Gene Symbol: Rab1a
Description: RAB1A, member RAS oncogene family
Alias: Gtbp, Rab-1, Rab1, Ypt1, mKIAA3012, ras-related protein Rab-1A, RAB1, member RAS oncogene family, YPT1-related protein, ras-related YPT1 protein
Species: mouse
Products:     Rab1a

Top Publications

  1. Wang C, Yoo Y, Fan H, Kim E, Guan K, Guan J. Regulation of Integrin ? 1 recycling to lipid rafts by Rab1a to promote cell migration. J Biol Chem. 2010;285:29398-405 pubmed publisher
    b>Rab1a is a member of the Rab family of small GTPases with a well characterized function in the regulation of vesicle trafficking from the endoplasmic reticulum to the Golgi apparatus and within Golgi compartments...
  2. Neunuebel M, Chen Y, Gaspar A, Backlund P, Yergey A, Machner M. De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila. Science. 2011;333:453-6 pubmed publisher
    ..host cell vesicle transport by transiently manipulating the activity of the small guanosine triphosphatase (GTPase) Rab1. The effector protein SidM recruits Rab1 to the Legionella-containing vacuole (LCV), where it activates Rab1 and ..
  3. Wedemeyer N, Lengeling A, Ronsiek M, Korthaus D, Baer K, Wuttke M, et al. YAC contigs of the Rab1 and wobbler (wr) spinal muscular atrophy gene region on proximal mouse chromosome 11 and of the homologous region on human chromosome 2p. Genomics. 1996;32:447-54 pubmed
    ..We have localized the wobbler spinal atrophy gene wr to proximal mouse Chr 11, tightly linked to Rab1, a gene coding for a small GTP-binding protein, and Glnsps1, an intronless pseudogene of the glutamine synthetase ..
  4. Ishida M, Ohbayashi N, Maruta Y, Ebata Y, Fukuda M. Functional involvement of Rab1A in microtubule-dependent anterograde melanosome transport in melanocytes. J Cell Sci. 2012;125:5177-87 pubmed publisher
    ..transport by expressing 60 different constitutive active (and negative) mutants, and succeeded in identifying Rab1A, originally described as a Golgi-resident Rab, as a prime candidate...
  5. Resch K, Korthaus D, Wedemeyer N, Lengeling A, Ronsiek M, Thiel C, et al. Homology between human chromosome 2p13.3 and the wobbler critical region on mouse chromosome 11: comparative high-resolution mapping of STS and EST loci on YAC/BAC contigs. Mamm Genome. 1998;9:893-8 pubmed
    ..11. The maps comprise several known genes, MEIS1/Meis1, RAB1a/Rab1a, MDH1/Mor2, OTX1/Otx1, and REL on human 2p13...
  6. Farg M, Sundaramoorthy V, Sultana J, Yang S, Atkinson R, Levina V, et al. C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. Hum Mol Genet. 2014;23:3579-95 pubmed publisher
    ..C9ORF72 colocalized with Rab proteins implicated in autophagy and endocytic transport: Rab1, Rab5, Rab7 and Rab11 in neuronal cell lines, primary cortical neurons and human spinal cord motor neurons, ..
  7. Lowe D, Capon D, Delwart E, Sakaguchi A, Naylor S, Goeddel D. Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. Cell. 1987;48:137-46 pubmed
    ..5% predicted amino acid identity to human R-ras. Human R-ras was localized to chromosome 19, a site different from ras p21 genes. Mouse R-ras is syntenic with c-H-ras on chromosome 7. ..
  8. Haubruck H, Disela C, Wagner P, Gallwitz D. The ras-related ypt protein is an ubiquitous eukaryotic protein: isolation and sequence analysis of mouse cDNA clones highly homologous to the yeast YPT1 gene. EMBO J. 1987;6:4049-53 pubmed
    The YPT1 gene of the yeast Saccharomyces cerevisiae codes for a guanine nucleotide-binding protein which is essential for cell viability...
