Ptx3

Summary

Gene Symbol: Ptx3
Description: pentraxin related gene
Alias: AI607804, TSG-14, pentraxin-related protein PTX3, pentaxin related, pentaxin-related protein PTX3, pentraxin 3, tumor necrosis factor-inducible gene 14 protein
Species: mouse
Products:     Ptx3

Top Publications

  1. Jaillon S, Peri G, Delneste Y, Fremaux I, Doni A, Moalli F, et al. The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med. 2007;204:793-804 pubmed
    ..We report that, unexpectedly, PTX3 is stored in specific granules and undergoes release in response to microbial recognition and inflammatory signals...
  2. Ravizza T, Moneta D, Bottazzi B, Peri G, Garlanda C, Hirsch E, et al. Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration. Neuroscience. 2001;105:43-53 pubmed
    b>Pentraxin 3, a prototypic long pentraxin, is induced by proinflammatory signals in the brain. Inflammatory cytokines are rapidly induced in glia by epileptic activity...
  3. Soares A, Souza D, Pinho V, Vieira A, Nicoli J, Cunha F, et al. Dual function of the long pentraxin PTX3 in resistance against pulmonary infection with Klebsiella pneumoniae in transgenic mice. Microbes Infect. 2006;8:1321-9 pubmed
    The long pentraxin PTX3 is expressed during acute inflammation and appears to control nitric oxide (NO) and tumor necrosis factor (TNF)-alpha production...
  4. Varani S, Elvin J, Yan C, DeMayo J, DeMayo F, Horton H, et al. Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility. Mol Endocrinol. 2002;16:1154-67 pubmed
    ..expression profiles using gene chip technology, we identified TNF-induced protein 6 (Tnfip6) and pentraxin 3 (Ptx3 or PTX3) as novel factors induced by GDF-9 in granulosa cells of preovulatory follicles...
  5. Deban L, Russo R, Sironi M, Moalli F, Scanziani M, Zambelli V, et al. Regulation of leukocyte recruitment by the long pentraxin PTX3. Nat Immunol. 2010;11:328-34 pubmed publisher
    Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate ..
  6. Jeannin P, Bottazzi B, Sironi M, Doni A, Rusnati M, Presta M, et al. Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors. Immunity. 2005;22:551-60 pubmed
    ..The TLR2-activated functional program includes production of the long pentraxin PTX3, a soluble pattern recognition receptor involved in resistance against diverse pathogens...
  7. D Angelo C, De Luca A, Zelante T, Bonifazi P, Moretti S, Giovannini G, et al. Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease. J Immunol. 2009;183:4609-18 pubmed publisher
    ..We found that the production of PTX3 was delayed in CGD mice in infection but exogenous administration of PTX3 early in infection restored antifungal ..
  8. Salio M, Chimenti S, De Angelis N, Molla F, Maina V, Nebuloni M, et al. Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction. Circulation. 2008;117:1055-64 pubmed publisher
    ..The long pentraxin PTX3 is conserved in evolution, is expressed in the heart under inflammatory conditions, and is a candidate prognostic ..
  9. Scarchilli L, Camaioni A, Bottazzi B, Negri V, Doni A, Deban L, et al. PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion. J Biol Chem. 2007;282:30161-70 pubmed
    b>Pentraxin 3 (PTX3) and heavy chains (HCs) of inter-alpha-trypsin inhibitor (IalphaI) are essential for hyaluronan (HA) organization within the extracellular matrix of the cumulus oophorus, which is critical for in vivo oocyte ..

More Information

Publications70

  1. Doni A, Mantovani G, Porta C, Tuckermann J, Reichardt H, Kleiman A, et al. Cell-specific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells. J Biol Chem. 2008;283:29983-92 pubmed publisher
    PTX3 (prototypic long pentraxin 3) is a fluid phase pattern recognition receptor, which plays nonredundant roles in the resistance against diverse pathogens, in the assembly of a hyaluronic acid-rich extracellular matrix, and in female ..
  2. Bozza S, Bistoni F, Gaziano R, Pitzurra L, Zelante T, Bonifazi P, et al. Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation. Blood. 2006;108:3387-96 pubmed
    ..b>Pentraxin 3 (PTX3), a member of the long pentraxin family, successfully restored antifungal immunity in experimental ..
