoforms) is associated with synaptic vesicle trafficking in ..
  21. Lonart G, Janz R, Johnson K, Sudhof T. Mechanism of action of rab3A in mossy fiber LTP. Neuron. 1998;21:1141-50 pubmed
    ..fiber synapses of the hippocampal CA3 region, LTP is induced by cAMP and requires the synaptic vesicle protein rab3A. In contrast, CA1-region synapses do not exhibit this type of LTP...
  22. Yang S, Farias M, Kapfhamer D, Tobias J, Grant G, Abel T, et al. Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse. Genes Brain Behav. 2007;6:77-96 pubmed
    ..A mouse mutant, earlybird (Ebd), with a point mutation in the GTP-binding domain of Rab3A (D77G), exhibits anomalies in circadian behavior and homeostatic response to sleep loss...
  23. Kuroda T, Fukuda M, Ariga H, Mikoshiba K. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Biochem Biophys Res Commun. 2002;293:899-906 pubmed
    ..family members, the SHD of Slp5 preferentially interacted with the GTP-bound form of Rab27A and marginally with Rab3A and Rab6A, both in vitro and in intact cells, but not with other Rabs tested (Rab1, Rab2, Rab4A, Rab5A, Rab7, Rab8,..
  24. Andrews Zwilling Y, Kawabe H, Reim K, Varoqueaux F, Brose N. Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2. J Biol Chem. 2006;281:19720-31 pubmed
    ..that the active zone recruitment of Munc13 isoforms Munc13-1 and ubMunc13-2 is regulated by their binding to the Rab3A-interacting molecule RIM1alpha, a key determinant of long term potentiation of synaptic transmission at mossy ..
  25. Wang X, Hu B, Zimmermann B, Kilimann M. Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha -helix motifs. J Biol Chem. 2001;276:32480-8 pubmed
    ..that is part of the Rab3-binding region of rabphilin-3, and indeed we observed low affinity, specific binding of Rab3A (K(d) on the order of magnitude of 10-100 microm) to this region of rabphilin-3 alone (amino acids 40-88), whereas ..
  26. Pavlos N, Cheng T, Qin A, Ng P, Feng H, Ang E, et al. Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption. Mol Cell Biol. 2011;31:1551-64 pubmed publisher
    ..Rab3D, a member of the Rab3 subfamily (Rab3A/B/C/D) of small exocytotic GTPases, represents a core component of the osteoclastic vesicle transport machinery...
  27. Dalfo E, Gomez Isla T, Rosa J, Nieto Bodelón M, Cuadrado Tejedor M, Barrachina M, et al. Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice. J Neuropathol Exp Neurol. 2004;63:302-13 pubmed
    ..studies with members of the Rab protein family have shown that alpha-synuclein from Tg mice interacts with Rab3a, Rab5, and Rab8...
  28. Silinsky E. Adenosine decreases both presynaptic calcium currents and neurotransmitter release at the mouse neuromuscular junction. J Physiol. 2004;558:389-401 pubmed
    ..In Rab3A knockout mice, which have been shown to have an increased sensitivity to adenosine, the simultaneous reduction in ..
  29. Chen R, Wislet Gendebien S, Samuel F, Visanji N, Zhang G, Marsilio D, et al. ?-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity. J Biol Chem. 2013;288:7438-49 pubmed publisher
    ..involved in ?-synuclein membrane interactions and showed that antibodies directed to the Ras-related GTPase Rab3a and its chaperone RabGDI abrogated ?-synuclein membrane binding...
  30. Coleman W, Bykhovskaia M. Rab3a-mediated vesicle recruitment regulates short-term plasticity at the mouse diaphragm synapse. Mol Cell Neurosci. 2009;41:286-96 pubmed publisher
    b>Rab3a is a small GTP-binding protein associated with presynaptic vesicles...
  31. Dechesne C, Kauff C, Stettler O, Tavitian B. Rab3A immunolocalization in the mammalian vestibular end-organs during development and comparison with synaptophysin expression. Brain Res Dev Brain Res. 1997;99:103-11 pubmed
    ..We report an immunocytochemical codetection of rab3A and synaptophysin in the vestibular end-organs of mouse, between fetal day 14 and adult, and of rat during the ..
  32. Castillo P, Janz R, Sudhof T, Tzounopoulos T, Malenka R, Nicoll R. Rab3A is essential for mossy fibre long-term potentiation in the hippocampus. Nature. 1997;388:590-3 pubmed
    ..Here we show that, although a variety of short-term plasticities are normal, LTP at mossy fibre synapses is abolished in mice lacking the synaptic vesicle protein Rab3A.
