Gene Symbol: Pygm
Description: muscle glycogen phosphorylase
Alias: AI115133, glycogen phosphorylase, muscle form, myophosphorylase
Species: mouse
Products:     Pygm

Top Publications

  1. Gabig T, Crean C, Klenk A, Long H, Copeland N, Gilbert D, et al. Expression and chromosomal localization of the Requiem gene. Mamm Genome. 1998;9:660-5 pubmed
    ..The gene is located in the proximal region of mouse Chromosome (Chr) 19. In the homologous human region at 11q13, it is located at about 150 kb centromeric from MLK3. ..
  2. Pederson B, Chen H, Schroeder J, Shou W, DePaoli Roach A, Roach P. Abnormal cardiac development in the absence of heart glycogen. Mol Cell Biol. 2004;24:7179-87 pubmed
  3. Dairou J, Pluvinage B, Noiran J, Petit E, Vinh J, Haddad I, et al. Nitration of a critical tyrosine residue in the allosteric inhibitor site of muscle glycogen phosphorylase impairs its catalytic activity. J Mol Biol. 2007;372:1009-21 pubmed
    ..Our findings suggest that GP functions may be regulated by tyrosine nitration. ..
  4. Müller M, Pedersen S, Walls A, Waagepetersen H, Bak L. Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes. Glia. 2015;63:154-62 pubmed publisher
    ..Our results indicate that the two GP isoforms expressed in astrocytes respond to different physiological triggers, therefore conferring distinct metabolic functions of brain glycogen. ..
  5. de Luna N, Brull A, Guiu J, Lucia A, Martín M, Arenas J, et al. Sodium valproate increases the brain isoform of glycogen phosphorylase: looking for a compensation mechanism in McArdle disease using a mouse primary skeletal-muscle culture in vitro. Dis Model Mech. 2015;8:467-72 pubmed publisher
    ..It is an autosomic recessive disorder that is caused by mutations in the PYGM gene and typically presents with exercise intolerance, i.e...
  6. Pinacho R, Vila E, Prades R, Tarrago T, Castro E, Ferrer I, et al. The glial phosphorylase of glycogen isoform is reduced in the dorsolateral prefrontal cortex in chronic schizophrenia. Schizophr Res. 2016;177:37-43 pubmed publisher
    ..The aim of this study was to explore whether the protein levels of the astrocyte isoform of glycogen phosphorylase (PYGM), key enzyme of glycogenolysis, and the isoform A of Ras-related C3 botulinum toxin substrate 1 (RAC1), a kinase ..
  7. Krag T, Pinós T, Nielsen T, Duran J, García Rocha M, Andreu A, et al. Differential glucose metabolism in mice and humans affected by McArdle disease. Am J Physiol Regul Integr Comp Physiol. 2016;311:R307-14 pubmed publisher
    McArdle disease (muscle glycogenosis type V) is a disease caused by myophosphorylase deficiency leading to "blocked" glycogen breakdown...
  8. Szepetowski P, Simon M, Grosgeorge J, Huebner K, Bastard C, Evans G, et al. Localization of 11q13 loci with respect to regional chromosomal breakpoints. Genomics. 1992;12:738-44 pubmed
  9. Cook S, Johnson K, Bronson R, Davisson M. Neuromuscular degeneration (nmd): a mutation on mouse chromosome 19 that causes motor neuron degeneration. Mamm Genome. 1995;6:187-91 pubmed
    ..CAST/Ei) to map the nmd mutation to mouse Chromosome (Chr) 19 with the most likely gene order: nmd-(D19Sel2, Pygm)-Cntf-Pomc2-D19Mit16-Cyp2c-Got1...

More Information


  1. Murdock D, Boone B, Esposito L, Wallace D. Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator. J Biol Chem. 1999;274:14429-33 pubmed
    ..These results indicate that identification of genes up-regulated in the skeletal muscle of the Ant1-deficient mouse provides a novel method for identifying mammalian genes required for mitochondrial biogenesis. ..
  2. Schliselfeld L, Danon M. Inverse relationship of skeletal muscle glycogen from wild-type and genetically modified mice to their phosphorylase a activity. Biochem Biophys Res Commun. 2002;290:874-7 pubmed
    ..00 mM AMP (4.8% and less glycogen phosphorylase a). This suggests that there is an inverse relationship between mouse muscle phosphorylase a and the muscle's glycogen content. ..
  3. Nogales Gadea G, Pinós T, Lucia A, Arenas J, Camara Y, Brull A, et al. Knock-in mice for the R50X mutation in the PYGM gene present with McArdle disease. Brain. 2012;135:2048-57 pubmed publisher
    ..the most common muscle glycogenosis, is a recessive disorder caused by mutations in PYGM, the gene encoding myophosphorylase. Patients with McArdle disease typically experience exercise intolerance manifested as acute crises of early ..
  4. Xu X, Mathieu C, Boitard S, Dairou J, Dupret J, Agbulut O, et al. Skeletal muscle glycogen phosphorylase is irreversibly inhibited by mercury: molecular, cellular and kinetic aspects. FEBS Lett. 2014;588:138-42 pubmed publisher
    ..Our data suggest that the irreversible inhibition of GP could represent one of the mechanisms that contribute to mercury-dependent muscle toxicity. ..
  5. Glaser T, Matthews K, Hudson J, Seth P, Housman D, Crerar M. Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively. Genomics. 1989;5:510-21 pubmed
    ..The genes encoding muscle, liver, and brain phosphorylases (Pygm, Pygl, and Pygb) are assigned to mouse chromosomes 19, 12, and 2, respectively...
  6. Johnson K, Lane P, Ward Bailey P, Davisson M. Mapping the mouse dactylaplasia mutation, Dac, and a gene that controls its expression, mdac. Genomics. 1995;29:457-64 pubmed
    ..We mapped mdac to the middle of Chr 13 by segregation analysis of both recombinant inbred strains and backcross progeny. ..