  3. He X, Han B, Bai X, Zhang Y, Cypel M, Mura M, et al. PTX3 as a potential biomarker of acute lung injury: supporting evidence from animal experimentation. Intensive Care Med. 2010;36:356-64 pubmed publisher
    Increased expression of long pentraxin 3 (PTX3) has been found in patients with sepsis or acute respiratory distress syndrome. Tissue factor (TF) activation plays an important role in the pathogenesis of acute lung injury...
  4. Souza D, Soares A, Pinho V, Torloni H, Reis L, Teixeira M, et al. Increased mortality and inflammation in tumor necrosis factor-stimulated gene-14 transgenic mice after ischemia and reperfusion injury. Am J Pathol. 2002;160:1755-65 pubmed
    TSG-14/PTX3 is a gene inducible by tumor necrosis factor (TNF)-alpha, interleukin-1 beta, and lipopolysaccharide in fibroblasts, macrophages, and endothelial cells...
  5. Inforzato A, Jaillon S, Moalli F, Barbati E, Bonavita E, Bottazzi B, et al. The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling. Tissue Antigens. 2011;77:271-82 pubmed publisher
    ..b>Pentraxin 3 (PTX3) is the prototypic member of the long pentraxins subfamily...
  6. Bottazzi B, Vouret Craviari V, Bastone A, De Gioia L, Matteucci C, Peri G, et al. Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component. J Biol Chem. 1997;272:32817-23 pubmed
    b>PTX3 is a prototypic long pentraxin consisting of a C-terminal 203-amino acid pentraxin-like domain coupled with an N-terminal 178-amino acid unrelated portion...
  7. Lee G, Lee T, Vilcek J. TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. J Immunol. 1993;150:1804-12 pubmed
    ..Our data strongly suggest that TSG-14 is a novel member of the pentaxin family of acute phase proteins. ..
  8. Norata G, Marchesi P, Pulakazhi Venu V, Pasqualini F, Anselmo A, Moalli F, et al. Deficiency of the long pentraxin PTX3 promotes vascular inflammation and atherosclerosis. Circulation. 2009;120:699-708 pubmed publisher
    ..in mice, which, in light of the cardioprotective effects recently reported, suggests a cardiovascular protective function of the long pentraxin 3 through the modulation of the immunoinflammatory balance in the cardiovascular system.
  9. Souza D, Amaral F, Fagundes C, Coelho F, Arantes R, Sousa L, et al. The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice. Am J Pathol. 2009;174:1309-18 pubmed publisher
    ..The long pentraxin PTX3 protein was originally described as able to be induced by pro-inflammatory stimuli in a variety of cell types...
  10. Moalli F, Doni A, Deban L, Zelante T, Zagarella S, Bottazzi B, et al. Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus. Blood. 2010;116:5170-80 pubmed publisher
    b>Pentraxin 3 (PTX3) is a soluble pattern recognition molecule playing a nonredundant role in resistance against Aspergillus fumigatus...
  11. Moalli F, Paroni M, Véliz Rodriguez T, Riva F, Polentarutti N, Bottazzi B, et al. The therapeutic potential of the humoral pattern recognition molecule PTX3 in chronic lung infection caused by Pseudomonas aeruginosa. J Immunol. 2011;186:5425-34 pubmed publisher
    ..aeruginosa from the airways. PTX3 is a soluble pattern recognition receptor that plays nonredundant roles in the innate immune response to fungi, ..
  12. Reading P, Bozza S, Gilbertson B, Tate M, Moretti S, Job E, et al. Antiviral activity of the long chain pentraxin PTX3 against influenza viruses. J Immunol. 2008;180:3391-8 pubmed
    ..In this study, we identify the long pentraxin PTX3 as a potent innate inhibitor of influenza viruses both in vitro and in vivo...
  13. Jaillon S, Mancuso G, Hamon Y, Beauvillain C, Cotici V, Midiri A, et al. Prototypic long pentraxin PTX3 is present in breast milk, spreads in tissues, and protects neonate mice from Pseudomonas aeruginosa lung infection. J Immunol. 2013;191:1873-82 pubmed publisher
    ..b>Pentraxin 3 (PTX3), the prototypic long pentraxin, is a soluble pattern recognition receptor involved in the initiation of ..
