Pum2

Summary

Gene Symbol: Pum2
Description: pumilio RNA-binding family member 2
Alias: 5730503J23Rik, Pumm2, pumilio homolog 2, pumilio 2
Species: mouse
Products:     Pum2

Top Publications

  1. Siemen H, Colas D, Heller H, Brüstle O, Pera R. Pumilio-2 function in the mouse nervous system. PLoS ONE. 2011;6:e25932 pubmed publisher
    ..Most recently, the mammalian Pumilio homolog Pumilio-2 (Pum2) has been found to play a role in the mammalian nervous system, in particular in regulating morphology, ..
  2. Vessey J, Vaccani A, Xie Y, Dahm R, Karra D, Kiebler M, et al. Dendritic localization of the translational repressor Pumilio 2 and its contribution to dendritic stress granules. J Neurosci. 2006;26:6496-508 pubmed
    ..Two Pumilio genes, Pum1 and Pum2, have been identified in mammals, but their function in neurons has not been identified...
  3. Xu E, Chang R, Salmon N, Reijo Pera R. A gene trap mutation of a murine homolog of the Drosophila stem cell factor Pumilio results in smaller testes but does not affect litter size or fertility. Mol Reprod Dev. 2007;74:912-21 pubmed
    ..Here we report characterization of a gene trap mutation that disrupts the mouse Pumilio-2 (Pum2) gene...
  4. Jenkins H, Baker Wilding R, Edwards T. Structure and RNA binding of the mouse Pumilio-2 Puf domain. J Struct Biol. 2009;167:271-6 pubmed publisher
    ..The vertebrate Pumilio homologue 2 (Pum2) has been implicated in controlling germ cell development through interactions with the RNA binding proteins ..
  5. Yamaji M, Tanaka T, Shigeta M, Chuma S, Saga Y, Saitou M. Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. Reproduction. 2010;139:381-93 pubmed publisher
    ..These findings unveil the presence of distinct posttranscriptional regulations in PGCs soon after their specification, for which RNA-binding proteins such as NANOS3 and TIAL1 would play critical functions. ..
  6. Lolicato F, Marino R, Paronetto M, Pellegrini M, Dolci S, Geremia R, et al. Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population. Dev Biol. 2008;313:725-38 pubmed
    ..These results allow to conclude that, in the prepuberal testis, Nanos3 is important to maintain undifferentiated spermatogonia via the regulation of their cell cycle. ..
  7. Spassov D, Jurecic R. Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins. Gene. 2002;299:195-204 pubmed
    ..The human genome contains two Pumilio related genes, PUM1 and PUM2, that encode 127 and 114 kDa proteins with evolutionarily highly conserved Pum RNA-binding domain (86 and 88% ..
  8. Mak W, Fang C, Holden T, Dratver M, Lin H. An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline. Biol Reprod. 2016;94:134 pubmed publisher
    ..In mammals, two homologs of Pumilio exist: Pumilio 1 (Pum1) and Pum2. Here, we report that PUMILIO (PUM) 1 plays an important role in the establishment of the primordial follicle pool, ..
  9. Miles W, Korenjak M, Griffiths L, Dyer M, Provero P, Dyson N. Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. EMBO J. 2014;33:2201-15 pubmed publisher
    ..Our data suggest that NANOS increases in importance in pRb-deficient cells and helps to maintain homeostasis by repressing the translation of transcripts containing PUM Regulatory Elements (PRE). ..

