Gene Symbol: Ptpre
Description: protein tyrosine phosphatase, receptor type, E
Alias: PTPe, PTPepsilon, RPTPepsilon, receptor-type tyrosine-protein phosphatase epsilon, R-PTP-epsilon, protein-tyrosine phosphatase epsilon
Species: mouse
Products:     Ptpre

Top Publications

  1. Yi T, Cleveland J, Ihle J. Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991;78:2222-8 pubmed
    ..Further characterization of these novel PTPs will provide insights into the growth regulation of hematopoietic cells. ..
  2. Elson A. Protein tyrosine phosphatase epsilon increases the risk of mammary hyperplasia and mammary tumors in transgenic mice. Oncogene. 1999;18:7535-42 pubmed
    ..We have previously shown that the transmembranal form of PTPase Epsilon (PTPepsilon) is upregulated in mouse mammary tumors initiated specifically by ras or neu, suggesting that PTPepsilon may ..
  3. Toledano Katchalski H, Tiran Z, Sines T, Shani G, Granot Attas S, den Hertog J, et al. Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon. Mol Cell Biol. 2003;23:5460-71 pubmed
    ..Furthermore, dimerization can be mediated by the D2 domain and does not strictly require the presence of PTP extracellular domains. ..
  4. Horvat Bröcker A, Reinhard J, Illes S, Paech T, Zoidl G, Harroch S, et al. Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina. Neuroscience. 2008;152:618-45 pubmed publisher
    ..Subsequently, the expression patterns of RPTPkappa, RPTPJ, RPTPRR, RPTPsigma, RPTPepsilon and RPTPgamma in the retina from embryonic stages to adult were analyzed in detail using quantitative real-time-..
  5. Elson A, Leder P. Protein-tyrosine phosphatase epsilon. An isoform specifically expressed in mouse mammary tumors initiated by v-Ha-ras OR neu. J Biol Chem. 1995;270:26116-22 pubmed
  6. Granot Attas S, Luxenburg C, Finkelshtein E, Elson A. Protein tyrosine phosphatase epsilon regulates integrin-mediated podosome stability in osteoclasts by activating Src. Mol Biol Cell. 2009;20:4324-34 pubmed publisher
    The nonreceptor isoform of tyrosine phosphatase epsilon (cyt-PTPe) supports osteoclast adhesion and activity in vivo, leading to increased bone mass in female mice lacking PTPe (EKO mice)...
  7. Sines T, Granot Attas S, Weisman Welcher S, Elson A. Association of tyrosine phosphatase epsilon with microtubules inhibits phosphatase activity and is regulated by the epidermal growth factor receptor. Mol Cell Biol. 2007;27:7102-12 pubmed
    ..We demonstrate that PTPepsilon associates with microtubules in vivo and is inhibited by them in a noncompetitive manner...
  8. Kollet O, Dar A, Shivtiel S, Kalinkovich A, Lapid K, Sztainberg Y, et al. Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med. 2006;12:657-64 pubmed
    ..circulation in a CXCR4- and MMP-9-dependent manner; however, RANKL did not induce mobilization in young female PTPepsilon-knockout mice with defective OCL bone adhesion and resorption...
  9. Chiusaroli R, Knobler H, Luxenburg C, Sanjay A, Granot Attas S, Tiran Z, et al. Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo. Mol Biol Cell. 2004;15:234-44 pubmed
    ..We demonstrate that young (<12 weeks) female mice lacking tyrosine phosphatase epsilon (PTPepsilon) exhibit increased trabecular bone mass due to cell-specific defects in osteoclast function...

More Information


  1. Elson A, Leder P. Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. Proc Natl Acad Sci U S A. 1995;92:12235-9 pubmed
    ..PTP epsilon-cytoplasmic is therefore the initial example to our knowledge of a nontransmembranal protein-tyrosine phosphatase that contains two tandem of catalytic domains. ..
  2. Gil Henn H, Elson A. Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells. J Biol Chem. 2003;278:15579-86 pubmed
    ..such a function, as cells from mammary epithelial tumors induced by activated Neu in mice genetically lacking RPTPepsilon appeared morphologically less transformed and exhibited reduced proliferation...
