Rab27b

Summary

Gene Symbol: Rab27b
Description: RAB27B, member RAS oncogene family
Alias: 2310021G14Rik, B130064M09Rik, ras-related protein Rab-27B
Species: mouse
Products:     Rab27b

Top Publications

  1. Singh R, Mizuno K, Wasmeier C, Wavre Shapton S, Recchi C, Catz S, et al. Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion. FEBS J. 2013;280:892-903 pubmed publisher
    ..using murine bone marrow-derived mast cells (BMMC) from Rab27-deficient mutant mice, we found that, in contrast to Rab27b, Rab27a primarily plays an inhibitory role in regulating degranulation...
  2. Strom M, Hume A, Tarafder A, Barkagianni E, Seabra M. A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. J Biol Chem. 2002;277:25423-30 pubmed
    ..Thus, melanophilin can associate simultaneously with activated Rab27a and myosin Va via distinct regions, and serve as a linker between these proteins. ..
  3. Ramalho J, Tolmachova T, Hume A, McGuigan A, Gregory Evans C, Huxley C, et al. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. BMC Genet. 2001;2:2 pubmed
    Rab GTPases are regulators of intracellular membrane traffic. The Rab27 subfamily consists of Rab27a and Rab27b. Rab27a has been recently implicated in Griscelli Disease, a disease combining partial albinism with severe immunodeficiency...
  4. Zhao S, Torii S, Yokota Hashimoto H, Takeuchi T, Izumi T. Involvement of Rab27b in the regulated secretion of pituitary hormones. Endocrinology. 2002;143:1817-24 pubmed
    ..In the present study we characterized another isoform, Rab27b, to further investigate the function of the Rab27 subfamily...
  5. Barral D, Ramalho J, Anders R, Hume A, Knapton H, Tolmachova T, et al. Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest. 2002;110:247-57 pubmed
    ..Here we present evidence that Rab27a function can be compensated by a closely related protein, Rab27b. Rab27b is expressed in platelets and other tissues but not in melanocytes or CTLs...
  6. Johnson J, Brzezinska A, Tolmachova T, Munafo D, Ellis B, Seabra M, et al. Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms. Traffic. 2010;11:533-47 pubmed publisher
    ..Using mouse neutrophils deficient in Rab27a (Rab27a(ash/ash)), Rab27b [Rab27b knockout (KO)] or both [Rab27a/b double KO (DoKo)], we investigated the role of the Rab27 isoforms in ..
  7. Gomi H, Mori K, Itohara S, Izumi T. Rab27b is expressed in a wide range of exocytic cells and involved in the delivery of secretory granules near the plasma membrane. Mol Biol Cell. 2007;18:4377-86 pubmed
    ..However, the roles of Rab27b, another Rab27 subfamily member, have not been well characterized. We disrupted the Rab27b gene in mice...
  8. Tolmachova T, Abrink M, Futter C, Authi K, Seabra M. Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci U S A. 2007;104:5872-7 pubmed
    The Rab27 GTPase subfamily consists of two closely related homologs, Rab27a and Rab27b. Rab27a has been shown previously to regulate organelle movement and regulated exocytosis in a wide variety of secretory cells...
  9. Saegusa C, Kanno E, Itohara S, Fukuda M. Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion. Arch Biochem Biophys. 2008;475:87-92 pubmed publisher
    ..Slp1 interacted with Rab27B in vivo and both proteins were co-localized on zymogen granules...

