Rab34

Summary

Gene Symbol: Rab34
Description: RAB34, member RAS oncogene family
Alias: AI326479, Narr, Rah, Rah1, ras-related protein Rab-34, RAB34, member of RAS oncogene family, rab-39, ras-related homolog, ras-related protein Rab-39, ras-related protein Rah
Species: mouse
Products:     Rab34

Top Publications

  1. Wang T, Hong W. Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein. Mol Biol Cell. 2002;13:4317-32 pubmed
    ..b>Rab34, a new member of the Rab GTPase family, is associated primarily with the Golgi apparatus...
  2. Morimoto B, Chuang C, Koshland D. Molecular cloning of a member of a new class of low-molecular-weight GTP-binding proteins. Genes Dev. 1991;5:2386-91 pubmed
    ..keeping with the current nomenclature for other members of the ras superfamily, we will designate this new class as rah (ras-related homolog)...
  3. Sun P, Yamamoto H, Suetsugu S, Miki H, Takenawa T, Endo T. Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J Biol Chem. 2003;278:4063-71 pubmed
    ..We have cloned the entire coding sequence of a member of the Rab family small GTPases, Rah/Rab34. It lacked a consensus sequence for GTP-binding/GTPase domain...
  4. Goldenberg N, Grinstein S, Silverman M. Golgi-bound Rab34 is a novel member of the secretory pathway. Mol Biol Cell. 2007;18:4762-71 pubmed
    Golgi-localized Rab34 has been implicated in repositioning lysosomes and activation of macropinocytosis. Using HeLa cells, we undertook a detailed investigation of Rab34 involvement in intracellular vesicle transport...
  5. Zougman A, Mann M, Wisniewski J. Identification and characterization of a novel ubiquitous nucleolar protein 'NARR' encoded by a gene overlapping the rab34 oncogene. Nucleic Acids Res. 2011;39:7103-13 pubmed publisher
    ..the mass spectrometric discovery and biochemical validation of the novel protein encoded by a gene overlapping rab34 oncogene. The novel protein is highly conserved in mammals...
  6. Pusapati G, Kong J, Patel B, Krishnan A, Sagner A, Kinnebrew M, et al. CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Dev Cell. 2018;44:113-129.e8 pubmed publisher
    ..Most positive regulators identified in our screens, including Rab34, Pdcl, and Tubd1, were involved in ciliary functions, confirming the central role for primary cilia in Hh ..
  7. Segre J, Nemhauser J, Taylor B, Nadeau J, Lander E. Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat. Genomics. 1995;28:549-59 pubmed
    ..Nature 372: 103-107, 1994). We report as well the mutations in the rat rnu allele and the complete coding sequence of the rat whn mRNA. ..
  8. Vokes S, Ji H, McCuine S, Tenzen T, Giles S, Zhong S, et al. Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development. 2007;134:1977-89 pubmed
    ..Transgenic analysis of binding regions in Nkx2.2, Nkx2.1 (Titf1) and Rab34 established these as direct Hh targets...
  9. Ohbayashi N, Maruta Y, Ishida M, Fukuda M. Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. J Cell Sci. 2012;125:1508-18 pubmed publisher
    ..These findings reveal a new mechanism by which the dynein-dynactin motor complex recognizes Mreg on mature melanosomes through interaction with RILP and is involved in the centripetal movement of melanosomes. ..

More Information

Publications11

  1. Kasmapour B, Gronow A, Bleck C, Hong W, Gutierrez M. Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34. Proc Natl Acad Sci U S A. 2012;109:20485-90 pubmed publisher
    ..Here, we show a specific role for Rab34 and mammalian uncoordinated 13-2 (Munc13-2) in phagolysosome biogenesis and cargo delivery...
  2. Kasmapour B, Cai L, Gutierrez M. Spatial distribution of phagolysosomes is independent of the regulation of lysosome position by Rab34. Int J Biochem Cell Biol. 2013;45:2057-65 pubmed publisher
    ..confirmed previous observations in epithelial cells that both changes in cytoplasmic pH and the levels of active Rab34 induced a re-distribution of lysosomes to the cell centre or periphery...