  33. Coleman W, Bill C, Bykhovskaia M. Rab3a deletion reduces vesicle docking and transmitter release at the mouse diaphragm synapse. Neuroscience. 2007;148:1-6 pubmed
    b>Rab3a is a small GTP binding protein associated with presynaptic vesicles that is thought to regulate vesicle targeting to active zones...
  34. Figueiredo A, Wasmeier C, Tarafder A, Ramalho J, Baron R, Seabra M. Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. J Biol Chem. 2008;283:23209-16 pubmed publisher
    ..Here, we studied the activation of Rab27a in melanocytes. We identify Rab3GEP, previously isolated as a GEF for Rab3a, as the non-redundant Rab27a GEF...
  35. Lang J. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem. 1999;259:3-17 pubmed
    ..The monomeric GTPase Rab3A controls insulin secretion through cycling between a guanosine triphosphate liganded vesicle-bound form and a ..
  36. Stubbusch J, Narasimhan P, Huber K, Unsicker K, Rohrer H, Ernsberger U. Synaptic protein and pan-neuronal gene expression and their regulation by Dicer-dependent mechanisms differ between neurons and neuroendocrine cells. Neural Dev. 2013;8:16 pubmed publisher
    ..Dicer 1-dependent regulation is required to establish high neuronal mRNA levels for synaptic proteins and to maintain repression of neurofilament messages in neuroendocrine cells. ..
  37. Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, et al. DJ-1 associates with synaptic membranes. Neurobiol Dis. 2011;43:651-62 pubmed publisher
    ..colocalizes with the Golgi apparatus proteins GM130 and the synaptic vesicle proteins such as synaptophysin and Rab3A. Förster resonance energy transfer analysis revealed that a small portion of DJ-1 interacts with synaptophysin in ..
  38. Riedel D, Antonin W, Fernandez Chacon R, Alvarez de Toledo G, Jo T, Geppert M, et al. Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Mol Cell Biol. 2002;22:6487-97 pubmed
    ..We conclude that Rab3D exerts its function during granule maturation, possibly by preventing homotypic fusion of secretory granules. ..
  39. Bednarek E, Caroni P. ?-Adducin is required for stable assembly of new synapses and improved memory upon environmental enrichment. Neuron. 2011;69:1132-46 pubmed publisher
    ..Our results provide evidence that synapse disassembly and the establishment of new synapses are both critically important for augmented long-term learning and memory upon environmental enrichment. ..
  40. Ruediger S, Vittori C, Bednarek E, Genoud C, Strata P, Sacchetti B, et al. Learning-related feedforward inhibitory connectivity growth required for memory precision. Nature. 2011;473:514-8 pubmed publisher
    ..In the absence of mossy fibre long-term potentiation in Rab3a(-/-) mice, c-Fos ensemble reorganization and feedforward inhibition growth were both absent in CA3 upon learning, ..
  41. Inagaki N, Mizuta M, Seino S. Cloning of a mouse Rabphilin-3A expressed in hormone-secreting cells. J Biochem. 1994;116:239-42 pubmed
    b>Rab3A, a ras p21-related small GTP-binding protein, is implicated in the exocytosis of neurotransmitters. Recently, Rabphilin-3A, a putative target protein for Rab3A, was identified and its cDNA has been cloned from bovine brain...
  42. Borisovska M, Zhao Y, Tsytsyura Y, Glyvuk N, Takamori S, Matti U, et al. v-SNAREs control exocytosis of vesicles from priming to fusion. EMBO J. 2005;24:2114-26 pubmed
    ..We demonstrate that dynamics of fusion pore dilation are regulated by v-SNAREs, indicating their action throughout exocytosis from priming to fusion of vesicles. ..
  43. Ostermeier C, Brunger A. Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A. Cell. 1999;96:363-74 pubmed
    The small G protein Rab3A plays an important role in the regulation of neurotransmitter release. The crystal structure of activated Rab3A/GTP/Mg2+ bound to the effector domain of rabphilin-3A was solved to 2.6 A resolution...
  44. Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, et al. Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. Proc Natl Acad Sci U S A. 2004;101:8313-8 pubmed
    ..Thus, Noc2, a critical effector of Rab3, is essential in normal regulation of exocytosis in both endocrine and exocrine cells. ..
  45. Armelloni S, Calvaresi N, Ikehata M, Corbelli A, Mattinzoli D, Giardino L, et al. Proteinuria and glomerular damage in Rab3A knockout mice chronically fed a high-glucose diet. Nephron Exp Nephrol. 2012;120:e69-80 pubmed publisher
    ..All Rab3A knockout (KO) mice spontaneously develop macroalbuminuria, but only male mice exhibit a glucose-intolerant ..
