Genomes and Genes
Gene Symbol: Pvalb
Alias: Parv, Pva, parvalbumin alpha
- Azim E, Jabaudon D, Fame R, Macklis J. SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. Nat Neurosci. 2009;12:1238-47 pubmed publisher..These data indicate that SOX6 is a central regulator of both progenitor and cortical interneuron diversity during neocortical development. ..
- Mandai K, Guo T, St Hillaire C, Meabon J, Kanning K, Bothwell M, et al. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron. 2009;63:614-27 pubmed publisher..These findings show that LIGs physically interact with RTKs and modulate their activities to control axonal extension, guidance and branching. ..
- Madisen L, Zwingman T, Sunkin S, Oh S, Zariwala H, Gu H, et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci. 2010;13:133-40 pubmed publisher..Our expression data are displayed in a public online database to help researchers assess the utility of various Cre-driver lines for cell-type-specific genetic manipulation. ..
- Xu Q, Guo L, Moore H, Waclaw R, Campbell K, Anderson S. Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates. Neuron. 2010;65:328-40 pubmed publisher..These results indicate that cortical interneuron diversity, a major determinant of cortical function, is critically influenced by differential levels of SHH signaling within the ventral telencephalon. ..
- Kerlin A, Andermann M, Berezovskii V, Reid R. Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex. Neuron. 2010;67:858-71 pubmed publisher..These results suggest that the sensory responses of layer 2/3 GABAergic neurons reflect the pooled activity of the surrounding population--a principle that may generalize across species and sensory modalities. ..
- Manseau F, Marinelli S, Mendez P, Schwaller B, Prince D, Huguenard J, et al. Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons. PLoS Biol. 2010;8: pubmed publisher..Since each FS cell contacts many P neurons, asynchronous release from a single interneuron may desynchronize a large portion of the local network and disrupt cortical information processing. ..
- Carlen M, Meletis K, Siegle J, Cardin J, Futai K, Vierling Claassen D, et al. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Mol Psychiatry. 2012;17:537-48 pubmed publisher..Our results provide evidence for the critical role of NMDAR in PV interneurons for expression of normal gamma rhythms and specific cognitive behaviors. ..
- Shamir A, Kwon O, Karavanova I, Vullhorst D, Leiva Salcedo E, Janssen M, et al. The importance of the NRG-1/ErbB4 pathway for synaptic plasticity and behaviors associated with psychiatric disorders. J Neurosci. 2012;32:2988-97 pubmed publisher..These findings are important to better understand ErbB4's role in complex behaviors and warrant further analysis of ErbB4 mutant mice lacking the receptor in distinct neuron types. ..
- Murray A, Sauer J, Riedel G, McClure C, Ansel L, Cheyne L, et al. Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory. Nat Neurosci. 2011;14:297-9 pubmed publisher..We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory. ..
- Chakkalakal J, Kuang S, Buffelli M, Lichtman J, Sanes J. Mouse transgenic lines that selectively label Type I, Type IIA, and Types IIX+B skeletal muscle fibers. Genesis. 2012;50:50-8 pubmed publisher..We demonstrate their use for motor unit reconstruction and live imaging of nerve-dependent alterations in fiber type. ..
- Vidaki M, Tivodar S, Doulgeraki K, Tybulewicz V, Kessaris N, Pachnis V, et al. Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex. Cereb Cortex. 2012;22:680-92 pubmed publisher..Rac1 is necessary for their transition from G1 to S phase, at least in part by regulating cyclin D levels and retinoblastoma protein phosphorylation. ..
- Runyan C, Schummers J, Van Wart A, Kuhlman S, Wilson N, Huang Z, et al. Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex. Neuron. 2010;67:847-57 pubmed publisher..These results suggest that subsets of parvalbumin interneurons are components of specific cortical networks and that perisomatic inhibition contributes to the generation of precise response properties. ..
- Sessa A, Mao C, Colasante G, Nini A, Klein W, Broccoli V. Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons. Genes Dev. 2010;24:1816-26 pubmed publisher..We thus propose that INPs are able to control simultaneously the increase of glutamatergic and GABAergic neuronal pools, thereby creating a simple way to intrinsically balance their relative accumulation. ..
- Stevens H, Smith K, Maragnoli M, Fagel D, Borok E, Shanabrough M, et al. Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. J Neurosci. 2010;30:5590-602 pubmed publisher..These data demonstrate that FGFR2 signaling expands the number of excitatory neurons in the mPFC and secondarily influences target neurons in subcortical stations of the limbic system. ..