  14. Camozzi M, Rusnati M, Bugatti A, Bottazzi B, Mantovani A, Bastone A, et al. Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3. J Biol Chem. 2006;281:22605-13 pubmed
    Long-pentraxin 3 (PTX3) is a soluble pattern recognition receptor with non-redundant functions in inflammation and innate immunity...
  15. Salustri A, Garlanda C, Hirsch E, De Acetis M, Maccagno A, Bottazzi B, et al. PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization. Development. 2004;131:1577-86 pubmed
    b>PTX3 is a prototypic long pentraxin that plays a non-redundant role in innate immunity against selected pathogens and in female fertility...
  16. Diniz S, Nomizo R, Cisalpino P, Teixeira M, Brown G, Mantovani A, et al. PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages. J Leukoc Biol. 2004;75:649-56 pubmed
    b>Pentraxin 3 (PTX3) is a tumor necrosis factor and interleukin-1beta-stimulated gene that encodes a long PTX with proinflammatory activity...
  17. Garlanda C, Hirsch E, Bozza S, Salustri A, De Acetis M, Nota R, et al. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature. 2002;420:182-6 pubmed
    ..To investigate the in vivo function of the long pentraxin PTX3, we generated mice deficient in Ptx3 by homologous recombination...
  18. Dias A, Goodman A, Dos Santos J, Gomes R, Altmeyer A, Bozza P, et al. TSG-14 transgenic mice have improved survival to endotoxemia and to CLP-induced sepsis. J Leukoc Biol. 2001;69:928-36 pubmed
    Tumor necrosis factor-stimulated gene 14 (TSG-14)/PTX3 was identified originally as a TNF-alpha and IL-1beta-stimulated gene from normal, human foreskin fibroblasts and vascular endothelial cells, respectively...
  19. Introna M, Alles V, Castellano M, Picardi G, De Gioia L, Bottazzai B, et al. Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites. Blood. 1996;87:1862-72 pubmed
    ..Here we report genomic and cDNA cloning of mouse ptx3 (mptx3), a member of the pentraxin gene family and characterize its extrahepatic expression in vitro and in vivo...
  20. Pauwels N, Bracke K, Maes T, Van Pottelberge G, Garlanda C, Mantovani A, et al. Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner. Respir Res. 2010;11:134 pubmed publisher
    ..Since Pentraxin-3 (PTX3) is a tuner of inflammatory responses and is produced by endothelial and inflammatory cells upon stimuli such as ..
  21. Jaillon S, Moalli F, Ragnarsdottir B, Bonavita E, Puthia M, Riva F, et al. The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection. Immunity. 2014;40:621-32 pubmed publisher
    ..We investigated the role of the soluble pattern recognition molecule pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity, in UTIs...
  22. Han B, Ma X, Zhang J, Zhang Y, Bai X, Hwang D, et al. Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice. Lab Invest. 2012;92:1285-96 pubmed publisher
    ..The underlying mechanisms of SARS are still largely undefined. Long pentraxin PTX3, a humoral mediator of innate immunity, has been reported to have anti-viral effects...
  23. Chorny A, Casas Recasens S, Sintes J, Shan M, Polentarutti N, García Escudero R, et al. The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells. J Exp Med. 2016;213:2167-85 pubmed publisher
    b>Pentraxin 3 (PTX3) is a fluid-phase pattern recognition receptor of the humoral innate immune system with ancestral antibody-like properties but unknown antibody-inducing function...
  24. Zelante T, Wong A, Mencarelli A, Foo S, Zolezzi F, Lee B, et al. Impaired calcineurin signaling in myeloid cells results in downregulation of pentraxin-3 and increased susceptibility to aspergillosis. Mucosal Immunol. 2017;10:470-480 pubmed publisher
    ..These findings are relevant to the clinical management of transplant patients with severe Aspergillus infections. ..
  25. Nagai K, Aratani Y, Shibuya A, Yamagata K. Involvement of pentraxin-3 in anti-neutrophil cytoplasmic antibody production induced by aluminum salt adjuvant. Clin Exp Rheumatol. 2017;35:735-738 pubmed
    b>Pentraxin 3 (PTX3) is a multifunctional soluble factor. PTX3 can be involved in the regulation of vasculitis and is expressed in the cytoplasm of neutrophils...
