Genomes and Genes
Gene Symbol: Ptpre
Description: protein tyrosine phosphatase, receptor type, E
Alias: PTPe, PTPepsilon, RPTPepsilon, receptor-type tyrosine-protein phosphatase epsilon, R-PTP-epsilon, protein-tyrosine phosphatase epsilon
- Elson A, Leder P. Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. Proc Natl Acad Sci U S A. 1995;92:12235-9 pubmed..PTP epsilon-cytoplasmic is therefore the initial example to our knowledge of a nontransmembranal protein-tyrosine phosphatase that contains two tandem of catalytic domains. ..
- Gil Henn H, Elson A. Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells. J Biol Chem. 2003;278:15579-86 pubmed..such a function, as cells from mammary epithelial tumors induced by activated Neu in mice genetically lacking RPTPepsilon appeared morphologically less transformed and exhibited reduced proliferation...
- Rousso Noori L, Knobler H, Levy Apter E, Kuperman Y, Neufeld Cohen A, Keshet Y, et al. Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner. Cell Metab. 2011;13:562-72 pubmed publisher..RPTPe is therefore an inhibitor of hypothalamic leptin signaling in vivo, and provides controlled negative-feedback regulation of this pathway following its activation. ..
- Mukouyama Y, Kuroyanagi H, Shirasawa T, Tomoda T, Saffen D, Oishi M, et al. Induction of protein tyrosine phosphatase epsilon transcripts during NGF-induced neuronal differentiation of PC12D cells and during the development of the cerebellum. Brain Res Mol Brain Res. 1997;50:230-6 pubmedWe have investigated a possible role played by protein tyrosine phosphatase epsilon (PTPepsilon), which was recently cloned and predominantly expressed in brain, in neural differentiation and function...
- Gil Henn H, Volohonsky G, Toledano Katchalski H, Gandre S, Elson A. Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control. Oncogene. 2000;19:4375-84 pubmedTwo protein forms of tyrosine phosphatase epsilon (PTPepsilon) are known - receptor-like (tm-PTPepsilon) and non receptor-like (cyt-PTPepsilon), with each form possessing unique tissue-specific expression patterns, subcellular ..
- Peretz A, Gil Henn H, Sobko A, Shinder V, Attali B, Elson A. Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. EMBO J. 2000;19:4036-45 pubmedb>Protein tyrosine phosphatase epsilon (PTP epsilon) is strongly expressed in the nervous system; however, little is known about its physiological role...
- De Franceschi L, Biondani A, Carta F, Turrini F, Laudanna C, Deana R, et al. PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells. Proteomics. 2008;8:4695-708 pubmed publisher..Here, we report that red blood cells (RBCs) from mice lacking PTPepsilon (Ptpre(-/-)) exhibit (i) abnormal morphology; (ii) increased Ca(2+)-activated-K(+) channel activity, which was ..
- Elson A, Kozak C, Morton C, Weremowicz S, Leder P. The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. Genomics. 1996;31:373-5 pubmedWe have mapped the mouse protein tyrosine phosphatase epsilon (PTP epsilon, gene symbol Ptpre) gene to the distal region of chromosome 7 by linkage analysis using two sets of multilocus genetic crosses...
- Schmidt A, Rutledge S, Endo N, Opas E, Tanaka H, Wesolowski G, et al. Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate. Proc Natl Acad Sci U S A. 1996;93:3068-73 pubmed..1.3.48), called PTPepsilon. Using osteoclast-like cells generated by coculturing mouse bone marrow cells with mouse calvaria osteoblasts, ..
- Schepens J, Zeeuwen P, Wieringa B, Hendriks W. Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain. Mol Biol Rep. 1992;16:241-8 pubmed..Phylogenetic reconstruction displayed considerable differences in mutation rates for closely related PTPases. ..
- Tiran Z, Peretz A, Sines T, Shinder V, Sap J, Attali B, et al. Tyrosine phosphatases epsilon and alpha perform specific and overlapping functions in regulation of voltage-gated potassium channels in Schwann cells. Mol Biol Cell. 2006;17:4330-42 pubmed..Functional interrelationships between PTPepsilon and PTPalpha and the mechanisms by which they regulate K+ channels and Src were analyzed in vivo in mice lacking ..