  9. Hardiman C, Roy C. AMPylation is critical for Rab1 localization to vacuoles containing Legionella pneumophila. MBio. 2014;5:e01035-13 pubmed publisher
    ..Several Legionella effector proteins modulate the function of the host protein Rab1, which is a GTPase that is recruited to the Legionella-containing vacuole (LCV)...

More Information


  1. Papadopoulos N, Nicolaides N, Liu B, Parsons R, Lengauer C, Palombo F, et al. Mutations of GTBP in genetically unstable cells. Science. 1995;268:1915-7 pubmed
    ..Here the gene encoding a G/T mismatch-binding protein (GTBP) was localized to within 1 megabase of the related hMSH2 gene on chromosome 2 and was found to be inactivated in ..
  2. Antony C, Huchet M, Changeux J, Cartaud J. Developmental regulation of membrane traffic organization during synaptogenesis in mouse diaphragm muscle. J Cell Biol. 1995;130:959-68 pubmed
  3. Rizzo R, Parashuraman S, Mirabelli P, Puri C, Lucocq J, Luini A. The dynamics of engineered resident proteins in the mammalian Golgi complex relies on cisternal maturation. J Cell Biol. 2013;201:1027-36 pubmed publisher
    ..Maturation models predict the progress of such polymerized residents through the stack along with cargo, but stable cisternae models do not. The results support the cisternal maturation mechanism. ..
  4. Chavrier P, Simons K, Zerial M. The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992;112:261-4 pubmed
    ..These results confirm that the overall diversity of the Rab and Rho protein subfamilies account for more than thirty different members in mammalian cells. ..
  5. Huang W, Wu G, Wang G. Cell type-specific and light-dependent expression of Rab1 and Rab6 GTPases in mammalian retinas. Vis Neurosci. 2009;26:443-52 pubmed publisher
    The Ras-like Rab1 and Rab6 GTPases modulate protein traffic along the early secretory pathway and are involved in the regulation of maturation of rhodopsin in the outer retina...
  6. Yamasaki A, Menon S, Yu S, Barrowman J, Meerloo T, Oorschot V, et al. mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles. Mol Biol Cell. 2009;20:4205-15 pubmed publisher
    The GTPase Rab1 regulates endoplasmic reticulum-Golgi and early Golgi traffic. The guanine nucleotide exchange factor (GEF) or factors that activate Rab1 at these stages of the secretory pathway are currently unknown...
  7. Gurkan C, Lapp H, Alory C, Su A, Hogenesch J, Balch W. Large-scale profiling of Rab GTPase trafficking networks: the membrome. Mol Biol Cell. 2005;16:3847-64 pubmed
    ..An interactive website for exploring datasets comprising components of the Rab-regulated hubs that define the membrome of different cell and organ systems in both human and mouse is available at http://www.membrome.org/. ..
  8. Wedemeyer N, Schmitt John T, Evers D, Thiel C, Eberhard D, Jockusch H. Conservation of the 3'-untranslated region of the Rab1a gene in amniote vertebrates: exceptional structure in marsupials and possible role for posttranscriptional regulation. FEBS Lett. 2000;477:49-54 pubmed
    ..Here we report that the most highly conserved nucleotide sequence of the Rab1a gene of amniote vertebrates corresponds to the 3'-untranslated region (3'-UTR) of the mRNA...
  9. Kelleher K, Matthaei K, Leck K, Hendry I. Developmental expression of messenger RNA levels of the alpha subunit of the GTP-binding protein, Gz, in the mouse nervous system. Brain Res Dev Brain Res. 1998;107:247-53 pubmed
    ..This further strengthens the hypothesis that Gzalpha is important in the transfer of information from target tissues to the innervating nerve cells. ..
  10. Korthaus D, Wedemeyer N, Wiegand C, Jockusch H. The gene for cytoplasmatic malate dehydrogenase, Mor2, is closely linked to the wobbler spinal muscular atrophy gene (wr). Mamm Genome. 1996;7:250 pubmed
  11. Taparowsky E, Shimizu K, Goldfarb M, Wigler M. Structure and activation of the human N-ras gene. Cell. 1983;34:581-6 pubmed
    ..From previous studies we conclude that amino acid substitutions in two distinct regions can activate the transforming potential of ras gene products. ..