More Information

Publications22

  1. Raji B, Dansault A, Leemput J, de la Houssaye G, Vieira V, Kobetz A, et al. The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye. Mol Vis. 2007;13:1412-27 pubmed
  2. Scott R, White Grindley E, Ruley H, Chesler E, Williams R. P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA. J Cell Physiol. 2005;204:99-105 pubmed
    ..tissues that were screened using the WebQTL database, a strong positive expression covariance between P2P-R and the Pum2 gene product also was observed...
  3. Marrero E, Rossi S, Darr A, Tsoulfas P, Rotundo R. Translational regulation of acetylcholinesterase by the RNA-binding protein Pumilio-2 at the neuromuscular synapse. J Biol Chem. 2011;286:36492-9 pubmed publisher
    ..Here, we show that Pumilio-2 (PUM2), an RNA binding translational repressor, is highly localized at the neuromuscular junction where AChE mRNA ..
  4. White E, Moore Jarrett T, Ruley H. PUM2, a novel murine puf protein, and its consensus RNA-binding site. RNA. 2001;7:1855-66 pubmed
    ..proteins that might regulate posttranscriptional gene expression, we have characterized a novel murine Puf protein, PUM2. Pum2 transcripts were expressed in all murine tissues examined, suggesting the gene influences processes common to ..
  5. Spassov D, Jurecic R. Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors. Blood Cells Mol Dis. 2003;30:55-69 pubmed
    ..Here we describe cloning and comparative sequence analysis of Pum1 and Pum2 genes, mouse members of the Pumilio family, and for the first time demonstrate expression of Pumilio genes in ..
  6. Ekdahl Y, Farahani H, Behm M, Lagergren J, Ohman M. A-to-I editing of microRNAs in the mammalian brain increases during development. Genome Res. 2012;22:1477-87 pubmed publisher
    ..Taken together, our results imply that RNA editing influences the miRNA repertoire during brain maturation. ..
  7. Moore F, Jaruzelska J, Fox M, Urano J, Firpo M, Turek P, et al. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. Proc Natl Acad Sci U S A. 2003;100:538-43 pubmed
    ..Here, we show that PUM2, a human homolog of Pumilio, a protein required to maintain germ line stem cells in Drosophila and Caenorhabditis ..
  8. Zagore L, Grabinski S, Sweet T, Hannigan M, Sramkoski R, Li Q, et al. RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development. Mol Cell Biol. 2015;35:4030-42 pubmed publisher
    ..Collectively, the data provide evidence for an important role for alternative splicing regulation in germ cell development and a central role for Ptbp2 in this process. ..
  9. Suzuki A, Niimi Y, Shinmyozu K, Zhou Z, Kiso M, Saga Y. Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development. EMBO Rep. 2016;17:37-46 pubmed publisher
    ..We also present the first evidence that the zinc finger domain of Nanos acts as a protein-interacting domain for another RBP, providing a novel insight into Nanos-mediated germ cell development. ..
  10. Follwaczny P, Schieweck R, Riedemann T, Demleitner A, Straub T, Klemm A, et al. Pumilio2-deficient mice show a predisposition for epilepsy. Dis Model Mech. 2017;10:1333-1342 pubmed publisher
    ..Here, we show that pumilio RNA-binding family member 2 (Pumilio2; Pum2) plays a role in the regulation of excitability in hippocampal neurons of weaned and 5-month-old male mice...
  11. Galarneau A, Richard S. Target RNA motif and target mRNAs of the Quaking STAR protein. Nat Struct Mol Biol. 2005;12:691-8 pubmed
    ..In addition, 24% are implicated in cell growth and/or maintenance, suggesting a role for QKI in cancer...
  12. Barrios F, Filipponi D, Pellegrini M, Paronetto M, Di Siena S, Geremia R, et al. Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells. J Cell Sci. 2010;123:871-80 pubmed publisher
    ..We found that NANOS2 interacts with PUM2, and that these two proteins colocalize in the ribonucleoparticle and polysomal fractions on sucrose gradients, ..
  13. Campbell Z, Menichelli E, Friend K, Wu J, Kimble J, Williamson J, et al. Identification of a conserved interface between PUF and CPEB proteins. J Biol Chem. 2012;287:18854-62 pubmed publisher
    ..The equivalent loop in human PUM2 is required for binding to human CPEB3 in vitro, although the primary sequences of the human and C...