  26. Ievoli E, Lindstedt R, Inforzato A, Camaioni A, Palone F, Day A, et al. Implication of the oligomeric state of the N-terminal PTX3 domain in cumulus matrix assembly. Matrix Biol. 2011;30:330-7 pubmed publisher
    b>Pentraxin 3 (PTX3) plays a key role in the formation of the hyaluronan-rich matrix of the cumulus oophorus surrounding ovulated eggs that is required for successful fertilization and female fertility...
  27. Lech M, Römmele C, Gröbmayr R, Eka Susanti H, Kulkarni O, Wang S, et al. Endogenous and exogenous pentraxin-3 limits postischemic acute and chronic kidney injury. Kidney Int. 2013;83:647-61 pubmed publisher
    Ischemia-reperfusion activates innate immunity and sterile inflammation, resulting in acute kidney injury. Since pentraxin 3 (PTX3) regulates multiple aspects of innate immunity and tissue inflammation, we tested whether PTX3 would be ..
  28. Bottazzi B, Santini L, Savino S, Giuliani M, Dueñas Díez A, Mancuso G, et al. Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant. PLoS ONE. 2015;10:e0120807 pubmed publisher
    Long pentraxin 3 (PTX3) is a non-redundant component of the humoral arm of innate immunity. The present study was designed to investigate the interaction of PTX3 with Neisseria meningitidis...
  29. Wallen A, Zetterström R, Solomin L, Arvidsson M, Olson L, Perlmann T. Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice. Exp Cell Res. 1999;253:737-46 pubmed
    ..We conclude that NURR1 plays a critical role in the maturation, migration, striatal target area innervation, and survival of differentiating mesencephalic DA cells. ..
  30. Yao G, Liang M, Liang N, Yin M, Lü M, Lian J, et al. MicroRNA-224 is involved in the regulation of mouse cumulus expansion by targeting Ptx3. Mol Cell Endocrinol. 2014;382:244-253 pubmed publisher
    ..In this study, miR-224 was found to target pentraxin 3 (Ptx3), a gene critical for cumulus expansion during ovulation...
  31. Job E, Bottazzi B, Short K, Deng Y, Mantovani A, Brooks A, et al. A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice. J Immunol. 2014;192:271-81 pubmed publisher
    The long pentraxin, pentraxin 3 (PTX3), can play beneficial or detrimental roles during infection and disease by modulating various aspects of the immune system...
  32. Lee E, Song D, Kim Y, Choi B, Chung Y, Kim S, et al. PTX3 stimulates osteoclastogenesis by increasing osteoblast RANKL production. J Cell Physiol. 2014;229:1744-52 pubmed publisher
    Pentraxin-3 (PTX3), also known as tumor necrosis factor-stimulated gene 14 (TSG-14), is produced by immune and vascular cells in response to pro-inflammatory signals and is therefore a multipotent inflammatory mediator...
  33. Chen J, Matzuk M, Zhou X, Lu C. Endothelial pentraxin 3 contributes to murine ischemic acute kidney injury. Kidney Int. 2012;82:1195-207 pubmed publisher
    ..DNA microarray analysis of ischemic kidneys from TLR4-sufficient and -deficient mice showed that pentraxin 3 (PTX3) was upregulated only on the former while transgenic knockout of PTX3 ameliorated acute kidney injury...
  34. Leali D, Inforzato A, Ronca R, Bianchi R, Belleri M, Coltrini D, et al. Long pentraxin 3/tumor necrosis factor-stimulated gene-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis. Arterioscler Thromb Vasc Biol. 2012;32:696-703 pubmed publisher
    ..a major proangiogenic inducer inhibited by the interaction with the soluble pattern recognition receptor long pentraxin 3 (PTX3)...
  35. Daigo K, Nakakido M, Ohashi R, Fukuda R, Matsubara K, Minami T, et al. Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis. Sci Signal. 2014;7:ra88 pubmed publisher
    b>Pentraxin 3 (PTX3), a member of the long pentraxin subfamily within the family of pentraxins, is a soluble pattern recognition molecule that functions in the innate immune system...
  36. Koh S, Shin S, Andrade M, Go R, Park S, Woo C, et al. Long pentraxin PTX3 mediates acute inflammatory responses against pneumococcal infection. Biochem Biophys Res Commun. 2017;493:671-676 pubmed publisher
    ..However, the role of the long pentraxin PTX3 in regulating pneumococcal infections is unknown...
