Gene Symbol: Rab38
Description: RAB38, member RAS oncogene family
Alias: 2310011F14Rik, AU043391, cht, ras-related protein Rab-38, RAB38, member of RAS oncogene family, chocolate
Species: mouse
Products:     Rab38

Top Publications

  1. Loftus S, Larson D, Baxter L, Antonellis A, Chen Y, Wu X, et al. Mutation of melanosome protein RAB38 in chocolate mice. Proc Natl Acad Sci U S A. 2002;99:4471-6 pubmed
    ..Comparative genomic analysis localizes human RAB38 to the mouse chocolate (cht) locus. A G146T mutation occurs in the conserved GTP binding domain of RAB38 in cht mice...
  2. Lopes V, Wasmeier C, Seabra M, Futter C. Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis. Mol Biol Cell. 2007;18:3914-27 pubmed
    ..Loss of functional Rab38 in the "chocolate" (cht) mouse causes dramatically reduced numbers of melanosomes in adult RPE, in contrast to the mild ..
  3. Brooks B, Larson D, Chan C, Kjellstrom S, Smith R, Crawford M, et al. Analysis of ocular hypopigmentation in Rab38cht/cht mice. Invest Ophthalmol Vis Sci. 2007;48:3905-13 pubmed
    ..b>Chocolate mice (cht, Rab38(cht/cht)) and control heterozygous (Rab38(cht/)(+)) and wild-type mice were examined clinically,..
  4. Anderson M, Hawes N, Trantow C, Chang B, John S. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res. 2008;21:565-78 pubmed publisher
    ..Combined, these findings illustrate the utility of studying iris phenotypes as a means of discovering new pathways, and re-linking old ones, to processes of pigmented cells in health and disease. ..
  5. Cuddy L, Winick Ng W, Rylett R. Regulation of the high-affinity choline transporter activity and trafficking by its association with cholesterol-rich lipid rafts. J Neurochem. 2014;128:725-40 pubmed publisher
    The sodium-coupled, hemicholinium-3-sensitive, high-affinity choline transporter (CHT) is responsible for transport of choline into cholinergic nerve terminals from the synaptic cleft following acetylcholine release and hydrolysis...
  6. Swank R, Novak E, McGarry M, Rusiniak M, Feng L. Mouse models of Hermansky Pudlak syndrome: a review. Pigment Cell Res. 1998;11:60-80 pubmed
  7. Marubashi S, Shimada H, Fukuda M, Ohbayashi N. RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J Biol Chem. 2016;291:1427-40 pubmed publisher
    Two cell type-specific Rab proteins, Rab32 and Rab38 (Rab32/38), have been proposed as regulating the trafficking of melanogenic enzymes, including tyrosinase and tyrosinase-related protein 1 (Tyrp1), to melanosomes in melanocytes...
  8. Osanai K, Nakase K, Sakuma T, Nishiki K, Nojiri M, Kato R, et al. Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant lung surfactant homeostasis in Ruby rats. Respir Res. 2017;18:70 pubmed publisher
  9. Wasmeier C, Romao M, Plowright L, Bennett D, Raposo G, Seabra M. Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. J Cell Biol. 2006;175:271-81 pubmed
    A mutation in the small GTPase Rab38 gives rise to the mouse coat color phenotype "chocolate" (cht), implicating Rab38 in the regulation of melanogenesis. However, its role remains poorly characterized...

More Information


  1. Charles J, Coury F, Sulyanto R, Sitara D, Wu J, Brady N, et al. The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone. 2012;51:902-12 pubmed publisher
    ..RANKL-induced, NFATc1-dependent transcripts in the osteoclast are described: Nhedc2, Rhoc, Serpind1, Adcy3 and Rab38. Despite reasonable hypotheses for the importance of these molecules in the bone resorption pathway and their ..
  2. Oguro K, Ito M, Tsuda H, Mutoh K, Shiraishi H, Shirasaka Y, et al. Association of NMDA receptor sites and seizures of El mice. Epilepsy Res. 1991;9:225-30 pubmed
    ..No significant change was observed in El(-) mice after postural stimulation. These results suggest that El(+) and El(-) mice share seizure propensity and that activation of NMDA receptors is involved in the seizures of El mice. ..
  3. Brandl C, Ortiz O, Röttig B, Wefers B, Wurst W, Kühn R. Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos. FEBS Open Bio. 2015;5:26-35 pubmed publisher
    ..Herein, we applied pairs of TALEN or sgRNAs and Cas9 to create deletions in the Rab38 gene. We found that the deletion of 3.2 or 9.3 kb, but not of 30 kb, occurs at a frequency of 6-37%...
  4. Meyer M, Ortiz O, Hrabe de Angelis M, Wurst W, Kühn R. Modeling disease mutations by gene targeting in one-cell mouse embryos. Proc Natl Acad Sci U S A. 2012;109:9354-9 pubmed publisher
    ..as template for homologous recombination, we introduced missense and silent mutations into the Rab38 gene, encoding a small GTPase that regulates intracellular vesicle trafficking...
  5. Osanai K, Oikawa R, Higuchi J, Kobayashi M, Tsuchihara K, Iguchi M, et al. A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice. Am J Pathol. 2008;173:1265-74 pubmed publisher
    The chocolate mutation, which is associated with oculocutaneous albinism in mice, has been attributed to a G146T transversion in the conserved GTP/GDP-interacting domain of Rab38, a small GTPase that regulates intracellular vesicular ..
  6. Wefers B, Meyer M, Ortiz O, Hrabe de Angelis M, Hansen J, Wurst W, et al. Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides. Proc Natl Acad Sci U S A. 2013;110:3782-7 pubmed publisher
    ..Within 2 d of embryo injection, we created and corrected chocolate missense mutations in the small GTPase RAB38; a regulator of intracellular vesicle trafficking and phenotypic ..
  7. Loftus S, Baxter L, Buac K, Watkins Chow D, Larson D, Pavan W. Comparison of melanoblast expression patterns identifies distinct classes of genes. Pigment Cell Melanoma Res. 2009;22:611-22 pubmed publisher
  8. Tamura K, Ohbayashi N, Maruta Y, Kanno E, Itoh T, Fukuda M. Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes. Mol Biol Cell. 2009;20:2900-8 pubmed publisher
    Two small GTPase Rabs, Rab32 and Rab38, have recently been proposed to regulate trafficking of melanogenic enzymes to melanosomes in mammalian epidermal melanocytes; however, the exact molecular mechanism of Rab32/38-mediated transport ..
  9. Wang F, Zhang H, Zhang X, Wang Y, Ren F, Zhang X, et al. Varp interacts with Rab38 and functions as its potential effector. Biochem Biophys Res Commun. 2008;372:162-7 pubmed publisher
    ..To further investigate the function of Varp, a yeast two-hybrid screen was performed and Rab38 was identified as a Varp-associated protein...
  10. Potter M, Rinchik E. Deletion mapping of the chocolate (cht) locus within the Fes-Hbb region of mouse chromosome 7. Mamm Genome. 1993;4:46-8 pubmed