  46. Wollert T, Patel A, Lee Y, Provance D, Vought V, Cosgrove M, et al. Myosin5a tail associates directly with Rab3A-containing compartments in neurons. J Biol Chem. 2011;286:14352-61 pubmed publisher
    ..A potential class of binding partners are Rab GTPases and Rab3A is known to associate with SVs and is involved in SV trafficking...
  47. Hirsh J, Searl T, Silinsky E. Regulation by Rab3A of an endogenous modulator of neurotransmitter release at mouse motor nerve endings. J Physiol. 2002;545:337-43 pubmed
    b>Rab3A, a small GTP-binding protein attached to synaptic vesicles, has been implicated in several stages in the process of neurosecretion, including a late stage occurring just prior to the actual release of neurotransmitter...
  48. Schardt A, Brinkmann B, Mitkovski M, Sereda M, Werner H, Nave K. The SNARE protein SNAP-29 interacts with the GTPase Rab3A: Implications for membrane trafficking in myelinating glia. J Neurosci Res. 2009;87:3465-79 pubmed publisher
    ..By yeast two-hybrid screen and coimmunoprecipitation, we found that the GTPases Rab3A, Rab24, and septin 4 bind to the N-terminal domain of SNAP-29...
  49. Rastaldi M, Armelloni S, Berra S, Li M, Pesaresi M, Poczewski H, et al. Glomerular podocytes possess the synaptic vesicle molecule Rab3A and its specific effector rabphilin-3a. Am J Pathol. 2003;163:889-99 pubmed
    ..In neurons, the small guanosine triphosphatase Rab3A and its effector rabphilin-3A form a complex required for the correct docking of synaptic vesicles to their target ..
  50. Fenster S, Chung W, Zhai R, Cases Langhoff C, Voss B, Garner A, et al. Piccolo, a presynaptic zinc finger protein structurally related to bassoon. Neuron. 2000;25:203-14 pubmed
    ..The Piccolo zinc fingers were found to interact with the dual prenylated rab3A and VAMP2/Synaptobrevin II receptor PRA1...
  51. Thakker Varia S, Alder J, Crozier R, Plummer M, Black I. Rab3A is required for brain-derived neurotrophic factor-induced synaptic plasticity: transcriptional analysis at the population and single-cell levels. J Neurosci. 2001;21:6782-90 pubmed
    ..of 11 genes as revealed by differential display, including the small GTP-binding vesicular trafficking protein Rab3A and the enzyme guanylate cyclase (GC). Slot blot analysis on a population of neurons confirmed an average of 3...
  52. Coleman W, Bykhovskaia M. Cooperative regulation of neurotransmitter release by Rab3a and synapsin II. Mol Cell Neurosci. 2010;44:190-200 pubmed publisher
    To understand how the presynaptic proteins synapsin and Rab3a may interact in the regulation of the synaptic vesicle cycle and the release process, we derived a double knockout (DKO) mouse lacking both synapsin II and Rab3a...
  53. Sedej S, Klemen M, Schlüter O, Rupnik M. Rab3a is critical for trapping alpha-MSH granules in the high Ca²?-affinity pool by preventing constitutive exocytosis. PLoS ONE. 2013;8:e78883 pubmed publisher
    b>Rab3a is a small GTPase of the Rab3 subfamily that acts during late stages of Ca²?-regulated exocytosis. Previous functional analysis in pituitary melanotrophs described Rab3a as a positive regulator of Ca²?-dependent exocytosis...
  54. Gogolla N, Galimberti I, Deguchi Y, Caroni P. Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus. Neuron. 2009;62:510-25 pubmed publisher
    ..fiber terminal (LMT) numbers, and spine plus synapse densities at LMTs, whereas a distinct mechanism depending on Rab3a promoted LMT volume growth. In parallel, EE increased postsynaptic CA3 pyramidal neuron Wnt7a/b levels...
  55. Masumoto N, Ikebuchi Y, Tahara M, Yokoi T, Tasaka K, Miyake A, et al. Expression of Rab3A in the cortical region in mouse metaphase II eggs. J Exp Zool. 1998;280:91-6 pubmed
    b>Rab3A, a member of the small GTP-binding protein superfamily, has been implicated in regulated exocytosis at presynapses...
  56. Baumert M, Fischer von Mollard G, Jahn R, Sudhof T. Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes. Biochem J. 1993;293 ( Pt 1):157-63 pubmed
    b>Rab3A is a neuronal low-molecular-mass GTP-binding protein that is modified post-translationally by two geranylgeranyl groups and specifically targeted to synaptic vesicles...