More Information

Publications30

  1. Bobrie A, Krumeich S, Reyal F, Recchi C, Moita L, Seabra M, et al. Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res. 2012;72:4920-30 pubmed publisher
    ..The small GTPases RAB27A and RAB27B regulate exocytosis of multivesicular endosomes, which lead to exosome secretion, in human HeLa cells...
  2. Fukuda M, Kuroda T. Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. J Biol Chem. 2002;277:43096-103 pubmed
  3. Bolasco G, Tracey White D, Tolmachova T, Thorley A, Tetley T, Seabra M, et al. Loss of Rab27 function results in abnormal lung epithelium structure in mice. Am J Physiol Cell Physiol. 2011;300:C466-76 pubmed publisher
    ..Previous studies indicated that Rab27a and Rab27b are expressed in the murine lung suggesting that they regulate secretory processes in the lung...
  4. Alexander M, Ramstead A, Bauer K, Lee S, Runtsch M, Wallace J, et al. Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli. J Immunol. 2017;199:3559-3570 pubmed publisher
    ..In this article, we demonstrate that Rab27a and Rab27b double-knockout (Rab27DKO) mice that are deficient in exosome secretion have a chronic, low-grade inflammatory ..
  5. Chen Y, Samaraweera P, Sun T, Kreibich G, Orlow S. Rab27b association with melanosomes: dominant negative mutants disrupt melanosomal movement. J Invest Dermatol. 2002;118:933-40 pubmed
    ..b>Rab27b and Rab27a share 72% identity and they belong to the same melanocyte/platelet subfamily of Rab proteins...
  6. Nabavi N, Pustylnik S, Harrison R. Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts. PLoS ONE. 2012;7:e46265 pubmed publisher
    ..identify the Rab GTPases that are up-regulated during a 5-day AA differentiation of OBs, namely Rab1, Rab3d, and Rab27b. Further, we investigated the role of identified Rabs in regulating the trafficking of collagen from the site of ..
  7. Saegusa C, Tanaka T, Tani S, Itohara S, Mikoshiba K, Fukuda M. Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells. Genes Cells. 2006;11:623-31 pubmed
    ..Based on these results, we propose that Slp2-a is part of the mucin secretory machinery in surface mucous cells of mouse stomach. ..
  8. Mizuno K, Tolmachova T, Ushakov D, Romao M, Abrink M, Ferenczi M, et al. Rab27b regulates mast cell granule dynamics and secretion. Traffic. 2007;8:883-92 pubmed
    ..Very little is known about the related isoform, Rab27b. Here we used genetically modified mice to study the involvement of the Rab27 proteins in mast cells, which play ..
  9. Kukimoto Niino M, Sakamoto A, Kanno E, Hanawa Suetsugu K, Terada T, Shirouzu M, et al. Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases. Structure. 2008;16:1478-90 pubmed publisher
    ..Mutations that disrupt the Rab27A/Slac2-a interaction cause human Griscelli syndrome. The other Rab27 isoform, Rab27B, also binds all of the known effectors of Rab27A...
  10. Singh R, Furze R, Birrell M, Rankin S, Hume A, Seabra M. A role for Rab27 in neutrophil chemotaxis and lung recruitment. BMC Cell Biol. 2014;15:39 pubmed publisher
    ..b>Rab27b has been implicated in primary granule exocytosis but its role in neutrophil migration has not been investigated...
  11. Chavas L, Torii S, Kamikubo H, Kawasaki M, Ihara K, Kato R, et al. Structure of the small GTPase Rab27b shows an unexpected swapped dimer. Acta Crystallogr D Biol Crystallogr. 2007;63:769-79 pubmed
    ..The Rab27 subfamily consists of Rab27a and Rab27b, which share 70% sequence identity...
  12. Ramalho J, Anders R, Jaissle G, Seeliger M, Huxley C, Seabra M. Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models. BMC Cell Biol. 2002;3:26 pubmed
    ..this hypothesis, we generated several lines of dominant-negative, constitutively-active and wild-type Rab27a (and Rab27b) transgenic mice whose expression was driven either by the pigment cell-specific tyrosinase promoter or the ..
  13. Meng Z, Edman M, Hsueh P, Chen C, Klinngam W, Tolmachova T, et al. Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome. Am J Physiol Cell Physiol. 2016;310:C942-54 pubmed publisher
    ..Here, we investigated the role of Rab3D, Rab27a, and Rab27b proteins in the enhanced release of CTSS from LGAC...
  14. Munoz I, Danelli L, Claver J, Goudin N, Kurowska M, Madera Salcedo I, et al. Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex. J Cell Biol. 2016;215:203-216 pubmed
    ..We identified Slp3 as the critical effector linking kinesin-1 to Rab27b-associated SGs...
  15. Tiwari S, Italiano J, Barral D, Mules E, Novak E, Swank R, et al. A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood. 2003;102:3970-9 pubmed
    ..number of Rab proteins with defective membrane association in gm/gm megakaryocytes prominently includes Rab27a and Rab27b. Normal expression of Rab27b is especially increased with terminal megakaryocyte differentiation and dependent on ..
  16. Kariya Y, Honma M, Hanamura A, Aoki S, Ninomiya T, Nakamichi Y, et al. Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells. J Bone Miner Res. 2011;26:689-703 pubmed publisher
    ..In this study we show that small GTPases Rab27a and Rab27b are involved in the stimulation-dependent RANKL release pathway in osteoblastic cells...
  17. Kierszenbaum A, Tres L, Rivkin E, Kang Decker N, van Deursen J. The acroplaxome is the docking site of Golgi-derived myosin Va/Rab27a/b- containing proacrosomal vesicles in wild-type and Hrb mutant mouse spermatids. Biol Reprod. 2004;70:1400-10 pubmed
    ..We suggest that nucleopodes develop at a site where a keratin 5-deficient acroplaxome may not withstand tension forces operating during spermatid nuclear shaping. ..
  18. Chiang L, Ngo J, Schechter J, Karvar S, Tolmachova T, Seabra M, et al. Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol. 2011;301:C507-21 pubmed publisher
    ..We investigated the role of Rab27b in the terminal release of these secretory vesicles...
  19. Chen Y, Guo X, Deng F, Liang F, Sun W, Ren M, et al. Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes. Proc Natl Acad Sci U S A. 2003;100:14012-7 pubmed
    ..We have investigated the possible role of Rab proteins in this delivery process, and found Rab27b to be expressed at an extraordinary high level (0...
  20. Hou Y, Chen X, Tolmachova T, Ernst S, Williams J. EPI64B acts as a GTPase-activating protein for Rab27B in pancreatic acinar cells. J Biol Chem. 2013;288:19548-57 pubmed publisher
    The small GTPase Rab27B localizes to the zymogen granule membranes and plays an important role in regulating protein secretion by pancreatic acinar cells, as does Rab3D...
  21. Hou Y, Ernst S, Lentz S, Williams J. Genetic deletion of Rab27B in pancreatic acinar cells affects granules size and has inhibitory effects on amylase secretion. Biochem Biophys Res Commun. 2016;471:610-5 pubmed publisher
    Small G protein Rab27B is expressed in various secretory cell types and plays a role in mediating secretion...