Genomes and Genes
Gene Symbol: Pygm
Description: muscle glycogen phosphorylase
Alias: AI115133, glycogen phosphorylase, muscle form, myophosphorylase
- Murdock D, Boone B, Esposito L, Wallace D. Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator. J Biol Chem. 1999;274:14429-33 pubmed..These results indicate that identification of genes up-regulated in the skeletal muscle of the Ant1-deficient mouse provides a novel method for identifying mammalian genes required for mitochondrial biogenesis. ..
- Schliselfeld L, Danon M. Inverse relationship of skeletal muscle glycogen from wild-type and genetically modified mice to their phosphorylase a activity. Biochem Biophys Res Commun. 2002;290:874-7 pubmed..00 mM AMP (4.8% and less glycogen phosphorylase a). This suggests that there is an inverse relationship between mouse muscle phosphorylase a and the muscle's glycogen content. ..
- Nogales Gadea G, Pinós T, Lucia A, Arenas J, Camara Y, Brull A, et al. Knock-in mice for the R50X mutation in the PYGM gene present with McArdle disease. Brain. 2012;135:2048-57 pubmed publisher..the most common muscle glycogenosis, is a recessive disorder caused by mutations in PYGM, the gene encoding myophosphorylase. Patients with McArdle disease typically experience exercise intolerance manifested as acute crises of early ..
- Xu X, Mathieu C, Boitard S, Dairou J, Dupret J, Agbulut O, et al. Skeletal muscle glycogen phosphorylase is irreversibly inhibited by mercury: molecular, cellular and kinetic aspects. FEBS Lett. 2014;588:138-42 pubmed publisher..Our data suggest that the irreversible inhibition of GP could represent one of the mechanisms that contribute to mercury-dependent muscle toxicity. ..
- Glaser T, Matthews K, Hudson J, Seth P, Housman D, Crerar M. Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively. Genomics. 1989;5:510-21 pubmed..The genes encoding muscle, liver, and brain phosphorylases (Pygm, Pygl, and Pygb) are assigned to mouse chromosomes 19, 12, and 2, respectively...
- Johnson K, Lane P, Ward Bailey P, Davisson M. Mapping the mouse dactylaplasia mutation, Dac, and a gene that controls its expression, mdac. Genomics. 1995;29:457-64 pubmed..We mapped mdac to the middle of Chr 13 by segregation analysis of both recombinant inbred strains and backcross progeny. ..