- Royer S, Zemelman B, Losonczy A, Kim J, Chance F, Magee J, et al. Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition. Nat Neurosci. 2012;15:769-75 pubmed publisher..These findings indicate that perisomatic and dendritic inhibition have distinct roles in controlling the rate, burst and timing of hippocampal pyramidal cells. ..
- Li K, Lu Y, Xu Z, Zhang J, Zhu J, Zhang J, et al. Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy. Nat Neurosci. 2011;15:267-73 pubmed publisher..Together, our findings suggest that NRG1-ErbB4 signaling contributes to human epilepsy through regulating the excitability of FS-PV interneurons. ErbB4 may be a new target for anticonvulsant drugs in epilepsy. ..
- Betley J, Wright C, Kawaguchi Y, Erdelyi F, Szabo G, Jessell T, et al. Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. Cell. 2009;139:161-74 pubmed publisher..The organization of a GABAergic circuit that mediates presynaptic inhibition in the mammalian CNS is therefore controlled by a stringent program of sensory recognition and signaling. ..
- Wilson N, Runyan C, Wang F, Sur M. Division and subtraction by distinct cortical inhibitory networks in vivo. Nature. 2012;488:343-8 pubmed publisher..These findings provide direct evidence that inhibitory neuronal subclasses have distinct and complementary roles in cortical computations. ..
- Mukhopadhyay A, McGuire T, Peng C, Kessler J. Differential effects of BMP signaling on parvalbumin and somatostatin interneuron differentiation. Development. 2009;136:2633-42 pubmed publisher..However, PV (also known as PVALB) is not expressed by interneurons until the second postnatal week after reaching the cortex, suggesting that ..
- Lovett Barron M, Turi G, Kaifosh P, Lee P, Bolze F, Sun X, et al. Regulation of neuronal input transformations by tunable dendritic inhibition. Nat Neurosci. 2012;15:423-30, S1-3 pubmed publisher..These results provide evidence for a division of labor in cortical circuits, where distinct computational functions are implemented by subtypes of local inhibitory neurons. ..
- Atallah B, Bruns W, Carandini M, Scanziani M. Parvalbumin-expressing interneurons linearly transform cortical responses to visual stimuli. Neuron. 2012;73:159-70 pubmed publisher..These results indicate that PV cells are ideally suited to modulate cortical gain and establish a causal relationship between a select neuron type and specific computations performed by the cortex during sensory processing. ..
- Meechan D, Tucker E, Maynard T, LaMantia A. Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome. Proc Natl Acad Sci U S A. 2009;106:16434-45 pubmed publisher..Such developmental disruption may alter cortical circuitry and establish vulnerability for developmental disorders, including schizophrenia and autism. ..
- Kanatani S, Yozu M, Tabata H, Nakajima K. COUP-TFII is preferentially expressed in the caudal ganglionic eminence and is involved in the caudal migratory stream. J Neurosci. 2008;28:13582-91 pubmed publisher..Thus, a locally expressed transcription factor determines the migratory direction of the cortical interneurons in a region-specific manner. ..
- Eggermann E, Jonas P. How the 'slow' Ca(2+) buffer parvalbumin affects transmitter release in nanodomain-coupling regimes. Nat Neurosci. 2011;15:20-2 pubmed publisher..Modeling suggests that, in high concentrations, parvalbumin may exert BAPTA-like effects, modulating nanodomain coupling via competition with local saturation of endogenous fixed buffers. ..
- Penagarikano O, Abrahams B, Herman E, Winden K, Gdalyahu A, Dong H, et al. Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Cell. 2011;147:235-46 pubmed publisher..These data demonstrate a functional role for CNTNAP2 in brain development and provide a new tool for mechanistic and therapeutic research in ASD. ..
- Orduz D, Bischop D, Schwaller B, Schiffmann S, Gall D. Parvalbumin tunes spike-timing and efferent short-term plasticity in striatal fast spiking interneurons. J Physiol. 2013;591:3215-32 pubmed publisher..This, in turn, may play a direct role in the generation and pathology-related worsening of motor rhythms. ..
- Taniguchi H, He M, Wu P, Kim S, Paik R, Sugino K, et al. A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron. 2011;71:995-1013 pubmed publisher..As such, this approach will accelerate the study of GABAergic circuits throughout the mammalian brain. ..
- Collin T, Chat M, Lucas M, Moreno H, Racay P, Schwaller B, et al. Developmental changes in parvalbumin regulate presynaptic Ca2+ signaling. J Neurosci. 2005;25:96-107 pubmed..Overall, PV arises as a major contributor to presynaptic Ca(i) signals and synaptic integration in the cerebellar cortex. ..