  37. Doni A, Musso T, Morone D, Bastone A, Zambelli V, Sironi M, et al. An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode. J Exp Med. 2015;212:905-25 pubmed publisher
    b>Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule and a key component of the humoral arm of innate immunity...
  38. Garlanda C, Jaillon S, Doni A, Bottazzi B, Mantovani A. PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition. Curr Opin Immunol. 2016;38:39-44 pubmed publisher
    Innate immunity consists of a cellular and a humoral arm. PTX3 is a fluid patter recognition molecule (PRM) with antibody-like properties...
  39. Tranguch S, Chakrabarty A, Guo Y, Wang H, Dey S. Maternal pentraxin 3 deficiency compromises implantation in mice. Biol Reprod. 2007;77:425-32 pubmed
    Reduced litter sizes in mice missing pentraxin 3 (Ptx3) have been attributed to fertilization failure...
  40. Suzuki S, Shishido T, Funayama A, Netsu S, Ishino M, Kitahara T, et al. Long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction. PLoS ONE. 2013;8:e53133 pubmed publisher
    Left ventricular hypertrophy is enhanced by an inflammatory state and stimulation of various cytokines. Pentraxin 3 (PTX3) is rapidly produced in response to inflammatory signals, and high plasma PTX3 levels are seen in patients with ..
  41. Ronca R, Alessi P, Coltrini D, Di Salle E, Giacomini A, Leali D, et al. Long pentraxin-3 as an epithelial-stromal fibroblast growth factor-targeting inhibitor in prostate cancer. J Pathol. 2013;230:228-38 pubmed publisher
    ..The soluble pattern recognition receptor long pentraxin-3 (PTX3) acts as a natural FGF antagonist that binds FGF2 and FGF8b via its N-terminal domain...
  42. Altmeyer A, Klampfer L, Goodman A, Vilcek J. Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein. J Biol Chem. 1995;270:25584-90 pubmed
  43. Mantovani A, Garlanda C, Bottazzi B. Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity. Vaccine. 2003;21 Suppl 2:S43-7 pubmed
    b>Pentraxin 3 (PTX3) is the first long pentraxin identified...
  44. Shimizu T, Suzuki S, Sato A, Nakamura Y, Ikeda K, Saitoh S, et al. Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury. J Mol Cell Cardiol. 2015;89:306-13 pubmed publisher
    ..b>Pentraxin 3 (PTX3), produced in response to inflammatory signals, acts as a humoral arm of the innate immunity...
  45. Pilling D, Cox N, Vakil V, Verbeek J, Gomer R. The long pentraxin PTX3 promotes fibrocyte differentiation. PLoS ONE. 2015;10:e0119709 pubmed publisher
    ..SAP is a member of the pentraxin family of proteins that includes C-reactive protein (CRP; PTX1) and pentraxin-3 (PTX3)...
  46. Carrizzo A, Lenzi P, Procaccini C, Damato A, Biagioni F, Ambrosio M, et al. Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/Matrix Metalloproteinase-1 Pathway. Circulation. 2015;131:1495-505; discussion 1505 pubmed publisher
    b>Pentraxin 3 (PTX3), the prototype of long pentraxins, has been described to be associated with endothelial dysfunction in different cardiovascular disorders...
  47. Ishino M, Shishido T, Suzuki S, Katoh S, Sasaki T, Funayama A, et al. Deficiency of Long Pentraxin PTX3 Promoted Neointimal Hyperplasia after Vascular Injury. J Atheroscler Thromb. 2015;22:372-8 pubmed publisher
    b>Pentraxin 3 (PTX3) is a novel marker for the primary local activation of innate immunity and inflammatory responses...
  48. Bozza S, Campo S, Arseni B, Inforzato A, Ragnar L, Bottazzi B, et al. PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis. J Immunol. 2014;193:2340-8 pubmed publisher
    The long pentraxin 3 (PTX3) modulates different effector pathways involved in innate resistance to Aspergillus fumigatus, including complement activation or promotion of phagocytosis by interacting with Fc?Rs...
  49. Ketter P, Guentzel M, Schaffer B, Herzig M, Wu X, Montgomery R, et al. Severe Acinetobacter baumannii sepsis is associated with elevation of pentraxin 3. Infect Immun. 2014;82:3910-8 pubmed publisher
    ..In this study, we examined the role of PTX3, a soluble pattern recognition receptor with reported antimicrobial properties and stored within neutrophil ..