  12. McGrath J, Capon D, Smith D, Chen E, Seeburg P, Goeddel D, et al. Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. Nature. 1983;304:501-6 pubmed
    ..This suggests that the functional gene may specify either of two related polypeptides depending on the pattern of RNA splicing...
  13. Ali N, Jurczyluk J, Shay G, Tnimov Z, Alexandrov K, Munoz M, et al. A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton. Small Gtpases. 2015;6:202-11 pubmed publisher
    ..Finally, we also detected a clear effect of subcutaneous ZOL administration in vivo on the prenylation of Rab1A, Rab5B, Rab7A and Rab14 in mouse peritoneal macrophages, confirming that systemic treatment with bisphosphonate ..
  14. Nabavi N, Pustylnik S, Harrison R. Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts. PLoS ONE. 2012;7:e46265 pubmed publisher
    ..analysis to identify the Rab GTPases that are up-regulated during a 5-day AA differentiation of OBs, namely Rab1, Rab3d, and Rab27b...
  15. Ishida M, Ohbayashi N, Fukuda M. Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP. Sci Rep. 2015;5:8238 pubmed publisher
    ..Here we discovered that small GTPase Rab1A on melanosomes recruits SKIP/PLEKHM2 as a Rab1A-specific effector and that Rab1A, SKIP, and a kinesin-1/(Kif5b+..
  16. Bell A, Ward M, Blackstock W, Freeman H, Choudhary J, Lewis A, et al. Proteomics characterization of abundant Golgi membrane proteins. J Biol Chem. 2001;276:5152-65 pubmed
  17. Cooper A, Gitler A, Cashikar A, Haynes C, Hill K, Bhullar B, et al. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science. 2006;313:324-8 pubmed
    ..Elevated expression of Rab1, the mammalian YPT1 homolog, protected against alphaSyn-induced dopaminergic neuron loss in animal models of PD...
  18. Fuchs S, Resch K, Thiel C, Ulbrich M, Platzer M, Jockusch H, et al. Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. BMC Genet. 2002;3:14 pubmed
    ..5 Mb between REL/Rel and RAB1A/Rab1a...
  19. Lengeling A, Zimmer W, Goodman S, Ma Y, Bloom M, Bruneau G, et al. Exclusion of two candidate genes, Spnb-2 and Dcd, for the wobbler spinal muscular atrophy gene on proximal mouse chromosome 11. Mamm Genome. 1994;5:163-6 pubmed
  20. Capon D, Chen E, Levinson A, Seeburg P, Goeddel D. Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature. 1983;302:33-7 pubmed
  21. Wichmann H, Jockusch H, Guenet J, Gallwitz D, Kaupmann K. The mouse homolog to the ras-related yeast gene YPT1 maps on chromosome 11 close to the wobbler (wr) locus. Mamm Genome. 1992;3:467-8 pubmed
  22. Loh E, Peter F, Subramaniam V, Hong W. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus. J Cell Sci. 2005;118:1209-22 pubmed
    ..We also show that Bet3 acts after COPII but before Rab1, alpha-SNAP and the EGTA-sensitive stage during ER-Golgi transport...
  23. Wu G, Yussman M, Barrett T, Hahn H, Osinska H, Hilliard G, et al. Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy. Circ Res. 2001;89:1130-7 pubmed
    ..GTPase expression can contribute to cardiomyopathy, we transgenically overexpressed in mouse hearts prototypical Rab1a, the small G protein that regulates vesicle transport from endoplasmic reticulum to and through Golgi...
  24. Fawell E, Hook S, Armstrong J. Nucleotide sequence of a gene encoding a YPT1-related protein from Schizosaccharomyces pombe. Nucleic Acids Res. 1989;17:4373 pubmed
  25. Wichmann H, Disela C, Haubruck H, Gallwitz D. Nucleotide sequence of the mouse ypt1 gene encoding a ras-related GTP-binding protein. Nucleic Acids Res. 1989;17:6737-8 pubmed