- Marin O, Anderson S, Rubenstein J. Origin and molecular specification of striatal interneurons. J Neurosci. 2000;20:6063-76 pubmed..Finally, we hypothesize that, within the MGE, radially migrating cells generally become projection neurons, whereas tangentially migrating cells mainly form interneurons of the striatum and cerebral cortex. ..
- Tourtellotte W, Milbrandt J. Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nat Genet. 1998;20:87-91 pubmed..These results indicate that type I myotubes are dependent upon Egr3-mediated transcription for proper spindle development. ..
- Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. A role for neuregulin1 signaling in muscle spindle differentiation. Neuron. 2002;36:1035-49 pubmed
- Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle D, et al. A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol. 2005;3:e159 pubmed..Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation. ..
- Xu Q, Wonders C, Anderson S. Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon. Development. 2005;132:4987-98 pubmed..These results combine in vitro and ex vivo analyses to link embryonic abnormalities in Shh signaling to postnatal alterations in cortical interneuron composition. ..
- Chen G, Racay P, Bichet S, Celio M, Eggli P, Schwaller B. Deficiency in parvalbumin, but not in calbindin D-28k upregulates mitochondrial volume and decreases smooth endoplasmic reticulum surface selectively in a peripheral, subplasmalemmal region in the soma of Purkinje cells. Neuroscience. 2006;142:97-105 pubmed..Rather the cell attempts to restore spatiotemporal aspects of Ca(2+) signals prevailing in the undisturbed (wildtype) situation by subtly fine tuning existing components involved in the regulation of Ca(2+) fluxes. ..
- Schwaller B, Dick J, Dhoot G, Carroll S, Vrbova G, Nicotera P, et al. Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout mice. Am J Physiol. 1999;276:C395-403 pubmed..Acceleration of the contraction-relaxation cycle of fast-twitch muscle fibers by PV may confer an advantage in the performance of rapid, phasic movements. ..
- Zhong J, Li X, McNamee C, Chen A, Baccarini M, Snider W. Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo. Nat Neurosci. 2007;10:598-607 pubmed..We conclude that Raf function is crucial for several aspects of DRG neuron development, including differentiation and axon growth. ..
- Caillard O, Moreno H, Schwaller B, Llano I, Celio M, Marty A. Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity. Proc Natl Acad Sci U S A. 2000;97:13372-7 pubmed..These data show that parvalbumin potently modulates short-term synaptic plasticity. ..
- Cobos I, Long J, Thwin M, Rubenstein J. Cellular patterns of transcription factor expression in developing cortical interneurons. Cereb Cortex. 2006;16 Suppl 1:i82-8 pubmed..This study is a first step to define the combinatorial codes of transcription factors that participate in regulating the specification and function of cortical interneuron subtypes. ..
- Moqrich A, Earley T, Watson J, Andahazy M, Backus C, Martin Zanca D, et al. Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat Neurosci. 2004;7:812-8 pubmed..The surviving presumptive TrkA-expressing neurons adopted a proprioceptive phenotype, indicating that neurotrophin signaling can specify sensory neuron subtypes. ..
- Chen G, Carroll S, Racay P, Dick J, Pette D, Traub I, et al. Deficiency in parvalbumin increases fatigue resistance in fast-twitch muscle and upregulates mitochondria. Am J Physiol Cell Physiol. 2001;281:C114-22 pubmed
- Kramer I, Sigrist M, de Nooij J, Taniuchi I, Jessell T, Arber S. A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification. Neuron. 2006;49:379-93 pubmed..Together, our findings suggest that Runx transcription factor signaling plays a key role in sensory neuron diversification. ..
- Cobos I, Calcagnotto M, Vilaythong A, Thwin M, Noebels J, Baraban S, et al. Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat Neurosci. 2005;8:1059-68 pubmed..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss. ..
- Tourtellotte W, Keller Peck C, Milbrandt J, Kucera J. The transcription factor Egr3 modulates sensory axon-myotube interactions during muscle spindle morphogenesis. Dev Biol. 2001;232:388-99 pubmed..We conclude that Egr3 has an essential role in regulating genes required for the transformation of undifferentiated myotubes into intrafusal fibers, and hence for the phenotypic differentiation of spindles. ..
- Ango F, Di Cristo G, Higashiyama H, Bennett V, Wu P, Huang Z. Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. Cell. 2004;119:257-72 pubmed..Disruption of NF186-ankyrinG interactions at AIS reduced pinceau synapse formation. These results implicate ankyrin-based localization of L1CAMs in subcellular organization of GABAergic synapses. ..
- Molliver D, Wright D, Leitner M, Parsadanian A, Doster K, Wen D, et al. IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron. 1997;19:849-61 pubmed..Together, our findings suggest that IB4-binding neurons switch from dependence on NGF in embryonic life to dependence on GDNF in postnatal life and are likely regulated by GDNF in maturity. ..