  57. van Weering J, Toonen R, Verhage M. The role of Rab3a in secretory vesicle docking requires association/dissociation of guanidine phosphates and Munc18-1. PLoS ONE. 2007;2:e616 pubmed
    b>Rab3a is a small GTPase that binds selectively to secretory vesicles and switches between active, GTP-bound and inactive, GDP-bound conformations. In yeast, Rab and SM-genes interact genetically to promote vesicle targeting/fusion...
  58. Stobrawa S, Breiderhoff T, Takamori S, Engel D, Schweizer M, Zdebik A, et al. Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. Neuron. 2001;29:185-96 pubmed
    ..Mice almost lacking the hippocampus survive and show several behavioral abnormalities but are still able to acquire motor skills. ..
  59. Bello O, Cappa A, de Paola M, Zanetti M, Fukuda M, Fissore R, et al. Rab3A, a possible marker of cortical granules, participates in cortical granule exocytosis in mouse eggs. Exp Cell Res. 2016;347:42-51 pubmed publisher
    ..b>Rab3A, a member of the small GTP-binding protein superfamily, has been implicated in calcium-dependent exocytosis and is ..
  60. Kapfhamer D, Valladares O, Sun Y, Nolan P, Rux J, Arnold S, et al. Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse. Nat Genet. 2002;32:290-5 pubmed
    b>Rab3a is the most abundant Rab (ras-associated binding) protein in the brain and has a regulatory role in synaptic vesicle trafficking...
  61. Schonn J, Desnos C, Darchen F, Henry J. Which step of exocytosis is regulated by the monomeric GTPase Rab3a?. Ann N Y Acad Sci. 2002;971:291-3 pubmed
  62. D Adamo P, Wolfer D, Kopp C, Tobler I, Toniolo D, Lipp H. Mice deficient for the synaptic vesicle protein Rab3a show impaired spatial reversal learning and increased explorative activity but none of the behavioral changes shown by mice deficient for the Rab3a regulator Gdi1. Eur J Neurosci. 2004;19:1895-905 pubmed
    ..Among the 60 different Rab proteins described in mammals, Rab3a is the most abundant in brain, where it is involved in synaptic vesicle fusion and neurotransmitter release...
  63. Giardino L, Armelloni S, Corbelli A, Mattinzoli D, Zennaro C, Guerrot D, et al. Podocyte glutamatergic signaling contributes to the function of the glomerular filtration barrier. J Am Soc Nephrol. 2009;20:1929-40 pubmed publisher
    ..To test this, we studied mice and cells lacking Rab3A, a small GTPase that regulates glutamate exocytosis...
  64. Vosseller K, Hansen K, Chalkley R, Trinidad J, Wells L, Hart G, et al. Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol. Proteomics. 2005;5:388-98 pubmed
    ..These results demonstate BEMAD is suitable for large-scale quantitative analysis of both protein expression and serine / threonine post-translational modifications. ..
  65. Wang X, Thiagarajan R, Wang Q, Tewolde T, Rich M, Engisch K. Regulation of quantal shape by Rab3A: evidence for a fusion pore-dependent mechanism. J Physiol. 2008;586:3949-62 pubmed publisher
    The function of Rab3A, a small GTPase located on synaptic vesicles, is not well understood...
  66. Sakane A, Manabe S, Ishizaki H, Tanaka Okamoto M, Kiyokage E, Toida K, et al. Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3. Proc Natl Acad Sci U S A. 2006;103:10029-34 pubmed
    b>Rab3A small G protein is a member of the Rab family and is most abundant in the brain, where it is localized on synaptic vesicles. Evidence is accumulating that Rab3A plays a key role in neurotransmitter release and synaptic plasticity...
  67. Fujimoto K, Shibasaki T, Yokoi N, Kashima Y, Matsumoto M, Sasaki T, et al. Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis. J Biol Chem. 2002;277:50497-502 pubmed
    ..Rim2. Piccolo complex is important in cAMP-induced insulin secretion. In addition, this study suggests that CAZ proteins similar to those in neurons are also function in pancreatic beta-cells. ..
  68. Lin Y, Lin Y, Kuo Y, Wang Y, Kuo P. Identification and characterization of a novel Rab GTPase-activating protein in spermatids. Int J Androl. 2011;34:e358-67 pubmed publisher
    ..This MgcRabGAP is co-localized with its candidate substrate Rab3A at the acrosome/acroplaxome and neck regions of spermatids...
  69. Ferrero J, Alvarez A, Ramírez Franco J, Godino M, Bartolomé Martín D, Aguado C, et al. ?-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1? interaction to potentiate glutamate release at cerebrocortical nerve terminals. J Biol Chem. 2013;288:31370-85 pubmed publisher
    ..the active zone protein Munc13-1 from soluble to particulate fractions; it increased the association between Rab3A and RIM1? and redistributed synaptic vesicles closer to the presynaptic membrane...
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