- Finkelshtein E, Lotinun S, Levy Apter E, Arman E, den Hertog J, Baron R, et al. Protein tyrosine phosphatases ? and ? perform nonredundant roles in osteoclasts. Mol Biol Cell. 2014;25:1808-18 pubmed publisher..express the receptor-type PTP ? (RPTPa), which is absent from podosomes, and the nonreceptor form of PTP ? (cyt-PTPe), which is present in these structures...
- Levy Apter E, Finkelshtein E, Vemulapalli V, Li S, Bedford M, Elson A. Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase Ïµ in osteoclasts. J Biol Chem. 2014;289:36048-58 pubmed publisherThe non-receptor isoform of protein-tyrosine phosphatase Ïµ (cyt-PTPe) supports adhesion of bone-resorbing osteoclasts by activating Src downstream of integrins...
- Kraut Cohen J, Muller W, Elson A. Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling. J Biol Chem. 2008;283:4612-21 pubmed..Protein-tyrosine phosphatase epsilon (PTPepsilon) performs two potentially opposing roles: in Neu-induced mammary tumors, PTPepsilon activates Src downstream of ..
- Branco M, King M, Perez García V, Bogutz A, Caley M, Fineberg E, et al. Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 2016;36:152-63 pubmed publisher..Our results reveal that maternal DNA methylation controls multiple differentiation-related and physiological processes in trophoblast via both imprinting-dependent and -independent mechanisms. ..
- Akimoto M, Mishra K, Lim K, Tani N, Hisanaga S, Katagiri T, et al. Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses. Scand J Immunol. 2009;69:401-11 pubmed publisher..Here, we show that protein tyrosine phosphatase epsilon (PTPepsilon; Ptpre) plays key regulatory roles during mast-cell activation mediated by the high-..
- Granot Attas S, Elson A. Protein tyrosine phosphatase epsilon activates Yes and Fyn in Neu-induced mammary tumor cells. Exp Cell Res. 2004;294:236-43 pubmedThe receptor-type form of protein tyrosine phosphatase epsilon (RPTP) is among the few tyrosine phosphatases that can support the transformed phenotype of tumor cells...
- Ohyama K, Ikeda E, Kawamura K, Maeda N, Noda M. Receptor-like protein tyrosine phosphatase zeta/RPTP beta is expressed on tangentially aligned neurons in early mouse neocortex. Brain Res Dev Brain Res. 2004;148:121-7 pubmed..These results indicate that PTPzeta is a useful marker for early-generated neocortical neurons in mice: Cajal-Retzius neurons as well as the subplate neurons. ..
- Huang K, Sommers C, Grinberg A, Kozak C, Love P. Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow. Oncogene. 1996;13:1567-73 pubmed..The high level expression of PTP-K1 mRNA in bone marrow suggests that PTP-K1 may be involved in signal transduction in growth and differentiation of hematopoietic cells. ..
- Watanabe T, Mukouyama Y, Rhodes M, Thomas M, Kume T, Oishi M. Chromosomal location of murine protein tyrosine phosphatase (Ptprj and Ptpre) genes. Genomics. 1995;29:793-5 pubmed..the gene for PTP beta 2, Ptprj, is located in the middle region of chromosome 2, and the gene for PTP epsilon, Ptpre, was mapped in the vicinity of the imprinted regions in the distal part of chromosome 7...
- Kaneko Y, Takano S, Okumura K, Takenawa J, Higashituji H, Fukumoto M, et al. Identification of protein tyrosine phosphatases expressed in murine male germ cells. Biochem Biophys Res Commun. 1993;197:625-31 pubmed
- Hendriks W, Schepens J, Brugman C, Zeeuwen P, Wieringa B. A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain. Biochem J. 1995;305 ( Pt 2):499-504 pubmed..This suggests a role for PTP-SL in cell-cell signalling processes in the brain. ..
- Aicher A, Kollet O, Heeschen C, Liebner S, Urbich C, Ihling C, et al. The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche. Circ Res. 2008;103:796-803 pubmed publisher..of vasculogenic progenitors required the presence of functionally active osteoclasts, as demonstrated in PTPepsilon-deficient mice with defective osteoclast function...
- Aga Mizrachi S, Brutman Barazani T, Jacob A, Bak A, Elson A, Sampson S. Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle. Endocrinology. 2008;149:605-14 pubmed..In this study, we examined the possibility that cytosolic PTPepsilon (cytPTPepsilon) is involved in IR signaling. Studies were performed on L6 skeletal muscle cells...