- Inoue K, Ozaki S, Shiga T, Ito K, Masuda T, Okado N, et al. Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci. 2002;5:946-54 pubmed..Our data demonstrate that Runx3 is critical in regulating the axonal projections of a specific subpopulation of DRG neurons. ..
- Huang E, Liu W, Fritzsch B, Bianchi L, Reichardt L, Xiang M. Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons. Development. 2001;128:2421-32 pubmed..Thus, Brn3a must control additional downstream genes that are required for axon pathfinding. ..
- Schmidt H, Werner M, Heppenstall P, Henning M, Moré M, Kühbandner S, et al. cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons. J Cell Biol. 2002;159:489-98 pubmed..Our studies therefore reveal that cGMP signaling is important for axonal growth in vivo and in vitro. ..
- Ohkubo Y, Uchida A, Shin D, Partanen J, Vaccarino F. Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouse. J Neurosci. 2004;24:6057-69 pubmed..We conclude that Fgfr1 is necessary for hippocampal growth, because it promotes the proliferation of hippocampal progenitors and stem cells during development. ..
- Stenman J, Yu R, Evans R, Campbell K. Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development. 2003;130:1113-22 pubmed..This correlates well with the malformation of the lateral and basolateral amygdala in Tlx mutants, both of which have been suggested to derive from ventral portions of the pallium. ..
- Patel T, Kramer I, Kucera J, Niederkofler V, Jessell T, Arber S, et al. Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents. Neuron. 2003;38:403-16 pubmed..Finally, addition of NT3 to DRG explant cultures resulted in induction of ER81 protein. Our data indicate that NT3 mediates the formation of proprioceptive afferent-motor neuron connections via regulation of ER81. ..
- Pagliardini S, Ren J, Wevrick R, Greer J. Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin. Am J Pathol. 2005;167:175-91 pubmed
- Racay P, Gregory P, Schwaller B. Parvalbumin deficiency in fast-twitch muscles leads to increased 'slow-twitch type' mitochondria, but does not affect the expression of fiber specific proteins. FEBS J. 2006;273:96-108 pubmed..We propose that 'slow-twitch type' mitochondria in PV-/- fast muscles are aimed to functionally replace the slow-onset buffer PV based on similar kinetic properties of Ca2+ removal. ..
- Chen L, Liao G, Waclaw R, Burns K, Linquist D, Campbell K, et al. Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. J Neurosci. 2007;27:3884-93 pubmed..Moreover, they indicate that Rac1 has a critical role in axon guidance and in acquisition of migratory competency during differentiation of the progenitors for the ventral telencephalon-derived interneurons. ..
- Vreugdenhil M, Jefferys J, Celio M, Schwaller B. Parvalbumin-deficiency facilitates repetitive IPSCs and gamma oscillations in the hippocampus. J Neurophysiol. 2003;89:1414-22 pubmed
- Leu M, Bellmunt E, Schwander M, Farinas I, Brenner H, Muller U. Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development. Development. 2003;130:2291-301 pubmed..However, functional spindles never develop. Taken together, our data suggest that Erbb2 signaling regulates the formation of both neuromuscular synapses and muscle spindles. ..
- Levanon D, Bettoun D, Harris Cerruti C, Woolf E, Negreanu V, Eilam R, et al. The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J. 2002;21:3454-63 pubmed..The data provide new genetic insights into the neurogenesis of DRGs and may help elucidate the molecular mechanisms underlying somatosensory-related ataxia in humans. ..
- Feng Y, Walsh C. Mitotic spindle regulation by Nde1 controls cerebral cortical size. Neuron. 2004;44:279-93 pubmed..Our data show that mitotic spindle function and orientation are essential for normal development of mammalian cerebral cortex. ..
- Woodruff A, Sah P. Networks of parvalbumin-positive interneurons in the basolateral amygdala. J Neurosci. 2007;27:553-63 pubmed..We propose that these properties allow networks of parvalbumin-expressing neurons to perform an array of information-processing tasks within the BLA. ..
- Maricich S, Herrup K. Pax-2 expression defines a subset of GABAergic interneurons and their precursors in the developing murine cerebellum. J Neurobiol. 1999;41:281-94 pubmed..Finally, our data support the hypothesis that the basket and stellate cells arise from neuronally restricted, migratory precursors located in the early postnatal cerebellar white matter. ..
- Liodis P, Denaxa M, Grigoriou M, Akufo Addo C, Yanagawa Y, Pachnis V. Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci. 2007;27:3078-89 pubmed..We also show that Lhx6 activity is required for the normal tangential and radial migration of GABAergic interneurons in the cortex. ..