  3. Rousso Noori L, Knobler H, Levy Apter E, Kuperman Y, Neufeld Cohen A, Keshet Y, et al. Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner. Cell Metab. 2011;13:562-72 pubmed publisher
    ..RPTPe is therefore an inhibitor of hypothalamic leptin signaling in vivo, and provides controlled negative-feedback regulation of this pathway following its activation. ..
  4. Mukouyama Y, Kuroyanagi H, Shirasawa T, Tomoda T, Saffen D, Oishi M, et al. Induction of protein tyrosine phosphatase epsilon transcripts during NGF-induced neuronal differentiation of PC12D cells and during the development of the cerebellum. Brain Res Mol Brain Res. 1997;50:230-6 pubmed
    We have investigated a possible role played by protein tyrosine phosphatase epsilon (PTPepsilon), which was recently cloned and predominantly expressed in brain, in neural differentiation and function...
  5. Gil Henn H, Volohonsky G, Toledano Katchalski H, Gandre S, Elson A. Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control. Oncogene. 2000;19:4375-84 pubmed
    Two protein forms of tyrosine phosphatase epsilon (PTPepsilon) are known - receptor-like (tm-PTPepsilon) and non receptor-like (cyt-PTPepsilon), with each form possessing unique tissue-specific expression patterns, subcellular ..
  6. Peretz A, Gil Henn H, Sobko A, Shinder V, Attali B, Elson A. Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. EMBO J. 2000;19:4036-45 pubmed
    b>Protein tyrosine phosphatase epsilon (PTP epsilon) is strongly expressed in the nervous system; however, little is known about its physiological role...
  7. De Franceschi L, Biondani A, Carta F, Turrini F, Laudanna C, Deana R, et al. PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells. Proteomics. 2008;8:4695-708 pubmed publisher
    ..Here, we report that red blood cells (RBCs) from mice lacking PTPepsilon (Ptpre(-/-)) exhibit (i) abnormal morphology; (ii) increased Ca(2+)-activated-K(+) channel activity, which was ..
  8. Elson A, Kozak C, Morton C, Weremowicz S, Leder P. The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. Genomics. 1996;31:373-5 pubmed
    We have mapped the mouse protein tyrosine phosphatase epsilon (PTP epsilon, gene symbol Ptpre) gene to the distal region of chromosome 7 by linkage analysis using two sets of multilocus genetic crosses...
  9. Schmidt A, Rutledge S, Endo N, Opas E, Tanaka H, Wesolowski G, et al. Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate. Proc Natl Acad Sci U S A. 1996;93:3068-73 pubmed
    ..1.3.48), called PTPepsilon. Using osteoclast-like cells generated by coculturing mouse bone marrow cells with mouse calvaria osteoblasts, ..
  10. Reinhard J, Horvat Bröcker A, Illes S, Zaremba A, Knyazev P, Ullrich A, et al. Protein tyrosine phosphatases expression during development of mouse superior colliculus. Exp Brain Res. 2009;199:279-97 pubmed publisher
  11. Schepens J, Zeeuwen P, Wieringa B, Hendriks W. Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain. Mol Biol Rep. 1992;16:241-8 pubmed
    ..Phylogenetic reconstruction displayed considerable differences in mutation rates for closely related PTPases. ..
  12. Ebner Bennatan S, Patrich E, Peretz A, Kornilov P, Tiran Z, Elson A, et al. Multifaceted modulation of K+ channels by protein-tyrosine phosphatase ? tunes neuronal excitability. J Biol Chem. 2012;287:27614-28 pubmed publisher
  13. Tiran Z, Peretz A, Sines T, Shinder V, Sap J, Attali B, et al. Tyrosine phosphatases epsilon and alpha perform specific and overlapping functions in regulation of voltage-gated potassium channels in Schwann cells. Mol Biol Cell. 2006;17:4330-42 pubmed
    ..Functional interrelationships between PTPepsilon and PTPalpha and the mechanisms by which they regulate K+ channels and Src were analyzed in vivo in mice lacking ..
  14. Finkelshtein E, Lotinun S, Levy Apter E, Arman E, den Hertog J, Baron R, et al. Protein tyrosine phosphatases ? and ? perform nonredundant roles in osteoclasts. Mol Biol Cell. 2014;25:1808-18 pubmed publisher the receptor-type PTP ? (RPTPa), which is absent from podosomes, and the nonreceptor form of PTP ? (cyt-PTPe), which is present in these structures...