  50. Rudnicki A, Shivatzki S, Beyer L, Takada Y, Raphael Y, Avraham K. microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation. Hum Mol Genet. 2014;23:3138-46 pubmed publisher
    ..report that inflammatory stimuli in the inner ear induce activation of the innate immune system via miR-224 and pentraxin 3 (Ptx3). miR-224 is a transcriptional target of nuclear factor ?B, a key mediator of innate immunity...
  51. Foo S, Chen W, Taylor A, Sheng K, Yu X, Teng T, et al. Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation. PLoS Pathog. 2015;11:e1004649 pubmed publisher
    ..The immune responses underlying alphavirus virulence remain enigmatic. We found that pentraxin 3 (PTX3) was highly expressed in CHIKV and RRV patients during acute disease...
  52. Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, et al. PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer. Cell. 2015;160:700-714 pubmed publisher
    b>PTX3 is an essential component of the humoral arm of innate immunity, playing a nonredundant role in resistance against selected microbes and in the regulation of inflammation...
  53. Real J, Spilborghs G, Morato Marques M, de Moura R, Negri E, Camargo A, et al. Pentraxin 3 accelerates lung injury in high tidal volume ventilation in mice. Mol Immunol. 2012;51:82-90 pubmed publisher
    ..b>Pentraxin 3 (PTX3) is an acute phase protein with important regulatory functions in inflammation which has been found ..
  54. Kim J, Su S, Wang H, Cheng A, Cassady J, Lodato M, et al. Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell. 2011;9:413-9 pubmed publisher
    ..Thus, iDA neurons generated from abundant somatic fibroblasts by direct lineage reprogramming hold promise for modeling neurodegenerative disease and for cell-based therapies of PD. ..
  55. Ronca R, Giacomini A, Di Salle E, Coltrini D, Pagano K, Ragona L, et al. Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy. Cancer Cell. 2015;28:225-39 pubmed publisher
    ..The soluble pattern recognition receptor long-pentraxin 3 (PTX3) acts as a multi-FGF antagonist...
  56. Paeschke A, Possehl A, Klingel K, Voss M, Voss K, Kespohl M, et al. The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3. Eur J Immunol. 2016;46:619-33 pubmed publisher
    ..immunoproteasome-dependent proteolysis, we investigated the function and regulation of the soluble PRR Pentraxin3 (PTX3)...
  57. Lech M, Römmele C, Kulkarni O, Susanti H, Migliorini A, Garlanda C, et al. Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus. PLoS ONE. 2011;6:e20118 pubmed publisher
    The long pentraxin PTX3 has multiple roles in innate immunity. For example, PTX3 regulates C1q binding to pathogens and dead cells and regulates their uptake by phagocytes. It also inhibits P-selectin-mediated recruitment of leukocytes...
  58. Cappuzzello C, Doni A, Dander E, Pasqualini F, Nebuloni M, Bottazzi B, et al. Mesenchymal Stromal Cell-Derived PTX3 Promotes Wound Healing via Fibrin Remodeling. J Invest Dermatol. 2016;136:293-300 pubmed publisher
    ..Because a nonredundant role of pentraxin 3 (PTX3) in tissue repair and remodeling has been recently described, here we sought to determine whether MSC-..
  59. Norata G, Marchesi P, Pirillo A, Uboldi P, Chiesa G, Maina V, et al. Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells. Arterioscler Thromb Vasc Biol. 2008;28:925-31 pubmed publisher
    ..pentraxin superfamily, such as C-reactive protein (CRP), serum amyloid P component protein (SAP), and the long pentraxin 3 (PTX3) by HDL in human endothelial cells...
  60. Wang L, Cano M, Datta S, Wei H, Ebrahimi K, Gorashi Y, et al. Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation. J Pathol. 2016;240:495-506 pubmed publisher
    ..b>Pentraxin 3 (PTX3), an essential component of the innate immunity system that plays a non-redundant role in controlling ..
  61. Matsuda M, Hirata M. Phospholipase C-related but catalytically inactive proteins regulate ovarian follicle development. J Biol Chem. 2017;292:8369-8380 pubmed publisher
    ..Female DKO mice had higher serum levels of insulin, testosterone, and uncarboxylated osteocalcin, which, together with reduced fertility, are reminiscent of polycystic ovary syndrome in humans. ..