  15. Levy Apter E, Finkelshtein E, Vemulapalli V, Li S, Bedford M, Elson A. Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts. J Biol Chem. 2014;289:36048-58 pubmed publisher
    The non-receptor isoform of protein-tyrosine phosphatase ϵ (cyt-PTPe) supports adhesion of bone-resorbing osteoclasts by activating Src downstream of integrins...
  16. Kraut Cohen J, Muller W, Elson A. Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling. J Biol Chem. 2008;283:4612-21 pubmed
    ..Protein-tyrosine phosphatase epsilon (PTPepsilon) performs two potentially opposing roles: in Neu-induced mammary tumors, PTPepsilon activates Src downstream of ..
  17. Wang P, Wang J, Xiao Z, Pallen C. Protein-tyrosine phosphatase alpha acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelination. J Biol Chem. 2009;284:33692-702 pubmed publisher
  18. Branco M, King M, Perez García V, Bogutz A, Caley M, Fineberg E, et al. Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 2016;36:152-63 pubmed publisher
    ..Our results reveal that maternal DNA methylation controls multiple differentiation-related and physiological processes in trophoblast via both imprinting-dependent and -independent mechanisms. ..
  19. Akimoto M, Mishra K, Lim K, Tani N, Hisanaga S, Katagiri T, et al. Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses. Scand J Immunol. 2009;69:401-11 pubmed publisher
    ..Here, we show that protein tyrosine phosphatase epsilon (PTPepsilon; Ptpre) plays key regulatory roles during mast-cell activation mediated by the high-..
  20. Granot Attas S, Elson A. Protein tyrosine phosphatase epsilon activates Yes and Fyn in Neu-induced mammary tumor cells. Exp Cell Res. 2004;294:236-43 pubmed
    The receptor-type form of protein tyrosine phosphatase epsilon (RPTP) is among the few tyrosine phosphatases that can support the transformed phenotype of tumor cells...
  21. Ohyama K, Ikeda E, Kawamura K, Maeda N, Noda M. Receptor-like protein tyrosine phosphatase zeta/RPTP beta is expressed on tangentially aligned neurons in early mouse neocortex. Brain Res Dev Brain Res. 2004;148:121-7 pubmed
    ..These results indicate that PTPzeta is a useful marker for early-generated neocortical neurons in mice: Cajal-Retzius neurons as well as the subplate neurons. ..
  22. Huang K, Sommers C, Grinberg A, Kozak C, Love P. Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow. Oncogene. 1996;13:1567-73 pubmed
    ..The high level expression of PTP-K1 mRNA in bone marrow suggests that PTP-K1 may be involved in signal transduction in growth and differentiation of hematopoietic cells. ..
  23. Watanabe T, Mukouyama Y, Rhodes M, Thomas M, Kume T, Oishi M. Chromosomal location of murine protein tyrosine phosphatase (Ptprj and Ptpre) genes. Genomics. 1995;29:793-5 pubmed
    ..the gene for PTP beta 2, Ptprj, is located in the middle region of chromosome 2, and the gene for PTP epsilon, Ptpre, was mapped in the vicinity of the imprinted regions in the distal part of chromosome 7...
  24. Kaneko Y, Takano S, Okumura K, Takenawa J, Higashituji H, Fukumoto M, et al. Identification of protein tyrosine phosphatases expressed in murine male germ cells. Biochem Biophys Res Commun. 1993;197:625-31 pubmed
  25. Hendriks W, Schepens J, Brugman C, Zeeuwen P, Wieringa B. A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain. Biochem J. 1995;305 ( Pt 2):499-504 pubmed
    ..This suggests a role for PTP-SL in cell-cell signalling processes in the brain. ..
  26. Aicher A, Kollet O, Heeschen C, Liebner S, Urbich C, Ihling C, et al. The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche. Circ Res. 2008;103:796-803 pubmed publisher
    ..of vasculogenic progenitors required the presence of functionally active osteoclasts, as demonstrated in PTPepsilon-deficient mice with defective osteoclast function...
  27. Aga Mizrachi S, Brutman Barazani T, Jacob A, Bak A, Elson A, Sampson S. Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle. Endocrinology. 2008;149:605-14 pubmed
    ..In this study, we examined the possibility that cytosolic PTPepsilon (cytPTPepsilon) is involved in IR signaling. Studies were performed on L6 skeletal muscle cells...